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Inflammatory microcrystals induce murine macrophage survival and DNA synthesis

The interaction of particulates with resident macrophages is a consistent feature in certain forms of crystal-induced inflammation, for example, in synovial tissues, lung, and the peritoneum. The mitogenic act...

Authors: John A Hamilton, Geraldine McCarthy and Genevieve Whitty

Citation: Arthritis Research & Therapy 2001 3:242

Content type: Research article Published on: 26 March 2001
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Links between complement deficiency and apoptosis

Deficiency in the classical pathway complement components displays a hierarchical association with the development of systemic lupus erythematosus (SLE). In addition, SLE causes consumption of complement. C1q-...

Authors: Marina Botto

Citation: Arthritis Research & Therapy 2001 3:207

Content type: Commentary Published on: 26 March 2001
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NF-κB in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction

The transcription factor NF-κB has been well recognized as a pivotal regulator of inflammation in rheumatoid arthritis (RA), but recent developments revealed a broad involvement of NF-κB in other aspects of RA...

Authors: Sergei S Makarov

Citation: Arthritis Research & Therapy 2001 3:200

Content type: Commentary Published on: 26 March 2001
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B cells, BAFF/zTNF4, TACI, and systemic lupus erythematosus

B cells and B-cell/T-cell collaborations are instrumental in the pathophysiology of systemic lupus erythematosus (SLE). This commentary highlights in particular the newly discovered role of B-cell-activating f...

Authors: Thomas Dörner and Chaim Putterman

Citation: Arthritis Research & Therapy 2001 3:197

Content type: Commentary Published on: 20 March 2001
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B lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selection

The synovial membrane (SM) of affected joints in ankylosing spondylitis (AS) is infiltrated by germinal center-like aggregates (foci) of lymphocytes similar to rheumatoid arthritis (RA). We characterized the r...

Authors: Jan Voswinkel, Kerstin Weisgerber, Michael Pfreundschuh and Angela Gause

Citation: Arthritis Research & Therapy 2001 3:189

Content type: Research article Published on: 1 March 2001
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Genetic epidemiology: Giant cell arteritis and polymyalgia rheumatica

Giant cell arteritis (GCA) (temporal arteritis) and polymyalgia rheumatica (PMR) are common, frequently related conditions in people generally over 50 years of age. Most studies have shown an association of GC...

Authors: Miguel A Gonzalez-Gay

Citation: Arthritis Research & Therapy 2001 3:154

Content type: Review Published on: 26 February 2001
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Negative regulation of BMP signaling by Tob

Authors: Riako Masuda

Citation: Arthritis Research & Therapy 2001 3:66887

Content type: Paper Report Published on: 23 February 2001
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Autoreactive T cells respond to nucleobindin

Authors: Fanny Monneaux

Citation: Arthritis Research & Therapy 2001 3:66886

Content type: Paper Report Published on: 23 February 2001
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Angiogenesis in the pathogenesis of inflammatory joint and lung diseases

This paper reviews hypotheses about roles of angiogenesis in the pathogenesis of inflammatory disease in two organs, the synovial joint and the lung. Neovascularisation is a fundamental process for growth and ...

Authors: David A Walsh and Claire I Pearson

Citation: Arthritis Research & Therapy 2001 3:147

Content type: Review Published on: 23 February 2001
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Hyposecretion of the adrenal androgen dehydroepiandrosterone sulfate and its relation to clinical variables in inflammatory arthritis

Hypothalamic–pituitary–adrenal underactivity has been reported in rheumatoid arthritis (RA). This phenomenon has implications with regard to the pathogenesis and treatment of the disease. The present study was...

Authors: Patrick H Dessein, Barry I Joffe, Anne E Stanwix and Zubair Moomal

Citation: Arthritis Research & Therapy 2001 3:183

Content type: Research article Published on: 21 February 2001
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Low HLA-DM expression in RA

Authors: Robert Busch

Citation: Arthritis Research & Therapy 2001 3:66885

Content type: Paper Report Published on: 20 February 2001
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Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within pa...

Authors: Agneta Scheja, Anita Åkesson, Pierre Geborek, Marie Wildt, Claes B Wollheim, Frank A Wollheim and Ulrich M Vischer

Citation: Arthritis Research & Therapy 2001 3:178

Content type: Research article Published on: 19 February 2001
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Future of adenoviruses in the gene therapy of arthritis

Recombinant adenoviruses are straightforward to produce at high titres, have a promiscuous host-range, and, because of their ability to infect nondividing cells, lend themselves to in vivo gene delivery. Such adv...

