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  1. Suppression of type II collagen (COL2A1) cleavage by transforming growth factor (TGF)-β2 in cultured human osteoarthritic cartilage has been shown to be associated with decreased expression of collagenases, cy...

    Authors: Elena V Tchetina, John A Di Battista, David J Zukor, John Antoniou and A Robin Poole
    Citation: Arthritis Research & Therapy 2007 9:R75
    Content type: Research article Published on:

  2. Primary Sjögren's syndrome (pSS) is an autoimmune disorder characterized by specific pathological features. A hallmark of pSS is B-cell hyperactivity as manifested by the production of autoantibodies, hypergam...

    Authors: Arne Hansen, Peter E Lipsky and Thomas Dörner
    Citation: Arthritis Research & Therapy 2007 9:218
    Content type: Review Published on:

  3. The objective of this study was to identify, on a symptomatic knee osteoarthritis (OA) cohort, the risk factors associated with the progression of the disease. More specifically, we investigated the correlatio...

    Authors: Jean-Pierre Pelletier, Jean-Pierre Raynauld, Marie-Josée Berthiaume, François Abram, Denis Choquette, Boulos Haraoui, John F Beary, Gary A Cline, Joan M Meyer and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2007 9:R74
    Content type: Research article Published on:

  4. Rheumatoid arthritis (RA) is associated with neuroendocrine and immunologic dysfunction leading to rheumatoid cachexia. Although excess proinflammatory cytokines can decrease somatotropic axis activity, little...

    Authors: Marc R Blackman, Ranganath Muniyappa, Mildred Wilson, Barbara E Moquin, Howard L Baldwin, Kelli A Wong, Christopher Snyder, Michael Magalnick, Shaan Alli, James Reynolds, Seth M Steinberg and Raphaela Goldbach-Mansky
    Citation: Arthritis Research & Therapy 2007 9:R73
    Content type: Research article Published on:

  5. Current treatment strategies aim to achieve clinical remission in order to prevent the long-term consequences of rheumatoid arthritis (RA). Several composite indices are available to assess remission. All of t...

    Authors: Theresa Kapral, Florian Dernoschnig, Klaus P Machold, Tanja Stamm, Monika Schoels, Josef S Smolen and Daniel Aletaha
    Citation: Arthritis Research & Therapy 2007 9:R72
    Content type: Research article Published on:

  6. TNF receptor-associated periodic syndrome (TRAPS) is a dominantly inherited disease caused by missense mutations in the TNF receptor 1 (TNFR1) gene. Patients suffer from periodic bouts of severe abdominal pain...

    Authors: Fiona C Kimberley, Adrian A Lobito, Richard M Siegel and Gavin R Screaton
    Citation: Arthritis Research & Therapy 2007 9:217
    Content type: Review Published on:

  7. We sought to identify an altered peptide ligand (APL) based on the endogenously expressed synovial auto-epitope of human cartilage glycoprotein-39 (HC gp-39) for modulation of cognate, HLA-DR4-restricted T cel...

    Authors: Annemieke MH Boots, Henk Hubers, Milou Kouwijzer, Leontien den Hoed-van Zandbrink, Bernice M Westrek-Esselink, Cindy van Doorn, Rachel Stenger, Ebo S Bos, Marie-jose C van Lierop, Gijs F Verheijden, Cornelis M Timmers and Catharina J van Staveren
    Citation: Arthritis Research & Therapy 2007 9:R71
    Content type: Research article Published on:

  8. Complementary and alternative medicine products are increasingly being used for the treatment of autoimmune diseases. However, the mechanisms of action of these agents are not fully defined. Using the rat adju...

    Authors: Li Tong and Kamal D Moudgil
    Citation: Arthritis Research & Therapy 2007 9:R70
    Content type: Research article Published on:

  9. In previous work we demonstrated that the matrix-forming phenotype of cultured human cells from whole meniscus was enhanced by hypoxia (5% oxygen). Because the meniscus contains an inner region that is devoid ...

    Authors: Adetola B Adesida, Lisa M Grady, Wasim S Khan, S Jane Millward-Sadler, Donald M Salter and Timothy E Hardingham
    Citation: Arthritis Research & Therapy 2007 9:R69
    Content type: Research article Published on:

  10. Systemic lupus erythematosus is characterized by antibodies to a variety of intracellular self-antigens, such as dsDNA and Sm, and these serve as hallmarks in the diagnosis of systemic autoimmune diseases. Sev...

