Articles

Validation of prediction models of severe disease course and non-achievement of remission in juvenile idiopathic arthritis: part 1—results of the Canadian model in the Nordic cohort

Models to predict disease course and long-term outcome based on clinical characteristics at disease onset may guide early treatment strategies in juvenile idiopathic arthritis (JIA). Before a prediction model ...

Authors: Veronika Rypdal, Jaime Guzman, Andrew Henrey, Thomas Loughin, Mia Glerup, Ellen Dalen Arnstad, Kristiina Aalto, Marite Rygg, Susan Nielsen, Troels Herlin, Anders Fasth, Lillemor Berntson, Martin Rypdal and Ellen Nordal

Safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06650833, a selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, in single and multiple ascending dose randomized phase 1 studies in healthy subjects

PF-06650833 is a potent, selective inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). Two randomized, double-blind, sponsor-open phase 1 studies evaluated the safety, pharmacokinetics, and pharma...

Authors: Spencer I. Danto, Negin Shojaee, Ravi Shankar P. Singh, Cheryl Li, Steven A. Gilbert, Zorayr Manukyan and Iain Kilty

Circulating calprotectin (S100A8/A9) is higher in rheumatoid arthritis patients that relapse within 12 months of tapering anti-rheumatic drugs

To investigate whether calprotectin (S100A8/A9 or MRP8/14), an inflammatory complex released by monocytes, could indicate residual subclinical inflammation in rheumatoid arthritis (RA) patients who are in stab...

Authors: Emma C. de Moel, Jürgen Rech, Michael Mahler, Johannes Roth, Thomas Vogl, Anne Schouffoer, Robbert J. Goekoop, Tom W. J. Huizinga, Cornelia F. Allaart, René E. M. Toes, Georg Schett and Diane van der Woude

Diagnostic performance of serum cystatin C and complement component 1q in lupus nephritis

The information concerning non-invasive, easily obtainable, and accurate biomarkers for diagnosis of lupus nephritis (LN) is extremely limited. The aim of this study was to evaluate the diagnostic performance ...

Authors: Bei Xu, Ya-mei Zhang, Yu-wei Yang, Yun-shuang Liu and Jia-fu Feng

Secukinumab efficacy on resolution of enthesitis in psoriatic arthritis: pooled analysis of two phase 3 studies

Enthesitis is one of the psoriatic arthritis (PsA) domains. Patients with enthesitis are associated with worse outcomes than those without enthesitis. The effect of secukinumab on the resolution of enthesitis ...

Authors: Laura C. Coates, Johan K. Wallman, Dennis McGonagle, Georg A. Schett, Iain B. McInnes, Philip J. Mease, Lawrence Rasouliyan, Erhard Quebe-Fehling, Darren L. Asquith, Andreas E. R. Fasth, Luminita Pricop and Corine Gaillez

Progressive structural bone changes and their relationship with treatment in patients with psoriatic arthritis: a longitudinal HR-pQCT study

Although the short-term effects of tumor necrosis factor alpha (TNF-α) and interleukin-17A (IL-17A) inhibition on the structural changes in psoriatic arthritis (PsA) using high-resolution peripheral quantitati...

Authors: Dongze Wu, James F. Griffith, Steven H. M. Lam, Priscilla C. H. Wong, Lin Shi, Edmund K. Li, Isaac T. Cheng, Tena K. Li, Vivian W. Hung, Ling Qin and Lai-Shan Tam

Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis

In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring systems, and no systematic relationship with functional deficits has ...

Authors: Anne-Laure Mausset-Bonnefont, Maïlys Cren, Rita Vicente, Julie Quentin, Christian Jorgensen, Florence Apparailly and Pascale Louis-Plence

Effects of upadacitinib on patient-reported outcomes: results from SELECT-BEYOND, a phase 3 randomized trial in patients with rheumatoid arthritis and inadequate responses to biologic disease-modifying antirheumatic drugs

Patient-reported outcomes (PROs) are important when evaluating treatment benefits in rheumatoid arthritis (RA). We compared upadacitinib, an oral, selective JAK-1 inhibitor, with placebo to assess clinically m...

