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  1. Rheumatoid arthritis (RA) is characterized by progressive inflammation associated with rampantly proliferating synoviocytes and joint destruction due to oxidative stress. Recently, we described nuclear factor ...

    Authors: Athanassios Fragoulis, Jendrik Laufs, Susanna Müller, Ulf Soppa, Stephanie Siegl, Lucy Kathleen Reiss, Mersedeh Tohidnezhad, Christian Rosen, Klaus Tenbrock, Deike Varoga, Sebastian Lippross, Thomas Pufe and Christoph Jan Wruck
    Citation: Arthritis Research & Therapy 2012 14:R220
    Content type: Research article Published on:

  2. Fibromyalgia (FM), characterized by wide-spread diffuse pain and sensory abnormalities, is associated with elevated indices of distress and pain-related catastrophizing compared to both pain-free samples and t...

    Authors: Claudia M Campbell, Lea McCauley, Sara C Bounds, Vani A Mathur, Lora Conn, Mpepera Simango, Robert R Edwards and Kevin R Fontaine
    Citation: Arthritis Research & Therapy 2012 14:R231
    Content type: Research article Published on:

  3. While adalimumab is licensed for ankylosing spondylitis (AS), open uncontrolled studies suggest therapeutic efficacy of TNF-inhibitors in juvenile onset AS (JoAS).

    Authors: Gerd Horneff, Sigrid Fitter, Ivan Foeldvari, Kirsten Minden, Jasmin Kuemmerle-Deschner, Nicolay Tzaribacev, Angelika Thon, Michael Borte, Gerd Ganser, Rolf Trauzeddel and Hans-Iko Huppertz
    Citation: Arthritis Research & Therapy 2012 14:R230
    Content type: Research article Published on:

  4. Fibrosis in scleroderma is associated with collagen deposition and myofibroblast accumulation. Peroxisome proliferator activated receptor gamma (PPAR-γ), a master regulator of adipogenesis, inhibits profibroti...

    Authors: Feng Fang, Lei Liu, Yang Yang, Zenshiro Tamaki, Jun Wei, Roberta G Marangoni, Swati Bhattacharyya, Ross S Summer, Boping Ye and John Varga
    Citation: Arthritis Research & Therapy 2012 14:R229
    Content type: Research article Published on:

  5. The immunoregulatory function of interleukin (IL)-29 has recently been recognized. However, little is known about the involvement of IL-29 in the pathogenesis of rheumatoid arthritis (RA). This study aimed to ...

    Authors: Fang Wang, Lingxiao Xu, Xiaoke Feng, Dunming Guo, Wenfeng Tan and Miaojia Zhang
    Citation: Arthritis Research & Therapy 2012 14:R228
    Content type: Research article Published on:

  6. In autoimmune diseases, IL-17 producing T-cells (Th17), a pro-inflammatory subset of T-cells, are pathophysiologically involved. There is little knowledge on the role of Th17 cells in granulomatosis with polya...

    Authors: Benjamin Wilde, Marielle Thewissen, Jan Damoiseaux, Marc Hilhorst, Pieter van Paassen, Oliver Witzke and Jan Willem Cohen Tervaert
    Citation: Arthritis Research & Therapy 2012 14:R227
    Content type: Research article Published on:

  7. Inflammatory arthritis is associated with increased bone resorption and suppressed bone formation. The Wnt antagonist dickkopf-1 (DKK1) is secreted by synovial fibroblasts in response to inflammation and this ...

    Authors: Rowan Hardy, Maria Juarez, Amy Naylor, Jinwen Tu, Elizabeth H Rabbitt, Andrew Filer, Paul M Stewart, Christopher D Buckley, Karim Raza and Mark S Cooper
    Citation: Arthritis Research & Therapy 2012 14:R226
    Content type: Research article Published on:

  8. Elevated serum levels of the proinflammatory cytokine tumor necrosis factor alpha (TNFα) correlate with an increased risk for atherothrombotic events and TNFα is known to induce prothrombotic molecules in endo...

