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  1. Accelerated atherosclerosis is one of the major causes of morbidity in patients with systemic lupus erythematosus (SLE). Endothelial dysfunction (ED) is considered an early marker of atherosclerosis. It is a r...

    Authors: Agostino Virdis, Chiara Tani, Emiliano Duranti, Sabrina Vagnani, Linda Carli, Anja A. Kühl, Anna Solini, Chiara Baldini, Rosaria Talarico, Stefano Bombardieri, Stefano Taddei and Marta Mosca
    Citation: Arthritis Research & Therapy 2015 17:277
    Content type: Research article Published on:

  2. Recently, arrays have become available that allow the simultaneous analysis of several anti-citrullinated protein antibody (ACPA) reactivities using distinct citrullinated peptides. Such assays are designed fo...

    Authors: Jurgen van Heemst, Leendert A. Trouw, Leonor Nogueira, Hanna W. van Steenbergen, Annette H. M. van der Helm-van Mil, Cornelia F. Allaart, Guy Serre, Rikard Holmdahl, Tom W. J. Huizinga, René E. M. Toes and Diane van der Woude
    Citation: Arthritis Research & Therapy 2015 17:276
    Content type: Research article Published on:

  3. Fatigue is a frequent symptom in several inflammatory diseases, particularly in rheumatic diseases. Elements of disease activity and cognitive and behavior aspects have been reported as causes of fatigue in pa...

    Authors: Karine Louati and Francis Berenbaum
    Citation: Arthritis Research & Therapy 2015 17:254
    Content type: Review Published on:

  4. Proto-oncogene survivin is a member of the inhibitor of apoptosis (IAP) family of proteins. The presence of serous antibodies against survivin in patients with systemic sclerosis has been previously reported; ...

    Authors: Sho Mokuda, Tatsuhiko Miyazaki, Yoshifumi Ubara, Masamoto Kanno, Eiji Sugiyama, Kiyoshi Takasugi and Junya Masumoto
    Citation: Arthritis Research & Therapy 2015 17:275
    Content type: Research article Published on:

  5. Infection with Epstein-Barr virus (EBV) has been suggested to contribute to the pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). We sought to determine whether prior infection with the...

    Authors: Robert J. Ball, Alison Avenell, Lorna Aucott, Peter Hanlon and Mark A. Vickers
    Citation: Arthritis Research & Therapy 2015 17:274
    Content type: Research article Published on:

  6. The aim of this study was to investigate the diagnostic performance of measuring antibodies to the glycopeptidolipid (GPL) core antigen specific to Mycobacterium avium complex (MAC) in patients with rheumatoid ar...

    Authors: Wataru Hirose, Takashi Uchiyama, Asuka Nemoto, Masayoshi Harigai, Kenji Itoh, Toshiaki Ishizuka, Mitsuyo Matsumoto, Kazue Yamaoka and Toshihiro Nanki
    Citation: Arthritis Research & Therapy 2015 17:273
    Content type: Research article Published on:

  7. Bone marrow lesions (BMLs) are features detected on MRI that are important in the pathogenesis of knee osteoarthritis. Since BMLs reflect heterogeneous pathologies this prospective cohort study examined whethe...

    Authors: Anita E. Wluka, Andrew J. Teichtahl, Rheza Maulana, Bonnie M. Liu, Yuanyuan Wang, Graham G. Giles, Richard O’Sullivan, David Findlay and Flavia M. Cicuttini
    Citation: Arthritis Research & Therapy 2015 17:270
    Content type: Research article Published on:

  8. Fibromyalgia (FM) is a prevalent disorder. However, few studies have evaluated the effect of treatment interventions on biomarker expression. The aim of this review was to explore the efficacy of non-pharmacol...

    Authors: Kenji Sanada, Marta Alda Díez, Montserrat Salas Valero, María Cruz Pérez-Yus, Marcelo M P Demarzo, Mauro García-Toro and Javier García-Campayo
    Citation: Arthritis Research & Therapy 2015 17:272
    Content type: Research article Published on:

  9. Osteoarthritis (OA) is a common joint disease that can cause gradual disability among the aging population. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor that regulates the e...

