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Assessing the diagnostic value of a potential screening tool for detecting early interstitial lung disease at the onset of inflammatory rheumatic diseases

Arthritis Research & Therapy volume 24, Article number: 107 (2022) Cite this article

Abstract

Background

Interstitial lung disease (ILD) is a severe pulmonary complication in inflammatory rheumatic diseases (IRD) and associated with significantly increased morbidity and mortality. That is why ILD screening at a very early stage, at the onset of IRD, is essential. The objective of the present study was to evaluate the diagnostic value and utility of a stepwise approach as a potential ILD screening tool in patients with newly diagnosed IRD.

Methods

Consecutively, 167 IRD patients were enrolled. To homogenize the study cohort, an age and gender matching was performed. The case-control study included 126 patients with new onset of IRD (mainly connective tissue diseases [CTD], small vessel vasculitis, and myositis). We applied a stepwise screening algorithm in which all patients underwent pulmonary function testing (PFT) and/or additional chest radiography. If there was at least one abnormal finding, pulmonary high-resolution computed tomography (HRCT) was subsequently performed.

Results

With our stepwise diagnostic approach, we identified 63 IRD patients with ILD (ILD group) and 63 IRD patients without ILD (non-ILD group). A reduced diffusing capacity for carbon monoxide (DLCO) < 80% showed a sensitivity of 83.6% and a specificity of 45.8% compared to chest X-ray with 64.2% and 73.6%, respectively, in detecting ILD. The combination of reduced DLCO and chest X-ray revealed a sensitivity of 95.2% and a specificity of 38.7%. The highest sensitivity (95.2%) and specificity (77.4%) were observed for the combination of reduced DLCO, chest X-ray, and pulmonary HRCT. The most common pulmonary abnormalities on HRCT were ground-glass opacities (GGO; 36.5%), followed by non-specific interstitial pneumonia (NSIP; 31.8%) and usual interstitial pneumonia (UIP; 9.5%).

Conclusions

The combination of reduced DLCO (< 80%), chest X-ray, and pulmonary HRCT yielded the highest sensitivity and specificity in detecting ILD at the onset of IRD. Therefore, this stepwise approach could be a new screening algorithm to identify IRD patients with pulmonary involvement already at the time of the initial IRD diagnosis.

Introduction

Based on growing insights into the immunopathological pathways, rheumatology has changed over the years from a discipline that focused mainly on joint diseases to a wide spectrum of inflammatory rheumatic diseases (IRD), encompassing inflammatory joint diseases, connective tissue diseases (CTD), and myositis as well as vasculitis [1,2,3,4,5,6].

Many IRD present with complex clinical pictures, involving other tissues, of which the lungs are a frequent target of autoimmune-mediated injury (10–65% depending on the disease) [7,8,9,10,11,12]. Among many diverse types of IRD-associated lung involvements, the most common is interstitial lung disease (ILD) which clinical manifestations and severity can vary from subclinical abnormality to dyspnea, respiratory failure, and death [13,14,15]. ILD in IRD is associated with a significant morbidity [16, 17] and, for example, the leading cause of mortality in SSc patients, accounting for approximately 35% of SSc-related deaths [18] and a mortality risk nearly three times greater than SSc patients without ILD [19].

Therefore, effective screening to improve the early diagnosis of IRD patients with associated ILD is of paramount importance [13, 14]. Most published data relate to the detection of ILD in the presence of longer-established IRD (e.g., within the first 3–5 years after SSc diagnosis) with minimal standardized screening recommendations for ILD in patients with CTD [20]. Given the poor prognosis and the availability of a new therapeutic option (nintedanib) in pulmonary fibrosis in rheumatic systemic diseases, an organ screening should be performed much earlier—at the time of the initial diagnosis of an IRD—to detect pulmonary involvement. As shown in various studies, 54 to 65% of patients with SSc or dermatomyositis presented with lung involvement at the onset of their disease [8, 21]. However, only less than half of SSc patients underwent a basic organ screening at the time of initial diagnosis, as shown in a survey with members of the Scleroderma Society of Canada [22].

Therefore, the aim of our study was to determine the value of a stepwise diagnostic screening approach for ILD in IRD. All patients with an initial diagnosis of IRD underwent pulmonary function testing (PFT) and chest radiography. In case of at least one pathologic finding, a pulmonary high-resolution computed tomography (HRCT) was subsequently performed.

Patients and methods

Patients

Consecutively, 167 patients (127 women and 40 men, mean age 54.7 ± 15.3 years) were maintained at the onset of IRD between 2005 and 2020. All participants were examined and treated at the Department of Rheumatology, University Hospital Jena/Germany. Based on the diagnostic procedure, 68 patients with ILD and 99 patients without ILD were identified.

