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  1. Research article

    Biosemantics guided gene expression profiling of Sjögren’s syndrome: a comparative analysis with systemic lupus erythematosus and rheumatoid arthritis

    Sjögren's syndrome (SS) shares many clinical and pathological similarities with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). These autoimmune diseases mostly affect women. In this study, c...

    Nirav R. Shah, Braxton D. Noll, Craig B. Stevens, Michael T. Brennan, Farah B. Mougeot and Jean-Luc C. Mougeot

    Arthritis Research & Therapy 2017 19:192

    Published on: 17 August 2017

  2. Research article

    Frequency, distribution and immunologic nature of infusion reactions in subjects receiving pegloticase for chronic refractory gout

    To assess frequency and distribution of infusion reactions (IRs) in responders and nonresponders in randomized clinical trials (RCTs) of intravenous pegloticase and the utility of the National Institute of All...

    Leonard H. Calabrese, Arthur Kavanaugh, Anthony E. Yeo and Peter E. Lipsky

    Arthritis Research & Therapy 2017 19:191

    Published on: 17 August 2017

  4. Research article

    The isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients

    Anti-carbamylated protein (anti-CarP) antibodies have recently been reported to occur in around 45% of rheumatoid arthritis (RA) patients and to have prognostic and diagnostic properties. At present, the bread...

    Myrthe A. M. van Delft, Marije K. Verheul, Leonie E. Burgers, Veerle F. A. M. Derksen, Annette H. M. van der Helm-van Mil, Diane van der Woude, Tom W. J. Huizinga, René E. M. Toes and Leendert A. Trouw

    Arthritis Research & Therapy 2017 19:190

    Published on: 15 August 2017

  5. Research article

    The impact of age and gut microbiota on Th17 and Tfh cells in K/BxN autoimmune arthritis

    Age is an important risk factor for rheumatoid arthritis (RA), which often develops in middle age. However, how age-associated changes in immunity impact RA is poorly understood. Gut microbiota are known to be...

    Fei Teng, Krysta M. Felix, C. Pierce Bradley, Debdut Naskar, Heqing Ma, Walid A. Raslan and Hsin-Jung Joyce Wu

    Arthritis Research & Therapy 2017 19:188

    Published on: 15 August 2017

  6. Research article

    A novel scoring system based on common laboratory tests predicts the efficacy of TNF-inhibitor and IL-6 targeted therapy in patients with rheumatoid arthritis: a retrospective, multicenter observational study

    Currently, although several categories of biological disease-modifying antirheumatic drugs (bDMARDs) are available, there are few data informing selection of initial treatment for individual patients with rheu...

    Jin Nakagawa, Yoshinobu Koyama, Atsushi Kawakami, Yukitaka Ueki, Hiroshi Tsukamoto, Takahiko Horiuchi, Shuji Nagano, Ayumi Uchino, Toshiyuki Ota, Mitsuteru Akahoshi and Koichi Akashi

    Arthritis Research & Therapy 2017 19:185

    Published on: 11 August 2017

  7. Research article

    Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP)

    Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the k...

    Anja J. de Jong, Inge R. Klein-Wieringa, Stefan N. Andersen, Joanneke C. Kwekkeboom, Linda Herb-van Toorn, Badelog J. E. de Lange-Brokaar, Danny van Delft, John Garcia, Wu Wei, Huub J. L. van der Heide, Yvonne M. Bastiaansen-Jenniskens, Gerjo J. V. M. van Osch, Annemarie M. Zuurmond, Vedrana Stojanovic-Susulic, Rob G. H. H. Nelissen, René E. M. Toes…

    Arthritis Research & Therapy 2017 19:186

    Published on: 11 August 2017

  8. Research article

    Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity

    Bortezomib (Bz) is a proteasome inhibitor that directly targets antibody-producing plasma cells. We recently reported the first randomized control trial that evaluated the effects of Bz in patients with system...

    Tomoko Ikeda, Hiroshi Fujii, Masato Nose, Yukiko Kamogawa, Tsuyoshi Shirai, Yuko Shirota, Tomonori Ishii and Hideo Harigae

    Arthritis Research & Therapy 2017 19:187

    Published on: 11 August 2017

  9. Editorial

    Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room?

    The first prospective population-based study to examine risk of erectile dysfunction in men with gout in the western world has been published. It reports that following their first diagnosis of gout, men have ...