    Authors: Dawei Cai, Shasha Yin, Jun Yang, Qing Jiang and Wangsen Cao
    Citation: Arthritis Research & Therapy 2015 17:269
    Content type: Research article Published on:

  10. Rheumatoid arthritis (RA) is often associated with diminished muscle mass, reflecting an imbalance between protein synthesis and protein breakdown. To investigate the anabolic potential of both exercise and nu...

    Authors: Ulla Ramer Mikkelsen, Kasper Dideriksen, Mads Bisgaard Andersen, Anders Boesen, Nikolai Mølkjær Malmgaard-Clausen, Inge Juul Sørensen, Peter Schjerling, Michael Kjær and Lars Holm
    Citation: Arthritis Research & Therapy 2015 17:271
    Content type: Research article Published on:

  11. Residual subclinical synovitis can still be present in joints of rheumatoid arthritis (RA) patients despite clinical remission and has been linked to ongoing radiological damage. The aim of the present study w...

    Authors: Yoony Y. J. Gent, Marieke M. ter Wee, Alexandre E. Voskuyl, Debby den Uyl, Nazanin Ahmadi, Cristina Dowling, Cornelis van Kuijk, Otto S. Hoekstra, Maarten Boers, Willem F. Lems and Conny J. van der Laken
    Citation: Arthritis Research & Therapy 2015 17:266
    Content type: Research article Published on:

  12. Juvenile idiopathic arthritis (JIA) often causes inflammation of the temporomandibular joint (TMJ) and has been treated with both systemic and intra-articular steroids, with concerns about effects on growing b...

    Authors: Mitchell Knudsen, Matthew Bury, Callie Holwegner, Adam L. Reinhardt, Fang Yuan, Yijia Zhang, Peter Giannini, David B. Marx, Dong Wang and Richard A. Reinhardt
    Citation: Arthritis Research & Therapy 2015 17:267
    Content type: Research article Published on:

  13. Chronic back pain (CBP) is frequently the presenting symptom in patients with suspected axial spondyloarthritis (axSpA). Presence of sacroiliitis on magnetic-resonance-imaging (MRI) or HLA-B27 adds to diagnost...

    Authors: Victoria Navarro-Compán, Eugenio de Miguel, Désirée van der Heijde, Robert Landewé, Raquel Almodóvar, Carlos Montilla, Emma Beltrán and Pedro Zarco
    Citation: Arthritis Research & Therapy 2015 17:265
    Content type: Research article Published on:

  14. In vitro and animal model of osteoarthritis (OA) studies suggest that TGF-β signalling is involved in OA, but human data is limited. We undertook this study to elucidate the role of TGF-β signalling pathway in...

    Authors: Erfan Aref-Eshghi, Ming Liu, Patricia E. Harper, Jules Doré, Glynn Martin, Andrew Furey, Roger Green, Proton Rahman and Guangju Zhai
    Citation: Arthritis Research & Therapy 2015 17:264
    Content type: Research article Published on:

  15. Both sugar-sweetened beverage (SSB) intake and body mass index (BMI) are associated with elevated serum urate concentrations and gout risk. The aim of this study was to determine whether the associations of SS...

    Authors: Nicola Dalbeth, Amanda Phipps-Green, Meaghan E. House, Gregory D. Gamble, Anne Horne, Lisa K. Stamp and Tony R. Merriman
    Citation: Arthritis Research & Therapy 2015 17:263
    Content type: Research article Published on:

  16. In the present study, we sought to identify markers in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) that distinguish those achieving remission at 6 months following rit...

    Authors: Mazen Nasrallah, Yannick Pouliot, Bjoern Hartmann, Patrick Dunn, Elizabeth Thomson, Jeffrey Wiser and Atul J. Butte
    Citation: Arthritis Research & Therapy 2015 17:262
    Content type: Research article Published on:

  17. Patients with rheumatoid arthritis (RA) risk impaired shoulder function due to the inflammatory process. The knowledge of shoulder function in the early years of the disease is limited. The aim was to compare ...

