Pain in Europe Survey. [http://www.painineurope.com]
Watkins LR, Maier SF: Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov. 2003, 2: 973-985. 10.1038/nrd1251.
Article
CAS
PubMed
Google Scholar
Hedbom E, Häuselmann HJ: Molecular aspects of pathogenesis in osteoarthritis: the role of inflammation. Cell Mol Life Sci. 2002, 59: 45-53. 10.1007/s00018-002-8404-z.
Article
CAS
PubMed
Google Scholar
Dorn G, Patel S, Wotherspoon G, Hemmings-Mieszczak M, Barclay J, Natt FJ, Martin P, Bevan S, Fox A, Ganju P, Wishart W, Hall J: siRNA relieves chronic neuropathic pain. Nucleic Acids Res. 2004, 32: e49-10.1093/nar/gnh044.
Article
PubMed Central
PubMed
Google Scholar
Cheng HY, Penninger JM: When the DREAM is gone: from basic science to future prospectives in pain management and beyond. Expert Opin Ther Targets. 2003, 7: 249-263.
CAS
PubMed
Google Scholar
Cheng HY, Penninger JM: DREAMing about arthritic pain. Ann Rheum Dis. 2004, 63 (Suppl 2): ii72-ii75. 10.1136/ard.2004.029942.
PubMed Central
PubMed
Google Scholar
Vogt BA: Knocking out the DREAM to study pain. N Engl J Med. 2002, 347: 362-364. 10.1056/NEJMcibr021152.
Article
CAS
PubMed
Google Scholar
Carrion AM, Mellstrom B, Luckman SM, Naranjo JR: Stimulus-specific hierarchy of enhancer elements within the rat prodynorphin promoter. J Neurochem. 1998, 70: 914-921.
Article
CAS
PubMed
Google Scholar
Carrion AM, Link WA, Ledo F, Mellstrom B, Naranjo JR: DREAM is a Ca2+-regulated transcriptional repressor. Nature. 1999, 398: 80-84. 10.1038/18044.
Article
CAS
PubMed
Google Scholar
Brookoff D: Chronic pain: 1. A new disease?. Hosp Pract (Off Ed). 2000, 35: 45-52.
Article
CAS
Google Scholar
Cheng HY, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, Wada T, Joza NA, Crackower M, Goncalves J, Sarosi I, Woodgett JR, Oliveira-dos-Santos AJ, Ikura M, Kooy van der D, Salter MW, Penninger JM: DREAM is a critical transcriptional repressor for pain modulation. Cell. 2002, 108: 31-43. 10.1016/S0092-8674(01)00629-8.
Article
CAS
PubMed
Google Scholar
Rivas M, Mellstrom B, Naranjo JR, Santisteban P: Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression. J Biol Chem. 2004, 279: 33114-33122. 10.1074/jbc.M403526200.
Article
CAS
PubMed
Google Scholar
D'Andrea B, Di Palma T, Mascia A, Motti ML, Viglietto G, Nitsch L, Zannini M: The transcriptional repressor DREAM is involved in thyroid gene expression. Exp Cell Res. 2005, 305: 166-178. 10.1016/j.yexcr.2004.12.012.
Article
PubMed
Google Scholar
Sanz C, Mellstrom B, Link WA, Naranjo JR, Fernandez-Luna JL: Interleukin 3-dependent activation of DREAM is involved in transcriptional silencing of the apoptotic Hrk gene in hematopoietic progenitor cells. Embo J. 2001, 20: 2286-2292. 10.1093/emboj/20.9.2286.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sanz C, Horita M, Fernandez-Luna JL: Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells. Haematologica. 2002, 87: 903-907.
CAS
PubMed
Google Scholar
Link WA, Ledo F, Torres B, Palczewska M, Madsen TM, Savignac M, Albar JP, Mellström B, Naranjo JR: Day-night changes in downstream regulatory element antagonist modulator/potassium channel interacting protein activity contribute to circadian gene expression in pineal gland. J Neurosci. 2004, 24: 5346-5355. 10.1523/JNEUROSCI.1460-04.2004.
