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  1. A considerable proportion of patients with rheumatoid arthritis (RA) also suffer from hand osteoarthritis (OA). We here assess the association between conventional synthetic (cs) and biological (b) disease-mod...

    Authors: C. A. Lechtenboehmer, T. Burkard, S. Reichenbach, U. A. Walker, A. M. Burden and T. Hügle

    Citation: Arthritis Research & Therapy 2021 23:267

    Content type: Research article

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  2. Connective tissue growth factor (CTGF)-induced angiogenesis is a crucial factor in rheumatoid arthritis (RA), but CTGF-interacting protein and related molecular mechanism of their interaction have not been ful...

    Authors: Guoyu Yin, Chenglin Yang, Gan Wu, Xinxin Yu, Qingqing Tian, Daoxing Chen, Ben Cao, Lin Zhao, Nannan Xu, Shengwei Jin, Wei Zhang and Jianguang Wang

    Citation: Arthritis Research & Therapy 2021 23:266

    Content type: Research article

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  3. The development and optimization of therapies for rheumatoid arthritis (RA) is currently hindered by a lack of methods for early non-invasive monitoring of treatment response. Annexin A2, an inflammation-assoc...

    Authors: Shaw-Wei D. Tsen, Luke E. Springer, Krishna Sharmah Gautam, Rui Tang, Kexian Liang, Gail Sudlow, Amir Kucharski, Christine T. N. Pham and Samuel Achilefu

    Citation: Arthritis Research & Therapy 2021 23:265

    Content type: Research article

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  4. Infectious disease is an increasing threat to patients with systemic lupus erythematosus (SLE); however, the long-term outcome in critically ill septic patients with SLE remains unclear, and we aimed to addres...

    Authors: Hsin-Hua Chen, Hsian-Min Chen, Yi-Ming Chen, Yi-Hsing Chen, Ching-Heng Lin and Wen-Cheng Chao

    Citation: Arthritis Research & Therapy 2021 23:264

    Content type: Research article

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  5. An amendment to this paper has been published and can be accessed via the original article.

    Authors: R. E. Costello, J. H. Humphreys, J. C. Sergeant, M. Haris, F. Stirling, K. Raza, D. van Schaardenburg and Ian N. Bruce

    Citation: Arthritis Research & Therapy 2021 23:263

    Content type: Correction

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    The original article was published in Arthritis Research & Therapy 2021 23:210

  6. The identification of patients with knee osteoarthritis (OA) likely to progress rapidly in terms of structure is critical to facilitate the development of disease-modifying drugs.

    Authors: Jean-Baptiste Schiratti, Rémy Dubois, Paul Herent, David Cahané, Jocelyn Dachary, Thomas Clozel, Gilles Wainrib, Florence Keime-Guibert, Agnes Lalande, Maria Pueyo, Romain Guillier, Christine Gabarroca and Philippe Moingeon

    Citation: Arthritis Research & Therapy 2021 23:262

    Content type: Research article

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  7. Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare inflammatory arthritis, with a higher incidence of malignancy. The aim of this study is to identify biomarkers for predicting mali...

    Authors: Yuzhou Gan, Yi Sun, Jiayang Jin, Yifan Wang, Jiali Chen, Yukchiu Chung, Xue Li and Hua Ye

    Citation: Arthritis Research & Therapy 2021 23:261

    Content type: Research article

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  8. To identify potential biomarkers to distinguish familial Mediterranean fever (FMF) from sepsis.

    Authors: Tomohiro Koga, Kaori Furukawa, Kiyoshi Migita, Shimpei Morimoto, Toshimasa Shimizu, Shoichi Fukui, Masataka Umeda, Yushiro Endo, Remi Sumiyoshi, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Tomoki Origuchi, Takahiro Maeda, Akihiro Yachie…

    Citation: Arthritis Research & Therapy 2021 23:260

    Content type: Research article

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  9. Serum proteins can be readily assessed during routine clinical care. However, it is unclear to what extent serum proteins reflect the molecular dysregulations of peripheral blood cells (PBCs) or affected end-o...