    Authors: Annelie Bilberg, Tomas Bremell, Istvan Balogh and Kaisa Mannerkorpi
    Citation: Arthritis Research & Therapy 2015 17:261
    Content type: Research article Published on:

  18. C-X-C motif chemokine 10 (CXCL10) is produced in response to interferon-γ, and tumor necrosis factor-α (TNF-α) triggers the accumulation of activated lymphocytes. CXCL13 is constitutively expressed in secondar...

    Authors: Jae Ho Han, Chang-Hee Suh, Ju-Yang Jung, Jin-Young Nam, Jee Eun Kwon, Hyunee Yim and Hyoun-Ah Kim
    Citation: Arthritis Research & Therapy 2015 17:260
    Content type: Research article Published on:

  19. Interleukin-1β (IL-1β) is a major inflammatory cytokine, produced predominantly by innate immune cells through NLRP3-inflammasome activation. Both intrinsic and extrinsic danger signals may activate NLRP3. Gen...

    Authors: Christianna Choulaki, Garyfallia Papadaki, Argyro Repa, Eleni Kampouraki, Konstantinos Kambas, Konstantinos Ritis, George Bertsias, Dimitrios T. Boumpas and Prodromos Sidiropoulos
    Citation: Arthritis Research & Therapy 2015 17:257
    Content type: Research article Published on:

  20. Patients with active rheumatoid arthritis (RA) despite anti–tumor necrosis factor(anti-TNF)agent treatment can switch to either a subsequent anti-TNF agent or a biologic with an alternative mechanism of action...

    Authors: Leslie R. Harrold, George W. Reed, Robert Magner, Ashwini Shewade, Ani John, Jeffrey D. Greenberg and Joel M. Kremer
    Citation: Arthritis Research & Therapy 2015 17:256
    Content type: Research article Published on:

  23. Nutrient deprivation is a likely contributor to intervertebral disc (IVD) degeneration. Silent mating type information regulator 2 homolog 1 (SIRT1) protects cells against limited nutrition by modulation of ap...

    Authors: Shingo Miyazaki, Kenichiro Kakutani, Takashi Yurube, Koichiro Maeno, Toru Takada, Zhongying Zhang, Takuto Kurakawa, Yoshiki Terashima, Masaaki Ito, Takeshi Ueha, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka and Kotaro Nishida
    Citation: Arthritis Research & Therapy 2015 17:253
    Content type: Research article Published on:

  24. Calprotectin, a heterodimeric complex of S100A8/9 (MRP8/14), has been proposed as an important serum biomarker that reflects disease activity and structural joint damage in rheumatoid arthritis (RA). The objec...

    Authors: Jana Hurnakova, Jakub Zavada, Petra Hanova, Hana Hulejova, Martin Klein, Herman Mann, Olga Sleglova, Marta Olejarova, Sarka Forejtova, Olga Ruzickova, Martin Komarc, Jiri Vencovsky, Karel Pavelka and Ladislav Senolt
    Citation: Arthritis Research & Therapy 2015 17:252
    Content type: Research article Published on:

  25. This work was undertaken to delineate intracellular signaling pathways for the PDE4 inhibitor apremilast and to examine interactions between apremilast, methotrexate and adenosine A2A receptors (A2AR).

    Authors: Miguel Perez-Aso, M. Carmen Montesinos, Aránzazu Mediero, Tuere Wilder, Peter H. Schafer and Bruce Cronstein
    Citation: Arthritis Research & Therapy 2015 17:249
    Content type: Research article Published on:

  26. We investigated the inflammatory potential of O-linked N-acetylglucosamine glycosylation (O-GlcNAcylation) of p65 in rheumatoid arthritis (RA).

