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  2. Authors: F Barone, M Bombardieri, J Spencer, P Isaacson, F Humby, P Morgan, S Challacombe, G Valesini and C Pitzalis
    Citation: Arthritis Research & Therapy 2007 9(Suppl 3):P15
    Content type: Poster presentation Published on:

    This article is part of a Supplement: Volume 9 Supplement 3

  6. The transcription factor SOX9 is important in maintaining the chondrocyte phenotype. To identify novel genes regulated by SOX9 we investigated changes in gene expression by microarray analysis following retrov...

    Authors: Simon R Tew, Peter D Clegg, Christopher J Brew, Colette M Redmond and Timothy E Hardingham
    Citation: Arthritis Research & Therapy 2007 9:R107
    Content type: Research article Published on:

  7. In order to identify pathogenic correlates of refractory rheumatoid arthritis (RA), antibodies against anti-cyclic citrullinated protein (ACPAs) were investigated in RA patients in whom the dysregulated immune...

    Authors: YK Onno Teng, Robert J Verburg, Kirsten N Verpoort, Gwendolyn MP Diepenhorst, Ingeborg M Bajema, Maarten JD van Tol, Els CM Jol-van der Zijde, Rene EM Toes, Tom WJ Huizinga and Jacob M van Laar
    Citation: Arthritis Research & Therapy 2007 9:R106
    Content type: Research article Published on:

  8. Regulated differentiation of chondrocytes is essential for both normal skeletal development and maintenance of articular cartilage. The intracellular pathways that control these events are incompletely underst...

    Authors: Laura Bursell, Anita Woods, Claudine G James, Daphne Pala, Andrew Leask and Frank Beier
    Citation: Arthritis Research & Therapy 2007 9:R105
    Content type: Research article Published on:

  9. The aim of this study was to determine the effects of glucosamine on matrix metalloprotease (MMP) production, on mitogen-activated protein kinase (MAPK) phosphorylation, and on activator protein (AP)-1 transcr...

    Authors: Anna Scotto d'Abusco, Valentina Calamia, Claudia Cicione, Brunella Grigolo, Laura Politi and Roberto Scandurra
    Citation: Arthritis Research & Therapy 2007 9:R104
    Content type: Research article Published on:

  10. In this study, we compare the health-related quality of life (HRQoL) of patients with moderate-to-severe rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS), and study the eff...

    Authors: Chenglong Han, Josef S Smolen, Arthur Kavanaugh, Désirée van der Heijde, Jürgen Braun, René Westhovens, Ning Zhao, Mahboob U Rahman, Daniel Baker and Mohan Bala
    Citation: Arthritis Research & Therapy 2007 9:R103
    Content type: Research article Published on:

  11. Bone morphogenetic protein-2 (BMP-2) has been proposed as a tool for cartilage repair and as a stimulant of chondrogenesis. In healthy cartilage, BMP-2 is hardly present, whereas it is highly expressed during ...

    Authors: Esmeralda N Blaney Davidson, Elly L Vitters, Peter LEM van Lent, Fons AJ van de Loo, Wim B van den Berg and Peter M van der Kraan
    Citation: Arthritis Research & Therapy 2007 9:R102
    Content type: Research article Published on:

  12. The aim of the present study was to perform an immunohistological assessment of the synovial tissue from involved small joints in rheumatoid arthritis (RA) and to explore the reliability of a mini-invasive ult...

    Authors: Carlo Alberto Scirè, Oscar Epis, Veronica Codullo, Frances Humby, Patrizia Morbini, Antonio Manzo, Roberto Caporali, Costantino Pitzalis and Carlomaurizio Montecucco
    Citation: Arthritis Research & Therapy 2007 9:R101
    Content type: Research article Published on:

  13. Osteoarthritis (OA) is characterized by alterations to subchondral bone as well as articular cartilage. Changes to bone in OA have also been identified at sites distal to the affected joint, which include incr...

    Authors: Blair Hopwood, Anna Tsykin, David M Findlay and Nicola L Fazzalari
    Citation: Arthritis Research & Therapy 2007 9:R100
    Content type: Research article Published on:

  14. The nonobese diabetic (NOD) Nss1 and Idd5 loci have been associated with sialadenitis development in mice. In this study the NOD Nss1 and Idd5 loci were backcrossed onto the healthy control strain B10.Q by using ...