    Authors: Victor Farutin, Elma Kurtagic, Joël R. Pradines, Ishan Capila, Maureen D. Mayes, Minghua Wu, Anthony M. Manning and Shervin Assassi

    Citation: Arthritis Research & Therapy 2021 23:259

    Content type: Research article

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  10. Patients with rheumatoid arthritis (RA) are almost twice as likely to develop cardiovascular disease (CVD) as those without. However, traditional CVD risks have been shown to underperform in RA patients; thus,...

    Authors: Seungwoo Han, Na-Ri Kim, Jong-Wan Kang, Jung-Su Eun and Young-Mo Kang

    Citation: Arthritis Research & Therapy 2021 23:258

    Content type: Research article

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  11. Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease which has focal lymphocytic infiltration including a majority of CD4+ T cells. This study was to investigate the correlation of periphe...

    Authors: Qi Wang, Nan Che, Chengyin Lu, Xiaoxuan Sun, Yanyan Wang, Qiang Wang, Wenfeng Tan, Lanlan Zhou, Xiaojun Zhang, Dong Xu, Lei Gu and Miaojia Zhang

    Citation: Arthritis Research & Therapy 2021 23:257

    Content type: Research article

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  12. Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder. Diagnosing AOSD can be challenging, as disease presentation and clinical course are highly heterogeneous. For unclear reasons, a few...

    Authors: Anaïs Wahbi, Benoît Tessoulin, Cédric Bretonnière, Julien Boileau, Dorothée Carpentier, Olivier Decaux, Laurence Fardet, Guillaume Geri, Pascal Godmer, Cécile Goujard, Hervé Maisonneuve, Arnaud Mari, Jacques Pouchot, Jean-Marc Ziza, Sophie Georgin-Lavialle, Mohamed Hamidou…

    Citation: Arthritis Research & Therapy 2021 23:256

    Content type: Research article

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  13. Authors: Bianka Marklein, Madeleine Jenning, Zoltán Konthur, Thomas Häupl, Franziska Welzel, Ute Nonhoff, Sylvia Krobitsch, Debbie M. Mulder, Marije I. Koenders, Vijay Joshua, Andrew P. Cope, Mark J. Shlomchik, Hans-Joachim Anders, Gerd R. Burmester, Aase Hensvold, Anca I. Catrina…

    Citation: Arthritis Research & Therapy 2021 23:255

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2021 23:239

  14. Few studies on rheumatoid arthritis (RA) have generated machine learning models to predict biologic disease-modifying antirheumatic drugs (bDMARDs) responses; however, these studies included insufficient analy...

    Authors: Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hong-Hee Won, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh and Hoon-Suk Cha

    Citation: Arthritis Research & Therapy 2021 23:254

    Content type: Research article

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  15. The objective of this study was to determine if mechanistic target of rapamycin (mTOR) inhibition with or without AMP-activated protein kinase (AMPK) activation can protect against primary, age-related OA.

    Authors: Dennis M. Minton, Christian J. Elliehausen, Martin A. Javors, Kelly S. Santangello and Adam R. Konopka

    Citation: Arthritis Research & Therapy 2021 23:253

    Content type: Research article

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  16. The occurrence of health events preceding a psoriatic arthritis (PsA) diagnosis may serve as predictors of diagnosis. We sought to assess patients’ real-world experiences in obtaining a PsA diagnosis.

    Authors: Alexis Ogdie, Martin Rozycki, Theresa Arndt, Cheng Shi, Nina Kim and Peter Hur

    Citation: Arthritis Research & Therapy 2021 23:252

    Content type: Research article

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  17. Hypertrophy of ligamentum flavum (HLF) is a common lumbar degeneration disease (LDD) with typical symptoms of low back pain and limb numbness owing to an abnormal pressure on spinal nerves. Previous studies re...