Authors: Vibeke Strand, Michael Schiff, Namita Tundia, Alan Friedman, Sebastian Meerwein, Aileen Pangan, Arijit Ganguli, Mahesh Fuldeore, Yan Song and Janet Pope

Inflammatory stays inflammatory: a subgroup of systemic sclerosis characterized by high morbidity and inflammatory resistance to cyclophosphamide

Elevated levels of C-reactive protein (CRP) in systemic sclerosis (SSc) have been linked to early inflammatory stages of the disease. This study has been designed to investigate CRP levels longitudinally in a ...

Authors: Aleksey Mitev, Lisa Christ, Daria Feldmann, Moritz Binder, Kim Möller, Anna-Maria Kanne, Thomas Hügle, Peter M. Villiger, Reinhard E. Voll, Stephanie Finzel and Florian Kollert

ALW peptide ameliorates lupus nephritis in MRL/lpr mice

Lupus nephritis (LN) is a common and serious complication of systemic lupus erythematosus. Anti-double-stranded (ds) DNA immunoglobulin G (IgG) plays a pivotal role in the pathogenesis of LN. Currently, there ...

Authors: Huixia Wang, Mei Lu, Siyue Zhai, Kunyi Wu, Lingling Peng, Jie Yang and Yumin Xia

Interferon score is increased in incomplete systemic lupus erythematosus and correlates with myxovirus-resistance protein A in blood and skin

Patients with incomplete systemic lupus erythematosus (iSLE) have lupus features, but do not meet classification criteria for SLE. Type I interferons (IFN) are important early mediators in SLE, and IFN upregul...

Authors: Wietske M. Lambers, Karina de Leeuw, Berber Doornbos-van der Meer, Gilles F.H. Diercks, Hendrika Bootsma and Johanna Westra

Increased levels of anti-dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus

Immune complexes are of importance in systemic lupus erythematosus pathogenesis, and autoantibodies are believed to participate in immune complex formation. Quantification of autoantibody levels in circulating...

Authors: Azita Sohrabian, Ioannis Parodis, Nellie Carlströmer-Berthén, Martina Frodlund, Andreas Jönsen, Agneta Zickert, Christopher Sjöwall, Anders A. Bengtsson, Iva Gunnarsson and Johan Rönnelid

NEMO score in nailfold videocapillaroscopy is a good tool to assess both steady state levels and overtime changes of disease activity in patients with systemic sclerosis: a comparison with the proposed composite indices for this disease status entity

In previous studies, we demonstrated that the NEMO score, i.e. the cumulative number of microhaemorrhages (MHEs) and microthromboses (MTs), observed in nailfold videocapillaroscopy was a good indicator of the ...

Authors: Francesca Pignataro, Wanda Maglione, Antonina Minniti, Domenico Sambataro, Gianluca Sambataro, Francesco Campanaro, Gabriele Valentini, Claudio Vitali and Nicoletta Del Papa

Association between pain phenotype and disease activity in rheumatoid arthritis patients: a non-interventional, longitudinal cohort study

In well-controlled rheumatoid arthritis (RA) without significant joint damage, a substantial proportion of patients complain of persistent pain. Previous studies have identified different pain phenotypes in RA...

Authors: P. M. ten Klooster, N. de Graaf and H. E. Vonkeman

Associations between certolizumab pegol serum levels, anti-drug antibodies and treatment response in patients with inflammatory joint diseases: data from the NOR-DMARD study

To identify a therapeutic target interval for certolizumab pegol drug levels and examine the influence of anti-drug antibodies in patients with inflammatory joint diseases.

