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  1. Fibromyalgia (FM) is characterized by chronic pain. Impaired growth hormone responses and reduced serum insulin-like growth factor 1 (IGF-1) are common in FM. The aim was to examine changes in serum IGF-1, cer...

    Authors: Jan L Bjersing, Mats Dehlin, Malin Erlandsson, Maria I Bokarewa and Kaisa Mannerkorpi
    Citation: Arthritis Research & Therapy 2012 14:R162
    Content type: Research article Published on:

  2. The prediction of therapeutic response to rituximab in rheumatoid arthritis is desirable. We evaluated whether analysis of B lymphocyte subsets by flow cytometry would be useful to identify non-responders to r...

    Authors: Hans-Peter Brezinschek, Franz Rainer, Kerstin Brickmann and Winfried B Graninger
    Citation: Arthritis Research & Therapy 2012 14:R161
    Content type: Research article Published on:

  3. Insulin resistance (IR), a risk factor for the development of cardiovascular disease, is common among patients with rheumatoid arthritis (RA). Inflammation, and especially tumour necrosis factor alpha (TNFα), ...

    Authors: Antonios Stavropoulos-Kalinoglou, Giorgos S Metsios, Vasileios F Panoulas, Peter Nightingale, Yiannis Koutedakis and George D Kitas
    Citation: Arthritis Research & Therapy 2012 14:R160
    Content type: Research article Published on:

  4. The microenvironment surrounding inflamed synovium leads to the activation of fibroblast-like synoviocytes (FLSs), which are important contributors to cartilage destruction in rheumatoid arthritic (RA) joints....

    Authors: Annie Lauzier, Martine Charbonneau, Marilène Paquette, Kelly Harper and Claire M Dubois
    Citation: Arthritis Research & Therapy 2012 14:R159
    Content type: Research article Published on:

  5. Monosodium urate monohydrate (MSU) crystals synergize with various toll-like receptor (TLR) ligands to induce cytokine production via activation of the NOD-like receptor (NLR) family, pyrin domain-containing 3...

    Authors: Eleni E Mylona, Maria Mouktaroudi, Tania O Crisan, Stamatoula Makri, Aikaterini Pistiki, Marianna Georgitsi, Athina Savva, Mihai G Netea, Jos WM van der Meer, Evangelos J Giamarellos-Bourboulis and Leo AB Joosten
    Citation: Arthritis Research & Therapy 2012 14:R158
    Content type: Research article Published on:

  6. Anti-endothelial cell antibodies (AECAs) are thought to be critical for vasculitides in collagen diseases, but most were directed against molecules localized within the cell and not expressed on the cell surfa...

    Authors: Tsuyoshi Shirai, Hiroshi Fujii, Masao Ono, Kyohei Nakamura, Ryu Watanabe, Yumi Tajima, Naruhiko Takasawa, Tomonori Ishii and Hideo Harigae
    Citation: Arthritis Research & Therapy 2012 14:R157
    Content type: Research article Published on:

  7. In rheumatic and other chronic inflammatory diseases, high amounts of energy for the activated immune system have to be provided and allocated by energy metabolism. In recent time many new insights have been g...

    Authors: Cornelia M Spies, Rainer H Straub and Frank Buttgereit
    Citation: Arthritis Research & Therapy 2012 14:216
    Content type: Review Published on:

  8. In development of the American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) rheumatoid arthritis (RA) remission definitions using clinical trials data, one criterion used to compare...

    Authors: Bin Zhang, Bernard Combe, Nathalie Rincheval and David T Felson
    Citation: Arthritis Research & Therapy 2012 14:R156
    Content type: Research article Published on:

  10. Plasmacytoid dendritic cells (pDCs) constitutively express two members of the Toll-like receptor (TLR) family, TLR-9 and TLR-7, through which they can be stimulated to produce high levels of interferon (IFN)-α...

    Authors: Karim Sacre, Lindsey A Criswell and Joseph M McCune
    Citation: Arthritis Research & Therapy 2012 14:R155
    Content type: Research article Published on:

  12. The hepatitis C virus (HCV) is both hepatotropic and lymphotropic, responsible for a great number of hepatic and extrahepatic immune-system disorders that comprise the so-called HCV syndrome. HCV-associated rh...