    Authors: Yanlin Cao, Yenan Zhan, Sujun Qiu, Zhong Chen, Kaiqin Gong, Songjia Ni and Yang Duan

    Citation: Arthritis Research & Therapy 2021 23:251

    Content type: Research article

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  18. Patients with autoimmune diseases often present with olfactory impairment. The aim of the study was to assess the olfactory functions of patients with primary Sjögren’s syndrome and to correlate these findings...

    Authors: Xue Xu, Linyu Geng, Chen Chen, Wentao Kong, Baojie Wen, Wei Kong, Siwen Chen, Huayong Zhang, Jun Liang and Lingyun Sun

    Citation: Arthritis Research & Therapy 2021 23:250

    Content type: Research article

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  19. Retroperitoneal fibrosis (RPF) is characterized by a highly fibrotic retroperitoneal mass and encompasses the idiopathic form and secondary to malignancies. Because we have limited knowledge whether RPF is ass...

    Authors: Sang Jin Lee, Jung Su Eun, Min Jung Kim, Yeong Wook Song and Young Mo Kang

    Citation: Arthritis Research & Therapy 2021 23:249

    Content type: Research article

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  20. REFLECTIONS B538–02 is a randomized, double-blind comparative study of the adalimumab (ADL) biosimilar PF-06410293, (ADL-PF), and reference ADL sourced from the European Union (ADL-EU) in patients with active ...

    Authors: Roy M. Fleischmann, Daniel F. Alvarez, Amy E. Bock, Carol Cronenberger, Ivana Vranic, Wuyan Zhang and Rieke Alten

    Citation: Arthritis Research & Therapy 2021 23:248

    Content type: Research article

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  21. In patients with axial spondyloarthritis (axSpA), monocytes show a pre-activated phenotype. Gut inflammation is a trigger of monocyte activation and may also affect their development in the bone marrow (BM). A...

    Authors: Fabian Karow, Biljana Smiljanovic, Joachim R. Grün, Denis Poddubnyy, Fabian Proft, Alice Talpin, Christophe Hue, Anne Boland, Jean-François Deleuze, Henri-Jean Garchon, Ilkay Ergenç, Ann-Sophie De Craemer, Ulrike Erben, Thomas Häupl, Dirk Elewaut, Maxime Breban…

    Citation: Arthritis Research & Therapy 2021 23:246

    Content type: Research article

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  22. Certain risk alleles associated with autoantibody-positive rheumatoid arthritis (RA) have been linked to poorer prognoses. In patients with autoantibody-positive RA, abatacept shows differential efficacy to tu...

    Authors: William Rigby, Jane H. Buckner, S. Louis Bridges Jr, Marleen Nys, Sheng Gao, Martin Polinsky, Neelanjana Ray and Vivian Bykerk

    Citation: Arthritis Research & Therapy 2021 23:245

    Content type: Research article

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  23. Isopsoralen (IPRN), one of the active ingredients of Psoralea corylifolia Linn, has anti-inflammatory properties. We attempted to investigate the inhibitory effects of IPRN on rheumatoid arthritis (RA) and charac...

    Authors: Yi Han, Jinguang Wang, Shufeng Li, Yi Li, Yongli Zhang, Ruojia Zhang, Yuang Zhang, Huancai Fan, Haojun Shi, Jihong Pan, Guanhua Song, Luna Ge and Lin Wang

    Citation: Arthritis Research & Therapy 2021 23:243

    Content type: Research article

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  24. TPX-100, a promotor of osteoblast and chondroblast differentiation, is a potential osteoarthritis (OA) therapy. This retrospective study compared MRI 3D femoral bone shape changes (B-scores) after intra-articular...