    Authors: Joachim Pircher, Monika Merkle, Markus Wörnle, Andrea Ribeiro, Thomas Czermak, Yvonn Stampnik, Hanna Mannell, Markus Niemeyer, Volker Vielhauer and Florian Krötz
    Citation: Arthritis Research & Therapy 2012 14:R225
    Content type: Research article Published on:

  9. To investigate the effects of bisphosphonates (Bis) (etidronate, alendronate, and risedronate), alone and in combination with statin, on the BMD (bone mineral density) and bone metabolism of rheumatoid arthrit...

    Authors: Masakazu Nagashima, Hiroshi Takahashi, Kenichi Shimane, Yuichi Nagase and Koichi Wauke
    Citation: Arthritis Research & Therapy 2012 14:R224
    Content type: Research article Published on:

  10. Recent studies revealed that co-morbidity and mortality due to cardiovascular disease are increased in patients with rheumatoid arthritis (RA) but little is known about factors involved in these manifestations...

    Authors: Qin Shi, Jamilah Abusarah, Ghayath Baroudi, Julio C Fernandes, Hassan Fahmi and Mohamed Benderdour
    Citation: Arthritis Research & Therapy 2012 14:R223
    Content type: Research article Published on:

  11. The association between rheumatoid arthritis (RA) and periodontitis is suggested to be linked to the periodontal pathogen Porphyromonas gingivalis. Colonization of P. gingivalis in the oral cavity of RA patients ...

    Authors: Menke de Smit, Johanna Westra, Arjan Vissink, Berber Doornbos-van der Meer, Elisabeth Brouwer and Arie Jan van Winkelhoff
    Citation: Arthritis Research & Therapy 2012 14:R222
    Content type: Research article Published on:

  12. Systemic lupus erythematosus (SLE) is a T and B cell-dependent autoimmune disease characterized by the appearance of autoantibodies, a global regulatory T cells (Tregs) depletion and an increase in Th17 cells....

    Authors: Benjamin Terrier, Nicolas Derian, Yoland Schoindre, Wahiba Chaara, Guillaume Geri, Noël Zahr, Kubéraka Mariampillai, Michelle Rosenzwajg, Wassila Carpentier, Lucile Musset, Jean-Charles Piette, Adrien Six, David Klatzmann, David Saadoun, Cacoub Patrice and Nathalie Costedoat-Chalumeau
    Citation: Arthritis Research & Therapy 2012 14:R221
    Content type: Research article Published on:

  13. In granulomatosis with polyangiitis (GPA), a complex autoimmune small-vessel vasculitis frequently associated with chronic necrotizing inflammation of the nasal mucosa, elevated nasal Staphylococcus (S.) aureus c...

    Authors: Janet Wohlers, Katrin Breucker, Rainer Podschun, Jürgen Hedderich, Peter Lamprecht, Petra Ambrosch and Martin Laudien
    Citation: Arthritis Research & Therapy 2012 14:R203
    Content type: Research article Published on:

  14. The aim of this study was to investigate the role of hand bone mineral density (BMD) loss analyzed with digital X-ray radiogrammetry (DXR) in early rheumatoid arthritis (RA) as a predictor for progression of j...

    Authors: Kristina Forslind, Johan Kälvesten, Ingiäld Hafström and Björn Svensson
    Citation: Arthritis Research & Therapy 2012 14:R219
    Content type: Research article Published on:

  15. A role for mannose binding lectin (MBL) in autoimmune diseases has been demonstrated earlier and elevated level of MBL has been shown in systemic lupus erythematosus (SLE) patients. In the current study, we in...

    Authors: Aditya K Panda, Jyoti R Parida, Rina Tripathy, Sarit S Pattanaik, Balachandran Ravindran and Bidyut K Das
    Citation: Arthritis Research & Therapy 2012 14:R218
    Content type: Research article Published on:

  16. Fibromyalgia is a chronic disorder characterized by widespread pain and tenderness. Prior trials have demonstrated the efficacy of pregabalin for the relief of fibromyalgia symptoms, and it is approved for the...