Based on the heterogeneity concerning age and sex of the study cohort, an age and gender matching was performed to homogenize and standardized the study cohort using the concept of a case-control study. The case-control study encompasses 126 patients (ILD group n = 63, non-ILD group n = 63).

All patients were diagnosed with newly IRD on the basis of a comprehensive rheumatologic assessment; no patient has been previously evaluated for ILD. The exclusion criteria were defined as (I) already known diagnosed IRD, (II) immunosuppressive treatment, or (III) antifibrotic treatment. There were no exclusion criteria for other pulmonary pre-existing diseases. The diagnosis of ILD in IRD was performed in a consensus panel by rheumatologists, pulmonologists, and radiologists using the clinical, laboratory, and imaging findings.

IRD encompassed connective tissue disease ([CTD], systemic lupus erythematosus [SLE], SSc, Sjögren’s syndrome, Sharp syndrome), small vessel vasculitis (granulomatosis with polyangiitis [GPA], microscopic polyangiitis [MPA], eosinophilic granulomatosis with polyangiitis [EGPA]) and myositis (dermatomyositis, polymyositis, necrotizing myositis, Jo1-anti-synthetase syndrome).

Methods

Medical history and clinical examination

A detailed medical history was taken in all patients with regard to clinical ILD symptoms including cough, dyspnea, and sputum. On physical examination, lung auscultation focussed on inspiratory crepitations (sclerosiphonia). In addition, pulmonary comorbidities (chronic obstructive pulmonary disease [COPD] and severe emphysema) and smoking status were documented.

PFT and chest X-ray

All patients underwent PFT with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity (TLC), transfer factor of the lung for carbon monoxide (TLCO), and diffusing capacity for carbon monoxide (DLCO). DCLO < 80% was considered as a reduced diffusing capacity. In addition, a chest X-ray was also performed.

HRCT

Patients with at least one suspicious finding in PFT (in case of DLCO < 80%) or chest X-ray (findings reported as suspicious for ILD by the radiologist) underwent pulmonary HRCT, using the standard protocol of the manufacturers. All scans were analyzed with respect to parenchymal changes (including ground-glass opacities [GGO] and granuloma/proliferations) in lung window images and evaluated in collaboration with two chest radiologists and a rheumatologist according to the recommendations/criteria by the American Thoracic Society/European Respiratory Society and the Fleischner Society White Paper [23,24,25].

Additionally, each chest X-ray and HR-CT were scored by a radiologist and a rheumatologist in consensus. In the case of ambiguity, a second radiologist reviewed the radiographs or HRCT. The radiologists were experts in ILD and each has experience > 15 years.

Statistical analysis

The data were documented in Microsoft Excel® (Microsoft Windows, Redmond, WA, USA). The statistical analysis was performed by IBM SPSS Statistics 25 (IBM SPSS Statistics, Chicago, IL, USA, for Windows). The statistical analysis included the following steps:

  1. I.

    At the beginning, a case-control matching was performed with the support of IBM SPSS Statistics 25. It was matched by gender and age. The tolerance/fuzz factor for age was 40.

  2. II.

    In the following, a descriptive statistic was used to evaluate the data.

  3. III.

    The sensitivity and specificity were verified by crosstabs and receiver operating characteristic (ROC) curve analysis. Considering that it is a case-control study, the prevalence independent positive and negative likelihood ratio (LR) was used. The area under the curve (AUC) was used to summarize the diagnostic accuracy of the evaluated diagnostic test. According to Hosmer, a value of 0.5 suggest no discrimination by the test, 0.7 to 0.8 is acceptable, 0.8 to 0.9 is excellent, and > 0,9 is considered outstanding [26].

  4. IV.

    Moreover, the following statistical tests were used to verify the differences and to objectify correlations: t-test (t) and Pearson’s chi-squared test (χ2) for independent samples. As correlation coefficients: Cramer’s V as a measure of the strength of the relationship between more than two dichotomous characteristics. According to Cohen, for the correlation coefficient (Cramer’s V): small effect size 0.1 to < 0.3, medium effect size 0.3 to < 0.5, and large effect size ≥ 0.5 [27]. A P < 0.05 was considered as statistically significant.

  5. V.

    To verify the results of the case-control study on a representative clinical collective, the sensitivity, specificity, positive predictive value, and negative predictive value were evaluated using ROC curve analysis on 167 consecutive IRD patients.

Results

Baseline characteristics (see Tables 1 and 2)

The study included 126 patients with the initial diagnosis of IRD. With our stepwise diagnostic approach, we identified 63 IRD patients with ILD and 63 IRD patients without ILD (non-ILD group). Due to case-control matching, there were no significant differences in age, gender, or the performance of PFT or chest X-ray. However, in the ILD group, there were significant more participants with small vessel vasculitis (ILD group: N = 16 [25.4%]; non-ILD group: N = 3 [4.8%]) and myositis (ILD group: N = 12 [19.0%]; non-ILD group: N = 5 [7.9%]). Cramer’s V shows a medium effect size.