    Authors: Dawn McGuire, Michael Bowes, Alan Brett, Neil A. Segal, Meghan Miller, David Rosen and Yoshinari Kumagai

    Citation: Arthritis Research & Therapy 2021 23:242

    Content type: Research article

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  25. Synovial macrophages perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune surveillance, and resolution of inflammation. The functional diversity of macrophag...

    Authors: Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Tannin A. Schmidt, Jennifer Totonchy and Khaled A. Elsaid

    Citation: Arthritis Research & Therapy 2021 23:241

    Content type: Research article

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  26. Growing evidences indicate that the alterations in gut microbiota are associated with the efficacy of glucocorticoids (GCs) in the treatment of systemic lupus erythematosus (SLE). However, there is no evidence...

    Authors: Mingzhu Wang, Zhengyang Zhu, Xiaoying Lin, Haichang Li, Chengping Wen, Jie Bao and Zhixing He

    Citation: Arthritis Research & Therapy 2021 23:240

    Content type: Research article

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  27. There is a need for biomarker to identify patients “at risk” for rheumatoid arthritis (risk-RA) and to better predict the therapeutic response and in this study we tested the hypothesis that novel native and c...

    Authors: Bianka Marklein, Madeleine Jenning, Zoltán Konthur, Thomas Häupl, Franziska Welzel, Ute Nonhoff, Sylvia Krobitsch, Debbie M. Mulder, Marije I. Koenders, Vijay Joshua, Andrew P. Cope, Mark J. Shlomchik, Hans-Joachim Anders, Gerd R. Burmester, Aase Hensvold, Anca I. Catrina…

    Citation: Arthritis Research & Therapy 2021 23:239

    Content type: Research article

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:255

  28. This study aimed to identify new characteristics of elderly onset large-vessel vasculitis (EOLVV) by focusing on human leucocyte antigen (HLA) genotype, polymyalgia rheumatica (PMR), and affected vascular lesi...

    Authors: Kazuo Kushimoto, Masahiro Ayano, Keisuke Nishimura, Miki Nakano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi and Hiroaki Niiro

    Citation: Arthritis Research & Therapy 2021 23:238

    Content type: Research article

    Published on:

  29. Citation: Arthritis Research & Therapy 2021 23:237

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2021 23:152

  30. Understanding the evolving treatment patterns in patients with rheumatoid arthritis (RA) is important for rheumatologists to make the best practice decisions and optimize treatment. Here, we describe treatment...

    Authors: Philip J. Mease, Scott Stryker, Mei Liu, Bob Salim, Sabrina Rebello, Mahdi Gharaibeh and David H. Collier

    Citation: Arthritis Research & Therapy 2021 23:236

    Content type: Research article

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  31. Evidence on prognostic factors associated with progression to total hip replacement (THR) in hip osteoarthritis (OA) is for the most patient- and disease-specific characteristics either conflicting or inconclu...

    Authors: Stine Clausen, Jan Hartvigsen, Eleanor Boyle, Ewa M. Roos, Dorte Thalund Grønne, Martin Thomsen Ernst, Bodil Arnbak and Søren T. Skou

    Citation: Arthritis Research & Therapy 2021 23:235

    Content type: Research article

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  32. The TβRII∆k-fib transgenic (TG) mouse model of scleroderma replicates key fibrotic and vasculopathic complications of systemic sclerosis through fibroblast-directed upregulation of TGFβ signalling. We have exa...

    Authors: Emma Derrett-Smith, Kristina E. N. Clark, Xu Shiwen, David J. Abraham, Rachel K. Hoyles, Olivier Lacombe, Pierre Broqua, Jean Louis Junien, Irena Konstantinova, Voon H. Ong and Christopher P. Denton

    Citation: Arthritis Research & Therapy 2021 23:234

    Content type: Research article

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  33. An increasing number of diagnostic decision support systems (DDSS) exist to support patients and physicians in establishing the correct diagnosis as early as possible. However, little evidence exists that supp...