Authors: Johanna Elin Gehin, Guro Løvik Goll, David John Warren, Silje Watterdal Syversen, Joseph Sexton, Eldri Kveine Strand, Tore Kristian Kvien, Nils Bolstad and Elisabeth Lie

Risk stratification and clinical course of hepatitis B virus reactivation in rheumatoid arthritis patients with resolved infection: final report of a multicenter prospective observational study at Japanese Red Cross Hospital

The prophylaxis for hepatitis B virus (HBV) reactivation assumes that hepatic injury after reactivation is often rapidly progressive and can evoke fulminant hepatitis. The incidence and prognosis of reactivati...

Authors: Wataru Fukuda, Tadamasa Hanyu, Masaki Katayama, Shinichi Mizuki, Akitomo Okada, Masayuki Miyata, Yuichi Handa, Masatoshi Hayashi, Yoshinobu Koyama, Kaoru Arii, Toshiyuki Kitaori, Hiroyuki Hagiyama, Yoshinori Urushidani, Takahito Yamasaki, Yoshihiko Ikeno, Takeshi Suzuki…

Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain

Osteoarthritis is increasingly recognized as the result of a complex interplay between inflammation, chrondrodegeneration, and pain. Joint mast cells are considered to play a key role in orchestrating this det...

Authors: Marika Cordaro, Rosalba Siracusa, Daniela Impellizzeri, Ramona D’ Amico, Alessio Filippo Peritore, Rosalia Crupi, Enrico Gugliandolo, Roberta Fusco, Rosanna Di Paola, Carlo Schievano and Salvatore Cuzzocrea

Arterial stiffness correlates with progressive nailfold capillary microscopic changes in systemic sclerosis: results from a cross-sectional study

While microangiopathy is well-documented in systemic sclerosis (SSc), a potential link between SSc and macrovascular disease is highly debated and remains to be established. The aim of the present study is to ...

Authors: Stergios Soulaidopoulos, Eleni Pagkopoulou, Niki Katsiki, Eva Triantafyllidou, Asterios Karagiannis, Alexandros Garyfallos, George D. Kitas and Theodoros Dimitroulas

Contribution of adipocyte precursors in the phenotypic specificity of intra-articular adipose tissues in knee osteoarthritis patients

Intra-articular adipose tissues (IAATs) are involved in osteoarthritis (OA) pathophysiology. We hypothesize that mesenchymal cells residing in IAATs may account for the specific inflammatory and metabolic patt...

Authors: Florent Eymard, Audrey Pigenet, Cindy Rose, Anouchka Bories, Charles-Henri Flouzat-Lachaniette, Francis Berenbaum, Xavier Chevalier, Xavier Houard and Geoffroy Nourissat

The effect of pilocarpine on dental caries in patients with primary Sjögren’s syndrome: a database prospective cohort study

Primary Sjögren’s syndrome (pSS) is associated with dental caries. Pilocarpine, a salivary stimulant, can improve the amount and flow rate of saliva in patients with pSS. This study aimed to assess whether the...

Authors: Chung-Yuan Hsu, Kuo-Chun Hung, Ming-Shyan Lin, Chi-Hua Ko, Yu-Sheng Lin, Tien-Hsing Chen, Chun-Yu Lin and Ying-Chou Chen

Hydroxychloroquine inhibits IL-1β production from amyloid-stimulated human neutrophils

Hydroxychloroquine (HCQ) is used for the treatment of patients with rheumatic diseases. We tested the hypothesis that HCQ affects the NLRP3 inflammasome, which is involved in autoinflammation.

Authors: Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Yashiro Furuya, Tomoyuki Asano, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Takeshi Urano, Hideko Kozuru, Hiroshi Yatsuhashi, Tomohiro Koga, Atsushi Kawakami and Kiyoshi Migita

A search to the target tissue in which RA-specific inflammation starts: a detailed MRI study to improve identification of RA-specific features in the phase of clinically suspect arthralgia

Based on a unique cohort of clinically suspect arthralgia (CSA) patients, we analysed which combinations of MRI features at onset were predictive for rheumatoid arthritis (RA) development. This was done to inc...

