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  1. Circumstantial evidence suggests that retroviruses play a role in the pathogenesis of Sjögren's syndrome. Such evidence, derived from studies of patients with Sjögren's syndrome, includes the following: the pr...

    Authors: Nikolaos V Sipsas, Maria N Gamaletsou and Haralampos M Moutsopoulos
    Citation: Arthritis Research & Therapy 2011 13:212
    Content type: Review Published on:

  2. Folate receptor beta (FRβ) is only detectable in placenta and limited to some hematopoietic cells of myeloid lineage in healthy people. Studies have indicated that FRβ is over-expressed in activated macrophage...

    Authors: Yang Feng, Jiayin Shen, Emily D Streaker, Michael Lockwood, Zhongyu Zhu, Philip S Low and Dimiter S Dimitrov
    Citation: Arthritis Research & Therapy 2011 13:R59
    Content type: Research article Published on:

  3. The purpose of this study was to explore a data set of patients with fibromyalgia (FM), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) who completed the Revised Fibromyalgia Impact Questionna...

    Authors: Ronald Friend and Robert M Bennett
    Citation: Arthritis Research & Therapy 2011 13:R58
    Content type: Research article Published on:

  4. A number of genetic-association studies have identified genes contributing to ankylosing spondylitis (AS) susceptibility but such approaches provide little information as to the gene activity changes occurring...

    Authors: Fernando M Pimentel-Santos, Dário Ligeiro, Mafalda Matos, Ana F Mourão, José Costa, Helena Santos, Anabela Barcelos, Fátima Godinho, Patricia Pinto, Margarida Cruz, João E Fonseca, Henrique Guedes-Pinto, Jaime C Branco, Matthew A Brown and Gethin P Thomas
    Citation: Arthritis Research & Therapy 2011 13:R57
    Content type: Research article Published on:

  6. Chemerin is a chemokine that, through the engagement of its counter-receptor, ChemR23, attracts pro-inflammatory cells. However, chemerin has been shown to play other functions and a recent study by Berg and c...

    Authors: Florenzo Iannone and Giovanni Lapadula
    Citation: Arthritis Research & Therapy 2011 13:104
    Content type: Editorial Published on:

  8. Folate receptor (FR)-expressing macrophages have been shown to accumulate at sites of inflammation, where they promote development of inflammatory symptoms. To target such a macrophage population, we designed ...

    Authors: Yingjuan Lu, Torian W Stinnette, Elaine Westrick, Patrick J Klein, Mark A Gehrke, Vicky A Cross, Iontcho R Vlahov, Philip S Low and Christopher P Leamon
    Citation: Arthritis Research & Therapy 2011 13:R56
    Content type: Research article Published on:

  9. Synovial tissue of patients with rheumatoid arthritis (RA) spontaneously produces several cytokines, of which a fundamental role in joint inflammation and destruction has been established. However, the factors...

    Authors: Shahla Abdollahi-Roodsaz, Fons AJ van de Loo and Wim B van den Berg
    Citation: Arthritis Research & Therapy 2011 13:105
    Content type: Editorial Published on:

  10. The objective of this study was to investigate which genes are regulated by osteogenic protein-1 (OP-1) in human articular chondrocytes using Affimetrix gene array, in order to understand the role of OP-1 in c...

    Authors: Susan Chubinskaya, Lori Otten, Stephan Soeder, Jeffrey A Borgia, Thomas Aigner, David C Rueger and Richard F Loeser
    Citation: Arthritis Research & Therapy 2011 13:R55
    Content type: Research article Published on:

  11. Collagen-induced arthritis (CIA) is a mouse model for rheumatoid arthritis (RA) and is induced after immunization with type II collagen (CII). CIA, like RA, is an autoimmune disease leading to destruction of c...

    Authors: Alexandra Bäcklund, Meirav Holmdahl, Ragnar Mattsson, Katarina Håkansson, Veronica Lindström, Kutty Selva Nandakumar, Anders Grubb and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2011 13:R54
    Content type: Research article Published on:

  12. We report the impact of canakinumab, a fully human anti-interleukin-1β monoclonal antibody, on inflammation and health-related quality of life (HRQoL) in patients with difficult-to-treat Gouty Arthritis.