Table 1 Baseline characteristics of the ILD group and non-ILD group
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Table 2 Distribution of IRD in the ILD group and non-ILD group
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In total, 60.3% (N = 76) of patients showed pulmonary symptoms, but there was no significant difference regarding symptomatic and asymptomatic patients (P = 0.069) (see Table 1). Furthermore, ILD patients presented with a significant higher rate of dyspnea (57.1%) and sclerosiphonia (31.7%), compared to non-ILD patients (dyspnea 34.9%, sclerosiphonia 7.9%, P < 0.05).

Regarding pulmonary comorbidities, there was no significant difference in COPD (ILD group n = 3, non-ILD group n = 1, p = n. s.) and emphysema (ILD group n = 2, Non-ILD group n = 3, P = n. s.). There was also no significant difference for smoking status (active smoker: ILD group n = 10, non-ILD group n = 11, P = n. s.; ex-smoker: ILD group n = 18, non-ILD group n = 8, P = n. s.) or pack years (ILD group 21.7 ± 12.3, non-ILD group 22.7 ± 13.9, P = n. s.).

PFT (see Tables 3 and 4)

For DLCO < 80%, the sensitivity and specificity for the detection of ILD in patients with IRD were 83.6% and 45.8%, respectively. DLCO < 70% revealed a sensitivity and specificity of 67.2% and 76.3%, respectively. Regarding FVC < 80%, FEV1 < 80%, TLC < 80%, and TLCO < 80%, a lower sensitivity with a higher specificity was observed. The highest area under the curve (AUC) was achieved by DLCO (0.772). Moreover, the lowest negative LR was observed by DLCO < 80% (0.36).

Table 3 Pulmonary function tests, chest X-ray, HRCT, and origin of pathologies in HRCT, differentiated regarding the ILD group and non-ILD group
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Table 4 Area under the curves (AUC), sensitivity, specificity, positive likelihood ratio (LR+), and negative likelihood ratio (LR−) for different cutoffs in the detection of lung involvement in IRD patients by different examinations in the ILD group
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Regarding the differentiation of IRD subgroups, the highest sensitivity with 91.7% and specificity of 45.8% was evaluated for DLCO < 80% in patients with myositis. Participants with small vessel vasculitis showed the lowest sensitivity (66.7%) and specificity (45.8%).

Chest X-ray (see Tables 3 and 4)

Chest X-ray revealed a sensitivity of 64.2% and a specificity of 73.6% in detecting ILD in IRD patients. For IRD subgroups, the sensitivity was 63.3% for CTD patients, 61.5% for small vessel vasculitis, and 70.0% for myositis with a specificity of 73.6% for all three aetiologies.

Pulmonary HRCT findings at the onset of IRD (see Fig. 1)

The most common pulmonary abnormalities on HRCT were GGO (in total 28.6% of patients; ILD group: 36.5%; non-ILD group: 20.6%, P < 0.01), followed by non-specific interstitial pneumonia (NSIP) (in total 16.7%; ILD group: 31.8%; non-ILD group: 1.6%, P < 0.01), usual interstitial pneumonia (UIP) (in total 6.3%; ILD group: 9.5%; non-ILD group: 3.2%, P < 0.01), and probable UIP (in total 5.6%; ILD group: 11.1%; non-ILD group: 0%, P < 0.01). Finally, 33.3% of patients in the non-ILD group showed no lung parenchyma abnormality on HRCT. The sensitivity and specificity of HRCT in detecting IRD-ILD were 100.0% and 55.3%, respectively.

Fig. 1
figure 1

HRCT pattern at the onset of ILD in IRD patients. COP - cryptogenic organizing pneumonia; LIP - lymphoid interstitial pneumonia; NSIP - non-specific interstitial pneumonia; UIP - usual interstitial pneumonia

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Combination of DLCO and chest X-ray (see Table 5 and Fig. 2)

The combination of DLCO < 80% and chest X-ray resulted in a sensitivity and specificity of 95.2% and 38.7%. In patients with CTD, small vessel vasculitis, and myositis, chest X-ray combined with DLCO was associated with an increase of sensitivity (CTD 94.1%, small vessel vasculitis 93.8%, myositis 100.0%) with a specificity of 38.7%. By using this combination, a negative likelihood ratio of 0.12 with a positive likelihood ratio of 1.55 could be achieved (see Table 5). Consequently, a negative test result is 8.3 times more likely in non-ILD patients than in ILD patients.