    Abhishek Abhishek and Michael Doherty

    Arthritis Research & Therapy 2017 19:184

    Published on: 10 August 2017

    The original article was published in Arthritis Research & Therapy 2017 19:123

  10. Research article

    Hydroxychloroquine inhibits CD154 expression in CD4+ T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling

    Overexpression of membranous CD154 in T lymphocytes has been found previously in systemic lupus erythematosus (SLE). Because hydroxychloroquine (HCQ) has been used frequently in the treatment of lupus, we soug...

    Shu-Fen Wu, Chia-Bin Chang, Jui-Mei Hsu, Ming-Chi Lu, Ning-Sheng Lai, Chin Li and Chien-Hsueh Tung

    Arthritis Research & Therapy 2017 19:183

    Published on: 9 August 2017

  11. Research article

    IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis

    Methotrexate (MTX) is the standard first-line therapy in rheumatoid arthritis (RA) with variable clinical efficacy that is difficult to predict. The glycosylation status of immunoglobulin G (IgG) is altered in...

    Susanna L. Lundström, Aase H. Hensvold, Dorothea Rutishauser, Lars Klareskog, A. Jimmy Ytterberg, Roman A. Zubarev and Anca I. Catrina

    Arthritis Research & Therapy 2017 19:182

    Published on: 9 August 2017

  13. Research article

    Safety, tolerability, clinical, and joint structural outcomes of a single intra-articular injection of allogeneic mesenchymal precursor cells in patients following anterior cruciate ligament reconstruction: a controlled double-blind randomised trial

    Few clinical trials have investigated the safety and efficacy of mesenchymal stem cells for the management of post-traumatic osteoarthritis. The objectives of this pilot study were to determine the safety and ...

    Yuanyuan Wang, Andrew Shimmin, Peter Ghosh, Paul Marks, James Linklater, David Connell, Stephen Hall, Donna Skerrett, Silviu Itescu and Flavia M. Cicuttini

    Arthritis Research & Therapy 2017 19:180

    Published on: 2 August 2017

  14. Research article

    Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis

    Lysyl oxidase like-2 (LOXL2) is a copper-dependent amine oxidase. Our previous studies showed that LOXL2 is elevated during mouse fracture healing. The goal of this study was to evaluate the potential of LOXL2...

    Weam Alshenibr, Mustafa M. Tashkandi, Saqer F. Alsaqer, Yazeed Alkheriji, Amelia Wise, Sadanand Fulzele, Pushkar Mehra, Mary B. Goldring, Louis C. Gerstenfeld and Manish V. Bais

    Arthritis Research & Therapy 2017 19:179

    Published on: 2 August 2017

  15. Research article

    CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity

    Primary Sjögren’s syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation. In the current study, we aimed to in...

    Cristiano Alessandri, Francesco Ciccia, Roberta Priori, Elisa Astorri, Giuliana Guggino, Riccardo Alessandro, Aroldo Rizzo, Fabrizio Conti, Antonina Minniti, Cristiana Barbati, Marta Vomero, Monica Pendolino, Annacarla Finucci, Elena Ortona, Tania Colasanti, Marina Pierdominici…

    Arthritis Research & Therapy 2017 19:178

    Published on: 25 July 2017

  16. Research article

    Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody

    A novel anti-mouse CD3ε antibody, Dow2, recognizes mouse CD3ε without activating T cells and suppresses T-cell activation. The purpose of this study was to determine whether Dow2 can inhibit T cells in uveitis.

    Sunao Sugita, Jun Shimizu, Kenichi Makabe, Hiroshi Keino, Takeshi Watanabe and Masayo Takahashi

    Arthritis Research & Therapy 2017 19:176

    Published on: 25 July 2017

  17. Research article

    Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection

    The study was performed to evaluate whether targeted alpha-2-macroglobulin (A2M) variants have a similar or enhanced function at wild-type (wt)-A2M to attenuate cartilage degeneration in vivo.

    Yang Zhang, Xiaochun Wei, Shawn Browning, Gaetano Scuderi, Lewis S. Hanna and Lei Wei

    Arthritis Research & Therapy 2017 19:175

    Published on: 25 July 2017

  18. Research article

    Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis

    Ankylosing spondylitis (AS) is a chronic rheumatic and autoimmune disease. Little is known about the potential role of DNA methylation in the pathogenesis of AS. This study was undertaken to explore the potent...

