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  1. Content type: Research article

    The aim of this study was to identify fibrosis-related serological surrogate outcome measures in patients with immunoglobulin G4-related disease (IgG4-RD).

    Authors: Shin-ya Kawashiri, Tomoki Origuchi, Masataka Umeda, Ayako Nishino, Toshimasa Shimizu, Shoichi Fukui, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Takahiro Maeda, Mitsuhiro Kawano, Motohisa Yamamoto, Yasumori Izumi and Atsushi Kawakami

    Citation: Arthritis Research & Therapy 2018 20:277

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  2. Content type: Research article

    Calprotectin is a biomarker of disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and predicts relapse in juvenile idiopathic arthritis. Higher drug trough serum levels are associated ...

    Authors: José Inciarte-Mundo, Julio Ramirez, Maria Victoria Hernández, Virginia Ruiz-Esquide, Andrea Cuervo, Sonia Raquel Cabrera-Villalba, Mariona Pascal, Jordi Yagüe, Juan D. Cañete and Raimon Sanmarti

    Citation: Arthritis Research & Therapy 2018 20:275

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  3. Content type: Research article

    The objective was to evaluate the 25(OH) vitamin D (25(OH)D) status of patients with juvenile idiopathic arthritis (JIA) and determine whether the 25(OH)D level is associated with disease activity and the cour...

    Authors: Claudia Sengler, Julian Zink, Jens Klotsche, Martina Niewerth, Ina Liedmann, Gerd Horneff, Christoph Kessel, Gerd Ganser, Angelika Thon, Johannes-Peter Haas, Anton Hospach, Frank Weller-Heinemann, Arnd Heiligenhaus, Dirk Foell, Angela Zink and Kirsten Minden

    Citation: Arthritis Research & Therapy 2018 20:276

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  4. Content type: Research article

    Rheumatoid arthritis (RA) is associated with a high prevalence of atherosclerosis. Recently increased levels of microparticles (MPs) have been reported in patients with RA. MPs could represent a link between a...

    Authors: Cristiana Barbati, Marta Vomero, Tania Colasanti, Marco Diociaiuti, Fulvia Ceccarelli, Sara Ferrigno, Annacarla Finucci, Francesca Miranda, Lucia Novelli, Carlo Perricone, Francesca Romana Spinelli, Simona Truglia, Fabrizio Conti, Guido Valesini and Cristiano Alessandri

    Citation: Arthritis Research & Therapy 2018 20:273

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  5. Content type: Research

    Secukinumab has demonstrated sustained improvement in the signs and symptoms of psoriatic arthritis (PsA) over 2 years in the FUTURE 2 study (NCT01752634). This post hoc analysis assessed the ability of secuki...

    Authors: L. C. Coates, D. D. Gladman, P. Nash, O. FitzGerald, A. Kavanaugh, T. K. Kvien, L. Gossec, V. Strand, L. Rasouliyan, L. Pricop, K. Ding, S. M. Jugl and C. Gaillez

    Citation: Arthritis Research & Therapy 2018 20:272

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  6. Content type: Research article

    Although accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent. To examine such a putative association, this analysis repo...

    Authors: Lebin Song, Yi Wang, Jiayi Zhang, Ninghong Song, Xiaoyun Xu and Yan Lu

    Citation: Arthritis Research & Therapy 2018 20:270

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  7. Content type: Research article

    Increasing evidence indicates a pathogenic role of deregulated autophagy in rheumatoid arthritis (RA). We examined the relationship between autophagy and inflammatory parameters in patients with RA receiving b...

    Authors: Yi-Ming Chen, Chun-Yu Chang, Hsin-Hua Chen, Chia-Wei Hsieh, Kuo-Tung Tang, Meng-Chun Yang, Joung-Liang Lan and Der-Yuan Chen

    Citation: Arthritis Research & Therapy 2018 20:268

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  8. Content type: Research

    Comorbidities are common in chronic systemic connective tissue diseases and are associated with adverse outcomes, increased morbidity and mortality. Although the prevalence of comorbidities has been well-studi...