Table 5 Sensitivity, specificity, positive likelihood ratio (LR+), and negative likelihood ratio (LR−) for different combinations and cutoffs of diagnostic procedures in the detection of lung involvement in IRD patients with ILD
Full size table
Fig. 2
figure 2

ROC curve analysis as well as sensitivity and specificity of different cutoffs in DLCO, chest X-ray, and a combination (DLCO < 80% or/and pathological findings in chest X-ray) in relation to subpopulations of the ILD group. A Complete ILD group. B CTD group. C Vasculitis group. D Myositis group

Full size image

Combination of DLCO, chest X-ray, and pulmonary HRCT (see Table 5 and Fig. 2)

If the DLCO (< 80%) and the first chest X-ray were combined and added to the following pulmonary HRCT (if ≥ 1 pathologic finding present), a sensitivity and a specificity of 95.2% and 77.4%, respectively, were achieved. This stepwise approach obtains a negative likelihood ratio of 0.06 and a positive likelihood ratio of 4.12.

Sub-analysis with pulmonary HRCT in all patients (see Table 6)

Because pulmonary HRCT is the gold standard for diagnosing ILD in IRD, a sub-analysis was performed, in which each patient received pulmonary HRCT (see Table 6). The sub-analysis encompassed 76 patients (38 IRD patients with ILD and 38 IRD patients without ILD). There were no significant differences in the baseline characteristics. The DLCO, FVC, FEV1, and TLC revealed the significant differences in group comparisons. For DLCO < 80%, the sensitivity and specificity for the detection of ILD in IRD were 86.5% and 36.1%, respectively. Regarding FVC < 80%, FEV1 < 80%, TLC < 80%, and TLCO < 80%, a lower sensitivity with a higher specificity was observed. The highest area under the curve (AUC) was also achieved by DLCO (0.745).

Table 6 Sub-analysis of patients who all received a pulmonary HRCT. Baseline characteristics and sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR−), and area under the curve (AUC) for different diagnostic procedures in the detection of lung involvement in IRD patients with ILD
Full size table

The combination of DLCO < 80% and chest X-ray resulted in a sensitivity and a specificity of 89.5% and 26.3%, respectively, with a negative LR of 0.40 could be achieved. With a modified cutoff (DLCO < 70%), the negative LR was reduced to 0.32 (sensitivity of 84.2%, specificity of 50.0%).

Chest X-ray, PFT, and pulmonary HRCT on a representative clinical collective

The representative collective encompassed 167 patients (127 women and 40 men, mean age 54.7 ± 15.3), 68 patients with ILD and 99 patients without ILD. The AUC of PFT parameter are as follows: DLCO − 0.783; 95% CI 0.708–0.859; P ≤ 0.001 and FVC − 0.664; 95% CI 0.572–0.756; P = 0.001. This results in the following sensitivities and specificities for the selected cut-offs: DLCO < 80% — sensitivity 83.6%, specificity 48.3%, PPV 0.53, NPV 0.81; FVC < 80% — sensitivity 47.5%, specificity 79.8%, PPV 0.61, NPV 0.70.

The combination of DLCO < 80% and chest X-ray resulted in a sensitivity and a specificity of 94.1% and 47.5%, respectively, with a PPV of 0.55 and NPV of 0.92 could be achieved. In additional combination with the HRCT as a second step, a sensitivity and a specificity of 92.6% and 82.8%, respectively, could be achieved, with PPV of 0.79 and NPV of 0.94.

Discussion

The aim of the present study was to determine the value of a stepwise diagnostic screening approach, using PFT, chest radiography, and pulmonary HRCT for detecting ILD in newly diagnosed patients with IRD.

Given the high mortality in IRD and pulmonary manifestations and the availability of the new therapeutic option nintedanib for other chronic fibrosing ILD with a progressive phenotype beyond idiopathic pulmonary fibrosis (IPF) and SSc-ILD, an early pulmonary screening at the time of IRD diagnosis is essential and meaningful.

PFT

Caron et al. and Nihtyanova et al. showed that a reduced DLCO (< 80%) is associated with lung complications in patients with IRD [28, 29]. In our present study, DLCO < 80% revealed a sensitivity of 83.6% and a specificity of 45.8% for the detection of ILD in patients with IRD. This was in accordance with the data reported by Bernstein et al. yielding a sensitivity of 80.0% and specificity of 51.0% in detecting ILD in early SSc [21]. In addition, different studies showed similar sensitivities and specificities for other PFT parameters: Showalter et al. and Suliman et al. demonstrated a sensitivity and a specificity of 37.5 to 69.0% and 73.0 to 92.0%, respectively, for FVC < 80% [30, 31]. According to Newall et al., there were no significant differences for FVC, TLCO, or FEV1 between patients with or without ILD [32]. Rosenberg et al. showed sensitivities of 55% (FEV1) and 41% (FVC) [33]. Even the sub-analysis (only patients with pulmonary HRCT) showed no substantial changes in sensitivities and specificities. Consequently, FVC, TLCO, or FEV1 cannot be used to diagnose IRD-ILD. Additionally, our study showed that IRD patients without symptoms and a reduced DLCO (< 80%) presented IRD-ILD in 19.0% (N = 12) of cases and 23.8% (N = 15) had no ILD.