    Authors: Naomi Schlesinger, Marc De Meulemeester, Andrey Pikhlak, A Eftal Yücel, Dominik Richard, Valda Murphy, Udayasankar Arulmani, Peter Sallstig and Alexander So
    Citation: Arthritis Research & Therapy 2011 13:R53
    Content type: Research article Published on:

  13. Authors: Matthew R McCann, Roxana Monemdjou, Parisa Ghassemi-Kakroodi, Hassan Fahmi, Gemma Perez, Shangxi Liu, Xu Shi-wen, Sunil K Parapuram, Fumiaki Kojima, Christopher P Denton, David J Abraham, Johanne Martel-Pelletier, Leslie J Crofford, Andrew Leask and Mohit Kapoor
    Citation: Arthritis Research & Therapy 2011 13:402
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2011 13:R6

  14. There has been no report in the literature of a soluble form of interleukin (IL)-18 receptor α (IL-18Rα). In this study, we evaluated the levels and characteristics of soluble IL-18Rα (sIL-18Rα) in the sera of...

    Authors: Satoko Takei, Tomoaki Hoshino, Kazuko Matsunaga, Yuki Sakazaki, Masanori Sawada, Hanako Oda, Shin-ichi Takenaka, Haruki Imaoka, Takashi Kinoshita, Seiyo Honda, Hiroaki Ida, Taka-aki Fukuda and Hisamichi Aizawa
    Citation: Arthritis Research & Therapy 2011 13:R52
    Content type: Research article Published on:

  15. TNF-like weak inducer of apoptosis (TWEAK) has been proposed as a mediator of inflammation and bone erosion in rheumatoid arthritis (RA). This study aimed to investigate TWEAK and TWEAK receptor (Fn14) express...

    Authors: Anak ASSK Dharmapatni, Malcolm D Smith, Tania N Crotti, Christopher A Holding, Cristina Vincent, Helen M Weedon, Andrew CW Zannettino, Timothy S Zheng, David M Findlay, Gerald J Atkins and David R Haynes
    Citation: Arthritis Research & Therapy 2011 13:R51
    Content type: Research article Published on:

  16. The purpose of this study was to correlate the level of anabolic and catabolic biomarkers in synovial fluid (SF) from patients with rheumatoid arthritis (RA), patients with osteoarthritis (OA) and asymptomatic...

    Authors: Rediet Kokebie, Rohit Aggarwal, Sukhwinderjit Lidder, Arnavaz A Hakimiyan, David C Rueger, Joel A Block and Susan Chubinskaya
    Citation: Arthritis Research & Therapy 2011 13:R50
    Content type: Research article Published on:

  17. The objective was to investigate associations between the HLA-A gene and Behcet's disease (BD) and its clinical manifestations.

    Authors: Eun Ha Kang, Jeong Yeon Kim, Fujio Takeuchi, Joon Wan Kim, Kichul Shin, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Myoung Hee Park and Yeong Wook Song
    Citation: Arthritis Research & Therapy 2011 13:R49
    Content type: Research article Published on:

  18. It has previously been reported that local and referred pain from active myofascial trigger points (MTPs) in the neck and shoulder region contribute to fibromyalgia (FM) pain and that the pain pattern induced ...

    Authors: Hong-You Ge, Ying Wang, César Fernández-de-las-Peñas, Thomas Graven-Nielsen, Bente Danneskiold-Samsøe and Lars Arendt-Nielsen
    Citation: Arthritis Research & Therapy 2011 13:R48
    Content type: Research article Published on:

  19. T cell immunoglobulin and mucin domain-2 (TIM-2) has been shown to regulate CD4 T cell activation. However, the role of TIM-2 in the autoimmune disease models has not been clarified yet. In this study, we inve...

