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Taking responsibility for the early assessment and treatment of patients with musculoskeletal pain: a review and critical analysis

Musculoskeletal pain is common across all populations and costly in terms of impact on the individual and, more generally, on society. In most health-care systems, the first person to see the patient with a mu...

Authors: Nadine E Foster, Jan Hartvigsen and Peter R Croft

Citation: Arthritis Research & Therapy 2012 14:205

Content type: Review Published on: 29 February 2012
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Inhibiting citrullination in rheumatoid arthritis: taking fuel from the fire

Citrullination is a post-translational modification catalysed by peptidylarginine deiminase and is a common feature of inflammation. The presence of anti-citrullinated protein/peptide antibodies (ACPA), howeve...

Authors: Benjamin AC Fisher and Patrick J Venables

Citation: Arthritis Research & Therapy 2012 14:108

Content type: Editorial Published on: 29 February 2012
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The association of autoantibodies expression, Th1/Th2 cytokines balance and IFNG polymorphism with histological phenotype of lupusnephritis

Authors: Kusworini Handono, Atma Gunawan, Singgih Wahono, Rulli Rosandi, Wivina, Natalina Mallo and Handono Kalim

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P80

Content type: Poster presentation Published on: 29 February 2012

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AJAK inhibitor, tofacitinibreduces IL-6 and matrix metalloproteinase-3 productionin rheumatoid arthritis with suppressed cartilage destruction

Authors: Kunihiro Yamaoka, Satoshi Kubo, Koshiro Sonomoto, Keisuke Maeshima and Yoshiya Tanaka

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P77

Content type: Poster presentation Published on: 29 February 2012

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Human retrovirus promotes the plasticity of regulatory T cells into T helper type 1-like cells through the T-bet transcriptional activation in neuroinflammatory disease

Authors: Yoshihisa Yamano

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P76

Content type: Poster presentation Published on: 29 February 2012

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Brain perfusion in fibromyalgia patients and its differences between responders and poor responders to gabapentin

Authors: Chie Usui, Kotaro Hatta, Nagafumi Doi, Atsushi Nakanishi, Hiroyuki Nakamura and Kusuki Nishioka

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P72

Content type: Poster presentation Published on: 29 February 2012

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Unfolded protein response mediator, the IRE1α-XBP1 pathway is involved in osteoblast differentiation

Authors: Takahide Tohmonda, Kazuhiro Chiba, Yoshiaki Toyama and Keisuke Horiuchi

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P70

Content type: Poster presentation Published on: 29 February 2012

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Inhibition of Syndecan-4 by therapeutic antibodies reduces TNFα dependent joint destruction in mice

Authors: Athanasios Stratis, Katja Neugebauer, Mareike Frohling, Peter Paruzel, Berno Dankbar, Corinna Wemeyer, Christoph Cromme, Lars Godmann, Jessica Bertrand, Adelheide Korb, Frank Echtermeyer, George Kollias and Thomas Pap

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P64

Content type: Poster presentation Published on: 29 February 2012

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Methotrexate alone and methotrexate combined with etanercept in treatment of rheumatoid arthritis

Authors: Sylejman Rexhepi, Mjellma Rexhepi, Blerta Rexhepi, Vjollca Sahatçiu-Meka and Vigan Mahmutaj

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P60

Content type: Poster presentation Published on: 29 February 2012

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Smoking induces expression of ligands of the immune receptor NKG2D

Authors: Caroline Ospelt, Giovanni G Camici, Fabia Brentano, Peter Künzler, Christoph Kolling, Renate E Gay, Beat A Michel and Steffen Gay

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P58

Content type: Poster presentation Published on: 29 February 2012

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Active repression by Blimp1 play an important role in osteoclast differentiation

Authors: Keizo Nishikawa, Tomoki Nakashima, Mikihito Hayashi, Takanobu Fukunaga, Shigeaki Kato, Tatsuhiko Kodama, Satoru Takahashi, Kathryn Calame and Hiroshi Takayanagi

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P54

Content type: Poster presentation Published on: 29 February 2012

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Over expression of toll-like receptors in peripheral blood and synovial fluid monocytes of enthesitis related arthritis category of juvenile idiopathic arthritis (JIA-ERA) patients contributes to secretion of inflammatory mediators

Authors: Arpita Myles and Amita Aggarwal

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P50

Content type: Poster presentation Published on: 29 February 2012

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Maintenance of mitochondrial DNA copy number is essential for osteoclast survival