    Authors: Hiroyoshi Ohta, Hiroshi Oka, Chie Usui, Masayuki Ohkura, Makoto Suzuki and Kusuki Nishioka
    Citation: Arthritis Research & Therapy 2012 14:R217
    Content type: Research article Published on:

  17. Sclerostin levels have been reported to be low in ankylosing spondylitis (AS), but there is no data regarding the possible role of this Wnt inhibitor during anti-tumor necrosis factor (TNF) therapy. The presen...

    Authors: Carla GS Saad, Ana CM Ribeiro, Julio CB Moraes, Liliam Takayama, Celio R Goncalves, Marcelo B Rodrigues, Ricardo M de Oliveira, Clovis A Silva, Eloisa Bonfa and Rosa MR Pereira
    Citation: Arthritis Research & Therapy 2012 14:R216
    Content type: Research article Published on:

  18. Literature data suggest that sleep disturbances are prevalent among patients with ankylosing spondylitis (AS) and have a close correlation with pain. Other studies indicate that sleep disturbances are constant...

    Authors: Yan Li, Shengli Zhang, Jian Zhu, Xuna Du and Feng Huang
    Citation: Arthritis Research & Therapy 2012 14:R215
    Content type: Research article Published on:

  19. In many European countries, restrictions exist around the prescription of anti-tumor necrosis factor (anti-TNF) treatments for rheumatoid arthritis (RA). Eligibility and response to treatment is assessed by us...

    Authors: Darren Plant, Ibrahim Ibrahim, Mark Lunt, Stephen Eyre, Edward Flynn, Kimme L Hyrich, Ann W Morgan, Anthony G Wilson, John D Isaacs and Anne Barton
    Citation: Arthritis Research & Therapy 2012 14:R214
    Content type: Research article Published on:

  20. Pulmonary arterial hypertension (PAH) is a major cause of mortality in connective tissue disease (CTD). We sought to quantify survival and determine factors predictive of mortality in a cohort of patients with...

    Authors: Gene-Siew Ngian, Wendy Stevens, David Prior, Eli Gabbay, Janet Roddy, Ai Tran, Robert Minson, Catherine Hill, Ken Chow, Joanne Sahhar, Susanna Proudman and Mandana Nikpour
    Citation: Arthritis Research & Therapy 2012 14:R213
    Content type: Research article Published on:

  21. We aimed to explore the associations between knee osteoarthritis (OA)-related tissue abnormalities assessed by conventional radiography (CR) and by high-resolution 3.0 Tesla magnetic resonance imaging (MRI), a...

    Authors: Jesper Knoop, Joost Dekker, Jan-Paul Klein, Marike van der Leeden, Martin van der Esch, Dick Reiding, Ramon E Voorneman, Martijn Gerritsen, Leo D Roorda, Martijn PM Steultjens and Willem F Lems
    Citation: Arthritis Research & Therapy 2012 14:R212
    Content type: Research article Published on:

  22. We prospectively evaluated whether hepatic steatosis (HS) and the presence of carotid plaques (CPs) impacts on achieving minimal disease activity (MDA) in psoriatic arthritis (PsA) patients starting tumor necr...

    Authors: Matteo Nicola Dario Di Minno, Rosario Peluso, Salvatore Iervolino, Roberta Lupoli, Anna Russolillo, Giovanni Tarantino and Raffaele Scarpa
    Citation: Arthritis Research & Therapy 2012 14:R211
    Content type: Research article Published on:

  23. Toll-like receptor (TLR)4 promotes joint inflammation in mice. Despite that several studies report a functional link between TLR4 and interleukin-(IL-)1β in arthritis, TLR4-mediated regulation of the complicat...

    Authors: Hye Sung Kim and Doo Hyun Chung
    Citation: Arthritis Research & Therapy 2012 14:R210
    Content type: Research article Published on:

  24. Muscle symptoms in systemic sclerosis (SSc) may originate from altered skeletal muscle microcirculation, which can be investigated by means of blood oxygenation level dependent (BOLD) magnetic resonance imagin...