Authors: Xanthe M. E. Matthijssen, Fenne Wouters, Debbie M. Boeters, Aleid C. Boer, Yousra J. Dakkak, Ellis Niemantsverdriet and Annette H. M. van der Helm-van Mil

A distinct gut microbiota composition in patients with ankylosing spondylitis is associated with increased levels of fecal calprotectin

Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in t...

Authors: Eva Klingberg, Maria K. Magnusson, Hans Strid, Anna Deminger, Arne Ståhl, Johanna Sundin, Magnus Simrén, Hans Carlsten, Lena Öhman and Helena Forsblad-d’Elia

Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

Both loss- and gain-of-function of Wnt/β-catenin signaling in chondrocytes result in exacerbation of osteoarthritis (OA). Here, we examined the activity and roles of Wnt/β-catenin signaling in the superficial ...

Authors: Fengjun Xuan, Fumiko Yano, Daisuke Mori, Ryota Chijimatsu, Yuji Maenohara, Hideki Nakamoto, Yoshifumi Mori, Yuma Makii, Takeshi Oichi, Makoto Mark Taketo, Hironori Hojo, Shinsuke Ohba, Ung-il Chung, Sakae Tanaka and Taku Saito

Asthma and elevation of anti-citrullinated protein antibodies prior to the onset of rheumatoid arthritis

Anti-citrullinated protein antibodies (ACPA) are central to rheumatoid arthritis (RA) pathogenesis and may develop at inflamed mucosa. We investigated whether asthma, a disease of airway mucosal inflammation, ...

Authors: Alessandra Zaccardelli, Xinyi Liu, Julia A. Ford, Jing Cui, Bing Lu, Su H. Chu, Peter H. Schur, Cameron B. Speyer, Karen H. Costenbader, William H. Robinson, Jeremy Sokolove, Elizabeth W. Karlson, Carlos A. Camargo Jr and Jeffrey A. Sparks

B lymphocyte stimulator modulates number and function of endothelial progenitor cells in systemic lupus erythematosus

Circulating endothelial progenitor cells (EPCs) are biologic markers of endothelial function. In patients with systemic lupus erythematosus (SLE), the numerical reduction and functional impairment of EPCs cont...

Authors: Francesca Romana Spinelli, Cristiana Barbati, Fulvia Cecarelli, Francesca Morello, Tania Colasanti, Marta Vomero, Laura Massaro, Valeria Orefice, Cristiano Alessandri, Guido Valesini and Fabrizio Conti

Introducing our 20th anniversary collection

Authors: Christopher D Buckley and Harris Perlman

Predictors of good response to conventional synthetic DMARDs in early seronegative rheumatoid arthritis: data from the ESPOIR cohort

Early seronegative rheumatoid arthritis (RA) is considered a specific entity, especially regarding diagnostic issues and prognosis. Little is known about its potentially different initial clinical presentation...

Authors: Cédric Lukas, Julia Mary, Michel Debandt, Claire Daïen, Jacques Morel, Alain Cantagrel, Bruno Fautrel and Bernard Combe

Cardiovascular disease in the QUEST-RA study, 10 years later

Authors: Antonio Naranjo and Iván Ferraz-Amaro

European Network of Pregnancy Registers in Rheumatology (EuNeP)—an overview of procedures and data collection

The collaborative initiative of the European Network of Pregnancy Registers in Rheumatology (EuNeP) aims to combine data available in nationwide pregnancy registers to increase knowledge on pregnancy outcomes ...