    Authors: Clodoveo Ferri, Marco Sebastiani, Alessandro Antonelli, Michele Colaci, A Manfredi and Dilia Giuggioli
    Citation: Arthritis Research & Therapy 2012 14:215
    Content type: Review Published on:

  13. The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc).

    Authors: María Teruel, Carmen P Simeon, Jasper Broen, Madelon C Vonk, Patricia Carreira, Maria Teresa Camps, Rosa García-Portales, Esmeralda Delgado-Frías, Maria Gallego, Gerard Espinosa, Lorenzo Beretta, Paolo Airó, Claudio Lunardi, Gabriela Riemekasten, Torsten Witte, Thomas Krieg…
    Citation: Arthritis Research & Therapy 2012 14:R154
    Content type: Research article Published on:

  14. The main objective of this study was to determine whether meniscus cells from the outer (MCO) and inner (MCI) regions of the meniscus interact similarly to or differently with mesenchymal stromal stem cells (M...

    Authors: David JJ Saliken, Aillette Mulet-Sierra, Nadr M Jomha and Adetola B Adesida
    Citation: Arthritis Research & Therapy 2012 14:R153
    Content type: Research article Published on:

  15. Myopathy related to systemic sclerosis (Myo-SSc) is a disabling and unpredictable complication of SSc. We assessed the predictive value of serum aldolase, creatine kinase (CK), alanine transaminase (ALT), aspa...

    Authors: Cécile Tolédano, Murielle Gain, Adrien Kettaneh, Bruno Baudin, Catherine Johanet, Patrick Chérin, Sébastien Rivière, Jean Cabane and Kiet Phong Tiev
    Citation: Arthritis Research & Therapy 2012 14:R152
    Content type: Research article Published on:

  17. The mechanism by which intra-articular injection of hyaluronan (HA) ameliorates joint pathology is unknown. Animal studies have shown that HA can reduce synovial activation, periarticular fibrosis and cartilag...

    Authors: Jun Li, Daniel J Gorski, Wendy Anemaet, Jennifer Velasco, Jun Takeuchi, John D Sandy and Anna Plaas
    Citation: Arthritis Research & Therapy 2012 14:R151
    Content type: Research article Published on:

  18. Effective treatment of reactive arthritis would ideally achieve both control of inflammation and eradication of persisting arthritogenic pathogens. We use a model of experimental Chlamydia trachomatis-induced art...

    Authors: Robert D Inman and Basil Chiu
    Citation: Arthritis Research & Therapy 2012 14:R150
    Content type: Research article Published on:

  19. The receptor activator nuclear factor-kappaB ligand (RANKL) diffuses from articular cartilage to subchondral bone. However, the role of chondrocyte-synthesized RANKL in rheumatoid arthritis-associated juxta-ar...

    Authors: Maria J Martínez-Calatrava, Ivan Prieto-Potín, Jorge A Roman-Blas, Lidia Tardio, Raquel Largo and Gabriel Herrero-Beaumont
    Citation: Arthritis Research & Therapy 2012 14:R149
    Content type: Research article Published on:

  20. The objective of this prospective study was to assess short- and long-term efficacy of exercise training (ET) as add-on to medical therapy in patients with connective tissue disease-associated pulmonary arteri...

    Authors: Ekkehard Grünig, Felicitas Maier, Nicola Ehlken, Christine Fischer, Mona Lichtblau, Norbert Blank, Christoph Fiehn, Frank Stöckl, Felix Prange, Gerd Staehler, Frank Reichenberger, Henning Tiede, Michael Halank, Hans-Jürgen Seyfarth, Simone Wagner and Christian Nagel
    Citation: Arthritis Research & Therapy 2012 14:R148
    Content type: Research article Published on:

  21. The usefulness of interferon-gamma (IFN-γ) release assays for tuberculosis screening before tumor necrosis factor-alpha (TNF-α) antagonists and for monitoring during treatment is a contraversial issue. The aim...

    Authors: Gulen Hatemi, Melike Melikoglu, Fatma Ozbakir, Koray Tascilar and Hasan Yazici
    Citation: Arthritis Research & Therapy 2012 14:R147
    Content type: Research article Published on:

  22. Shoulder pathology is a growing concern for the aging population, athletes, and laborers. Shoulder osteoarthritis and rotator cuff disease represent the two most common disorders of the shoulder leading to pai...