    Authors: Han Byeol Kim, Sang Won Lee, Chin Hee Mun, Ji Young Yoon, Jaeyoung Pai, Injae Shin, Yong Beom Park, Soo Kon Lee and Jin Won Cho
    Citation: Arthritis Research & Therapy 2015 17:248
    Content type: Research article Published on:

  27. Animal models of osteoarthritis are extensively used for investigating disease pathways and for preclinical testing of novel therapies. Their predictive utility, however, has often been questioned, mainly beca...

    Authors: Anne-Marie Malfait and Christopher B. Little
    Citation: Arthritis Research & Therapy 2015 17:225
    Content type: Review Published on:

  28. Inflammation of the sacroiliac joints (SIJ) is a fundamental clinical feature of axial spondyloarthritis (SpA). The anatomy of the irregularly shaped SIJ is complex with an antero-inferior cartilaginous compar...

    Authors: Ulrich Weber, Walter P. Maksymowych, Stanley M. Chan, Kaspar Rufibach, Susanne J. Pedersen, Zheng Zhao, Veronika Zubler, Mikkel Østergaard and Robert GW Lambert
    Citation: Arthritis Research & Therapy 2015 17:246
    Content type: Research article Published on:

  29. Populations with knee joint damage, including arthritis, have noted impairments in the regulation of submaximal muscle force. It is difficult to determine the exact cause of such impairments given the joint pa...

    Authors: David A. Rice, Peter J. McNair, Gwyn N. Lewis and Jamie Mannion
    Citation: Arthritis Research & Therapy 2015 17:259
    Content type: Research article Published on:

  30. We designed OP3-4 (YCEIEFCYLIR), a cyclic peptide, to mimic the soluble osteoprotegerin (OPG), and was proven to bind to RANKL (receptor activator of NF-κB ligand), thereby inhibiting osteoclastogenesis. We re...

    Authors: Genki Kato, Yasuhiro Shimizu, Yuki Arai, Natsuki Suzuki, Yasutaka Sugamori, Miki Maeda, Mariko Takahashi, Yukihiko Tamura, Noriyuki Wakabayashi, Ramachandran Murali, Takashi Ono, Keiichi Ohya, Setsuko Mise-Omata and Kazuhiro Aoki
    Citation: Arthritis Research & Therapy 2015 17:251
    Content type: Research article Published on:

  31. We conducted a study to analyze how infection by hepatitis C virus (HCV) may influence the immunological serum pattern of patients with Sjögren syndrome (SS).

    Authors: Pilar Brito-Zerón, Hoda Gheitasi, Soledad Retamozo, Albert Bové, María Londoño, Jose-Maria Sánchez-Tapias, Miguel Caballero, Belchin Kostov, Xavier Forns, Srini V. Kaveri and Manuel Ramos-Casals
    Citation: Arthritis Research & Therapy 2015 17:250
    Content type: Research article Published on:

  32. Systemic sclerosis (SSc) is a complex and not fully understood autoimmune disease associated with fibrosis of multiple organs. The main effector cells, the myofibroblasts, are collagen-producing cells derived ...

    Authors: Paola Cipriani, Paola Di Benedetto, Piero Ruscitti, Daniela Verzella, Mariafausta Fischietti, Francesca Zazzeroni, Vasiliki Liakouli, Francesco Carubbi, Onorina Berardicurti, Edoardo Alesse and Roberto Giacomelli
    Citation: Arthritis Research & Therapy 2015 17:247
    Content type: Research article Published on:

  33. As patients with rheumatoid arthritis (RA) receive treatment with anti-tumour necrosis factors over several years, it is important to evaluate their long-term safety and efficacy. The objective of this study w...

    Authors: Josef S. Smolen, Ronald van Vollenhoven, Arthur Kavanaugh, Vibeke Strand, Jiri Vencovsky, Michael Schiff, Robert Landewé, Boulos Haraoui, Catherine Arendt, Irina Mountian, David Carter and Désirée van der Heijde
    Citation: Arthritis Research & Therapy 2015 17:245
    Content type: Research article Published on:

  34. Although rheumatoid arthritis (RA) is generally a chronic disease, a proportion of RA-patients achieve disease-modifying antirheumatic drug (DMARD)-free sustained remission, reflecting loss of disease-persiste...