Chest X-ray

We showed that the sole use of chest X-ray yielded a low sensitivity (64.2%) and a moderate specificity (73.6%) in detecting ILD. Similar results were reported by Hax et al. and applying a simple clinical decision rule developed by Steele et al. resulted in a sensitivity and specificity of 58.6 to 88.7% and 60.0%, respectively, in identifying ILD using physical examination or/and chest X-ray [34, 35].

HRCT

In our study, the most common pulmonary HRCT findings in patients with IRD-ILD were GGO (36.5%) and NSIP (31.8%), followed by UIP (9.5%), as also described by Capobianco et al. [36]. According to Goldin, among other changes, pure GGO (pGGO) is also a common finding in SSc-ILD [37]. Given that these are initial diagnosis of IRD in our study, predominant GGO often present without fibrotic patterns (reticulations or honeycombs) as a correlate of beginning ILD. In our study, HRCT showed the highest sensitivity (100.0%) with a specificity of 55.3%. Thus, our results are consistent with the majority of studies, regarding HRCT generally as the gold standard for the diagnosis of ILD [8, 30, 31, 34, 35, 38, 39]. In addition, the evidence-based European consensus statements for the identification and management of ILD in SSc recommend that SSc patients should be screened for ILD using HRCT, particularly if they are showing one or more risk factors [20]. However, it should be emphasized that HRCT is highly sensitive in detecting pulmonary morphologic changes, but IRD patients do not necessarily have ILD despite the presence of these changes. That is the reason why patients were partially excluded in some studies [30, 31].

Combination of pulmonary function test and imaging

The results of our study are in accordance with the literature, showing that a combination of several PFT parameters did not increase specificity without a significant loss of sensitivity in detecting ILD [30, 31].

We revealed a sensitivity and a specificity of 95.2% and 38.7% (positive LR 1.55 and negative LR 0.12), respectively, by using a combination of PFT (DLCO < 80%) and chest X-ray. Thus, a negative test result is 8.3 times more likely in non-ILD patients than in ILD patients. Also, in sub-analysis, we revealed a sensitivity and a specificity of 89.5% and 26.3% (positive LR 1.21 and negative LR 0.40), respectively, by using the same combination. These differences are caused by the facts that the sub-analysis is an already preselected group of patients, because the study was performed in Germany and, according to the recommendations, at least one risk factor should be present for performing a pulmonary HRCT [20]. Considering that, the loss of specificity of the DLCO can be explained. In summary, the sub-analysis shows comparable results. Also, in the representative clinical collective, similar results could be demonstrated, considering that there was no homogeneity in this collective.

Furthermore, the combination of TLC, TLCO, FVC, FEV1, and chest X-ray was associated with a lower sensitivity (64.5–80.6%), even in the sub-analysis. Steele et al. used chest X-ray or PFT (with FVC < 80% and FEV1/FVC > 70%). They could achieve a sensitivity and specificity of 60.5% and 77.3% with positive LR 2.67 and negative LR of 0.51, respectively [35]. Bernstein et al. and Suliman an co-workers showed a sensitivity and a specificity of 59.0 to 74.1% and 45.7 to 65.8%, respectively, with positive LR of 1.47 to 1.7 and negative LR of 0.36 to 0.6, by using a combination of FVC (< 80%) and DLCO (< 70% or < 80%) [21, 30]. With these algorithms, 25 to 40% of patients with ILD would be scored as false negative.

Furthermore, our study revealed a better sensitivity (83.6%) and specificity (83.1%) with the combination of PFT (DLCO < 80%) and HRCT. The best combination of sensitivity (95.2%) and specificity (77.4%) was observed for DLCO < 80% and/or suspicious chest X-ray findings, followed by HRCT (positive LR 4.21 and negative LR 0.06). Combining these examinations, a low rate of false-negative results could be achieved due to the high sensitivity. This procedure potential reflects a screening algorithm for the detection of IRD-ILD. Additionally, a screening algorithm in patients with newly diagnosed IRD should be highly sensitive with also low negative LR (even accepting a poorer specificity), because it concerns an already a pre-selected population with a high risk of pulmonary involvement and a high mortality over time.

A potential limitation of our study is the fact that we performed HRCT in IRD patients with a DCLO < 80%. Regarding the rules for the application of ionizing radiation, patients with a DLCO > 80% underwent no pulmonary HRCT or only in justified individual cases (other risk factors). Consequently, the diagnostic value of the presented algorithm could be potentially overestimated, because we did not perform HCRT on every study participant.