    Authors: Megan L Killian, Leonardo Cavinatto, Leesa M Galatz and Stavros Thomopoulos
    Citation: Arthritis Research & Therapy 2012 14:214
    Content type: Review Published on:

  23. Semaphorin 3A (sema3A) and neuropilin-1 (NP-1) play a regulatory role in immune responses and have a demonstrated effect on the course of collagen induced arthritis. This study was undertaken to evaluate the r...

    Authors: Zahava Vadasz, Tharwat Haj, Katalin Halasz, Itzhak Rosner, Gleb Slobodin, Dina Attias, Aharon Kessel, Ofra Kessler, Gera Neufeld and Elias Toubi
    Citation: Arthritis Research & Therapy 2012 14:R146
    Content type: Research article Published on:

  24. Recently, several studies assessing the clinical efficacy of rituximab (RTX) in systemic sclerosis (SSc) have reported encouraging results. We aimed at exploring whether RTX exerts its beneficial effects on fi...

    Authors: Dimitrios Daoussis, Athanassios C Tsamandas, Stamatis-Nick C Liossis, Ioannis Antonopoulos, Elli Karatza, Georgios Yiannopoulos and Andrew P Andonopoulos
    Citation: Arthritis Research & Therapy 2012 14:R145
    Content type: Research article Published on:

  25. Scleroderma or systemic sclerosis (SSc) is a complex connective tissue disease characterized by fibrosis of skin and internal organs. Transforming growth factor beta (TGF-β) plays a key role in the pathogenesi...

    Authors: Xiao-Yong Man, Kenneth W Finnson, Murray Baron and Anie Philip
    Citation: Arthritis Research & Therapy 2012 14:R144
    Content type: Research article Published on:

  26. Pulmonary arterial hypertension is a major cause of mortality in systemic sclerosis. N-terminal pro-brain natriuretic peptide (NT-proBNP) has emerged as a candidate biomarker that may enable the early detectio...

    Authors: Vivek Thakkar, Wendy M Stevens, David Prior, Owen A Moore, Jillian Byron, Danny Liew, Karen Patterson, Pravin Hissaria, Janet Roddy, Jane Zochling, Joanne Sahhar, Peter Nash, Kathleen Tymms, David Celermajer, Eli Gabbay, Peter Youssef…
    Citation: Arthritis Research & Therapy 2012 14:R143
    Content type: Research article Published on:

  27. Endosomal toll-like receptors (TLRs) have recently emerged as potential contributors to the inflammation observed in human and rodent models of rheumatoid arthritis (RA). This study aims to evaluate the role o...

    Authors: Saba Alzabin, Philip Kong, Mino Medghalchi, Andrew Palfreeman, Richard Williams and Sandra Sacre
    Citation: Arthritis Research & Therapy 2012 14:R142
    Content type: Research article Published on:

  28. Prevalence of insulin resistance and the metabolic syndrome has been reported to be high in rheumatoid arthritis (RA) patients. Tumor necrosis factor (TNF), a pro-inflammatory cytokine with a major pathogeneti...

    Authors: Ilias Stagakis, George Bertsias, Stylianos Karvounaris, Melina Kavousanaki, Dimitra Virla, Amalia Raptopoulou, Dimitrios Kardassis, Dimitrios T Boumpas and Prodromos I Sidiropoulos
    Citation: Arthritis Research & Therapy 2012 14:R141
    Content type: Research article Published on:

  29. The complement system is crucial for the development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In particular, C5a plays a central role. In this study, plasma and urinary levels...

    Authors: Jun Yuan, Shen-Ju Gou, Jing Huang, Jian Hao, Min Chen and Ming-Hui Zhao
    Citation: Arthritis Research & Therapy 2012 14:R140
    Content type: Research article Published on:

  30. Juvenile idiopathic arthritis (JIA) is characterized by synovial inflammation, followed by hyperplastic changes of the synovium, and destruction of articular cartilage along with underlying bone. This hyperpla...

    Authors: Elvira Lazić, Marija Jelušić, Danka Grčević, Ana Marušić and Nataša Kovačić
    Citation: Arthritis Research & Therapy 2012 14:R139
    Content type: Research article Published on:

  31. Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages secreting high amounts of i...

    Authors: Sebastian FN Bode, Kai Lehmberg, Andrea Maul-Pavicic, Thomas Vraetz, Gritta Janka, Udo zur Stadt and Stephan Ehl
    Citation: Arthritis Research & Therapy 2012 14:213
    Content type: Review Published on:

  32. Methotrexate (MTX) exerts at least part of its anti-inflammatory effects through adenosine receptors (ADOR). The aims of this study were to determine the expression of all four adenosine receptor genes (ADORA1, A...