    Authors: Michael Mahler, Aderajew Waka, F Hiepe and Marvin J Fritzler
    Citation: Arthritis Research & Therapy 2007 9:R68
    Content type: Research article Published on:

  11. Published reports in 2006 on systemic lupus erythematosus are reviewed with regard to preclinical and clinical studies on disturbances of the immune system including co-stimulation, cytokines and recent insigh...

    Authors: Arne Hansen, Falk Hiepe and Thomas Dörner
    Citation: Arthritis Research & Therapy 2007 9:215
    Content type: Review Published on:

  12. Infectious antigens may be triggers for the exacerbation of systemic lupus erythematosus. The underlying mechanism causing acceleration and exacerbation of lupus nephritis (LN) is largely unknown. Bacterial li...

    Authors: Shuk-Man Ka, Chao-Wen Cheng, Hao-Ai Shui, Wen-Mein Wu, Deh-Ming Chang, Yu-Chu Lin and Ann Chen
    Citation: Arthritis Research & Therapy 2007 9:R67
    Content type: Research article Published on:

  14. Autonomic nervous system dysfunction observed in fibromyalgia, characterized without exception by a sympathetic hyperactivity and hyporeactivity, has been reported. However, several studies demonstrated reduce...

    Authors: Jean Eisinger
    Citation: Arthritis Research & Therapy 2007 9:105
    Content type: Editorial Published on:

  15. The aim of the present study is to examine the effect of dietary antioxidants on knee structure in a cohort of healthy, middle-aged subjects with no clinical knee osteoarthritis.

    Authors: Yuanyuan Wang, Allison M Hodge, Anita E Wluka, Dallas R English, Graham G Giles, Richard O'Sullivan, Andrew Forbes and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2007 9:R66
    Content type: Research article Published on:

  16. Junctional adhesion molecule-C (JAM-C) is an adhesion molecule involved in transendothelial migration of leukocytes. In this study, we examined JAM-C expression in the synovium and investigated the role of thi...

    Authors: Gaby Palmer, Nathalie Busso, Michel Aurrand-Lions, Dominique Talabot-Ayer, Véronique Chobaz-Péclat, Claudia Zimmerli, Philippe Hammel, Beat A Imhof and Cem Gabay
    Citation: Arthritis Research & Therapy 2007 9:R65
    Content type: Research article Published on:

  17. Dried roots of the plants Acanthopanax senticosus, Angelica sinensis and Scutellaria baicalensis are used in traditional oriental medicine and reportedly possess anti-inflammatory properties. Using the murine air...

    Authors: Sung Mun Jung, H Ralph Schumacher, Hocheol Kim, Miyeon Kim, Seoung Hoon Lee and Frank Pessler
    Citation: Arthritis Research & Therapy 2007 9:R64
    Content type: Research article Published on:

  18. The integrin αvβ3, whose αv subunit is encoded by the ITGAV gene, plays a key role in angiogenesis. Hyperangiogenesis is involved in rheumatoid arthritis (RA) and the ITGAV gene is located in 2q31, one of the sug...

    Authors: Laurent Jacq, Sophie Garnier, Philippe Dieudé, Laëtitia Michou, Céline Pierlot, Paola Migliorini, Alejandro Balsa, René Westhovens, Pilar Barrera, Helena Alves, Carlos Vaz, Manuela Fernandes, Dora Pascual-Salcedo, Stefano Bombardieri, Jan Dequeker, Timothy R Radstake…
    Citation: Arthritis Research & Therapy 2007 9:R63
    Content type: Research article Published on:

  19. The objective of the present study was to test the hypothesis that experts recognize repair of erosions and, if so, to determine which, if any, morphologic features permitted them to recognize the repair. We a...

    Authors: Désirée van der Heijde, Robert Landewé, Annelies Boonen, Steve Einstein, Gertraud Herborn, Rolf Rau, Siegfried Wassenberg, Barbara N Weissman, Carl S Winalski and John T Sharp
    Citation: Arthritis Research & Therapy 2007 9:R62
    Content type: Research article Published on:

  20. The receptor activator of nuclear factor-κB ligand (RANKL), its cognate receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone r...

    Authors: Edward M Schwarz and Christopher T Ritchlin
    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S7
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  21. Total joint replacement, although considered an excellent surgical procedure, can be complicated by osteolysis induced by implant particles and subsequent aseptic loosening of the implant. The pathogenesis of ...

    Authors: Yousef Abu-Amer, Isra Darwech and John C Clohisy
    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S6
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  22. Establishment of skeletal metastasis involves bidirectional interactions between the tumor cell and the cellular elements in the bone microenvironment. A better understanding of the pathophysiology of bone met...