Conclusions

ILD in patients with IRD is associated with increased morbidity and mortality, and a new effective treatment option is now available. Therefore, screening for lung involvement at the onset of IRD is crucial. By using a stepwise approach, we found DLCO combined with chest X-ray proved to be a potential screening tool for detecting early lung manifestations in IRD patients. Based on the high sensitivity of DLCO in combination with chest X-ray, all patients with a reduced DLCO (< 80%) or/and suspicious chest X-ray findings should undergo pulmonary HRCT to detect inflammatory activity in the lungs and to exclude other pulmonary differential diagnoses. Further studies should be initiated to verify these initial findings.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

COP:

Cryptogenic organizing pneumonia

COPD:

Chronic obstructive pulmonary disease

CTD:

Connective tissue disease

DLCO:

Diffusing capacity for carbon monoxide

EGPA:

Eosinophilic granulomatosis with polyangiitis

FEV1 :

Forced expiratory volume in 1 s

FVC:

Forced vital capacity

GGO:

Ground-glass opacities

pGGO:

Pure ground-glass opacities

GPA:

Granulomatosis with polyangiitis

HRCT:

High-resolution computed tomography

ILD:

Interstitial lung disease

IPF:

Idiopathic pulmonary fibrosis

IRD:

Inflammatory rheumatic diseases

LIP:

Lymphoid interstitial pneumonia

MPA:

Microscopic polyangiitis

NSIP:

Non-specific interstitial pneumonia

PFT:

Pulmonary function tests

PY:

Pack years

RB-ILD:

Respiratory bronchiolitis interstitial lung disease

ROC:

Receiver operating characteristic

SLE:

Systemic lupus erythematosus

TLC:

Total lung capacity

TLCO:

Transfer factor of the lung for carbon monoxide

UIP:

Usual interstitial pneumonia

References

  1. Al Maini M, Adelowo F, Al Saleh J, Al Weshahi Y, Burmester GR, Cutolo M, et al. The global challenges and opportunities in the practice of rheumatology: white paper by the World Forum on Rheumatic and Musculoskeletal Diseases. Clin Rheumatol. 2015;34(5):819–29.

    Article  Google Scholar 

  2. Mandl P, Navarro-Compán V, Terslev L, Aegerter P, van der Heijde D, D’Agostino MA, et al. EULAR recommendations for the use of imaging in the diagnosis and management of spondyloarthritis in clinical practice. Ann Rheum Dis. 2015;74(7):1327–39.

    Article  CAS  Google Scholar 

  3. Kowal-Bielecka O, Fransen J, Avouac J, Becker M, Kulak A, Allanore Y, et al. Update of EULAR recommendations for the treatment of systemic sclerosis. Ann Rheum Dis. 2017;76(8):1327–39.

    Article  Google Scholar 

  4. Kerschbaumer A, Sepriano A, Smolen JS, van der Heijde D, Dougados M, van Vollenhoven R, et al. Efficacy of pharmacological treatment in rheumatoid arthritis: a systematic literature research informing the 2019 update of the EULAR recommendations for management of rheumatoid arthritis. Ann Rheum Dis. 2020;79(6):744–59.

    Article  CAS  Google Scholar 

  5. Mukhtyar C, Guillevin L, Cid MC, Dasgupta B, de Groot K, Gross W, et al. EULAR recommendations for the management of primary small and medium vessel vasculitis. Ann Rheum Dis. 2009;68(3):310–7.

    Article  CAS  Google Scholar 

  6. Mammen AL. Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis. Nat Rev Neurol. 2011;7(6):343–54.

    Article  CAS  Google Scholar 

  7. Fischer A, Strek ME, Cottin V, Dellaripa PF, Bernstein EJ, Brown KK, et al. Proceedings of the American College of Rheumatology/Association of Physicians of Great Britain and Ireland Connective Tissue Disease-Associated Interstitial Lung Disease Summit: a multidisciplinary approach to address challenges and opportunities. Arthritis Rheumatol. 2019;71(2):182–95.

    Article  Google Scholar 

  8. Fathi M, Dastmalchi M, Rasmussen E, Lundberg IE, Tornling G. Interstitial lung disease, a common manifestation of newly diagnosed polymyositis and dermatomyositis. Ann Rheum Dis. 2004;63(3):297–301.

    Article  CAS  Google Scholar 

  9. Schnabel A, Reuter M, Biederer J, Richter C, Gross WL. Interstitial lung disease in polymyositis and dermatomyositis: clinical course and response to treatment. Semin Arthritis Rheum. 2003;32(5):273–84.

    Article  Google Scholar 

  10. Guillevin L, Durand-Gasselin B, Cevallos R, Gayraud M, Lhote F, Callard P, et al. Microscopic polyangiitis: clinical and laboratory findings in eighty-five patients. Arthritis Rheum. 1999;42(3):421–30.