    Authors: H.W. van Steenbergen, J.A.B. van Nies, A. Ruyssen-Witrand, T.W.J. Huizinga, Al. Cantagrel, F. Berenbaum and A.H.M. van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2015 17:244
    Content type: Research article Published on:

  36. In the present study, we sought to quantify and contrast the secretome and biomechanical properties of the non-chondrodystrophic (NCD) and chondrodystrophic (CD) canine intervertebral disc (IVD) nucleus pulpos...

    Authors: William Mark Erwin, Leroi DeSouza, Martha Funabashi, Greg Kawchuk, Muhammad Zia Karim, Sarah Kim, Stefanie MÓ“dler, Ajay Matta, Xiaomei Wang and K. Arne Mehrkens
    Citation: Arthritis Research & Therapy 2015 17:240
    Content type: Research article Published on:

  37. This open-label pilot study aimed to investigate the efficacy of canakinumab in colchicine-resistant familial Mediterranean fever (FMF) patients.

    Authors: Ahmet Gül, Huri Ozdogan, Burak Erer, Serdal Ugurlu, Ozgur Kasapcopur, Nicole Davis and Serhan Sevgi
    Citation: Arthritis Research & Therapy 2015 17:243
    Content type: Research article Published on:

  38. Interleukin-6 (IL-6) cytokine signaling is key in Rheumatoid Arthritis (RA) pathophysiology. Blocking IL-6 receptor (IL6R) has proven to be a highly effective treatment to prevent joint damage. This study was ...

    Authors: Maria Lopez-Lasanta, Antonio Julià, Joan Maymó, Benjamín Fernández-Gutierrez, Inmaculada Ureña-Garnica, Francisco J. Blanco, Juan D. Cañete, Mercedes Alperi-López, Alex Olivè, Héctor Corominas, Jesus Tornero, Alba Erra, Miriam Almirall, Nuria Palau, Ana Ortiz, Gabriela Avila…
    Citation: Arthritis Research & Therapy 2015 17:242
    Content type: Research article Published on:

  39. In this study, we sought to address changes in blood lymphocyte subpopulations and labial salivary gland (LSG) inflammation after belimumab treatment in patients with primary Sjögren’s syndrome (pSS) and to id...

    Authors: Raphaèle Seror, Gaétane Nocturne, Thierry Lazure, Houria Hendel-Chavez, Frédéric Desmoulins, Rakiba Belkhir, Philippe Ravaud, Mohcine Benbijja, Vichnou Poirier-Colame, Yacine Taoufik and Xavier Mariette
    Citation: Arthritis Research & Therapy 2015 17:241
    Content type: Research article Published on:

  40. Receptor activator of nuclear factor kappa B ligand (RANKL) is a key regulator of bone metabolism. Anti-citrullinated protein antibodies (ACPA) have been suggested to cause bone destruction by osteoclast activ...

    Authors: Aase Haj Hensvold, Vijay Joshua, Wanying Li, Michaela Larkin, Ferhan Qureshi, Lena Israelsson, Leonid Padyukov, Karin Lundberg, Nadine Defranoux, Saedis Saevarsdottir and Anca Irinel Catrina
    Citation: Arthritis Research & Therapy 2015 17:239
    Content type: Research article Published on:

  41. Microchimeric cells have been studied for over a decade, with conflicting reports on their presence and role in autoimmune and other inflammatory diseases. To determine whether microchimeric cells were pathoge...

    Authors: Carol M. Artlett, Sihem Sassi-Gaha, Ronald C. Ramos, Frederick W. Miller and Lisa G. Rider
    Citation: Arthritis Research & Therapy 2015 17:238
    Content type: Research article Published on:

  42. Increasing evidence indicates that features suggestive of neuropathic pain may also be present in patients with common rheumatic conditions. The objective of this study was to examine neuropathic-like pain sym...

