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  1. Angiogenesis is an important factor in the development of osteoarthritis (OA). We investigated the efficacy of bevacizumab, an antibody against vascular endothelial growth factor and an inhibitor of angiogenes...

    Authors: Toshihiro Nagai, Masato Sato, Miyuki Kobayashi, Munetaka Yokoyama, Yoshiki Tani and Joji Mochida
    Citation: Arthritis Research & Therapy 2014 16:427
    Content type: Research article Published on:

  4. Authors: Arthi Reddy, XiaoQing Li, Jill P Buyon, Andrew G Franks, Richard A Furie, Diane L Kamen, Susan Manzi, Michelle Petri, Rosalind Ramsey-Goldman, Chung-E Tseng, Ronald F van Vollenhoven, Daniel J Wallace and Anca D Askanase
    Citation: Arthritis Research & Therapy 2014 16(Suppl 1):A49
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 16 Supplement 1

  6. Authors: Candace H Feldman, Linda T Hiraki, Wolfgang Winkelmayer, Francisco M Marty, Jessica M Franklin, Daniel H Solomon, Seoyoung C Kim and Karen H Costenbader
    Citation: Arthritis Research & Therapy 2014 16(Suppl 1):A37
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 16 Supplement 1

  7. Authors: Sasha Bernatsky, Rosalind Ramsey-Goldman, Jean-François Boivin, Lawrence Joseph, Michelle A Petri, Asad Zoma, Susan Manzi, Murray B Urowitz, Dafna D Gladman, Paul R Fortin, Ellen M Ginzler, Edward Yelin, Sang-Cheol Bae, Daniel J Wallace, Steven M Edworthy, Soren Jacobsen…
    Citation: Arthritis Research & Therapy 2014 16(Suppl 1):A35
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 16 Supplement 1

  10. Authors: Danieli Andrade, Mimi Kim, Luz P Blanco, S Ananth Karumanchi, Gloria C Koo, Patricia Redecha, Kyriakos Kirou, Angela M Alvarez, Melissa J Mulla, Mary K Crow, Vikki M Abrahams, Mariana J Kaplan and Jane E Salmon
    Citation: Arthritis Research & Therapy 2014 16(Suppl 1):A28
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 16 Supplement 1

  11. Authors: Zhi-Wei Lai, Rebecca Borsuk, Ashwini Shadakshari, Jianghong Yu, Maha Dawood, Ricardo Garcia, Lisa Francis, Hajra Tily, Adam Bartos, Stephen V Faraone, Paul Phillips and Andras Perl
    Citation: Arthritis Research & Therapy 2014 16(Suppl 1):A25
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 16 Supplement 1

  15. Authors: Silvia N Kariuki, Yogita Ghodke-Puranik, Jessica M Dorschner, Beverly S Chrabot, Jennifer A Kelly, Betty P Tsao, Robert P Kimberly, Marta E Alarcón-Riquelme, Chaim O Jacob, Lindsey A Criswell, Kathy L Sivils, Carl D Langefeld, John B Harley, Andrew D Skol and Timothy B Niewold
    Citation: Arthritis Research & Therapy 2014 16(Suppl 1):A10
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 16 Supplement 1

  19. Activation of the inflammasome has been implicated in the pathology of various autoinflammatory and autoimmune diseases. While the NLRP3 inflammasome has been linked to arthritis progression, little is known a...

    Authors: Claire J Greenhill, Gareth W Jones, Mari A Nowell, Zarabeth Newton, Ann K Harvey, Abdul N Moideen, Fraser L Collins, Anja C Bloom, Rebecca C Coll, Avril AB Robertson, Matthew A Cooper, Marcela Rosas, Philip R Taylor, Luke A O'Neill, Ian R Humphreys, Anwen S Williams…
    Citation: Arthritis Research & Therapy 2014 16:419
    Content type: Research Published on:

  20. The objective of this study was to evaluate the long-term safety and efficacy of tabalumab, a monoclonal antibody that neutralizes membrane-bound and soluble B-cell-activating factor, in rheumatoid arthritis (...

    Authors: Maria Greenwald, Leszek Szczepanski, Alastair Kennedy, Melissa Veenhuizen, Wendy J Komocsar, Emery Polasek, Kelly Guerrettaz, Pierre-Yves Berclaz and Chin Lee
    Citation: Arthritis Research & Therapy 2014 16:415
    Content type: Research article Published on:

  21. Rheumatic diseases (RDs) are associated with different cancers; however, it is unclear whether particular cancers are more prevalent in certain RDs. In the present study, we examined the relative incidence of ...