    Authors: Lisa K Stamp, Jody Hazlett, Rebecca L Roberts, Christopher Frampton, John Highton and Paul A Hessian
    Citation: Arthritis Research & Therapy 2012 14:R138
    Content type: Research article Published on:

  33. Osteoarthritis is a prevalent and disabling disease affecting an increasingly large swathe of the world population. While clinical osteoarthritis is a late-stage condition for which disease-modifying opportuni...

    Authors: Constance R Chu, Ashley A Williams, Christian H Coyle and Megan E Bowers
    Citation: Arthritis Research & Therapy 2012 14:212
    Content type: Review Published on:

  34. We sought to investigate the capacity of interleukin (IL)-7 to enhance collagen-induced arthritis and to study by what mechanisms this is achieved.

    Authors: Sarita AY Hartgring, Cynthia R Willis, Johannes WJ Bijlsma, Floris PJG Lafeber and Joel AG van Roon
    Citation: Arthritis Research & Therapy 2012 14:R137
    Content type: Research article Published on:

  35. Transplantation of mesenchymal stem cells (MSCs) derived from synovium is a promising therapy for cartilage regeneration. For clinical application, improvement of handling operation, enhancement of chondrogeni...

    Authors: Shiro Suzuki, Takeshi Muneta, Kunikazu Tsuji, Shizuko Ichinose, Hatsune Makino, Akihiro Umezawa and Ichiro Sekiya
    Citation: Arthritis Research & Therapy 2012 14:R136
    Content type: Research article Published on:

  36. Hydroxychloroquine (HCQ) is a common disease modifying therapy for the treatment of rheumatoid arthritis (RA). Prior research suggests that HCQ may reduce the risk of diabetes mellitus in patients with RA. To ...

    Authors: Emileigh Mercer, Laura Rekedal, Rajesh Garg, Bing Lu, Elena M Massarotti and Daniel H Solomon
    Citation: Arthritis Research & Therapy 2012 14:R135
    Content type: Research article Published on:

  37. Rheumatoid arthritis (RA) is a chronic progressive, inflammatory and destructive autoimmune disease, characterised by synovial joint inflammation and bone erosion. To better understand the pathophysiology and ...

    Authors: Sara M Atkinson, Pernille A Usher, Peter H Kvist, Helle Markholst, Claus Haase and Anneline Nansen
    Citation: Arthritis Research & Therapy 2012 14:R134
    Content type: Research article Published on:

  38. Bone morphogenetic proteins (BMPs) and Wnts are important signaling protein families with key roles in embryologic, patterning, development, and tissue remodeling in growth. BMP and Wnt-β-catenin are highly ev...

    Authors: Benjamin Y Chan and Christopher B Little
    Citation: Arthritis Research & Therapy 2012 14:119
    Content type: Editorial Published on:

  39. Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction and disability. Focal bone erosion is due to excess bone resorption of osteoclasts. Tumor necrosis factor receptor-assoc...

    Authors: Lang-Jing Zhu, Lie Dai, Dong-Hui Zheng, Ying-Qian Mo, Xia Ou-Yang, Xiu-Ning Wei, Jun Shen and Bai-Yu Zhang
    Citation: Arthritis Research & Therapy 2012 14:R133
    Content type: Research article Published on:

  40. Leptin has been suspected to contribute to the development of osteoarthritis (OA). However, this hypothesis has not been tested in large-scale hand OA cohorts. Our study aimed to determine whether there is a c...

    Authors: Mei Massengale, William M Reichmann, Elena Losina, Daniel H Solomon and Jeffrey N Katz
    Citation: Arthritis Research & Therapy 2012 14:R132
    Content type: Research article Published on:

  41. Magnetic resonance imaging (MRI) has been shown to be superior to radiography (XR) for assessing synovitis, osteitis, and bone erosion in rheumatoid arthritis (RA), particularly in clinical trials. However, re...

    Authors: Charles G Peterfy, Julie C DiCarlo, Ewa Olech, Maire-Agnes Bagnard, Annarita Gabriele and Norman Gaylis
    Citation: Arthritis Research & Therapy 2012 14:R131
    Content type: Research article Published on:

  42. Endothelial dysfunction (ED) participates to atherogenesis associated to rheumatoid arthritis. We recently reported increased arginase activity/expression in vessels from adjuvant-induced arthritis (AIA) rats....