    Authors: Mandeep S Virk and Jay R Lieberman
    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S5
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  23. Multiple myeloma, a cancer of plasma cells, is associated with excessive tumor-induced, osteoclast-mediated bone destruction. Hypercalcemia remains the most frequent metabolic complication of myeloma in patien...

    Authors: Babatunde O Oyajobi
    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S4
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  24. When the rate of bone resorption exceeds that of bone formation, destruction of bone tissue occurs, resulting in a fragile skeleton. The clinical consequences, namely osteoporosis and fragility fractures, are ...

    Authors: Michael McClung
    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  25. Inflammation and degradation of bone are two closely linked processes. Chronic inflammatory arthritis not only leads to inflammatory bone loss but it also involves local erosion of articular bone. This osteo-d...

    Authors: Georg Schett
    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S2
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  26. The discovery of the receptor activator of nuclear factor-κB ligand (RANKL)/RANK/osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies how both serendipity and a logic-base...

    Authors: Brendan F Boyce and Lianping Xing
    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S1
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 1

  27. The goal of the present study was to record changes in bone mineral density (BMD) and markers of bone turnover in patients with rheumatoid arthritis (RA) who were treated with methotrexate combined (or not com...

    Authors: Hubert Marotte, Beatrice Pallot-Prades, Laurent Grange, Philippe Gaudin, Christian Alexandre and Pierre Miossec
    Citation: Arthritis Research & Therapy 2007 9:R61
    Content type: Research article Published on:

  28. Currently, autologous chondrocyte transplantation (ACT) is used to treat traumatic cartilage damage or osteochondrosis dissecans, but not degenerative arthritis. Since substantial refinements in the isolation,...

    Authors: Reinout Stoop, Dirk Albrecht, Christoph Gaissmaier, Jürgen Fritz, Tino Felka, Maximilian Rudert and Wilhelm K Aicher
    Citation: Arthritis Research & Therapy 2007 9:R60
    Content type: Research article Published on:

  29. Genome-wide gene expression was comparatively investigated in early-passage rheumatoid arthritis (RA) and osteoarthritis (OA) synovial fibroblasts (SFBs; n = 6 each) using oligonucleotide microarrays; mRNA/protei...

    Authors: Dirk Pohlers, Andreas Beyer, Dirk Koczan, Thomas Wilhelm, Hans-Jürgen Thiesen and Raimund W Kinne
    Citation: Arthritis Research & Therapy 2007 9:R59
    Content type: Research article Published on:

  30. Pathogenic bone erosion is often associated with inflammation. The destructive bone erosion that is often seen in rheumatoid arthritis is probably due to the close proximity of inflamed tissues to bone. Over t...

    Authors: David R Haynes
    Citation: Arthritis Research & Therapy 2007 9:104
    Content type: Editorial Published on:

  32. The HLA system is being paid more and more attention because it is very significant in polymorphous immunological reactions. Several studies have suggested that genetic susceptibility to rheumatic fever (RF) a...

    Authors: Valda Stanevicha, Jelena Eglite, Dace Zavadska, Arturs Sochnevs, Ruta Shantere and Dace Gardovska
    Citation: Arthritis Research & Therapy 2007 9:R58
    Content type: Research article Published on:

  33. c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (MMP) gene expression and joint destruction in inflammatory arthritis. It is phosphorylated by at least two upstream kinases, the mitogen-activate...

    Authors: Deepa R Hammaker, David L Boyle, Tomoyuki Inoue and Gary S Firestein
    Citation: Arthritis Research & Therapy 2007 9:R57
    Content type: Research article Published on:

  34. The PTPN22 1858C/T polymorphism has been associated with several autoimmune diseases including rheumatoid arthritis (RA). We have shown that carriage of the T variant (CT or TT) of PTPN22 in combination with anti...

    Authors: Heidi Kokkonen, Martin Johansson, Lena Innala, Erik Jidell and Solbritt Rantapää-Dahlqvist
    Citation: Arthritis Research & Therapy 2007 9:R56
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2007 9:403

  37. Hyaline articular cartilage, the load-bearing tissue of the joint, has very limited repair and regeneration capacities. The lack of efficient treatment modalities for large chondral defects has motivated attem...

    Authors: Andre F Steinert, Steven C Ghivizzani, Axel Rethwilm, Rocky S Tuan, Christopher H Evans and Ulrich Nöth
    Citation: Arthritis Research & Therapy 2007 9:213
    Content type: Review Published on:

  39. Stem cells derived from the infrapatellar fat pad (IPFP) are a potential source of stem cells for the repair of articular cartilage defects. Hypoxia has been shown to improve chondrogenesis in adult stem cells...