    Authors: Toshio Kawamoto, Yoshiyuki Abe, Jun Ito, Fumihiko Makino, Yuko Kojima, Yoshihiko Usui, Juan Ma, Shinji Morimoto, Hideo Yagita, Ko Okumura, Yoshinari Takasaki and Hisaya Akiba
    Citation: Arthritis Research & Therapy 2011 13:R47
    Content type: Research article Published on:

  20. Intraarticular hyaluronan (HA) is used clinically for symptomatic relief in patients with knee osteoarthritis (OA); however, the mechanism of action is unclear. In this study, we examined the effects of a sing...

    Authors: Anna Plaas, Jun Li, Julie Riesco, Rosalina Das, John D Sandy and Andrew Harrison
    Citation: Arthritis Research & Therapy 2011 13:R46
    Content type: Research article Published on:

  22. Osteoarthritis is the most prevalent form of arthritis in the world. With the progressive ageing of the population, it is becoming a major public health problem. The involvement of certain signaling pathways, ...

    Authors: Nadia Sassi, Lilia Laadhar, Maha Driss, Meriam Kallel-Sellami, Slaheddine Sellami and Sondes Makni
    Citation: Arthritis Research & Therapy 2011 13:208
    Content type: Review Published on:

  24. The purpose of the present study was to investigate the frequency of the PTPN22 +1858 C/T single nucleotide polymorphism (SNP) (rs 2476601), previously shown to be associated with several autoimmune diseases, in ...

    Authors: Kristina Juneblad, Martin Johansson, Solbritt Rantapää-Dahlqvist and Gerd-Marie Alenius
    Citation: Arthritis Research & Therapy 2011 13:R45
    Content type: Research article Published on:

  25. Glucosamine is an amino-monosaccharide and precursor of glycosaminoglycans, major components of joint cartilage. Glucosamine has been clinically introduced for the treatment of osteoarthritis but the data abou...

    Authors: Nina Ivanovska and Petya Dimitrova
    Citation: Arthritis Research & Therapy 2011 13:R44
    Content type: Research article Published on:

  26. Macrophage migration inhibitory factor (MIF) is one of key regulators in acute and chronic immune-inflammatory conditions including rheumatoid arthritis (RA). We examined the effect of MIF on osteoclastogenesi...

    Authors: Hae-Rim Kim, Kyoung-Woon Kim, Hong Geun Jung, Kwang-Sup Yoon, Hye-Jwa Oh, Mi-La Cho and Sang-Heon Lee
    Citation: Arthritis Research & Therapy 2011 13:R43
    Content type: Research article Published on:

  27. Previously, secretory phospholipase A2 (sPLA2) inhibition has been used as an adjunct to conventional rheumatoid arthritis therapy in human clinical trials without significant improvement of arthritic pathology. ...

    Authors: Liam G Coulthard, Jaclyn Costello, Brent Robinson, Ian A Shiels, Stephen M Taylor and Trent M Woodruff
    Citation: Arthritis Research & Therapy 2011 13:R42
    Content type: Research article Published on:

  28. The Toll-like receptor 7 (TLR7) gene, encoded on human chromosome Xp22.3, is crucial for type I interferon production. A recent multicenter study in East Asian populations, comprising Chinese, Korean and Japanese...

    Authors: Aya Kawasaki, Hiroshi Furukawa, Yuya Kondo, Satoshi Ito, Taichi Hayashi, Makio Kusaoi, Isao Matsumoto, Shigeto Tohma, Yoshinari Takasaki, Hiroshi Hashimoto, Takayuki Sumida and Naoyuki Tsuchiya
    Citation: Arthritis Research & Therapy 2011 13:R41
    Content type: Research article Published on:

  29. Activated fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis (RA) share many characteristics with tumour cells and are key mediators of synovial tissue transformation and joint destruction. The glycop...

