Volume 5 Supplement 3

3rd World Congress of the Global Arthritis Research Network (GARN): International Arthritis Summit

Meeting abstracts

3rd World Congress of the Global Arthritis Research Network (GARN): International Arthritis Summit.

Summit Hall at Sheraton Resorts in Miyazaki, Japan14-17 September 2003

Page 2 of 4

Bone cell differentiation and the role of Fos/AP-1 proteins

Authors: E Wagner, R Eferl, A Hoebertz, L Kenner and K Matsuo

Citation: Arthritis Res Ther 2003 5(Suppl 3):49

Content type: Poster presentation Published on: 12 September 2003
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Bone sparing effect of osteoprotegerin and anti-inflammatory cytokines in collagen-induced arthritis

Authors: M de Vernejoul, N Saidenberg, M Boissier and M Cohen-Solal

Citation: Arthritis Res Ther 2003 5(Suppl 3):50

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The JAK/STAT pathway but not the Erk1/2 pathway mediates IL-6/sIL-6R downregulation of type II collagen, aggrecan core and link protein transcription in articular chondrocytes

Authors: P Bogdanowicz, F Legendre, J Dudhia and J-P Pujol

Citation: Arthritis Res Ther 2003 5(Suppl 3):51

Content type: Poster presentation Published on: 12 September 2003
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Induction of heme oxygenase-1 inhibits IL-1b nitrite oxide production in articular chondrocytes

Authors: F Rannou

Citation: Arthritis Res Ther 2003 5(Suppl 3):52

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Overexpression and induction of heat shock protein 70 protect chondrocytes from cell death in vitro and in vivo

Authors: L Grossin, C Cournil-Henrionnet, A Watrin-Pinzano, B Terlain, JY Jouzeau, P Netter and P Gillet

Citation: Arthritis Res Ther 2003 5(Suppl 3):53

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Role of HC-gp39 in chondrogenesis: upregulation of SOX-9 expression by HC-gp39 in mouse chondrocytes

Authors: C Jacques, A Recklies, A Levy, A Labat and F Berenbaum

Citation: Arthritis Res Ther 2003 5(Suppl 3):54

Content type: Poster presentation Published on: 12 September 2003
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Evidence that rosiglitazone acts as an antidegradative agent on cartilage cells in vitro

Authors: M Francois, L Tsagris, C Forest, P Richette, M Raymondjean and MT Corvol

Citation: Arthritis Res Ther 2003 5(Suppl 3):55

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The effect of cyclooxygenase-2 selective inhibitors on the proliferation and apoptosis of human articular chondrocytes

Authors: YW Song, EB Lee, EM Park, JC Lee and YJ Lee

Citation: Arthritis Res Ther 2003 5(Suppl 3):56

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The role of IL-4 in the control of mechanical stress-induced inflammatory mediators by rat chondrocytes

Authors: K Nishida, H Doi, A Shimizu, M Yorimitsu, M Takigawa and H Inoue

Citation: Arthritis Res Ther 2003 5(Suppl 3):57

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TNF-alpha induced chondrocyte apoptosis in NF-κB suppression is augmented by inhibition of p38 mitogen-activated protein kinase or phosphatidylinositol 3-kinase

Authors: H Kim

Citation: Arthritis Res Ther 2003 5(Suppl 3):58

Content type: Poster presentation Published on: 12 September 2003
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Cell biology and functional genomics of osteoarthritic chondrocytes

Authors: T Aigner, E Bartnik and R Zimmer

Citation: Arthritis Res Ther 2003 5(Suppl 3):59

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CCAAT/enhancer-binding proteins mediate the repression of transcription of cartilage-derived retinoic acid-sensitive protein induced by IL-1β

Authors: K Okazaki, Y Iwamoto and L Sandell

Citation: Arthritis Res Ther 2003 5(Suppl 3):60

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Tissue-engineered cartilage using thermoresponsive gelatin as an in situ forming and moldable scaffold with chondrocytes: in vitro and in vivo performances

Authors: S Ibusuki, T Matsuda and Y Iwamoto

Citation: Arthritis Res Ther 2003 5(Suppl 3):61

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Cartilage-derived morphogenetic protein-1 and cartilage-derived morphogenetic protein-2 are present in ligament fibroblasts and lead to chondrogenic differentiation

Authors: K Bobacz, L Erlacher, J Smolen and W Graninger

Citation: Arthritis Res Ther 2003 5(Suppl 3):62

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Altered phosphorylation of Syp may be responsible for abnormal insulin-like growth factor-1 signaling in human osteoarthritic osteoblasts

Authors: D Lajeunesse, F Massicotte, I Aubry, J Martel-Pelletier and J Pelletier

Citation: Arthritis Res Ther 2003 5(Suppl 3):63

Content type: Poster presentation Published on: 12 September 2003
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15-deoxy-delta^12,14-prostaglandin J₂ induces apoptosis in human articular chondrocytes

Authors: K Masuko-Hongo, Z-Z Shang, T Kato, H Nakamura and K Nishioka

Citation: Arthritis Res Ther 2003 5(Suppl 3):64

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Prostaglandin E₂is an enhancer for IL-1β-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts

Authors: F Kojima, H Naraba and S Kawai

Citation: Arthritis Res Ther 2003 5(Suppl 3):65

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IL-1 but not IL-18 induces osteoprotegerin and TRAIL in rheumatoid arthritis synovial fibroblasts

Authors: J Morel, R Audo and B Combe

Citation: Arthritis Res Ther 2003 5(Suppl 3):66

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Negative regulation of the hypoxia-inducible transcription factors by IPAS defines a novel anti-angiogenesis therapeutic strategy

Authors: Y Makino, L Poellinger, H Nakamura, C Morimoto and H Tanaka

Citation: Arthritis Res Ther 2003 5(Suppl 3):67

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Innate response cytokines in inflammatory synovitis: novel targets and strategies

Authors: I McInnes, BP Leung, JAG Gracie, D Xu, XQ Wei, J Brewer and FY Liew

Citation: Arthritis Res Ther 2003 5(Suppl 3):68

Content type: Poster presentation Published on: 12 September 2003
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Role of lipoxins, antiflammins and serum amyloid A signaling via the common ALXR receptor in joint tissue inflammation

Authors: S Fiore, S Sodin-Semrl, G Antico, A Spagnolo, B Barbaro, J Varga and L Miele

Citation: Arthritis Res Ther 2003 5(Suppl 3):69

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IL-6 as a therapeutic target in systemic-onset juvenile idiopathic arthritis

Authors: S Yokota, T Miyamae, T Imagawa and M Mori

Citation: Arthritis Res Ther 2003 5(Suppl 3):70

Content type: Poster presentation Published on: 12 September 2003
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Synergistic interactions of proinflammatory cytokines with oncostatin M: implications for joint destruction

Authors: T Cawston, H Wang, C Richards and A Rowan

Citation: Arthritis Res Ther 2003 5(Suppl 3):71

Content type: Poster presentation Published on: 12 September 2003
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Novel intracellular function of IL-1 receptor antagonist type 1 in endothelial cells

Authors: C Gabay, F Soussi and M Berti

Citation: Arthritis Res Ther 2003 5(Suppl 3):72

Content type: Poster presentation Published on: 12 September 2003
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Unbalanced levels of bone resorption promoting factors in bone marrow from patients with rheumatoid arthritis in comparison to osteoarthritis

Authors: W Maslinski, J Jaworski, M Ziolkowska, J Kowalczewski and J Pazdur

Citation: Arthritis Res Ther 2003 5(Suppl 3):73

Content type: Poster presentation Published on: 12 September 2003
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Molecular pain signalling in joints

Authors: H Sprott, H Shen, RE Gay, BA Michel, S Gay and A Aeschlimann

Citation: Arthritis Res Ther 2003 5(Suppl 3):74

Content type: Poster presentation Published on: 12 September 2003
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Functional haplotypes in citrullinating enzyme peptidylarginine deiminase 4 are associated with rheumatoid arthritis

Authors: K Yamamoto, A Suzuki, X Chang, S Tokuhiro, T Sawada, Y Nakamura and R Yamada

Citation: Arthritis Res Ther 2003 5(Suppl 3):75

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Analysis of IL-10 gene variants in rheumatoid arthritis

Authors: T Huizinga, J Schonkeren, F Kureeman, F van Gaalen, R Westendorp, FC Breedveld and R Toes

Citation: Arthritis Res Ther 2003 5(Suppl 3):76

Content type: Poster presentation Published on: 12 September 2003
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OLF1/EBF-associated zinc finger protein gene: a novel lupus susceptibility locus on chromosome 16q identified in a Chinese cohort

Authors: N Shen, XB Fong, SL Chen, Y Wang, BH Hahn and BP Tsao

Citation: Arthritis Res Ther 2003 5(Suppl 3):77

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Transcriptional co-activator CBP/p300 regulates chondrocyte-specific gene expression via association with Sox9

Authors: S Takahashi, M Tsuda, Y Takahashi and H Asahara

Citation: Arthritis Res Ther 2003 5(Suppl 3):78

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Sox9 represses gene expression via histone deacetylase activity

Authors: M Tsuda, S Takahashi, N Taniguchi, T Furumatsu and H Asahara

Citation: Arthritis Res Ther 2003 5(Suppl 3):79

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Novel function of GATA-3, revealed by conditional deficient mice

Authors: IC Ho, SY Pai and ML Truitt

Citation: Arthritis Res Ther 2003 5(Suppl 3):80

Content type: Poster presentation Published on: 12 September 2003
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Novel tools for molecular analysis in synovium

Authors: U Mueller-Ladner, E Neumann, I Tarner, J Grifka, O Distler, A Wunder and S Gay

Citation: Arthritis Res Ther 2003 5(Suppl 3):81

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Modulation of the gene expression pattern in peripheral blood mononuclear cells by biologicals in rheumatoid arthritis

Authors: J Kekow, D Koczan, S Drynda, A Drynda and H Thiesen

Citation: Arthritis Res Ther 2003 5(Suppl 3):82

Content type: Poster presentation Published on: 12 September 2003
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The new application of chip technology to transcriptome and proteome analysis of rheumatoid disease