    Authors: Stylianos Panopoulos, Maria Tektonidou, Alexandros A. Drosos, Stamatis-Nick Liossis, Theodoros Dimitroulas, Alexandros Garyfallos, Lazaros Sakkas, Dimitrios Boumpas, Paraskevi V. Voulgari, Dimitrios Daoussis, Konstantinos Thomas, Georgios Georgiopoulos, Georgios Vosvotekas, Dimitrios Vassilopoulos and Petros P. Sfikakis

    Citation: Arthritis Research & Therapy 2018 20:267

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  9. Content type: Research article

    Common carotid artery intima-media thickness (CIMT), as measured by ultrasound, has utility in stratification of the accelerated cardiovascular risk seen in rheumatoid arthritis (RA); however, the technique ha...

    Authors: Lesley-Anne Bissell, Bara Erhayiem, Graham Fent, Elizabeth M. A. Hensor, Agata Burska, Helena Donica, Sven Plein, Maya H. Buch, John P. Greenwood and Jacqueline Andrews

    Citation: Arthritis Research & Therapy 2018 20:266

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  10. Content type: Research article

    The aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG...

    Authors: Aurélie Najm, Benoît Le Goff, Carl Orr, Rogier Thurlings, Juan D. Cañete, Frances Humby, Stefano Alivernini, Antonio Manzo, Soeren Andreas Just, Vasco C. Romão, Veit Krenn, Ulf Müller-Ladner, Olga Addimanda, Sander W. Tas, Maria Stoenoiu, Laurent Meric de Bellefon…

    Citation: Arthritis Research & Therapy 2018 20:265

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  11. Content type: Research article

    Diagnosis of systemic autoimmune rheumatic diseases (SARD) relies on the presence of hallmark anti-nuclear antibodies (ANA), many of which can be detected years before clinical manifestations. However, ANAs ar...

    Authors: Yuriy Baglaenko, Nan-Hua Chang, Sindhu R. Johnson, Waleed Hafiz, Kieran Manion, Dario Ferri, Babak Noamani, Dennisse Bonilla, Sina Rusta-Sellehy, Larissa Lisnevskaia, Earl Silverman, Arthur Bookman, Carolina Landolt-Marticorena and Joan Wither

    Citation: Arthritis Research & Therapy 2018 20:264

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  12. Content type: Research article

    The cholinergic anti-inflammatory pathway (CAP) has a strong anti-inflammatory effect on collagen-induced arthritis (CIA), a classic animal model of rheumatoid arthritis (RA). However, the underlying immune re...

    Authors: Di Liu, Tong Li, Hui Luo, Xiaoxia Zuo, Sijia Liu and Shiyao Wu

    Citation: Arthritis Research & Therapy 2018 20:263

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  13. Content type: Research article

    We aimed to evaluate the 1-year and 2-year outcome of a health-enhancing physical activity (HEPA) support program on global pain, pressure pain sensitivity, and exercise-induced segmental and plurisegmental hy...

    Authors: Monika Löfgren, Christina H. Opava, Ingrid Demmelmaier, Cecilia Fridén, Ingrid E. Lundberg, Birgitta Nordgren and Eva Kosek

    Citation: Arthritis Research & Therapy 2018 20:262

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  14. Content type: Research article

    Fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA) are autonomously activated to maintain inflammation and joint destruction in co-transplantation models. To elucidate inducing me...

    Authors: Oliver Frey, Marion Hückel, Mieczyslaw Gajda, Peter K. Petrow and Rolf Bräuer

    Citation: Arthritis Research & Therapy 2018 20:261

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  15. Content type: Research article

    Interleukin (IL)-23 can facilitate the differentiation of IL-17-producing helper T cells (Th17). The IL-23/IL-17 axis is known to play a key role in the immunopathogenesis of ankylosing spondylitis (AS). We hy...