    Authors: Sung Hae Chang, Jin Kyun Park, Yun Jong Lee, Ji Ae Yang, Eun Young Lee, Yeong Wook Song and Eun Bong Lee
    Citation: Arthritis Research & Therapy 2014 16:428
    Content type: Research Published on:

  22. Research suggests that fibromyalgia is a central, widespread pain syndrome supported by a generalized disturbance in central nervous system pain processing. Over the past decades, multiple lines of research ha...

    Authors: Vitaly Napadow and Richard E Harris
    Citation: Arthritis Research & Therapy 2014 16:425
    Content type: Review Published on:

  23. Chronic inflammation combined with glucocorticoid treatment and immobilization puts juvenile idiopathic arthritis (JIA) patients at risk of impaired growth and reduced bone mineral density (BMD). Conventional ...

    Authors: Janneke Anink, Charlotte M Nusman, Lisette WA van Suijlekom-Smit, Rick R van Rijn, Mario Maas and Marion AJ van Rossum
    Citation: Arthritis Research & Therapy 2014 16:424
    Content type: Research Published on:

  25. Irritable bowel syndrome (IBS), lymphocytic enteritis (LE) and fibromyalgia syndrome (FMS) are three common disorders. Since a gluten-free diet (GFD) has been shown to be helpful in LE, we aimed to assess its ...

    Authors: Luis Rodrigo, Ignacio Blanco, Julio Bobes and Frederick J de Serres
    Citation: Arthritis Research & Therapy 2014 16:421
    Content type: Research article Published on:

  26. Accumulating evidence suggests an important role for interleukin 17 (IL-17) in the pathogenesis of several inflammatory diseases, including rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Accordingly,...

    Authors: Lisa GM van Baarsen, Maria C Lebre, Dennis van der Coelen, Saïda Aarrass, Man W Tang, Tamara H Ramwadhdoebe, Daniëlle M Gerlag and Paul P Tak
    Citation: Arthritis Research & Therapy 2014 16:426
    Content type: Research Published on:

  28. This study aimed to describe treatment changes (discontinuation, switching, and therapy add-on) following the initiation of biologic or nonbiologic oral disease-modifying antirheumatic drugs (DMARDs) in psoria...

    Authors: Huabin F Zhang, Geneviève Gauthier, Robert Hiscock and Jeffrey R Curtis
    Citation: Arthritis Research & Therapy 2014 16:420
    Content type: Research article Published on:

  29. This study aimed to compare the functional capacity and gene expression profile of monocyte-derived dendritic cells (MD-DCs) in HLA-B27+ axial spondyloarthritis (SpA) patients and healthy controls.

    Authors: Alice Talpin, Félicie Costantino, Nelly Bonilla, Ariane Leboime, Franck Letourneur, Sébastien Jacques, Florent Dumont, Sonia Amraoui, Charles-Antoine Dutertre, Henri-Jean Garchon, Maxime Breban and Gilles Chiocchia
    Citation: Arthritis Research & Therapy 2014 16:417
    Content type: Research article Published on:

  30. The degenerate intervertebral disc (IVD) becomes innervated by sensory nerve fibres, and vascularised by blood vessels. This study aimed to identify neurotrophins, neuropeptides and angiogenic factors within n...

    Authors: Abbie LA Binch, Ashley A Cole, Lee M Breakwell, Anthony LR Michael, Neil Chiverton, Alison K Cross and Christine L Le Maitre
    Citation: Arthritis Research & Therapy 2014 16:416
    Content type: Research article Published on:

  31. Genetic susceptibility to complex diseases has been intensively studied during the last decade, yet only signals with small effect have been found leaving open the possibility that subgroups within complex tra...

    Authors: Omri Snir, David Gomez-Cabrero, Ariana Montes, Eva Perez-Pampin, Juan J Gómez-Reino, Maria Seddighzadeh, Katharina U Klich, Lena Israelsson, Bo Ding, Anca I Catrina, Rikard Holmdahl, Lars Alfredsson, Lars Klareskog, Jesper Tegnér, Antonio Gonzalez, Vivianne Malmström…
    Citation: Arthritis Research & Therapy 2014 16:414
    Content type: Research article Published on:

  32. Biomarkers complementing clinical evaluations may help to reduce the length and size of proof-of-concept (PoC) trials aimed to obtain quick "go/no go" decisions in the clinical development of new treatments. W...