    Authors: Trond Ove R Hjelmervik, Anna-Karin Lindqvist, Kjell Petersen, Martina Johannesson, Anne-Kristin Stavrum, Ã…sa Johansson, Roland Jonsson, Rikard Holmdahl and Anne Isine Bolstad
    Citation: Arthritis Research & Therapy 2007 9:R99
    Content type: Research article Published on:

  15. Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed. By stud...

    Authors: Lina M Olsson, Anna-Karin Lindqvist, Henrik Källberg, Leonid Padyukov, Harald Burkhardt, Lars Alfredsson, Lars Klareskog and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2007 9:R98
    Content type: Research article Published on:

  16. Inhibition of NF-κB is known to be effective in reducing both inflammation and bone destruction in animal models of arthritis. Our previous study demonstrated that a small cell-permeable NF-κB inhibitor, dehyd...

    Authors: Tetsuo Kubota, Machiko Hoshino, Kazuhiro Aoki, Keiichi Ohya, Yukiko Komano, Toshihiro Nanki, Nobuyuki Miyasaka and Kazuo Umezawa
    Citation: Arthritis Research & Therapy 2007 9:R97
    Content type: Research article Published on:

  17. This study demonstrates that IL-23 stimulates the differentiation of human osteoclasts from peripheral blood mononuclear cells (PBMC). Furthermore, in vivo blockade of endogenous IL-23 activity by treatment with ...

    Authors: Toru Yago, Yuki Nanke, Manabu Kawamoto, Takefumi Furuya, Tsuyoshi Kobashigawa, Naoyuki Kamatani and Shigeru Kotake
    Citation: Arthritis Research & Therapy 2007 9:R96
    Content type: Research article Published on:

  18. Prior studies have suggested abnormalities of serum proteins, including paraproteins, in women with silicone implants but did not control for the presence of connective-tissue disease (CTD). This retrospective...

    Authors: Gyorgy Csako, Rene Costello, Ejaz A Shamim, Terrance P O'Hanlon, Anthony Tran, Daniel J Clauw, H James Williams and Frederick W Miller
    Citation: Arthritis Research & Therapy 2007 9:R95
    Content type: Research article Published on:

  19. Rheumatoid arthritis (RA) is characterized by the recruitment of leukocytes and the accumulation of inflammatory mediators within the synovial compartment. Release of the chemokine CCL18 has been widely attrib...

    Authors: Judith Auer, Markus Bläss, Hendrik Schulze-Koops, Stefan Russwurm, Thomas Nagel, Joachim R Kalden, Martin Röllinghoff and Horst Ulrich Beuscher
    Citation: Arthritis Research & Therapy 2007 9:R94
    Content type: Research article Published on:

  21. The immunodominant epitope of bovine type II collagen (CII256–270) in Aq mice carries a hydroxylysine-264 linked galactose (Gal-Hyl264), the recognition of which is central to the development of collagen-induced ...

    Authors: Simon Glatigny, Marie-Agnès Blaton, Julien Marin, Sylvie Mistou, Jean-Paul Briand, Gilles Guichard, Catherine Fournier and Gilles Chiocchia
    Citation: Arthritis Research & Therapy 2007 9:R92
    Content type: Research article Published on:

  22. In the present study, azothioprine, chloroquine, D-penicillamine, methotrexate and sodium aurothiomalate (gold salt) were evaluated for possible disease-modifying effects in the adjuvant-induced arthritis mode...

    Authors: Shabana Usman Simjee, Huma Jawed, Javeria Quadri and Sheikh Arshad Saeed
    Citation: Arthritis Research & Therapy 2007 9:R91
    Content type: Research article Published on:

  23. Corticosteroids are commonly used in empirical treatment of Behçet's disease (BD), a systemic inflammatory condition associated with reversible endothelial dysfunction. In the present study we aimed to dissect...

    Authors: Athanase D Protogerou, Petros P Sfikakis, Kimon S Stamatelopoulos, Christos Papamichael, Kostas Aznaouridis, Emmanuil Karatzis, Theodore G Papaioannou, Ignatios Ikonomidis, Phedon Kaklamanis, Myron Mavrikakis and John Lekakis
    Citation: Arthritis Research & Therapy 2007 9:R90
    Content type: Research article Published on:

  24. CD40–CD154 interaction is an important mediator of inflammation and has been implicated in T helper type 1-mediated autoimmune diseases including rheumatoid arthritis (RA). Linkage studies have shown associati...