    Authors: Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang and Ming-Chi Lu

    Citation: Arthritis Research & Therapy 2018 20:259

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  16. Content type: Research article

    Subclinical joint inflammation in patients with arthralgia is predictive for progression to rheumatoid arthritis (RA). However, the time course of progression for bone marrow edema (osteitis), synovitis, and/o...

    Authors: R. M. ten Brinck, H. W. van Steenbergen and A. H. M. van der Helm–van Mil

    Citation: Arthritis Research & Therapy 2018 20:260

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  17. Content type: Research article

    A multi-biomarker disease activity (MBDA) score has been validated as an objective measure of disease activity in rheumatoid arthritis (RA) and shown to track response to treatment with several disease-modifyi...

    Authors: Nadia M. T. Roodenrijs, Maria J. H. de Hair, Gill Wheater, Mohsen Elshahaly, Janneke Tekstra, Y. K. Onno Teng, Floris P. J. G. Lafeber, Ching Chang Hwang, Xinyu Liu, Eric H. Sasso and Jacob M. van Laar

    Citation: Arthritis Research & Therapy 2018 20:256

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  18. Content type: Research article

    Comorbidities are known to exist in many rheumatological conditions. Polymyalgia rheumatica (PMR) is a common inflammatory rheumatological condition affecting older people which, prior to effective treatment, ...

    Authors: Richard Partington, Toby Helliwell, Sara Muller, Alyshah Abdul Sultan and Christian Mallen

    Citation: Arthritis Research & Therapy 2018 20:258

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  19. Content type: Research article

    We showed previously that Japanese individuals with familial Mediterranean fever (FMF) have a more atypical phenotype compared to endemic areas. The clinical differences between young-onset FMF (YOFMF), adult-...

    Authors: Yushiro Endo, Tomohiro Koga, Midori Ishida, Yuya Fujita, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Remi Sumiyoshi, Takashi Igawa, Masataka Umeda, Shoichi Fukui, Ayako Nishino, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai…

    Citation: Arthritis Research & Therapy 2018 20:257

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  20. Content type: Research article

    Allopurinol dosing has frequently been limited based on creatinine clearance (CrCL), resulting in failure to achieve target serum urate (SU). The aim of this analysis was to determine how many milligrams of al...

    Authors: Lisa K. Stamp, Peter T. Chapman, Murray L. Barclay, Anne Horne, Christopher Frampton, Paul Tan, Jill Drake and Nicola Dalbeth

    Citation: Arthritis Research & Therapy 2018 20:255

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  21. Content type: Research article

    Neutrophil extracellular trap (NET) formation has been described to be closely involved in the pathogenesis of systemic lupus erythematosus (SLE). In this study, we aimed to investigate the effect of polydatin...

    Authors: Pan Liao, Yi He, Fangyuan Yang, Guihu Luo, Jian Zhuang, Zeqing Zhai, Lili Zhuang, Zhuomiao Lin, Jiehuang Zheng and Erwei Sun

    Citation: Arthritis Research & Therapy 2018 20:254

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  22. Content type: Research article

    Varicella zoster virus (VZV)-specific cellular immunity is essential for viral control, and the incidence of VZV reactivation is increased in patients with rheumatic diseases. Because knowledge of the influenc...

    Authors: David Schub, Gunter Assmann, Urban Sester, Martina Sester and Tina Schmidt

    Citation: Arthritis Research & Therapy 2018 20:252

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  23. Content type: Research article

    Evidence for non-pharmacological interventions in hand osteoarthritis is promising but still scarce. Combined interventions are most likely to best cover the clinical needs of patients with hand osteoarthritis...

    Authors: Michaela A. Stoffer-Marx, Meike Klinger, Simone Luschin, Silvia Meriaux-Kratochvila, Monika Zettel-Tomenendal, Valerie Nell-Duxneuner, Jochen Zwerina, Ingvild Kjeken, Marion Hackl, Sylvia Öhlinger, Anthony Woolf, Kurt Redlich, Josef S. Smolen and Tanja A. Stamm

    Citation: Arthritis Research & Therapy 2018 20:253

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  24. Content type: Review

    Lumbar disc herniation (LDH) is highly associated with inflammation in the context of low back pain. Currently, inflammation is associated with adverse symptoms related to the stimulation of nerve fibers that ...