    Authors: Maureen C Turina, Nataliya Yeremenko, Jacqueline E Paramarta, Leen De Rycke and Dominique Baeten
    Citation: Arthritis Research & Therapy 2014 16:413
    Content type: Research Published on:

  33. Human circulating monocytes express the calcium-sensing receptor (CaSR) and are involved in atherosclerosis. This study investigated the potential association between vascular calcification in rheumatoid arthr...

    Authors: Julien Paccou, Cédric Boudot, Cédric Renard, Sophie Liabeuf, Said Kamel, Patrice Fardellone, Ziad Massy, Michel Brazier and Romuald Mentaverri
    Citation: Arthritis Research & Therapy 2014 16:412
    Content type: Research Published on:

  34. Depression is frequent in ankylosing spondylitis (AS) patients. However, epidemiological data about the potential increase in risk are lacking. This study compares the rate of doctor-diagnosed depression in a ...

    Authors: Jorit JL Meesters, Ann Bremander, Stefan Bergman, Ingemar F Petersson, Aleksandra Turkiewicz and Martin Englund
    Citation: Arthritis Research & Therapy 2014 16:418
    Content type: Research article Published on:

  35. Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis of the skin and organs. Increase in oxidative stress and platelet-derived growth factor receptor (PDGFR) activation promote col...

    Authors: Pei-Suen Tsou, Beatrix Balogh, Adam J Pinney, George Zakhem, Ann Lozier, M Asif Amin, William A Stinson, Elena Schiopu, Dinesh Khanna, David A Fox and Alisa E Koch
    Citation: Arthritis Research & Therapy 2014 16:411
    Content type: Research Published on:

  36. A major subset of patients with rheumatoid arthritis (RA) is characterized by the presence of circulating autoantibodies directed to citrullinated proteins/peptides (ACPAs). These autoantibodies, which are com...

    Authors: Elena Ossipova, Cátia Fernandes Cerqueira, Evan Reed, Nastya Kharlamova, Lena Israelsson, Rikard Holmdahl, Kutty Selva Nandakumar, Marianne Engström, Ulrike Harre, Georg Schett, Anca I Catrina, Vivianne Malmström, Yngve Sommarin, Lars Klareskog, Per-Johan Jakobsson and Karin Lundberg
    Citation: Arthritis Research & Therapy 2014 16:R167
    Content type: Research article Published on:

  37. Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system, involved in both initiating immune responses and maintaining tolerance. Dysfunctional and via toll-like receptor (TLR) li...

    Authors: Petra Vogelsang, Marie Karlsen, Johan G Brun, Roland Jonsson and Silke Appel
    Citation: Arthritis Research & Therapy 2014 16:R166
    Content type: Research article Published on:

  38. Patients with systemic lupus erythematosus (SLE) have an abnormal population of neutrophils, called low-density granulocytes (LDGs), that express the surface markers of mature neutrophils, yet their nuclear mo...

    Authors: Namrata Singh, Pamela Traisak, Kayla A Martin, Mariana J Kaplan, Philip L Cohen and Michael F Denny
    Citation: Arthritis Research & Therapy 2014 16:R165
    Content type: Research article Published on:

  39. The arthritis-specific Work Productivity Survey (WPS) was developed to evaluate productivity limitations associated with arthritis within and outside the home. There is an unmet need for an instrument assessin...

    Authors: Jane T Osterhaus and Oana Purcaru
    Citation: Arthritis Research & Therapy 2014 16:R164
    Content type: Research article Published on:

  40. Osteoarthritis (OA) is a whole joint disease, and characterized by progressive degradation of articular cartilage, synovial hyperplasia, bone remodeling and angiogenesis in various joint tissues. Exosomes are ...

    Authors: Tomohiro Kato, Shigeru Miyaki, Hiroyuki Ishitobi, Yoshihiro Nakamura, Tomoyuki Nakasa, Martin K Lotz and Mitsuo Ochi
    Citation: Arthritis Research & Therapy 2014 16:R163
    Content type: Research article Published on:

  41. Soft tissue knee injury is a well-established and potent risk factor for development of knee osteoarthritis. However, there is a paucity of epidemiological data from the general population. Our aim was to esti...

    Authors: George Peat, Charlotte Bergknut, Richard Frobell, Anna Jöud and Martin Englund
    Citation: Arthritis Research & Therapy 2014 16:R162
    Content type: Research article Published on:

  42. Psoriasis and psoriatic arthritis (PsA) increase cardiovascular disease (CVD) risk, but surrogate markers for CVD in these disorders are inadequate. Because the presence of sacroiliitis may portend more severe...