Authors: Yvette Meissner, Anja Strangfeld, Nathalie Costedoat-Chalumeau, Frauke Förger, Doreen Goll, Anna Molto, Rebecca Özdemir, Marianne Wallenius and Rebecca Fischer-Betz

iNOS dependent and independent phases of lymph node expansion in mice with TNF-induced inflammatory-erosive arthritis

A pivotal effect of lymphatic vessel (LV) function in joint homeostasis was identified in the tumor necrosis factor-transgenic (TNF-Tg) mouse model of rheumatoid arthritis (RA). Specifically, loss of LV contra...

Authors: Richard D. Bell, Pamelia N. Slattery, Emily K. Wu, Lianping Xing, Christopher T. Ritchlin and Edward M. Schwarz

Bone marrow mesenchymal stem cells in rheumatoid arthritis, spondyloarthritis, and ankylosing spondylitis: problems rather than solutions?

Bone marrow mesenchymal stem cells (BM-MSCs) can dampen inflammation in animal models of inflammatory rheumatisms and human osteoarthritis. They are expected to be a solution for numerous human conditions. How...

Authors: Jean-Marie Berthelot, Benoit Le Goff and Yves Maugars

Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture

Most in vitro studies of potential osteoarthritis (OA) therapies have used cartilage monocultures, even though synovium is a key player in mediating joint inflammation and, thereby, cartilage degeneration. In ...

Authors: Shikhar Mehta, Sumayyah Akhtar, Ryan M. Porter, Patrik Önnerfjord and Ambika G. Bajpayee

Radiographic progression can still occur in individual patients with low or moderate disease activity in the current treat-to-target paradigm: real-world data from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry

The aim of this retrospective study was to examine the longitudinal association between disease activity and radiographic damage in a cohort of patients with early RA (symptom onset < 1 year) treated according...

Authors: Peter M. ten Klooster, Letty G. A. Versteeg, Martijn A. H. Oude Voshaar, Inmaculada de la Torre, Francesco De Leonardis, Walid Fakhouri, Liliana Zaremba-Pechmann and Mart van de Laar

Effective treatment of TNFα inhibitors in Chinese patients with Blau syndrome

Blau syndrome (BS) is a rare dominantly inherited autoinflammatory disorder associated with mutations in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene. Biologic therapy of BS yielded dive...

Authors: Jing Chen, Yi Luo, Mengzhu Zhao, Di Wu, Yunjiao Yang, Wen Zhang and Min Shen

Anti-TNF-alpha-induced lupus

Authors: Michel De Bandt

Population-specific factors associated with fractional excretion of uric acid

Reduced renal clearance of uric acid is a major contributor to hyperuricemia. The aim of this study was to examine clinical and genetic variables associated with fractional excretion of uric acid (FEUA).

Authors: Ravi K. Narang, Zoe Vincent, Amanda Phipps-Green, Lisa K. Stamp, Tony R. Merriman and Nicola Dalbeth

IL1 inhibition in gout—where are we a decade on?

Authors: Alexander So

High-quality cooperative research: studies that represent a triumph in the rheumatology community

Over the past 20 years, the rheumatoid arthritis (RA) treatment landscape has been continuously evolving. A range of novel biologic agents, different from the conventional therapies, became available. However,...

Authors: Teresa A. Simon

Disease activity improvements with optimal discriminatory ability between treatment arms: applicability in early and established rheumatoid arthritis clinical trials

The ACR20 has been validated as the best discriminator of efficacy in placebo-controlled trials, but not in head-to-head trials comparing effective therapies in patients with rheumatoid arthritis (RA). We asse...

Authors: Josef Smolen, Roy Fleischmann, Daniel Aletaha, Yihan Li, Yijie Zhou, Iain Sainsbury and Ivan Lagunes Galindo

The feasibility of developing biomarkers from peripheral blood mononuclear cell RNAseq data in children with juvenile idiopathic arthritis using machine learning approaches

The response to treatment for juvenile idiopathic arthritis (JIA) can be staged using clinical features. However, objective laboratory biomarkers of remission are still lacking. In this study, we used machine ...