    Authors: Carla Cunha, Ana J. Silva, Paulo Pereira, Rui Vaz, Raquel M. Gonçalves and Mário A. Barbosa

    Citation: Arthritis Research & Therapy 2018 20:251

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  25. Content type: Research article

    There is evidence that knee pain not only is a consequence of structural deterioration in osteoarthritis (OA) but also contributes to structural progression. Clarifying this is important because targeting the ...

    Authors: Yuanyuan Wang, Andrew J. Teichtahl, François Abram, Sultana Monira Hussain, Jean-Pierre Pelletier, Flavia M. Cicuttini and Johanne Martel-Pelletier

    Citation: Arthritis Research & Therapy 2018 20:250

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  26. Content type: Research article

    Although one of the three obstetric manifestations of antiphospholipid syndrome (APS) is intrauterine fetal death (IUFD), little is known about it in this context. We report the first large series of patients ...

    Authors: Mériem Belhocine, Laetitia Coutte, Nicolas Martin Silva, Nathalie Morel, Gaëlle Guettrot-Imbert, Romain Paule, Claire Le Jeunne, Micaela Fredi, Michel Dreyfus, Jean-Charles Piette, Odile Souchaud-Debouverie, Catherine Deneux-Tharaux, Vassilis Tsatsaris, Emmanuelle Pannier, Véronique Le Guern and Nathalie Costedoat-Chalumeau

    Citation: Arthritis Research & Therapy 2018 20:249

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  27. Content type: Correction

    Following publication of the original article [1], the authors reported a typesetting error.

    Authors: Giovanni Orsolini, Giovanni Adami, Maurizio Rossini, Angelo Fassio, Alessandro Giollo, Cristian Caimmi, Luca Idolazzi, Davide Gatti and Ombretta Viapiana

    Citation: Arthritis Research & Therapy 2018 20:248

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    The original article was published in Arthritis Research & Therapy 2018 20:233

  28. Content type: Research article

    Epidemiological evidence to suggest that periodontal disease (PD) is involved in the progression of rheumatoid arthritis (RA) is increasing. The complement system plays a critical role in immune responses. C5a...

    Authors: Syuichi Munenaga, Kazuhisa Ouhara, Yuta Hamamoto, Mikihito Kajiya, Katsuhiro Takeda, Satoshi Yamasaki, Toshihisa Kawai, Noriyoshi Mizuno, Tsuyoshi Fujita, Eiji Sugiyama and Hidemi Kurihara

    Citation: Arthritis Research & Therapy 2018 20:247

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  29. Content type: Research article

    Our aim was to investigate dynamic changes in hepatitis B virus (HBV) surface antibody (HBsAb) titer and the associated risk of HBV reactivation and clinical course in patients with HBV surface antigen negativ...

    Authors: Ya-Chih Tien, Hsu-Heng Yen, Ching-Fang Li, Mei-Ping Liu, Yin-Tzu Hsue, Ming-Hui Hung and Ying-Ming Chiu

    Citation: Arthritis Research & Therapy 2018 20:246

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  30. Content type: Research article

    Rheumatoid arthritis (RA) knowledge has been constructed with studies performed in Caucasians patients; Latin American patients present unique characteristics. Empowerment is a social multidimensional construc...

    Authors: Irazú Contreras-Yáñez, Emmanuel Ruiz-Medrano, Luz del Carmen R. Hernández and Virginia Pascual-Ramos

    Citation: Arthritis Research & Therapy 2018 20:244

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  31. Content type: Research article

    An association between gout and renal disease is well-recognised but few studies have examined whether gout is a risk factor for subsequent chronic kidney disease (CKD). Additionally, the impact of urate-lower...