Authors: Tsuyoshi Miyazaki, Shuuichi Mori, Kazuhiro Shigemoto, Nils-Goran Larsson, Takeshi Nakamura, Shigekaki Kato, Tomoki Nakashima, Hiroshi Takayanagi and Sakae Tanaka

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P49

Content type: Poster presentation Published on: 29 February 2012

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Overview of biotherapy in rheumatoid arthritis (RA)

Authors: Tsutomu Takeuchi and Hideto Kameda

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):O41

Content type: Oral presentation Published on: 29 February 2012

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Risk factors for latent tuberculosis infection in RA patients treated with anti-tumor necrosis factor

Authors: Shiang-Fen Huang, Wei-Juin Su, Sheng-Yuan Ruan, Chong-Jen Yu, Song-Chou Hsieh, Yu-Chih Liu, Yeong-Jian Jan Wu and Hsiao-Yi Lin

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P40

Content type: Poster presentation Published on: 29 February 2012

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Abnormal expressions of immune response-related genes in RA bone marrow cells

Authors: Hooi-Ming Lee, Chieko Aoki, Yasunori Shimaoka, Kensuke Ochi, Takahiro Ochi and Norihiro Nishimoto

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P39

Content type: Poster presentation Published on: 29 February 2012

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Fas deficiency attenuates bone loss during antigen induced arthritis in mice

Authors: Elvira Lazic Mosler, Sania Kuzmac, Sanja Ivcevic, Danka Grcevic, Ana Marusic and Natasa Kovacic

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P38

Content type: Poster presentation Published on: 29 February 2012

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T cell receptor rearrangement excision circles (TREC) study as an approach to "in vivo" thymus gland function investigation

Authors: Natalia Lakhonina, Mark Goloviznin, Almira Donetskova, Margarita Nikonova, Alexander Yarilin, Yulia Buldakova and Anna Tektova

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P37

Content type: Poster presentation Published on: 29 February 2012

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Interleukin-6 as a therapeutic target in locomotor disorders

Authors: Norihiro Nishimoto, Miho Murakami, Takaji Matsutani, Jun Hashimoto and Nobuhiro Takagi

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):O37

Content type: Oral presentation Published on: 29 February 2012

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LC-MS/MS-based shotgun proteomics identified the targets of arthritis-related microRNA

Authors: Riho Kurata, Tomo Yonezawa, Hideki Nakajima, Shyuji Takada and Hiroshi Asahara

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P36

Content type: Poster presentation Published on: 29 February 2012

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Decreased plating efficiency, proliferation and osteogenic differentiation of synovial fluid mesenchymal progenitors as a marker of severity of juvenile idiopathic arthritis

Authors: Elvira Lazic Mosler, Marija Jelusic-Drazic, Danka Grcevic, Ana Marusic and Natasa Kovacic

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P35

Content type: Poster presentation Published on: 29 February 2012

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New mechanisms of action and signaling by TNF-α

Authors: Lionel B Ivashkiv

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):O35

Content type: Oral presentation Published on: 29 February 2012

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From discovery of RANKL to clinical application of anti-human RANKL antibody

Authors: Hisataka Yasuda, Yuriko Furuya and Kohji Uchida

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):O33

Content type: Oral presentation Published on: 29 February 2012

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Cartilage-specific deletion of prar-gamma in mice results in early endochondral ossification defects and accelerated aging-dependent development of osteoarthritis

Authors: Roxana Monemdjou, Faezeh Vasheghani, Hassan Fahmi, Gemma Perez, Meryem Blati, Noboru Taniguchi, Martin Lotz, René St-Arnaud, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Frank Beier and Mohit Kapoor

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P31

Content type: Poster presentation Published on: 29 February 2012

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Methyl glyoxal increase apoptosis (CASPASE-3 expression) in pre-osteoblast MC3T3E1 cell line via SOD activity

Authors: Izaak Zoelkarnain Akbar, Handono Kalim, Djoko Wahono Soeatmadji and Mohammad Hidayat

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P29

Content type: Poster presentation Published on: 29 February 2012

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Adrenal function in rheumatoid arthritis: a correlation with disease activity

Authors: Richard Imrich, Miroslav Vlcek, Jana Kerlik, Michael Vogeser, Fabian Kirchhoff, Adela Penesova, Zofia Radikova, Jozef Lukac and Jozef Rovensky

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P27

Content type: Poster presentation Published on: 29 February 2012

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Association between serum level of Vitamin D with autoantibodies expression, disease activity (SLEDAI) and bone mineral density (BMD) in patients with Systemic Lupus Erythematosus (SLE)