    Authors: Trinidad Martin-Donaire, Ignacio Losada-Fernandez, Gema Perez-Chacon, Iñigo Rua-Figueroa, Celia Erausquin, Antonio Naranjo-Hernandez, Silvia Rosado, Florentino Sanchez, Ayoze Garcia-Saavedra, Maria Jesus Citores, Juan A Vargas and Paloma Perez-Aciego
    Citation: Arthritis Research & Therapy 2007 9:R89
    Content type: Research article Published on:

  25. We investigated the use of a commercial spectrocolorimeter and the application of two color models (L* a* b* colorimetric system and spectral reflectance distribution) to describe and quantify cartilage plugs ...

    Authors: Koji Hattori, Kota Uematsu, Yohei Tanikake, Takashi Habata, Yasuhito Tanaka, Hiroshi Yajima and Yoshinori Takakura
    Citation: Arthritis Research & Therapy 2007 9:R88
    Content type: Research article Published on:

  26. Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheuma...

    Authors: Viviana Lutzky, Suad Hannawi and Ranjeny Thomas
    Citation: Arthritis Research & Therapy 2007 9:219
    Content type: Review Published on:

  27. Expanded populations of CD4+ T cells lacking the co-stimulatory molecule CD28 (CD4+CD28null T cells) have been reported in several inflammatory disorders. In rheumatoid arthritis, increased frequencies of CD4+CD2...

    Authors: Andreas ER Fasth, Omri Snir, Anna AT Johansson, Birgitta Nordmark, Afsar Rahbar, Erik af Klint, Niklas K Björkström, Ann-Kristin Ulfgren, Ronald F van Vollenhoven, Vivianne Malmström and Christina Trollmo
    Citation: Arthritis Research & Therapy 2007 9:R87
    Content type: Research article Published on:

  28. The objectives of the present study were to evaluate the presence of antipolymer antibody (APA) seropositivity in 285 Italian patients affected by primary fibromyalgia (FM) and to verify whether APA levels cor...

    Authors: Laura Bazzichi, Camillo Giacomelli, Francesca De Feo, Tiziana Giuliano, Alessandra Rossi, Marica Doveri, Chiara Tani, Russell B Wilson and Stefano Bombardieri
    Citation: Arthritis Research & Therapy 2007 9:R86
    Content type: Research article Published on:

  29. The pathogenesis of systemic sclerosis (SSc) is characterized by autoimmunity, vasculopathy and fibrosis. IL-15 is a pleiotropic cytokine that has impact on immune, vascular and connective tissue cells. We the...

    Authors: Dirk M Wuttge, Marie Wildt, Pierre Geborek, Frank A Wollheim, Agneta Scheja and Anita Ã…kesson
    Citation: Arthritis Research & Therapy 2007 9:R85
    Content type: Research article Published on:

  30. Systemic lupus erythematosus (SLE) is associated with premature and accelerated atherosclerosis. Circulating progenitor cells (CPCs) are circulating bone-marrow derived cells that play an important role in the...

    Authors: Jan Renier AJ Moonen, Karina de Leeuw, Xavier J Gallego Y van Seijen, Cees GM Kallenberg, Marja JA van Luyn, Marc Bijl and Martin C Harmsen
    Citation: Arthritis Research & Therapy 2007 9:R84
    Content type: Research article Published on:

  32. Data implicate IL-1 in the altered matrix biology that characterizes human intervertebral disc (IVD) degeneration. In the current study we investigated the enzymic mechanism by which IL-1 induces matrix degrad...

    Authors: Christine L Le Maitre, Judith A Hoyland and Anthony J Freemont
    Citation: Arthritis Research & Therapy 2007 9:R83
    Content type: Research article Published on:

  33. Parvovirus (PV) B19 is the causative agent of the childhood disease erythema infectiosum. An association of PV B19 with chronic arthropathies, sometimes resembling rheumatoid arthritis or juvenile idiopathic a...

    Authors: Benedikt Weissbrich, Yvonne Süß-Fröhlich and Hermann J Girschick
    Citation: Arthritis Research & Therapy 2007 9:R82
    Content type: Research article Published on:

  36. It has been suggested that taurine chloramine (TauCl) plays an important role in the downregulation of proinflammatory mediators. However, little is known about its effect on the expression of matrix metallopr...