    Authors: Matthew Roughley, Alyshah Abdul Sultan, Lorna Clarson, Sara Muller, Rebecca Whittle, John Belcher, Christian D. Mallen and Edward Roddy

    Citation: Arthritis Research & Therapy 2018 20:243

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  32. Content type: Research article

    Different adiponectin isoforms appear to be differentially involved in the pathogenesis of various diseases. The purpose of this study was to generate monoclonal antibodies (mAbs) specific to different adipone...

    Authors: Yeon-Ah Lee, Dae-Hyun Hahm, Jung Yeon Kim, Bonjun Sur, Hyun Min Lee, Chun Jeih Ryu, Hyung-In Yang and Kyoung Soo Kim

    Citation: Arthritis Research & Therapy 2018 20:245

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  33. Content type: Research article

    The multiple disease domains affected in psoriatic arthritis (PsA) may make composite endpoints appropriate for assessing changes in disease activity over time. Tofacitinib is an oral Janus kinase inhibitor fo...

    Authors: Philip Helliwell, Laura C. Coates, Oliver FitzGerald, Peter Nash, Enrique R. Soriano, M. Elaine Husni, Ming-Ann Hsu, Keith S. Kanik, Thijs Hendrikx, Joseph Wu and Elizabeth Kudlacz

    Citation: Arthritis Research & Therapy 2018 20:242

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  34. Content type: Research article

    Dermatomyositis (DM) with rapidly progressive interstitial lung disease (DM RP-ILD) is a life-threatening condition. Serum cytokine levels are potentially suitable biomarkers for DM RP-ILD. However, the relati...

    Authors: Yuichi Ishikawa, Shigeru Iwata, Kentaro Hanami, Aya Nawata, Mingzeng Zhang, Kaoru Yamagata, Shintaro Hirata, Kei Sakata, Yasuyuki Todoroki, Kazuhisa Nakano, Shingo Nakayamada, Minoru Satoh and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2018 20:240

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  35. Content type: Research article

    Nailfold capillaroscopy (NC) is an important tool for the diagnosis of systemic sclerosis (SSc). The capillaroscopic skin ulcer risk index (CSURI) was suggested to identify patients at risk of developing digit...

    Authors: Ulrich A. Walker, Veronika K. Jaeger, Katharina M. Bruppacher, Rucsandra Dobrota, Lionel Arlettaz, Martin Banyai, Jörg Beron, Carlo Chizzolini, Ernst Groechenig, Rüdiger B. Mueller, François Spertini, Peter M. Villiger and Oliver Distler

    Citation: Arthritis Research & Therapy 2018 20:239

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  36. Content type: Research article

    In systemic lupus erythematosus (SLE), immune complexes (ICs) containing self-derived nucleic acids trigger the synthesis of proinflammatory cytokines by immune cells. We asked how an interleukin (IL)-1 recept...

    Authors: Karin Hjorton, Niklas Hagberg, Elisabeth Israelsson, Lisa Jinton, Olof Berggren, Johanna K. Sandling, Kristofer Thörn, John Mo, Maija-Leena Eloranta and Lars Rönnblom

    Citation: Arthritis Research & Therapy 2018 20:238

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  37. Content type: Research article

    The natural history of semi-quantitative magnetic resonance imaging (MRI)-detected osteophytes (MRI-detected OPs) has not been described and it is unknown whether knee structural abnormalities can predict MRI-...

    Authors: Zhaohua Zhu, Changhai Ding, Weiyu Han, Shuang Zheng, Tania Winzenberg, Flavia Cicuttini and Graeme Jones

    Citation: Arthritis Research & Therapy 2018 20:237

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  38. Content type: Research article

    We aimed to evaluate the phenotype, function, and microRNA (miRNA)17–92 cluster expression in Vγ9Vδ2 T-cell subsets and the correlation with immune response in rheumatoid arthritis (RA) patients.