    Article  CAS  Google Scholar 

  11. Kreider M, Highland K. Pulmonary involvement in Sjögren syndrome. Semin Respir Crit Care Med. 2014;35(2):255–64.

    Article  Google Scholar 

  12. McNearney TA, Reveille JD, Fischbach M, Friedman AW, Lisse JR, Goel N, et al. Pulmonary involvement in systemic sclerosis: associations with genetic, serologic, sociodemographic, and behavioral factors. Arthritis Rheum. 2007;57(2):318–26.

    Article  Google Scholar 

  13. Bouros D, Wells AU, Nicholson AG, Colby TV, Polychronopoulos V, Pantelidis P, et al. Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome. Am J Respir Crit Care Med. 2002;165(12):1581–6.

    Article  Google Scholar 

  14. Hoffmann T, Oelzner P, Böttcher J, Wolf G, Pfeil A. Analysis of referral diagnoses to the rheumatology department. Z Rheumatol. 2020;79(2):160–7.

    Article  CAS  Google Scholar 

  15. Doyle TJ, Hunninghake GM, Rosas IO. Subclinical interstitial lung disease: why you should care. Am J Respir Crit Care Med. 2012;185(11):1147–53.

    Article  Google Scholar 

  16. Alba MA, Flores-Suárez LF, Henderson AG, Xiao H, Hu P, Nachman PH, et al. Interstital lung disease in ANCA vasculitis. Autoimmun Rev. 2017;16(7):722–9.

    Article  Google Scholar 

  17. Fischer A, du Bois R. Interstitial lung disease in connective tissue disorders. Lancet. 2012;380(9842):689–98.

    Article  Google Scholar 

  18. Tyndall AJ, Bannert B, Vonk M, Airò P, Cozzi F, Carreira PE, et al. Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Ann Rheum Dis. 2010;69(10):1809–15.

    Article  Google Scholar 

  19. Rubio-Rivas M, Royo C, Simeón CP, Corbella X, Fonollosa V. Mortality and survival in systemic sclerosis: systematic review and meta-analysis. Semin Arthritis Rheum. 2014;44(2):208–19.

    Article  Google Scholar 

  20. Hoffmann-Vold A-M, Maher TM, Philpot EE, Ashrafzadeh A, Barake R, Barsotti S, et al. The identification and management of interstitial lung disease in systemic sclerosis: evidence-based European consensus statements. Lancet Rheumatol. 2020;2(2):e71–83.

    Article  Google Scholar 

  21. Bernstein EJ, Jaafar S, Assassi S, Domsic RT, Frech TM, Gordon JK, et al. Performance characteristics of pulmonary function tests for the detection of interstitial lung disease in adults with early diffuse cutaneous systemic sclerosis. Arthritis Rheumatol. 2020;72(11):1892–6.

    Article  CAS  Google Scholar 

  22. Johnson SR, Carette S, Dunne JV: Scleroderma: health services utilization from patients’ perspective. 2006(0315-162X (Print).

    Google Scholar 

  23. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med. 2002;165(2):277–304.

    Article  Google Scholar 

  24. Travis WD, Costabel U, Hansell DM, King TE Jr, Lynch DA, Nicholson AG, et al. An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 2013;188(6):733–48.

    Article  Google Scholar 

  25. Lynch DA, Sverzellati N, Travis WD, Brown KK, Colby TV, Galvin JR, et al. Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper. Lancet Respir Med. 2018;6(2):138–53.

    Article  Google Scholar 

  26. Hosmer DW, Lemeshow S. Applied logistic regression - second edition, vol. 2nd ed. New York: Wiley; 2000.

    Book  Google Scholar 

  27. Cohen J. Statistical power analysis for the behavioral sciences, vol. 2nd ed. Hillsdale: Lawrence Erlbaum Associates, Inc.; 1988.

    Google Scholar 

  28. Caron M, Hoa S, Hudson M, Schwartzman K, Steele R. Pulmonary function tests as outcomes for systemic sclerosis interstitial lung disease. Eur Respir Rev. 2018;27(148):170102.

  29. Nihtyanova SI, Schreiber BE, Ong VH, Rosenberg D, Moinzadeh P, Coghlan JG, et al. Prediction of pulmonary complications and long-term survival in systemic sclerosis. Arthritis Rheumatol. 2014;66(6):1625–35.

    Article  Google Scholar 

  30. Suliman YA, Dobrota R, Huscher D, Nguyen-Kim TD, Maurer B, Jordan S, et al. Brief report: pulmonary function tests: high rate of false-negative results in the early detection and screening of scleroderma-related interstitial lung disease. Arthritis Rheumatol. 2015;67(12):3256–61.

    Article  CAS  Google Scholar 

  31. Showalter K, Hoffmann A, Rouleau G, Aaby D, Lee J, Richardson C, et al. Performance of forced vital capacity and lung diffusion cutpoints for associated radiographic interstitial lung disease in systemic sclerosis. J Rheumatol. 2018;45(11):1572–6.