    Authors: Anna-Karin H Ekwall, Thomas Eisler, Christian Anderberg, Chunsheng Jin, Niclas Karlsson, Mikael Brisslert and Maria I Bokarewa
    Citation: Arthritis Research & Therapy 2011 13:R40
    Content type: Research article Published on:

  30. Authors: Sarah Djabarouti, Dominique Breilh, Pierre Duffau, Estibaliz Lazaro, Carine Greib, Olivier Caubet, Marie-Claude Saux, Jean-Luc Pellegrin and Jean-François Viallard
    Citation: Arthritis Research & Therapy 2011 13:401
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2010 12:R217

  31. The objective of this study was to investigate the contemporary incidence of gout, examine potential risk factors, and evaluate specific gout treatment patterns in the general population.

    Authors: Lucía Cea Soriano, Dietrich Rothenbacher, Hyon K Choi and Luis A García Rodríguez
    Citation: Arthritis Research & Therapy 2011 13:R39
    Content type: Research article Published on:

  32. The finding of antinuclear antibody (ANA) positivity in a healthy individual is usually of unknown significance and in most cases is benign. However, a subset of such individuals is at risk for development of ...

    Authors: Quan-Zhen Li, David R Karp, Jiexia Quan, Valerie K Branch, Jinchun Zhou, Yun Lian, Benjamin F Chong, Edward K Wakeland and Nancy J Olsen
    Citation: Arthritis Research & Therapy 2011 13:R38
    Content type: Research article Published on:

  33. Lead (Pb) is known to affect bone, and recent evidence suggests that it has effects on cartilage as well. As osteoarthritis (OA) is a highly prevalent disease affecting bone and cartilage, we undertook the pre...

    Authors: Amanda E Nelson, Xiaoyan A Shi, Todd A Schwartz, Jiu-Chiuan Chen, Jordan B Renner, Kathleen L Caldwell, Charles G Helmick and Joanne M Jordan
    Citation: Arthritis Research & Therapy 2011 13:R37
    Content type: Research article Published on:

  34. As the immunosuppressive potency of 15-deoxyspergualin (DSG) has been shown in the therapy of renal transplant rejection and Wegener's granulomatosis, the intention of this study was to evaluate the safety of ...

    Authors: Hanns-Martin Lorenz, Wilhelm H Schmitt, Vladimir Tesar, Ulf Müller-Ladner, Ingo Tarner, Ingeborg A Hauser, Falk Hiepe, Tobias Alexander, Heike Woehling, Kyuichi Nemoto and Peter A Heinzel
    Citation: Arthritis Research & Therapy 2011 13:R36
    Content type: Research article Published on:

  35. In vitro and in vivo experimental data have pointed to new immunopathogenic mechanisms in primary Sjögren's syndrome (pSS). The availability of targeted treatment modalities has opened new ways to selectively tar...

    Authors: Cees GM Kallenberg, Arjan Vissink, Frans GM Kroese, Wayel H Abdulahad and Hendrika Bootsma
    Citation: Arthritis Research & Therapy 2011 13:205
    Content type: Review Published on:

  39. The aims of the present study were to identify histopathological parameters which are linked to local clinical skin disease at two distinct anatomical sites in systemic sclerosis (SSc) patients with skin invol...

    Authors: Jens T Van Praet, Vanessa Smith, Marc Haspeslagh, Nele Degryse, Dirk Elewaut and Filip De Keyser
    Citation: Arthritis Research & Therapy 2011 13:R35
    Content type: Research article Published on:

  40. Cryopyrin-associated periodic syndrome (CAPS) represents a spectrum of three auto-inflammatory syndromes, familial cold auto-inflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multis...

    Authors: Jasmin B Kuemmerle-Deschner, Eduardo Ramos, Norbert Blank, Joachim Roesler, Sandra D Felix, Thomas Jung, Kirstin Stricker, Abhijit Chakraborty, Stacey Tannenbaum, Andrew M Wright and Christiane Rordorf
    Citation: Arthritis Research & Therapy 2011 13:R34
    Content type: Research article Published on:

  41. Historically, pregnancy in women with many inflammatory rheumatic diseases was not considered safe and was discouraged. Combined care allows these pregnancies to be managed optimally, with the majority of outc...