    Authors: Johannes Knitza, Koray Tascilar, Eva Gruber, Hannah Kaletta, Melanie Hagen, Anna-Maria Liphardt, Hannah Schenker, Martin Krusche, Jochen Wacker, Arnd Kleyer, David Simon, Nicolas Vuillerme, Georg Schett and Axel J. Hueber

    Citation: Arthritis Research & Therapy 2021 23:233

    Content type: Research article

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  34. Idiopathic inflammatory myopathies (IIM) are associated with a significantly higher risk of opportunistic infections including Pneumocystis jirovecii pneumonia (PJP), a potentially fatal opportunistic infection. ...

    Authors: Linlin Huang, Qiong Fu, Yan Ye, Yanwei Lin, Qingran Yan and Sheng Chen

    Citation: Arthritis Research & Therapy 2021 23:232

    Content type: Research article

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  35. To investigate the efficacy of secukinumab in patients with active non-radiographic axial spondyloarthritis (nr-axSpA) grouped by disease activity as assessed by C-reactive protein (CRP) levels and/or magnetic...

    Authors: Jürgen Braun, Ricardo Blanco, Helena Marzo-Ortega, Lianne S. Gensler, Filip van den Bosch, Stephen Hall, Hideto Kameda, Denis Poddubnyy, Marleen van de Sande, Anna S. Wiksten, Brian O. Porter, Abhijit Shete, Hanno B. Richards, Sibylle Haemmerle and Atul Deodhar

    Citation: Arthritis Research & Therapy 2021 23:231

    Content type: Research article

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  36. Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG cross-reactivity to multiple post-tra...

    Authors: Sanne Reijm, Theresa Kissel, Gerrie Stoeken-Rijsbergen, Linda M. Slot, Corrie M. Wortel, Hugo J. van Dooren, Nivine E. W. Levarht, Arieke S. B. Kampstra, Veerle F. A. M. Derksen, Pleuni Ooijevaar-de Heer, Holger Bang, Jan W. Drijfhout, Leendert A. Trouw, Tom W. J. Huizinga, Theo Rispens, Hans U. Scherer…

    Citation: Arthritis Research & Therapy 2021 23:230

    Content type: Research article

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  37. Systemic lupus erythematosus (SLE) is a chronic inflammatory multi systematic disease of unknown aetiology. SLE has a wide range of symptoms. The most common symptoms are joint pain, skin rash and fever. Oral ...

    Authors: Mayssoun Kudsi, Louei Darjazini Nahas, Rama Alsawah, Ahmad Hamsho and Abdullah Omar

    Citation: Arthritis Research & Therapy 2021 23:229

    Content type: Research article

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  38. The aim of this study was to compare the clinical effectiveness of tofacitinib and abatacept and clarify the impact of the HLA-DRB1 shared epitope (SE) on responses to these treatments in patients with rheumat...

    Authors: Wataru Hirose, Masayoshi Harigai, Koichi Amano, Toshihiko Hidaka, Kenji Itoh, Kazutoshi Aoki, Masahiro Nakashima, Hayato Nagasawa, Yukiko Komano and Toshihiro Nanki

    Citation: Arthritis Research & Therapy 2021 23:228

    Content type: Research article

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  39. Cartilage degeneration is assessed using various methods. Although macroscopic evaluation can directly measure cartilage degeneration, it cannot accurately assess cartilage properties. Histological examination...

    Authors: Taku Ukai, Masato Sato, Shiho Wasai, Takumi Takahashi, Haruka Omura and Masahiko Watanabe

    Citation: Arthritis Research & Therapy 2021 23:227

    Content type: Research article

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  40. To compare C-reactive protein (CRP) and matrix metalloproteinase-generated neoepitope of CRP (CRPM) as biomarkers of inflammation and radiographic severity in patients with knee osteoarthritis.