    Authors: Wasim S Khan, Adetola B Adesida and Timothy E Hardingham
    Citation: Arthritis Research & Therapy 2007 9:R55
    Content type: Research article Published on:

  41. The aim of this study was to perform a comprehensive gene expression analysis of cytokines, chemokines, and their receptors in Chlamydia trachomatis-infected human monocytes in order to elucidate molecular aspect...

    Authors: Sina Schrader, Andreas Klos, Simone Hess, Henning Zeidler, Jens G Kuipers and Markus Rihl
    Citation: Arthritis Research & Therapy 2007 9:R54
    Content type: Research article Published on:

  42. Chronic pain is associated with N-methyl-D-aspartate (NMDA) receptor activation and downstream production of nitric oxide, which has a pivotal role in multisynaptic local circuit nociceptive processing in the spi...

    Authors: Claudio Infante, Marcelo Díaz, Alejandro Hernández, Luis Constandil and Teresa Pelissier
    Citation: Arthritis Research & Therapy 2007 9:R53
    Content type: Research article Published on:

  43. Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) is hampered by gastrointestinal ulcer complications, such as ulcer bleeding and perforation. The efficacy of proton-pump inhibitors in the primary ...

    Authors: Harald E Vonkeman, Robert W Fernandes, Job van der Palen, Eric N van Roon and Mart AFJ van de Laar
    Citation: Arthritis Research & Therapy 2007 9:R52
    Content type: Research article Published on:

  44. Activating Fc gamma receptors (FcγRs) have been identified as having important roles in the inflammatory joint reaction in rheumatoid arthritis (RA) and murine models of arthritis. However, the role of the inh...

    Authors: Sofia E Magnusson, Marianne Engström, Uwe Jacob, Ann-Kristin Ulfgren and Sandra Kleinau
    Citation: Arthritis Research & Therapy 2007 9:R51
    Content type: Research article Published on:

  45. Indoleamine 2,3-dioxygenase (IDO) is one of the initial and rate-limiting enzymes involved in the catabolism of the essential amino acid tryptophan. In cultured cells, the induction of IDO leads to depletion o...

    Authors: Sándor Szántó, Tamás Koreny, Katalin Mikecz, Tibor T Glant, Zoltán Szekanecz and John Varga
    Citation: Arthritis Research & Therapy 2007 9:R50
    Content type: Research article Published on:

  46. Rheumatoid arthritis is an autoimmune disease characterized by hyperplasia of the synovial lining and destruction of cartilage and bone. Recent studies have suggested that a lack of apoptosis contributes to th...

    Authors: John C Scatizzi, Jack Hutcheson, Emily Bickel, G aKenneth Haines III and Harris Perlman
    Citation: Arthritis Research & Therapy 2007 9:R49
    Content type: Research article Published on:

  47. Thirteen patients with systemic lupus erythematosus and depression (Depressed-SLE), 10 Depressed-Control subjects, and 25 Healthy Control subjects completed cognitive testing and self-report questionnaires of ...

    Authors: Elizabeth Kozora, David B Arciniegas, Lening Zhang and Sterling West
    Citation: Arthritis Research & Therapy 2007 9:R48
    Content type: Research article Published on:

  48. After trauma, articular cartilage often does not heal due to incomplete bonding of the fractured surfaces. In this study we investigated the ability of chemical cross-linkers to facilitate bonding of articular...

    Authors: Carsten Englert, Torsten Blunk, Rainer Müller, Sabine Schulze von Glasser, Julia Baumer, Johann Fierlbeck, Iris M Heid, Michael Nerlich and Joachim Hammer
    Citation: Arthritis Research & Therapy 2007 9:R47
    Content type: Research article Published on:

  49. Over the past 40 years more than 100 genetic risk factors have been defined in systemic lupus erythematosus through a combination of case studies, linkage analyses of multiplex families, and case-control analy...

    Authors: Andrea L Sestak, Swapan K Nath, Amr H Sawalha and John B Harley
    Citation: Arthritis Research & Therapy 2007 9:210
    Content type: Review Published on:

  50. It has been postulated that bacteria attached to the surface of prosthetic hip joints can cause localised inflammation, resulting in failure of the replacement joint. However, diagnosis of infection is difficu...

    Authors: Kate E Dempsey, Marcello P Riggio, Alan Lennon, Victoria E Hannah, Gordon Ramage, David Allan and Jeremy Bagg
    Citation: Arthritis Research & Therapy 2007 9:R46
    Content type: Research article Published on:
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Arthritis Research & Therapy

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