    Authors: Varsha Jain and Caroline Gordon
    Citation: Arthritis Research & Therapy 2011 13:206
    Content type: Review Published on:

  42. The aim of this study was to examine the effect of blocking Toll-like receptor 2 (TLR2) in rheumatoid arthritis (RA) synovial cells.

    Authors: Sinéad Nic An Ultaigh, Tajvur P Saber, Jennifer McCormick, Mary Connolly, Jerome Dellacasagrande, Brian Keogh, William McCormack, Mary Reilly, Luke A O'Neill, Peter McGuirk, Ursula Fearon and Douglas J Veale
    Citation: Arthritis Research & Therapy 2011 13:R33
    Content type: Research article Published on:

  43. Health care utilization databases have been increasingly used for studies of rheumatoid arthritis (RA). However, the accuracy of RA diagnoses in these data has been inconsistent.

    Authors: Seo Young Kim, Amber Servi, Jennifer M Polinski, Helen Mogun, Michael E Weinblatt, Jeffrey N Katz and Daniel H Solomon
    Citation: Arthritis Research & Therapy 2011 13:R32
    Content type: Research article Published on:

  44. Changes in bone mineral density (BMD) in the hand as evaluated by digital X-ray radiogrammetry (DXR) of the second to fourth metacarpal bones has been suggested to predict future joint damage in patients with ...

    Authors: Meliha C Kapetanovic, Elisabet Lindqvist, Jakob Algulin, Kjell Jonsson, Tore Saxne, Kerstin Eberhardt and Pierre Geborek
    Citation: Arthritis Research & Therapy 2011 13:R31
    Content type: Research article Published on:

  45. Autoantibodies have a central role in systemic lupus erythematosus (SLE). The presence of autoantibodies preceding disease onset by years has been reported both in patients with SLE and in those with rheumatoi...

    Authors: Catharina Eriksson, Heidi Kokkonen, Martin Johansson, Göran Hallmans, Göran Wadell and Solbritt Rantapää-Dahlqvist
    Citation: Arthritis Research & Therapy 2011 13:R30
    Content type: Research article Published on:

  46. Ankylosing spondylitis (AS) is a chronic autoimmune disease, and the precise pathogenesis is largely unknown at present. Bone marrow-derived mesenchymal stem cells (BMSCs) with immunosuppressive and anti-infla...

    Authors: Yanfeng Wu, Mingliang Ren, Rui Yang, Xinjun Liang, Yuanchen Ma, Yong Tang, Lin Huang, Jichao Ye, Keng Chen, Peng Wang and Huiyong Shen
    Citation: Arthritis Research & Therapy 2011 13:R29
    Content type: Research article Published on:

  47. Hand osteoarthritis (OA) is associated with pain, reduced grip strength, loss of range of motion and joint stiffness leading to impaired hand function and difficulty with daily activities. The effectiveness of...

    Authors: Liuzhen Ye, Leonid Kalichman, Alicia Spittle, Fiona Dobson and Kim Bennell
    Citation: Arthritis Research & Therapy 2011 13:R28
    Content type: Research article Published on:

  48. Developmental dysplasia of the hip (DDH) is a common skeletal disease, which is characterized by abnormal seating of the femoral head in the acetabulum. Genetic factors play a considerable role in the etiology...

    Authors: Dongquan Shi, Jin Dai, Pengsheng Zhu, Jianghui Qin, Lunqing Zhu, Hongtao Zhu, Baocheng Zhao, Xusheng Qiu, Zhihong Xu, Dongyang Chen, Long Yi, Shiro Ikegawa and Qing Jiang
    Citation: Arthritis Research & Therapy 2011 13:R27
    Content type: Research article Published on:

  50. The long-term treatment of rheumatoid arthritis (RA) most often involves a sequence of different therapies. The response to therapy, disease progression and detailed knowledge of the role of different therapie...

    Authors: Regina Rendas-Baum, Gene V Wallenstein, Tamas Koncz, Mark Kosinski, Min Yang, John Bradley and Samuel H Zwillich
    Citation: Arthritis Research & Therapy 2011 13:R25
    Content type: Research article Published on:
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Arthritis Research & Therapy

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