Article
CAS
PubMed
Google Scholar
Gabellini N: Transcriptional regulation by cAMP and Ca2+ links the na+/ca2+ exchanger 3 to memory and sensory pathways. Mol Neurobiol. 2004, 30: 91-116. 10.1385/MN:30:1:091.
Article
CAS
PubMed
Google Scholar
Ledo F, Kremer L, Mellstrom B, Naranjo JR: Ca2+-dependent block of CREB-CBP transcription by repressor DREAM. Embo J. 2002, 21: 4583-4592. 10.1093/emboj/cdf440.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ledo F, Carrion AM, Link WA, Mellstrom B, Naranjo JR: DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription. Mol Cell Biol. 2000, 20: 9120-9126. 10.1128/MCB.20.24.9120-9126.2000.
Article
PubMed Central
CAS
PubMed
Google Scholar
An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ: Modulation of A-type potassium channels by a family of calcium sensors. Nature. 2000, 403: 553-556. 10.1038/35000592.
Article
CAS
PubMed
Google Scholar
Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W: Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat Med. 1998, 4: 1177-1181. 10.1038/2673.
Article
CAS
PubMed
Google Scholar
Jo DG, Jang J, Kim BJ, Lundkvist J, Jung YK: Overexpression of calsenilin enhances gamma-secretase activity. Neurosci Lett. 2005, 378: 59-64. 10.1016/j.neulet.2004.12.078.
Article
CAS
PubMed
Google Scholar
Lilliehook C, Bozdagi O, Yao J, Gomez-Ramirez M, Zaidi NF, Wasco W, Gandy S, Santucci AC, Haroutunian V, Huntley GW, Buxbaum JD: Altered Aβ formation and long-term potentiation in a calsenilin knock-out. J Neurosci. 2003, 23: 9097-9106.
CAS
PubMed
Google Scholar
Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M, Howell D, Kaplan D, Koopman W, Longley S, Mankin H, McShane DJ, Medsger T, Meenan R, Mikkelsen W, Moskowitz R, Murphy W, Rothschild B, Segal M, Sokoloff L, Wolfe F: Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986, 29: 1039-1049. 10.1002/art.1780290816.
Article
CAS
PubMed
Google Scholar
Sambrook J, Fritsch E, Maniatis T: Molecular Cloning: A Laboratory Manual. 1989, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
Google Scholar
Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods. 2001, 25: 402-408. 10.1006/meth.2001.1262.
Article
CAS
PubMed
Google Scholar
Donzé O, Picard D: RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase. Nucleic Acids Res. 2002, 30: e46-10.1093/nar/30.10.e46.
Article
PubMed Central
PubMed
Google Scholar
Caplen NJ, Parrish S, Imani F, Fire A, Morgan RA: Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci USA. 2001, 98: 9742-9747. 10.1073/pnas.171251798.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hammond PI, Craig TA, Kumar R, Brimijoin S: Regional and cellular distribution of DREAM in adult rat brain consistent with multiple sensory processing roles. Brain Res Mol Brain Res. 2003, 111: 104-110. 10.1016/S0169-328X(02)00693-9.
Article
CAS
PubMed
Google Scholar
Spreafico F, Barski JJ, Farina C, Meyer M: Mouse DREAM/calsenilin/KChIP3: gene structure, coding potential, and expression. Mol Cell Neurosci. 2001, 17: 1-16. 10.1006/mcne.2000.0913.
Article
CAS
PubMed
Google Scholar
Zaidi NF, Berezovska O, Choi EK, Miller JS, Chan H, Lilliehook C, Hyman BT, Buxbaum JD, Wasco W: Biochemical and immunocytochemical characterization of calsenilin in mouse brain. Neuroscience. 2002, 114: 247-263. 10.1016/S0306-4522(02)00251-8.
Article
CAS
PubMed
Google Scholar
Carrion AM, Mellstrom B, Naranjo JR: Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element. Mol Cell Biol. 1998, 18: 6921-6929.