    Authors: Sanne M. W. Koop, Peter M. ten Klooster, Harald E. Vonkeman, Laura M. M. Steunebrink and Mart A. F. J. van de Laar
    Citation: Arthritis Research & Therapy 2015 17:237
    Content type: Research article Published on:

  43. CD40 ligand (CD40L) blockade has demonstrated efficacy in experimental autoimmune models. However, clinical trials of hu5c8, an anti-human CD40L IgG1 antibody, in systemic lupus erythematosus (SLE) were halted du...

    Authors: Anthony Shock, Linda Burkly, Ian Wakefield, Christopher Peters, Ellen Garber, Janine Ferrant, Frederick R. Taylor, Lihe Su, Yen-Ming Hsu, David Hutto, Ali Amirkhosravi, Todd Meyer, John Francis, Sarah Malcolm, Martyn Robinson, Derek Brown…
    Citation: Arthritis Research & Therapy 2015 17:234
    Content type: Research article Published on:

  45. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by neutrophil articular infiltration, joint pain and the progressive destruction of cartilage and bone. IL-22 is a key effector molecule ...

    Authors: Larissa G. Pinto, Jhimmy Talbot, Raphael S. Peres, Rafael F. Franca, Sérgio H. Ferreira, Bernhard Ryffel, José Carlos F. Aves-Filho, Florêncio Figueiredo, Thiago M. Cunha and Fernando Q. Cunha
    Citation: Arthritis Research & Therapy 2015 17:235
    Content type: Research article Published on:

  46. There is growing interest in the role of bone in knee osteoarthritis. Bone is a dynamic organ, tightly regulated by a multitude of homeostatic controls, including genetic and environmental factors. One such ke...

    Authors: Andrew J. Teichtahl, Anita E. Wluka, Pushpika Wijethilake, Yuanyuan Wang, Ali Ghasem-Zadeh and Flavia M. Cicuttini
    Citation: Arthritis Research & Therapy 2015 17:207
    Content type: Review Published on:

  47. Flares in patients with rheumatoid arthritis are suggested to sometimes spontaneously resolve. Targeted therapy could then entail possible overtreatment. We aimed to determine the flare prevalence in patients ...

    Authors: Iris M. Markusse, Linda Dirven, Andreas H. Gerards, Johannes H L M van Groenendael, H. Karel Ronday, Pit J S M Kerstens, Willem F. Lems, Tom W J Huizinga and Cornelia F. Allaart
    Citation: Arthritis Research & Therapy 2015 17:232
    Content type: Research article Published on:

  48. DNA methylation is an epigenetic mechanism regulating gene expression that has been insufficiently studied in the blood of rheumatoid arthritis (RA) patients, as only T cells and total peripheral blood mononuc...

    Authors: María C. de Andres, Eva Perez-Pampin, Manuel Calaza, Francisco J. Santaclara, Ignacio Ortea, Juan J. Gomez-Reino and Antonio Gonzalez
    Citation: Arthritis Research & Therapy 2015 17:233
    Content type: Research article Published on:

  49. Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the mark...

    Authors: Silje Reiseter, Øyvind Molberg, Ragnar Gunnarsson, May Brit Lund, Trond Mogens Aalokken, Pål Aukrust, Thor Ueland, Torhild Garen, Cathrine Brunborg, Annika Michelsen, Aurelija Abraityte and Anna-Maria Hoffmann-Vold
    Citation: Arthritis Research & Therapy 2015 17:231
    Content type: Research article Published on:

  50. Although the prognostic value of rheumatoid factor (RF) and autoantibodies against citrullinated proteins (ACPAs) in patients with rheumatoid arthritis (RA) is well established, their association with RA disea...

    Authors: Daniel Aletaha, Farideh Alasti and Josef S. Smolen
    Citation: Arthritis Research & Therapy 2015 17:229
    Content type: Research article Published on:
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Arthritis Research & Therapy

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