    Authors: Shawn Rose, Jenny Dave, Corina Millo, Haley B Naik, Evan L Siegel and Nehal N Mehta
    Citation: Arthritis Research & Therapy 2014 16:R161
    Content type: Research article Published on:

  43. As translational clinical researchers familiar with the risk-benefit of hematopoietic stem cell transplantation in autoimmune diseases, we are intrigued by the recent report of umbilical cord mesenchymal stem ...

    Authors: Thasia G Woodworth and Daniel E Furst
    Citation: Arthritis Research & Therapy 2014 16:113
    Content type: Editorial Published on:

  44. In this study, we evaluated the clinical relevance of serum drug levels and antidrug antibodies (ADAbs) with regard to response to treatment, as well as to relapse upon treatment discontinuation, in peripheral...

    Authors: Jacqueline E Paramarta and Dominique L Baeten
    Citation: Arthritis Research & Therapy 2014 16:R160
    Content type: Research article Published on:

  45. Nerve growth factor (NGF) has an important role in the generation of discogenic pain. We hypothesized that annular rupture is a trigger for discogenic pain through the action of NGF. In this study, the protein...

    Authors: Yasuchika Aoki, Arata Nakajima, Seiji Ohtori, Hiroshi Takahashi, Fusako Watanabe, Masato Sonobe, Fumiaki Terajima, Masahiko Saito, Kazuhisa Takahashi, Tomoaki Toyone, Atsuya Watanabe, Takayuki Nakajima, Makoto Takazawa and Koichi Nakagawa
    Citation: Arthritis Research & Therapy 2014 16:R159
    Content type: Research article Published on:

  46. Small increases in mean serum creatinine (SCr) were observed in studies of rheumatoid arthritis patients during tofacitinib treatment. These SCr changes were investigated and potential mechanisms explored.

    Authors: John D Isaacs, Andrea Zuckerman, Sriram Krishnaswami, Chudy Nduaka, Shuping Lan, Matthew M Hutmacher, Mary G Boy, Ken Kowalski, Sujatha Menon and Richard Riese
    Citation: Arthritis Research & Therapy 2014 16:R158
    Content type: Research article Published on:

  47. Interleukin-6 (IL-6) is a pleiotropic cytokine for which preliminary data have suggested that it might contribute to systemic sclerosis (SSc). Our aims were to investigate, firstly, IL-6 expression in patients...

    Authors: Lucille Desallais, Jérôme Avouac, Maxime Fréchet, Muriel Elhai, Rojo Ratsimandresy, Matthieu Montes, Hadley Mouhsine, Hervé Do, Jean-François Zagury and Yannick Allanore
    Citation: Arthritis Research & Therapy 2014 16:R157
    Content type: Research article Published on:

  48. Immunoglobulin G4 (IgG4)–related aortitis/periaortitis and periarteritis are vascular manifestations of IgG4-related disease. In this disease, the affected aneurysmal lesion has been suspected to be at risk of...

    Authors: Ichiro Mizushima, Dai Inoue, Motohisa Yamamoto, Kazunori Yamada, Takako Saeki, Yoshifumi Ubara, Shoko Matsui, Yasufumi Masaki, Takashi Wada, Satomi Kasashima, Kenichi Harada, Hiroki Takahashi, Kenji Notohara, Yasuni Nakanuma, Hisanori Umehara, Masakazu Yamagishi…
    Citation: Arthritis Research & Therapy 2014 16:R156
    Content type: Research article Published on:

  49. Evaluation of disease severity in experimental models of rheumatoid arthritis is inevitably associated with assessment of structural bone damage. A noninvasive imaging technology allowing objective quantificat...

    Authors: Ingo M Irmler, Peter Gebhardt, Bianca Hoffmann, Thomas Opfermann, Marc-Thilo Figge, Hans P Saluz and Thomas Kamradt
    Citation: Arthritis Research & Therapy 2014 16:R155
    Content type: Research article Published on:

  50. Real-world evidence of the effectiveness of pharmacological thromboprophylaxis for venous thromboembolism (VTE) is limited. Our objective was to assess the effectiveness and safety of thromboprophylactic regim...

    Authors: Kiyoshi Migita, Seiji Bito, Mashio Nakamura, Shigeki Miyata, Masanobu Saito, Hirosi Kakizaki, Yuichiro Nakayama, Tomohiro Matsusita, Itaru Furuichi, Yoshihiro Sasazaki, Takaaki Tanaka, Mamoru Yoshida, Hironori Kaneko, Isao Abe, Takatomo Mine, Kazuhiko Ihara…
    Citation: Arthritis Research & Therapy 2014 16:R154
    Content type: Research article Published on:
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Arthritis Research & Therapy

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