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  1. Electronic health records (EHRs) offer a wealth of observational data. Machine-learning (ML) methods are efficient at data extraction, capable of processing the information-rich free-text physician notes in EH...

    Authors: T. D. Maarseveen, M. P. Maurits, E. Niemantsverdriet, A. H. M. van der Helm-van Mil, T. W. J. Huizinga and R. Knevel

    Citation: Arthritis Research & Therapy 2021 23:174

    Content type: Research article

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  2. The structural and functional changes of the skeletal muscles in idiopathic inflammatory myopathies (IIM) caused by inflammation and immune changes can be severely disabling. The objective of this study was to...

    Authors: Maja Špiritović, Barbora Heřmánková, Sabína Oreská, Hana Štorkánová, Olga Růžičková, Lucia Vernerová, Martin Klein, Kateřina Kubínová, Hana Šmucrová, Adéla Rathouská, Petr Česák, Martin Komarc, Václav Bunc, Karel Pavelka, Ladislav Šenolt, Heřman Mann…

    Citation: Arthritis Research & Therapy 2021 23:173

    Content type: Research article

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  3. The pathogenesis of lupus nephritis (LN) remains not fully understood. In this study, we aimed to explore the pathogenic roles of autoantibodies against human renal glomerular endothelial cells (HRGEC) in LN p...

    Authors: Ya-Chiao Hu, I-Jung Tsai, Hui-Yao Hsu, Bor-Luen Chiang and Yao-Hsu Yang

    Citation: Arthritis Research & Therapy 2021 23:171

    Content type: Research article

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  4. Early diffuse cutaneous systemic sclerosis (dcSSc) has the highest case fatality among rheumatic diseases. We report baseline characteristics, current immunosuppressive therapies, progression of skin and inter...

    Authors: Sara Jaafar, Alain Lescoat, Suiyuan Huang, Jessica Gordon, Monique Hinchcliff, Ami A. Shah, Shervin Assassi, Robyn Domsic, Elana J. Bernstein, Virginia Steen, Sabrina Elliott, Faye Hant, Flavia V. Castelino, Victoria K. Shanmugam, Chase Correia, John Varga…

    Citation: Arthritis Research & Therapy 2021 23:170

    Content type: Research article

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  5. Pain is a major symptom in patients with rheumatoid arthritis (RA). In early RA, pain is usually due to synovitis, but can also persist despite effective anti-inflammatory treatment. The objective of this stud...

    Authors: Anna Eberhard, Stefan Bergman, Thomas Mandl, Tor Olofsson, Maria Rydholm, Lennart Jacobsson and Carl Turesson

    Citation: Arthritis Research & Therapy 2021 23:169

    Content type: Research article

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  6. Twenty to thirty percent of psoriasis (Pso) patients will develop psoriatic arthritis (PsA). Detection of Pso patients that are (at risk for) developing PsA is essential to prevent structural damage. We conduc...

    Authors: Michelle L. M. Mulder, Tamara W. van Hal, Mark H. Wenink, Hans J. P. M. Koenen, Frank H. J. van den Hoogen, Elke M. G. J. de Jong, Juul M. P. A. van den Reek and Johanna E. Vriezekolk

    Citation: Arthritis Research & Therapy 2021 23:168

    Content type: Review

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  7. To investigate the regulation of T follicular regulatory (Tfr) and T follicular (Tfh) cell subtypes by low-dose IL-2 in systemic lupus erythematosus (SLE) in a randomized, double-blind, placebo-controlled clin...

    Authors: Miao Miao, Xian Xiao, Jiayi Tian, Yunzhi Zhufeng, Ruiling Feng, Ruijun Zhang, Jiali Chen, Xiaoying Zhang, Bo Huang, Yuebo Jin, Xiaolin Sun, Jing He and Zhanguo Li

    Citation: Arthritis Research & Therapy 2021 23:167

    Content type: Research article

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  8. To investigate whether methotrexate treatment may affect the susceptibility to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

    Authors: Fabian Schälter, Kerstin Dürholz, Laura Bucci, Gerd Burmester, Roberto Caporali, Camille Figuereido, Jaime Fogagnolo Cobra, Bernhard Manger, Mario M. Zaiss and Georg Schett

    Citation: Arthritis Research & Therapy 2021 23:166

    Content type: Research article

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  9. Enthesitis is a hallmark of spondyloarthritis (SpA) with a substantial impact on quality of life. Reports of treatment effectiveness across individual enthesitis sites in real-world patients with axial SpA (ax...