    Authors: Sasan Partovi, Anja-Carina Schulte, Markus Aschwanden, Daniel Staub, Daniela Benz, Stephan Imfeld, Björn Jacobi, Pavel Broz, Kurt A Jäger, Martin Takes, Rolf W Huegli, Deniz Bilecen and Ulrich A Walker
    Citation: Arthritis Research & Therapy 2012 14:R209
    Content type: Research article Published on:

  25. Smoking increases the risk of developing rheumatoid arthritis (RA) and affects the severity of established RA. Smoking can impact on Th17 lymphocyte differentiation and function through activation of the aryl ...

    Authors: Marina G Kazantseva, John Highton, Lisa K Stamp and Paul A Hessian
    Citation: Arthritis Research & Therapy 2012 14:R208
    Content type: Research article Published on:

  26. Insulin-like growth factor I (IGF-I) regulates articular cartilage homeostasis. During osteoarthritis (OA), the anabolic responses of chondrocytes to IGF-I are likely to be prevented by the enhanced production...

    Authors: Giorgio Gasparini, Marco De Gori, Francesco Paonessa, Eusebio Chiefari, Antonio Brunetti and Olimpio Galasso
    Citation: Arthritis Research & Therapy 2012 14:R207
    Content type: Research article Published on:

  27. Inflammation associated with synovial expression of TNFα is a recognised feature of osteoarthritis (OA), although no studies have yet reported beneficial effects of anti-TNFα therapy on clinical manifestations...

    Authors: Walter P Maksymowych, Anthony S Russell, Peter Chiu, Alex Yan, Niall Jones, Tracey Clare and Robert GW Lambert
    Citation: Arthritis Research & Therapy 2012 14:R206
    Content type: Research article Published on:

  28. We aimed to describe the distribution of radiographic chondrocalcinosis (CC) and to examine whether metacarpophalangeal joint (MCPJ) calcification and CC at other joints occurs in the absence of knee involvement.

    Authors: Abhishek Abhishek, Sally Doherty, Rose Maciewicz, Kenneth Muir, Weiya Zhang and Michael Doherty
    Citation: Arthritis Research & Therapy 2012 14:R205
    Content type: Research article Published on:

  29. Matrix metalloproteinases (MMPs) are implicated in the destruction of the joint and have been shown to be strongly associated with inflammation in rheumatoid arthritis (RA). Circulating MMPs have also been ass...

    Authors: Derek L Mattey, Nicola B Nixon and Peter T Dawes
    Citation: Arthritis Research & Therapy 2012 14:R204
    Content type: Research article Published on:

  30. Chondroitin sulfate (CS) is a symptomatic slow-acting drug for osteoarthritis (OA) widely used in the clinic. The aim of this work is to find proteins whose secretion from cartilage cells under proinflammatory...

    Authors: Valentina Calamia, Lucía Lourido, Patricia Fernández-Puente, Jesús Mateos, Beatriz Rocha, Eulalia Montell, Josep Vergés, Cristina Ruiz-Romero and Francisco J Blanco
    Citation: Arthritis Research & Therapy 2012 14:R202
    Content type: Research article Published on:

  31. Autoantibodies directed against citrullinated proteins/peptides (ACPAs) are highly specific and predictive for the development of rheumatoid arthritis (RA). Different subgroups of RA patients, which have diffe...

    Authors: Monika Hansson, Linda Mathsson, Thomas Schlederer, Lena Israelsson, Per Matsson, Leonor Nogueira, Per-Johan Jakobsson, Karin Lundberg, Vivianne Malmström, Guy Serre, Rikard Holmdahl, Mats Nystrand, Lars Klareskog and Johan Rönnelid
    Citation: Arthritis Research & Therapy 2012 14:R201
    Content type: Research article Published on:
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Arthritis Research & Therapy

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