Authors: Kerry E. Poppenberg, Kaiyu Jiang, Lu Li, Yijun Sun, Hui Meng, Carol A. Wallace, Teresa Hennon and James N. Jarvis

Acute kidney injury associated with febuxostat and allopurinol: a post-marketing study

For patients with recurrent flares of gout, tophi, urate crystal arthropathy, and renal stones, urate-lowering therapies (ULTs, including allopurinol and febuxostat) are the first-line treatment. Due to the wi...

Authors: Amayelle Rey, Benjamin Batteux, Solène M. Laville, Justine Marienne, Kamel Masmoudi, Valérie Gras-Champel and Sophie Liabeuf

Comparative risk of malignancies and infections in patients with rheumatoid arthritis initiating abatacept versus other biologics: a multi-database real-world study

Patients with rheumatoid arthritis (RA) are at an increased risk of developing certain cancers and infections compared with the general population. Biologic and targeted synthetic disease-modifying antirheumat...

Authors: Teresa A. Simon, Maarten Boers, Marc Hochberg, Nicole Baker, Mary L. Skovron, Nitesh Ray, Sanket Singhal, Samy Suissa and Andres Gomez-Caminero

How thorough clinical observational studies on rheumatoid arthritis can have an impact on the field

Authors: A. H. M. van der Helm-van Mil

Early rheumatoid arthritis is characterised by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

A study by Raza et al., published in this journal in 2005, identified that RA patients, within 3 months of symptom onset, had a synovial fluid cytokine profile that was distinct from that of patients with othe...

Authors: K. Raza

Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS

A decade has passed since the publication on the comparison of the effect of adalimumab with data from a historic cohort on the progression of structural damage in the spine of patients with ankylosing spondyl...

Authors: Désirée van der Heijde and Robert Landewé

Serum lysophosphatidylcholines to phosphatidylcholines ratio is associated with symptomatic responders to symptomatic drugs in knee osteoarthritis patients

Identification of the optimal treatment for a given patient is of paramount importance. This is of particular relevance in osteoarthritis (OA) because of the high prevalence of the disease, extensive heterogen...

Authors: Guangju Zhai, Jean-Pierre Pelletier, Ming Liu, Edward W. Randell, Proton Rahman and Johanne Martel-Pelletier

Fatigue severity in anti-nuclear antibody-positive individuals does not correlate with pro-inflammatory cytokine levels or predict imminent progression to symptomatic disease

Fatigue is a common symptom of systemic autoimmune rheumatic disease (SARD). Patients with SARD have a protracted pre-clinical phase during which progressive immunologic derangements occur culminating in disea...

Authors: Waleed Hafiz, Rawad Nori, Ariana Bregasi, Babak Noamani, Dennisse Bonilla, Larissa Lisnevskaia, Earl Silverman, Arthur A. M. Bookman, Sindhu R. Johnson, Carolina Landolt-Marticorena and Joan Wither

Factors related to the use of opioids as early treatment in patients with knee osteoarthritis

To examine factors related to the use of opioids as an early treatment option for knee OA patients

Authors: Soo-Kyung Cho, Sun-Young Jung, Seongmi Choi, Seul Gi Im, Hyoungyoung Kim, Woo Seok Choi, Eun Jin Jang and Yoon-Kyoung Sung

The impact of sex and disease classification on patient-reported outcome measures in axial spondyloarthritis: a descriptive prospective cross-sectional study

The aim of this study was to explore the impact of sex and disease classification on outcomes in axial spondyloarthritis (axSpA) patients, including both radiographic (r-) axSpA and non-radiographic (nr-) axSp...

Authors: Rikke A. Andreasen, Lars E. Kristensen, Kenneth Egstrup, Xenofon Baraliakos, Vibeke Strand, Hans Christian Horn, Inger M. J. Hansen, Robin Christensen and Torkell Ellingsen