    Jiangcan Hao, Yang Liu, Jiawen Xu, Wenyu Wang, Yan Wen, Awen He, Qianrui Fan, Xiong Guo and Feng Zhang

    Arthritis Research & Therapy 2017 19:177

    Published on: 25 July 2017

  19. Research article

    Incidence of and risk factors for nephrolithiasis in patients with gout and the general population, a cohort study

    Nephrolithiasis (NL) is known to be associated with gout, although there are few comparative studies on risk and risk factors for NL in gout compared to population cohorts. In this cohort study we investigated...

    A. J. Landgren, L. T. H. Jacobsson, U. Lindström, T. Z. S. Sandström, P. Drivelegka, L. Björkman, E. Fjellstedt and M. Dehlin

    Arthritis Research & Therapy 2017 19:173

    Published on: 24 July 2017

  20. Review

    Emerging technologies in autoantibody testing for rheumatic diseases

    Testing for the presence of antinuclear antibodies (ANAs) is a key step in the diagnosis of systemic lupus erythematosus (SLE) and other systemic autoimmune rheumatic diseases (SARD). The standard slide-based ...

    Nancy J. Olsen, May Y. Choi and Marvin J. Fritzler

    Arthritis Research & Therapy 2017 19:172

    Published on: 24 July 2017

  21. Research article

    RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis

    Dermatomyositis (DM) is inflammatory myopathy or myositis characterized by muscle weakness and skin manifestations. In the differential diagnosis of DM the evaluation of the muscle biopsy is of importance amon...

    Xavier Suárez-Calvet, Eduard Gallardo, Iago Pinal-Fernandez, Noemi De Luna, Cinta Lleixà, Jordi Díaz-Manera, Ricardo Rojas-García, Ivan Castellví, M. Angeles Martínez, Josep M. Grau, Albert Selva-O’Callaghan and Isabel Illa

    Arthritis Research & Therapy 2017 19:174

    Published on: 24 July 2017

  22. Research article

    Ultrasonography and dual-energy computed tomography provide different quantification of urate burden in gout: results from a cross-sectional study

    Ultrasonography (US) and dual-energy computed tomography (DECT) can assess urate burden in gout. The objective of this study was to compare the quantification of urate deposition provided by US to the one prov...

    Tristan Pascart, Agathe Grandjean, Laurène Norberciak, Vincent Ducoulombier, Marguerite Motte, Hélène Luraschi, Marie Vandecandelaere, Catherine Godart, Eric Houvenagel, Nasser Namane and Jean-François Budzik

    Arthritis Research & Therapy 2017 19:171

    Published on: 21 July 2017

  23. Research article

    Identification of differential co-expressed gene networks in early rheumatoid arthritis achieving sustained drug-free remission after treatment with a tocilizumab-based or methotrexate-based strategy

    Methotrexate is endorsed to be used as first-line treatment in rheumatoid arthritis (RA). However, a large proportion of patients need additional treatment with a biological disease-modifying anti-rheumatic dr...

    Xavier M. Teitsma, Johannes W. G. Jacobs, Michal Mokry, Michelle E. A. Borm, Attila Pethö-Schramm, Jacob M. van Laar, Johannes W. J. Bijlsma and Floris P. J. Lafeber

    Arthritis Research & Therapy 2017 19:170

    Published on: 20 July 2017

  24. Research article

    Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

    There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in a 2-year randomized controlled trial in patients with kn...

    Johanne Martel-Pelletier, Jean-Pierre Raynauld, François Mineau, François Abram, Patrice Paiement, Philippe Delorme and Jean-Pierre Pelletier

    Arthritis Research & Therapy 2017 19:169

    Published on: 20 July 2017

  25. Review

    Settings and artefacts relevant for Doppler ultrasound in large vessel vasculitis

    Ultrasound is used increasingly for diagnosing large vessel vasculitis (LVV). The application of Doppler in LVV is very different from in arthritic conditions. This paper aims to explain the most important Dop...

    L. Terslev, A. P. Diamantopoulos, U. Møller Døhn, W. A. Schmidt and S. Torp-Pedersen

    Arthritis Research & Therapy 2017 19:167

    Published on: 20 July 2017

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