Authors: Christopher H Evans, Steven C Ghivizzani, Thomas A Oligino and Paul D Robbins

Citation: Arthritis Research & Therapy 2001 3:142

Content type: Commentary Published on: 19 February 2001
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Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

Authors: Jose L Pablos

Citation: Arthritis Research & Therapy 2001 3:66884

Content type: Paper Report Published on: 15 February 2001
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The double-edged sword of donor T-cell chimerism in skin grafts

Authors: Nathalie Lambert

Citation: Arthritis Research & Therapy 2001 3:66883

Content type: Paper Report Published on: 14 February 2001
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Is negative regulation by CD45 involved in lupus?

Authors: Thomas Dorner

Citation: Arthritis Research & Therapy 2001 3:66882

Content type: Paper Report Published on: 14 February 2001
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The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity

The classification of T helper cells into type 1 (Th1) and type 2 (Th2) led to the hypothesis that Th1 cells and their cytokines (interleukin [IL]-2, interferon [IFN]-γ) are involved in cell-mediated autoimmun...

Authors: Argyrios N Theofilopoulos, Stefanos Koundouris, Dwight H Kono and Brian R Lawson

Citation: Arthritis Research & Therapy 2001 3:136

Content type: Commentary Published on: 14 February 2001
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Interphase fluorescence in situ hybridization analysis of fibroblast-like synoviocytes of patients with rheumatoid arthritis and osteoarthritis

Authors: HP Kiener, J Ackermann, K Redlich, I Radda, CW Steiner, P Bitzan, JS Smolen and J Drach

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P119

Content type: Meeting abstract Published on: 9 February 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Arthritiswebsite

Authors: Stefano Fiore

Citation: Arthritis Research & Therapy 2001 3:0019

Content type: Web Report Published on: 9 February 2001
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Targeting the HIF system

Authors: Oliver Distler

Citation: Arthritis Research & Therapy 2001 3:66881

Content type: Paper Report Published on: 1 February 2001
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Collagen type I stimulates T cells

Authors: Sarah Parry

Citation: Arthritis Research & Therapy 2001 3:66880

Content type: Paper Report Published on: 1 February 2001
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T-cell-mediated control of autoimmunity

Inflammatory responses provoked by pathogens are antigen-specific in their induction but are nonspecific in their effects. Consequently, they are potentially damaging to the host that produces them. In additio...

Authors: Don Mason

Citation: Arthritis Research & Therapy 2001 3:133

Content type: Commentary Published on: 1 February 2001
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Nucleosome is a necrosis inducer for lymphocytes: consequences in systemic lupus erythematosus

Authors: P Decker and HG Rammensee

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P114

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Protein kinase C inhibition dephosphorylates the ribosomal P proteins while inducing apoptosis in Jurkat cells and peripheral human T cells

Authors: X Wu, S Schatt and P Hasler

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P112

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Time to lupus nephritis: impact of gender and ethnicity

Authors: VA Seligman, H Li, JL Olson and LA Criswell

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P110

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Disparate associations of the FcgammaRIIIa 158/V variant with RA in two diverse populations

Authors: A Milicic, R Misra, MA Brown and BP Wordsworth

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P108

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Juvenile idiopathic arthritis is associated to a functionally active polymorphism in the SH2D2A gene

Authors: A Smerdel, K-Z Dai, B Flato, R Ploski, O Forre and A Spurkland

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P106

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Positivity of HLA-DRB1 rheumatoid epitope does not predict the course of juvenile idiopathic arthritis in Czech children

Authors: O Cinek, P Vavrincová, P Drevínek, M Suková, S Rádová and J Vavrinec

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P104

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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New antirheumatic effects of biphosphonate treatment

Authors: L Konenkova, E Zonova, A Sizikov, M Korolev, S Tsareva and V Kozlov

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P100

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Heterogeneous behaviour of anti-beta₂-glycoprotein I antibodies on different "high binding" microtiter plates

Authors: A Ambrozic, T Kveder, K Ichikawa, T Avcin, M Hojnik, B Bozic and T Koike

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P081

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Immuno-serological profile of Systemic Erythemic Lupus (SLE) patients with neuropsychiatric manifestations (NP)

Authors: L Stojanovich, V Mircetic, R Stojanovich, V Kostich and D Popovich

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P077

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Dominance of hydrophobic reading frames in complementarity determining region 3 of variable heavy chain genes from a patient with untreated SLE

Authors: B Yazdani-Biuki, R Brezinschek, T Dörner, J Hermann, H Mitterhammer, G Tilz, U Demel, T Müller, S Eder, J Gretler and HP Brezinschek