Authors: Handono Kalim, Singgih Wahono, Putra Suryana BP, Lenny Puspitasari, Fajar Hadi Wijayanto and Kusworini Handono

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P23

Content type: Poster presentation Published on: 29 February 2012

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Synoviolin meets metabolic disorders

Authors: Naoko Yagishita, Satoko Aratani, Daisuke Hasegawa, Yoshihisa Yamano, Kusuki Nishioka and Toshihiro Nakajima

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):O23

Content type: Oral presentation Published on: 29 February 2012

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T-regs/Th17 function defect in systemic autoimmunity as a result of "recent thymic emigrants" maturation defect

Authors: Mark Goloviznin, Natalia Lakhonina, Alexander Yarilin, Yulia Buldakova, Vitaly Timofeev, Tatiana Kremenchugskaya and Marina Struchkova

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P21

Content type: Poster presentation Published on: 29 February 2012

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Regulation of inflammatory immune responses leading to the development of bone destructive autoimmune disease rheumatoid arthritis by IL-27

Authors: Takayuki Yoshimoto, Mingli Xu, Izuru Mizuguchi, Yukino Chiba, Sadahiro Kamiya, Masanori Matsui, Shiva Shahrara and Junichiro Mizuguchi

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):O21

Content type: Oral presentation Published on: 29 February 2012

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Therapeutic targets for rheumatoid arthritis: lessons from animal models

Authors: Yoichiro Iwakura, Shinobu Saijo, Susumu Nakae, Noriyuki Fujikado, Harumichi Ishigame and Masanori Murayama

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):O18

Content type: Oral presentation Published on: 29 February 2012

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GCIP, Id like HLH protein, negatively regulates cell proliferation of rheumatoid synovial cells via interaction with CBP

Authors: Hidetoshi Fujita, Minako Nakazawa, Satoko Aratani, Kusuki Nishioka, Akiyoshi Fukamizu and Toshihiro Nakajima

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P17

Content type: Poster presentation Published on: 29 February 2012

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Fcγ receptor targeting in RA

Authors: Toshiyuki Takai, Akira Nakamura, Akiko Tobinai, Shota Endo and Masanori Inui

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):O17

Content type: Oral presentation Published on: 29 February 2012

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Immune cell - derived microparticles contribute to the resistance of rheumatoid arthritis synovial fibroblasts to death receptor-mediated apoptosis

Authors: Mojca Frank, Meike Dahlhaus, Maria Filkova, Christoph Kolling, Beat A Michel, Diego Kyburz, Blaž Rozman, Renate E Gay, David Pisetsky, Steffen Gay and Astrid Jüngel

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P15

Content type: Poster presentation Published on: 29 February 2012

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Evidence for synovial fibroblasts spreading rheumatoid arthritis

Authors: Ulf Müller-Ladner, Stefanie Lefèvre, Birgit Zimmermann, Ingo H Tarner, Robert Dinser, Thomas Pap, Steffen Gay and Elena Neumann

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):O15

Content type: Oral presentation Published on: 29 February 2012

This article is part of a Supplement: Volume 14 Supplement 1
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MiRs in RA: possible biomarkers and therapeutic targets

Authors: Maria Filkova, Caroline Ospelt, Joanna Stanczyk, Serena Vettori, Ladislav Senolt, Mojca Frank, Christoph Kolling, Beat A Michel, Renate E Gay, Steffen Gay and Astrid Jüngel

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P14

Content type: Poster presentation Published on: 29 February 2012

This article is part of a Supplement: Volume 14 Supplement 1
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Assessment of histological alterations in cartilage and extracellular matrix driven by collagen-induced arthritis in Macaca fascicularis

Authors: Norio Amizuka, Hiromi Hongo, Muneteru Sasaki, Tomoka Hasegawa, Paulo Henrique Luiz de Freitas, Hiroshi Mori and Minqi Li

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):O14

Content type: Oral presentation Published on: 29 February 2012

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Anti-Fas IgM monoclonal antibody (anti-Fas mAb) effect on haemophilic arthropathy (HA) synoviocytes

Authors: Serena Guiducci, Eloisa Romano, Claudia Ceccarelli, Daniela Melchiorre, Mirko Manetti, Anna F Milia, Lidia Ibba Manneshi, Kusuki Nishioka and Marco Matucci Cerinic

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):O11

Content type: Oral presentation Published on: 29 February 2012

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Acute Serum Amyloid A induces cell migration cytoskeletal rearrangement and Notch signalling in rheumatoid arthritis