    Authors: Louie C. Alexander Jr, Grant McHorse, Janet L. Huebner, Anne-Christine Bay-Jensen, Morten A. Karsdal and Virginia B. Kraus

    Citation: Arthritis Research & Therapy 2021 23:226

    Content type: Research article

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  41. Osteoarthritis (OA) is the most common form of arthritis with multiple risk factors implicated including female sex and obesity. Metabolic dysregulation associated with obesity leading to metabolic syndrome is...

    Authors: Stefan Kluzek, Katrine Hass Rubin, Maria Sanchez-Santos, Mary S. O’Hanlon, Marianne Andersen, Dorte Glintborg and Bo Abrahamsen

    Citation: Arthritis Research & Therapy 2021 23:225

    Content type: Research article

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  42. Behçet’s disease (BD), a chronic systemic vasculitis, has distinct geographical and ethnic variation. Data regarding the epidemiology of patients with BD in the U.S. are limited; therefore, we sought to descri...

    Authors: Nevin Hammam, Jing Li, Michael Evans, Julia L. Kay, Zara Izadi, Christine Anastasiou, Milena A. Gianfrancesco, Jinoos Yazdany and Gabriela Schmajuk

    Citation: Arthritis Research & Therapy 2021 23:224

    Content type: Research article

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  43. Screening abnormal pathways and complement components in the kidneys of patients with lupus nephritis (LN) and NZB/W mice may help to identify complement-related therapeutic targets for LN.

    Authors: Tao Liu, Mingyue Yang, Ying Xia, Chuan Jiang, Chenxu Li, Zhenyu Jiang and Xiaosong Wang

    Citation: Arthritis Research & Therapy 2021 23:223

    Content type: Research article

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  44. The incidence of rheumatoid arthritis is correlated with age. In this study, we analyzed the association of the incidence and severity of glucose-6-phosphate isomerase (G6PI)-induced arthritis with age in two ...

    Authors: Nico Andreas, Sylvia Müller, Nicole Templin, Paul M. Jordan, Harald Schuhwerk, Michael Müller, Jana Gerstmeier, Laura Miek, Saskia Andreas, Oliver Werz and Thomas Kamradt

    Citation: Arthritis Research & Therapy 2021 23:222

    Content type: Research article

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  45. Peficitinib (ASP015K), a novel oral Janus kinase inhibitor, has demonstrated efficacy and safety in the treatment of patients with rheumatoid arthritis (RA). This study evaluated the effect of peficitinib on p...

    Authors: Yoshiya Tanaka, Tsutomu Takeuchi, Hiroyuki Izutsu, Yuichiro Kaneko, Daisuke Kato, Musashi Fukuda, Mitsuhiro Rokuda and Neil M. Schultz

    Citation: Arthritis Research & Therapy 2021 23:221

    Content type: Research article

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  46. This post hoc analysis assessed clinical and functional responses to tofacitinib monotherapy, tofacitinib + methotrexate (MTX), and adalimumab + MTX, in patients with rheumatoid arthritis enrolled in the ORAL ...

    Authors: Tsutomu Takeuchi, Roy Fleischmann, Noriko Iikuni, Harry Shi, Koshika Soma, Jerome Paulissen, Tomohiro Hirose and Josef S. Smolen

    Citation: Arthritis Research & Therapy 2021 23:220

    Content type: Research article

    Published on:

  47. TNF-α-stimulated gene 6 (TSG-6) protein, a TNF-α-responsive hyaladherin, possesses enzymatic activity that can catalyze covalent crosslinks of the polysaccharide hyaluronic acid (HA) to another protein to form...

    Authors: Diana C. Fasanello, Jin Su, Siyu Deng, Rose Yin, Marshall J. Colville, Joshua M. Berenson, Carolyn M. Kelly, Heather Freer, Alicia Rollins, Bettina Wagner, Felipe Rivas, Adam R. Hall, Elaheh Rahbar, Paul L. DeAngelis, Matthew J. Paszek and Heidi L. Reesink

    Citation: Arthritis Research & Therapy 2021 23:218

    Content type: Research article

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