    Authors: Giuliana Guggino, Valentina Orlando, Laura Saieva, Piero Ruscitti, Paola Cipriani, Marco Pio La Manna, Roberto Giacomelli, Riccardo Alessandro, Giovanni Triolo, Francesco Ciccia, Francesco Dieli and Nadia Caccamo

    Citation: Arthritis Research & Therapy 2018 20:236

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  39. Content type: Research article

    Systemic sclerosis is a disease that has significant clinical heterogeneity. This study aims to determine the causes and risk factors of death in a single center European League Against Rheumatism Scleroderma ...

    Authors: Shasha Hu, Yong Hou, Qian Wang, Mengtao Li, Dong Xu and Xiaofeng Zeng

    Citation: Arthritis Research & Therapy 2018 20:235

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  40. Content type: Research article

    It is estimated that 50–70% of patients with rheumatoid arthritis (RA) are non-adherent to their recommended treatment. Non-adherent patients have a higher risk of not reaching an optimal clinical outcome. We ...

    Authors: Valentin Ritschl, Angelika Lackner, Carina Boström, Erika Mosor, Michaela Lehner, Maisa Omara, Romualdo Ramos, Paul Studenic, Josef Sebastian Smolen and Tanja Alexandra Stamm

    Citation: Arthritis Research & Therapy 2018 20:234

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  41. Content type: Letter

    Authors: Giovanni Orsolini, Giovanni Adami, Maurizio Rossini, Angelo Fassio, Alessandro Giollo, Cristian Caimmi, Luca Idolazzi, Davide Gatti and Ombretta Viapiana

    Citation: Arthritis Research & Therapy 2018 20:233

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2018 20:248

    The original article was published in Arthritis Research & Therapy 2018 20:162

  42. Content type: Research article

    Obesity is a primary risk factor for the development of knee osteoarthritis (OA). However, there remains a lack of in vivo data on the influence of obesity on knee cartilage mechanics and composition. The purpose...

    Authors: Amber T Collins, Micaela L Kulvaranon, Hattie C Cutcliffe, Gangadhar M Utturkar, Wyatt A R Smith, Charles E Spritzer, Farshid Guilak and Louis E DeFrate

    Citation: Arthritis Research & Therapy 2018 20:232

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  43. Content type: Research article

    This study aimed to investigate whether the presence of low bone mineral density (BMD) in patients with axial spondyloarthritis (axSpA) predicts formation of new syndesmophytes over 2 years.

    Authors: Hyoung Rae Kim, Yeon Sik Hong, Sung-Hwan Park, Ji Hyeon Ju and Kwi Young Kang

    Citation: Arthritis Research & Therapy 2018 20:231

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  44. Content type: Research article

    We previously identified, in newly diagnosed rheumatoid arthritis (RA) patients, networks of co-expressed genes and proteomic biomarkers associated with achieving sustained drug-free remission (sDFR) after tre...

    Authors: Xavier M Teitsma, Wei Yang, Johannes W G Jacobs, Attila Pethö-Schramm, Michelle E A Borm, Amy C Harms, Thomas Hankemeier, Jacob M van Laar, Johannes W J Bijlsma and Floris P J G Lafeber

    Citation: Arthritis Research & Therapy 2018 20:230

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  45. Content type: Review

    Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in many aspects of immune regulation. Anti-TNF biological therapy has been considered a breakthrough in the treatment of chronic autoimmune diseas...

    Authors: Jean-Luc Davignon, Benjamin Rauwel, Yannick Degboé, Arnaud Constantin, Jean-Fredéric Boyer, Andrey Kruglov and Alain Cantagrel

    Citation: Arthritis Research & Therapy 2018 20:229

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  46. Content type: Review

    Musculoskeletal ultrasound (US) is frequently used in several rheumatology practices to detect subclinical inflammation in patients with joint symptoms suspected for progression to inflammatory arthritis. Eval...

    Authors: Rosaline van den Berg, Sarah Ohrndorf, Marion C. Kortekaas and Annette H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2018 20:228

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