Authors: Mary Connolly, Peadar Rooney, Wei Gao, Douglas Veale and Ursula Fearon

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P10

Content type: Poster presentation Published on: 29 February 2012

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PTEN in antigen presenting cells is a master regulator for Th17-mediated autoimmune pathology

Authors: Stephan Blüml, Gernot Schabbauer, Eva Hainzl, Birgit Niederreiter, Anastasia Hladik, Tobias Lohmeyer, Michael Bonelli, Elisabeth Zinser, Marije Koenders, Wim van den Berg, Giulio Superti-Furga, Josef S Smolen and Kurt Redlich

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P9

Content type: Poster presentation Published on: 29 February 2012

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The bacterial effector protein YopM reduces rheumatoid arthritis (RA) outcome by inhibiting inflammation and bone destruction

Authors: J Bertrand, C Rueter, C Cromme, J Scharnert, A Schmidt and T Pap

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P8

Content type: Poster presentation Published on: 29 February 2012

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Death receptor-induced apoptosis signalling - essential guardian against autoimmune disease

Authors: Andreas Strasser, Lorraine A O'Reilly, Philipp Jost, Thomas Kaufmann, Stephanie Grabow, Elizabeth Kruse, Lin Tai, Mark Smyth and Philippe Bouillet

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):O8

Content type: Oral presentation Published on: 29 February 2012

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A novel role for monosodium urate monohydrate crystals and gouty synovial fluids in monocyte migration in gout

Authors: M Asif Amin, Qiang Shu, Jonathon W Vargo, Jeffrey H Ruth, Takeo Isozaki, Solhee Lee and Alisa E Koch

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P5

Content type: Poster presentation Published on: 29 February 2012

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From rheumatic diseases to cancer - role of autoantibodies as diagnostic biomarkers

Authors: Eng M Tan

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):O2

Content type: Oral presentation Published on: 29 February 2012

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Reconstruction of injured spinal cord by epigenetic regulation of transplanted neural stem cells

Authors: Masahiko Abematsu, Keita Tsujimura, Mariko Yamano, Michiko Saito, Kenji Kohno, Takao Setoguchi, Kazunori Yone, Kinichi Nakashima and Setsuro Komiya

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P1

Content type: Poster presentation Published on: 29 February 2012

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Usage of skin care products and risk of rheumatoid arthritis: results from the Swedish EIRA study

The aim of this study was to investigate the association between exposure to cosmetics, often containing mineral oil, and the risk of developing rheumatoid arthritis (RA). The study was performed against the b...

Authors: Berit M Sverdrup, Henrik Källberg, Lars Klareskog and Lars Alfredsson

Citation: Arthritis Research & Therapy 2012 14:R41

Content type: Research article Published on: 28 February 2012
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Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2mouse model of Sjögren's syndrome

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a key negative costimulatory molecule that displays a wide range of anti-inflammatory properties and is currently approved to treat rheumatoid arthritis as a recomb...

Authors: Hongen Yin, Cuong Q Nguyen, Yuval Samuni, Toshimitsu Uede, Ammon B Peck and John A Chiorini

Citation: Arthritis Research & Therapy 2012 14:R40

Content type: Research article Published on: 27 February 2012
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The BRIC-GARN Meeting 2011: of mice and men

Authors: David S Pisetsky

Citation: Arthritis Research & Therapy 2012 14:107

Content type: Editorial Published on: 24 February 2012
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How does BAFF activate B cells in patients with autoimmune diseases?

In a study in a recent issue of Arthritis Research & Therapy, Yoshimoto and colleagues demonstrate that peripheral monocytes from patients with Sjögren's syndrome (SS) produce significantly higher amounts of B ce...

Authors: Xavier Mariette

Citation: Arthritis Research & Therapy 2012 14:106

Content type: Editorial Published on: 24 February 2012
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Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study

The aim of this study was to explore the presence and localization of myocardial citrullination in samples from rheumatoid arthritis (RA) patients compared to rheumatic and non-rheumatic disease control groups.

Authors: Jon T Giles, Justyna Fert-Bober, Jin Kyun Park, Clifton O Bingham III, Felipe Andrade, Karen Fox-Talbot, Dimitrios Pappas, Antony Rosen, Jennifer van Eyk, Joan M Bathon and Marc K Halushka

Citation: Arthritis Research & Therapy 2012 14:R39

Content type: Research article Published on: 24 February 2012
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