    Authors: Kyoung Soo Kim, Eun Kyung Park, Seung Min Ju, Hye-Sook Jung, Jun Soo Bang, Chaekyun Kim, Yeon-Ah Lee, Seung-Jae Hong, Sang-Hoon Lee, Hyung-In Yang and Myung Chul Yoo
    Citation: Arthritis Research & Therapy 2007 9:R80
    Content type: Research article Published on:

  37. Despite advances in elucidating the pathogenic factors responsible for its development, systemic sclerosis remains complex and poorly understood, and treatment options are limited. Multidisciplinary collaborat...

    Authors: Lewis J Rubin, Carol M Black, Christopher P Denton and James R Seibold
    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S10
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  38. Systemic vasculitis, an inflammatory necrotizing disease of the blood vessel walls, can occur secondary to autoimmune diseases, including connective tissue diseases. Various pathogenic mechanisms have been imp...

    Authors: Loic Guillevin and Thomas Dörner
    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S9
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  40. The pathogenesis of systemic sclerosis (SSc) is complex and largely unclear. The clinical heterogeneity of the disease and its progression over a number of years makes the choice of endpoints in the design of ...

    Authors: Marco Matucci-Cerinic, Virginia D Steen, Daniel E Furst and James R Seibold
    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S7
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  41. The precise aetiology of systemic sclerosis (SSc) remains elusive, but significant advances over the past few years have improved our understanding of the underlying pathogenic processes and identified key pat...

    Authors: Christopher P Denton
    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S6
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  42. A number of genetic loci have been identified that appear to be associated with systemic sclerosis (SSc; scleroderma). There is mounting evidence suggesting that these genetic associations may in fact be assoc...

    Authors: Maureen D Mayes and Maria Trojanowska
    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S5
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  43. Fibrosis, characterized by excessive extracellular matrix accumulation, is a common feature of many connective tissue diseases, notably scleroderma (systemic sclerosis). Experimental studies suggest that a com...

    Authors: Thomas Krieg, David Abraham and Robert Lafyatis
    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S4
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  44. Angiogenesis is important in the pathogenesis of systemic inflammatory rheumatic diseases, a family of related disorders that includes rheumatoid arthritis and systemic sclerosis. Rheumatoid arthritis is the r...

    Authors: Alisa E Koch and Oliver Distler
    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  45. A considerable amount of research time has been invested in studies aimed at elucidating pathogenic processes in systemic sclerosis (SSc). Despite this, major challenges for biomedical science remain, such as ...

    Authors: David Abraham and Oliver Distler
    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S2
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  47. Currently, autologous chondrocyte implantation (ACI) is the most commonly used cell-based therapy for the treatment of isolated femoral condyle lesions of the knee. A small number of centres performing ACI hav...

    Authors: Aarti Sharma, Lindsay D Wood, James B Richardson, Sally Roberts and Nicola J Kuiper
    Citation: Arthritis Research & Therapy 2007 9:R79
    Content type: Research article Published on:

  48. The objective of this study was to determine the prevalence, mutual associations, clinical manifestations, and diagnoses associated with serum autoantibodies, as detected using recently available immunoassays,...

    Authors: Martial Koenig, Marvin J Fritzler, Ira N Targoff, Yves Troyanov and Jean-Luc Senécal
    Citation: Arthritis Research & Therapy 2007 9:R78
    Content type: Research article Published on:

  49. Low back pain is a common and debilitating disorder. Current evidence implicates intervertebral disc (IVD) degeneration and herniation as major causes, although the pathogenesis is poorly understood. While sev...

    Authors: Christine Lyn Le Maitre, Judith Alison Hoyland and Anthony J Freemont
    Citation: Arthritis Research & Therapy 2007 9:R77
    Content type: Research article Published on:

  50. Osteoarthritis (OA) affects a large segment of the aging population and is a major cause of pain and disability. At present, there is no specific treatment available to prevent or retard the cartilage destruct...

    Authors: Moti L Tiku, Haritha Narla, Mohit Jain and Praveen Yalamanchili
    Citation: Arthritis Research & Therapy 2007 9:R76
    Content type: Research article Published on:
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