Article
PubMed Central
CAS
PubMed
Google Scholar
Collins-Hicok J, Lin L, Spiro C, Laybourn PJ, Tschumper R, Rapacz B, McMurray CT: Induction of the rat prodynorphin gene through Gs-coupled receptors may involve phosphorylation-dependent derepression and activation. Mol Cell Biol. 1994, 14: 2837-2848.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lilliehook C, Chan S, Choi EK, Zaidi NF, Wasco W, Mattson MP, Buxbaum JD: Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling. Mol Cell Neurosci. 2002, 19: 552-559. 10.1006/mcne.2001.1096.
Article
CAS
PubMed
Google Scholar
Osawa M, Tong KI, Lilliehook C, Wasco W, Buxbaum JD, Cheng HY, Penninger JM, Ikura M, Ames JB: Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3. J Biol Chem. 2001, 276: 41005-41013. 10.1074/jbc.M105842200.
Article
CAS
PubMed
Google Scholar
Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, Wasco W: Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. J Biol Chem. 2001, 276: 19197-19204. 10.1074/jbc.M008597200.
Article
CAS
PubMed
Google Scholar
Choi EK, Miller JS, Zaidi NF, Salih E, Buxbaum JD, Wasco W: Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3. Mol Cell Neurosci. 2003, 23: 495-506. 10.1016/S1044-7431(03)00072-1.
Article
CAS
PubMed
Google Scholar
Stein C, Schäfer M, Machelska H: Attacking pain at its source: new perspectives on opioids. Nat Med. 2003, 9: 1003-1008. 10.1038/nm908.
Article
CAS
PubMed
Google Scholar
Rittner HL, Machelska H, Stein C: Leukocytes in the regulation of pain and analgesia. J Leukoc Biol. 2005, 78: 1215-1222. 10.1189/jlb.0405223.
Article
CAS
PubMed
Google Scholar
Cabot PJ, Carter L, Gaiddon C, Zhang Q, Schäfer M, Loeffler JP, Stein C: Immune cell-derived beta-endorphin. Production, release, and control of inflammatory pain in rats. J Clin Invest. 1997, 100: 142-148. 10.1172/JCI119506.
Article
PubMed Central
CAS
PubMed
Google Scholar
Machelska H, Cabot PJ, Mousa SA, Zhang Q, Stein C: Pain control in inflammation governed by selectins. Nat Med. 1998, 4: 1425-1428. 10.1038/4017.
Article
CAS
PubMed
Google Scholar
Cabot PJ, Carter L, Schafer M, Stein C: Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain. Pain. 2001, 93: 207-212. 10.1016/S0304-3959(01)00322-0.
Article
CAS
PubMed
Google Scholar
Gardell LR, King T, Ossipov MH, Rice KC, Lai J, Vanderah TW, Porreca F: Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery. Neurosci Lett. 2006, 396: 44-49. 10.1016/j.neulet.2005.11.009.
Article
CAS
PubMed
Google Scholar
Vanderah TW, Laughlin T, Lashbrook JM, Nichols ML, Wilcox GL, Ossipov MH, Malan TP, Porreca F: Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats: blockade by MK-801 but not naloxone. Pain. 1996, 68: 275-281. 10.1016/S0304-3959(96)03225-3.
Article
CAS
PubMed
Google Scholar
Laughlin TM, Larson AA, Wilcox GL: Mechanisms of induction of persistent nociception by dynorphin. J Pharmacol Exp Ther. 2001, 299: 6-11.
CAS
PubMed
Google Scholar
Laughlin TM, Vanderah TW, Lashbrook J, Nichols ML, Ossipov M, Porreca F, Wilcox GL: Spinally administered dynorphin A produces long-lasting allodynia: involvement of NMDA but not opioid receptors. Pain. 1997, 72: 253-260. 10.1016/S0304-3959(97)00046-8.
Article
CAS
PubMed
Google Scholar
Shen H, Aeschlimann A, Reisch N, Gay RE, Simmen BR, Michel BA, Gay S, Sprott H: Kappa and delta opioid receptors are expressed but down-regulated in fibroblast-like synoviocytes of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum. 2005, 52: 1402-1410. 10.1002/art.21141.
Article
CAS
PubMed
Google Scholar