Authors: T Nakanishi, K Nishida, K Ohyama, M Takigawa and H Inoue

Citation: Arthritis Res Ther 2003 5(Suppl 3):83

Content type: Poster presentation Published on: 12 September 2003
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Gene hunting in primary osteoarthritis

Authors: J Loughlin

Citation: Arthritis Res Ther 2003 5(Suppl 3):84

Content type: Poster presentation Published on: 12 September 2003
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New approach to chemical biology for drug discovery: construction of new affinity beads and their application

Authors: H Handa

Citation: Arthritis Res Ther 2003 5(Suppl 3):85

Content type: Poster presentation Published on: 12 September 2003
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Repertoire analysis of anergic B cells from patients with systemic lupus erythematosus

Authors: NS Longo, R Fischer, J Daruwalla, AC Grammer and PE Lipsky

Citation: Arthritis Res Ther 2003 5(Suppl 3):86

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Transplant-tolerance induction by CTLA-4Ig in liver-transplanted rats: a lesson for the treatment of autoimmune diseases?

Authors: U Fischer, S Boas-Knoop and U Neumann

Citation: Arthritis Res Ther 2003 5(Suppl 3):87

Content type: Poster presentation Published on: 12 September 2003
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The Th2 cytokines IL-4 and IL-10 are internal controllers of human Th1-biased immunity in vivo

Authors: A Skapenko, GU Niedobitek, JR Kalden, PE Lipsky and H Schulze-Koops

Citation: Arthritis Res Ther 2003 5(Suppl 3):88

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Post-translational modification of type II collagen influences T-cell tolerance to self-type II collagen

Authors: H Yamada, R Holmdahl, T Shuto, Y Nakajima, J Shida, T Mawatari and Y Iwamoto

Citation: Arthritis Res Ther 2003 5(Suppl 3):89

Content type: Poster presentation Published on: 12 September 2003
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Does sustained downregulation of the TCRzeta chain define the transition from antigen mode to inflammation mode in effector T lymphocytes?

Authors: A Cope, Z Zhang, J Clark, N Panesar and P Amjadi

Citation: Arthritis Res Ther 2003 5(Suppl 3):90

Content type: Poster presentation Published on: 12 September 2003
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Role of β1 integrin and its signaling molecule, Cas-L, in pathophysiology and therapeutic interventigens of rheumatoid arthritis

Authors: C Morimoto

Citation: Arthritis Res Ther 2003 5(Suppl 3):91

Content type: Poster presentation Published on: 12 September 2003
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Human cartilage glycoprotein-39 directed T-cell responses in health and arthritic diseases

Authors: R Toes, J Van Bilsen, L Lard, A Miltenburg, F Breedveld, T Huizinga and R De Vries

Citation: Arthritis Res Ther 2003 5(Suppl 3):92

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IL-12 priming during initial antigen contact increases generation of effector and memory CD8 T cells by changing properties

Authors: J Chang, J-H Cho, S-Y Choi, S-J Ha and Y-C Sung

Citation: Arthritis Res Ther 2003 5(Suppl 3):93

Content type: Poster presentation Published on: 12 September 2003
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Establishment of juvenile and tolerant immune systems in patients with autoimmune diseases treated with immunoablation and autologous stem cell therapy

Authors: A Radbruch, A Thiel, S Kimmig, T Alexander, E Gromnica-Ihle, F Hiepe and R Arnold

Citation: Arthritis Res Ther 2003 5(Suppl 3):94

Content type: Poster presentation Published on: 12 September 2003
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The physiological immunosuppressive network and its putative role in the pathogenesis of autoimmunity: inhibition through signaling, cellular contact, anergy, apoptosis

Authors: H Lorenz, N Blank, M Kriegel, M Schiller, E Scherb, S Winkler and JR Kalden

Citation: Arthritis Res Ther 2003 5(Suppl 3):95

Content type: Poster presentation Published on: 12 September 2003
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Circulating anergic B cells in the periphery of active systemic lupus erythematosus patients: functional and phenotypic characterization

Authors: A Grammer, R Fischer, R Slota, N Longo, H Sohn, C Yarboro, G Illei, S Pierce and P Lipsky

Citation: Arthritis Res Ther 2003 5(Suppl 3):96

Content type: Poster presentation Published on: 12 September 2003
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Novel B-lymphocyte-deleting agents for the treatment of autoimmune diseases: induction of the mitochondrial pathway of apoptosis

Authors: G Silverman and CS Goodyear

Citation: Arthritis Res Ther 2003 5(Suppl 3):97

Content type: Poster presentation Published on: 12 September 2003
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Impact of altered peptide derived from collagen II on T-cell activation and collagen-induced arthritis

Authors: Z Li, Q Zhou, Y Cheng and H Lu

Citation: Arthritis Res Ther 2003 5(Suppl 3):98

Content type: Poster presentation Published on: 12 September 2003
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3rd World Congress of the Global Arthritis Research Network (GARN): International Arthritis Summit

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