    Article  Google Scholar 

  32. Newall C, Schinke S, Savage CO, Hill S, Harper L. Impairment of lung function, health status and functional capacity in patients with ANCA-associated vasculitis. Rheumatology (Oxford). 2005;44(5):623–8.

    Article  CAS  Google Scholar 

  33. Rosenberg DM, Weinberger SE, Fulmer JD, Flye MW, Fauci AS, Crystal RG. Functional correlates of lung involvement in Wegener’s granulomatosis. Use of pulmonary function tests in staging and follow-up. Am J Med. 1980;69(3):387–94.

    Article  CAS  Google Scholar 

  34. Hax V, Bredemeier M, Didonet Moro AL, Pavan TR, Vieira MV, Pitrez EH, et al. Clinical algorithms for the diagnosis and prognosis of interstitial lung disease in systemic sclerosis. Semin Arthritis Rheum. 2017;47(2):228–34.

    Article  Google Scholar 

  35. Steele R, Hudson M, Lo E, Baron M. Clinical decision rule to predict the presence of interstitial lung disease in systemic sclerosis. Arthritis Care Res (Hoboken). 2012;64(4):519–24.

    Article  Google Scholar 

  36. Capobianco J, Grimberg A, Thompson BM, Antunes VB, Jasinowodolinski D, Meirelles GS. Thoracic manifestations of collagen vascular diseases. Radiographics. 2012;32(1):33–50.

    Article  Google Scholar 

  37. Goldin JG, Lynch DA, Strollo DC, Suh RD, Schraufnagel DE, Clements PJ, et al. High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung disease. Chest. 2008;134(2):358–67.

    Article  Google Scholar 

  38. Chua F, Higton AM, Colebatch AN, O’Reilly K, Grubnic S, Vlahos I, et al. Idiopathic inflammatory myositis-associated interstitial lung disease: ethnicity differences and lung function trends in a British cohort. Rheumatology (Oxford). 2012;51(10):1870–6.

    Article  Google Scholar 

  39. Hervier B, Devilliers H, Stanciu R, Meyer A, Uzunhan Y, Masseau A, et al. Hierarchical cluster and survival analyses of antisynthetase syndrome: phenotype and outcome are correlated with anti-tRNA synthetase antibody specificity. Autoimmun Rev. 2012;12(2):210–7.

    Article  CAS  Google Scholar 

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Acknowledgements

The authors thank Dr. Med. Katrina Recker, Hamburg, for the support in editing the manuscript.

Funding

Open Access funding enabled and organized by Projekt DEAL. This study is a part of the investigator-initiated study “Diagnostic procedures for detection of pulmonary manifestations at the onset of inflammatory rheumatic diseases (IRD)” which is supported by Boehringer Ingelheim Pharma GmbH & Co. KG, Binger Str. 173, 55216 Ingelheim, Germany.

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Authors and Affiliations

  1. Department of Internal Medicine III, Jena University Hospital – Friedrich Schiller University Jena, Am Klinikum 1, 07747, Jena, Germany

    Tobias Hoffmann, Peter Oelzner, Joachim Böttcher, Gunter Wolf & Alexander Pfeil

  2. Department of Internal Medicine I, Jena University Hospital – Friedrich Schiller University Jena, Am Klinikum 1, 07747, Jena, Germany

    Marcus Franz, Martin Förster, Claus Kroegel & P. Christian Schulze

  3. Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Am Klinikum 1, 07747, Jena, Germany

    Ulf Teichgräber

  4. Institute of Diagnostic and Interventional Radiology, Department of Pediatric Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Diane Renz

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  1. Tobias Hoffmann
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Contributions

AP and TH designed the study, analyzed the data, performed the statistical analysis, wrote the manuscript, and revised the manuscript. AP, DR, and JB evaluated the HRCT. TH, MF, and MF performed the data collection and participated in the statistical analysis. GW, PCS, UT, PO, and JB edited and drafted the manuscript. CK was involved in the development of the study design. AP and TH revised the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Tobias Hoffmann.

Ethics declarations

Ethics approval and consent to participate

All examinations were performed in accordance with the rules and regulations of the local Human Research and Ethics Committee of the Friedrich-Schiller-University Jena (Germany). The study is registered under the following number: “2020-1845-Daten.” All chest X-rays and HRCT were obtained for clinical routine and not for study purposes.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Claus Kroegel is deceased.

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Hoffmann, T., Oelzner, P., Franz, M. et al. Assessing the diagnostic value of a potential screening tool for detecting early interstitial lung disease at the onset of inflammatory rheumatic diseases. Arthritis Res Ther 24, 107 (2022). https://doi.org/10.1186/s13075-022-02786-x

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Keywords

Arthritis Research & Therapy

ISSN: 1478-6362

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