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P075

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Structure and function of an autoantigen, alpha-enloase

Authors: S Moscato, F Bongiorni, F Pratesi, M Scavuzzo, S Bombardieri and P Migliorini

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P073

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Study of the anti-idiotypic resonse to anti-LA/SSB autoantibodies using complementary peptides to B- and T-cell epitopes of La/SSB

Authors: JG Routsias, E Touloupi, A Moulia, M Sakarellos-Daitsiotis, H Dotsika, C Sakarellos, HM Moutsopoulos and AG Tzioufas

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P071

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Detection of anti-B/B' UsnRNP antibodies in connective tissue disease sera by Western immunoblot

Authors: A Ghirardello, A Doria, S Zampieri, D Villalta, F Vescovi and PF Gambari

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P069

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Dendritic cell subsets in rheumatoid arthritis

Authors: K Summers, J O'Donnell and A Rothwell

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P067

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Macrophages expressing the scavenger receptor CD163: a link between immune alterations of the gut and synovial inflammation in spondyloarthropathy

Authors: D Baeten, P Demetter, C Cuvelier, E Kruithof, N Van Damme, M De Vos, EM Veys and F De Keyser

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P065

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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The RIIbeta-subunit of protein kinase A (PKA) inhibits c-fos synthesis in T cells

Authors: N Mishra, M Tolnay, MR Elliott, DR Brown, GC Tsokos and GM Kammer

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P042

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Detection of the "Kreisler" (maf B) gene by combination of in situ-hybridization and immunohistochemistry of RA-, osteoarthritis- and normal controls-synovial tissue samplings as a potential significant marker for early RA

Authors: U Vigna, B Ostendorf, T Pauly, T Giel, U Jeffry, R Murray and M Schneider

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P040

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Redox-sensitive changes in conformation and cellular localization of LAT and downstream TCR signaling lead to hyporesponsiveness of synovial fluid T cells in rheumatoid arthritis

Authors: SI Gringhuis, PHJ Remans, EAM Papendrecht-van der Voort, A Leow, EWN Levarht, FC Breedveld and CL Verweij

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P038

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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T lymphocytes of patients with SLE lack Stat4

Authors: M Aringer, GH Stummvoll, G Steiner, CW Steiner, I Radda, JS Smolen and WB Graninger

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P036

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Elevated levels of soluble intercellular adhesion molecule -1 in systemic lupus erythematosus

Authors: N Kljukvina, S Shekshina, E Alexandrova, A Novicov and E Nassonov

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P034

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Association between TNF -308A and systemic lupus erythematosus in relation to HLA-DR3 and six microsatellite markers on the short arm of chromosome VI

Authors: MW van der Linden, A van der Slik, E Pieterman, E Zanelli, MJ Giphart, FC Breedveld, RGJ Westendorp and TWJ Huizinga

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P032

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Cartilage-derived morphogenetic protein-1 and -2 are endogenously expressed and stimulate proteoglycan synthesis in healthy and osteoarthritic human articular chondrocytes

Authors: K Bobacz, A Soleiman, W Graninger and L Erlacher

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P029

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Normal and pathological bone development controlled by the AP-1 transcription factor complex

Authors: EF Wagner

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):L025

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Molecular events in cartilage formation and remodeling

Authors: Dick Heinegård

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):L023

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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The pathogenesis of osteoarthritis: potential targets for therapy

Authors: S Abramson

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):L020

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Detection of rheumatoid arthritis-specific anti-filaggrin antibodies by line immunoassay shows complementarity to RF and corresponds to the AFA-blot using natural antigen

Authors: A Union, R Humbel, K Conrad, G Steiner, P Schmit, A Vos, K De Bosschere, S Dincq, H Pottel, L Meheus, L Nogueira, G Serre and F De Keyser

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P006

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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Expression of citrullin-containing antigens in RA synovium

Authors: TJ Smeets, ER Vossenaar, MC Kraan, WAM van Mansum, JM Raats, WJ van Venrooij and PP Tak

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P004

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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The significance of antibodies to cyclic citrullinated peptide, antikeratin antibodies, anti-perinuclear factor, rheumatoid factor isotypes and HLA shared epitope in prediction of erosive disease in early rheumatoid arthritis patients

Authors: J Vencovsky, L Sedova, S Machacek, J Gatterova, V Pesakova, J Kafkova and O Krystufkova

Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P002

Content type: Meeting abstract Published on: 26 January 2001

This article is part of a Supplement: Volume 3 Supplement 2
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