    Authors: Clément Prati, Alain Berthelot, Bernadette Kantelip, Daniel Wendling and Céline Demougeot
    Citation: Arthritis Research & Therapy 2012 14:R130
    Content type: Research article Published on:

  43. The Rheumatoid Arthritis Impact of Disease (RAID) is a patient-reported outcome measure evaluating the impact of rheumatoid arthritis (RA) on patient quality of life. It comprises 7 domains that are evaluated ...

    Authors: Maxime Dougados, Yves Brault, Isabelle Logeart, Désirée van der Heijde, Laure Gossec and Tore Kvien
    Citation: Arthritis Research & Therapy 2012 14:R129
    Content type: Research article Published on:

  44. Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component and is characterized by chronic inflammation and the production of anti-nuclear auto-antibodies. In the era of genome...

    Authors: Sandra G Guerra, Timothy J Vyse and Deborah S Cunninghame Graham
    Citation: Arthritis Research & Therapy 2012 14:211
    Content type: Review Published on:

  45. Classic anti-nucleolar antibodies anti-Th/To and U3 ribonucleoprotein (-U3RNP) can help in the diagnosis, prediction of organ involvement and prognosis in systemic sclerosis (SSc); however, no validated commer...

    Authors: Angela Ceribelli, Minoru Satoh and Edward KL Chan
    Citation: Arthritis Research & Therapy 2012 14:R128
    Content type: Research article Published on:

  46. The pathology of ankylosing spondylitis (AS) suggests that certain cytokines and matrix metalloproteinases (MMPs) might provide useful markers of disease activity. Serum levels of some cytokines and MMPs have ...

    Authors: Derek L Mattey, Jonathan C Packham, Nicola B Nixon, Lucy Coates, Paul Creamer, Sarah Hailwood, Gordon J Taylor and Ashok K Bhalla
    Citation: Arthritis Research & Therapy 2012 14:R127
    Content type: Research article Published on:

  47. Microthrombosis is often observed in lupus nephritis (LN) lesions, but its clinical significance is unknown. We evaluated the clinicopathologic correlations of renal microthrombosis and inflammatory markers in...

    Authors: Elena Gonzalo, Oscar Toldos, María P Martínez-Vidal, María C Ordoñez, Begoña Santiago, Antonio Fernández-Nebro, Estíbaliz Loza, Isabel García, Myriam León, José L Pablos and María Galindo
    Citation: Arthritis Research & Therapy 2012 14:R126
    Content type: Research article Published on:

  48. Ankylosing spondylitis (AS) is a familial, heritable disease specified by syndesmophyte formation leading to an ankylosed spine. Endoplasmic reticulum aminopeptidase 1 (ERAP1) genetic variations have been wide...

    Authors: Chin-Man Wang, Huei-Huang Ho, Su-Wei Chang, Yeong-Jian Jan Wu, Jing-Chi Lin, Pi-Yueh Chang, Jianming Wu and Ji-Yih Chen
    Citation: Arthritis Research & Therapy 2012 14:R125
    Content type: Research article Published on:

  49. Erosions of the sacroiliac joints (SIJ) on pelvic radiographs of patients with ankylosing spondylitis (AS) are an important feature of the modified New York classification criteria. However, radiographic SIJ e...

    Authors: Ulrich Weber, Susanne J Pedersen, Mikkel Østergaard, Kaspar Rufibach, Robert GW Lambert and Walter P Maksymowych
    Citation: Arthritis Research & Therapy 2012 14:R124
    Content type: Research article Published on:

  50. CD200 is a type I transmembrane glycoprotein that can regulate the activation threshold of inflammatory immune responses, polarize cytokine production, and maintain immune homeostasis. We therefore evaluated t...

    Authors: Yang Li, Li-dan Zhao, Lu-sha Tong, Su-ning Qian, Yan Ren, Lei Zhang, Xin Ding, Yang Chen, Yan-xia Wang, Wen Zhang, Xiao-feng Zeng, Feng-chun Zhang, Fu-lin Tang, Xuan Zhang, De-nian Ba, Wei He…
    Citation: Arthritis Research & Therapy 2012 14:R123
    Content type: Research article Published on:
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Arthritis Research & Therapy

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