    Authors: Michael J. Nissen, Burkhard Möller, Adrian Ciurea, Ruediger B. Mueller, Patrick Zueger, Martin Schulz, Fabiana Ganz, Almut Scherer, Eleftherios Papagiannoulis and Thomas Hügle

    Citation: Arthritis Research & Therapy 2021 23:165

    Content type: Research article

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  10. Rheumatoid arthritis (RA) is a chronic, autoimmune disorder characterized by joint inflammation and pain. In patients with RA, metabolomic approaches, i.e., high-throughput profiling of small-molecule metaboli...

    Authors: Benjamin Hur, Vinod K. Gupta, Harvey Huang, Kerry A. Wright, Kenneth J. Warrington, Veena Taneja, John M. Davis III and Jaeyun Sung

    Citation: Arthritis Research & Therapy 2021 23:164

    Content type: Research article

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  11. Mucosal sites are hypothesized to play a role in the development of rheumatoid arthritis (RA). Since serum anti-peptidylarginine deiminase (PAD)4 antibodies, including a subset that cross-react with PAD3 (PAD3...

    Authors: M. Kristen Demoruelle, Hong Wang, Ryan L. Davis, Ashley Visser, Johnny Hoang, Jill M. Norris, V. Michael Holers, Kevin D. Deane and Erika Darrah

    Citation: Arthritis Research & Therapy 2021 23:163

    Content type: Research article

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  12. Previous studies have shown that risk chart algorithms, such as the Systematic Coronary Risk Assessment (SCORE), often underestimate the actual cardiovascular (CV) risk of patients with rheumatoid arthritis (R...

    Authors: Iván Ferraz-Amaro, Alfonso Corrales, Juan Carlos Quevedo-Abeledo, Nuria Vegas-Revenga, Ricardo Blanco, Virginia Portilla, Belén Atienza-Mateo and Miguel Á. González-Gay

    Citation: Arthritis Research & Therapy 2021 23:162

    Content type: Research article

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  13. A variety of chronic inflammatory diseases are linked to ischemic heart disease (IHD); however, this association is less well studied in patients with Behçet’s syndrome (BS). The primary objective of this stud...

    Authors: Chun-Yu Lin, Hung-An Chen, Chun-Hsin Wu, Yu-Jih Su, Tsai-Ching Hsu and Chung-Yuan Hsu

    Citation: Arthritis Research & Therapy 2021 23:161

    Content type: Research article

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  14. The aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over 1 to 2 years in people with painful medial knee osteoarthritis.

    Authors: Milena Simic, Alison R. Harmer, Maria Agaliotis, Lillias Nairn, Lisa Bridgett, Lyn March, Milana Votrubec, John Edmonds, Mark Woodward, Richard Day and Marlene Fransen

    Citation: Arthritis Research & Therapy 2021 23:160

    Content type: Research article

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  15. Circular RNAs (circRNAs) can act as vital players in osteoarthritis (OA). However, the roles of circRNAs in OA remain obscure. Herein, we explored the roles of exosomal circRNA bromodomain and WD repeat domain...

    Authors: Zhenye Guo, Huan Wang, Feng Zhao, Min Liu, Feida Wang, Mingming Kang, Weifu He and Zhi Lv

    Citation: Arthritis Research & Therapy 2021 23:159

    Content type: Research article

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  16. Aortic stiffness index (AoSI) has to be considered a proxy outcome measure in patients with rheumatoid arthritis (RA). The aim of this study was to comparatively describe AoSI progression in two groups of RA p...

    Authors: Alessandro Giollo, Giovanni Cioffi, Federica Ognibeni, Giovanni Orsolini, Andrea Dalbeni, Riccardo Bixio, Giovanni Adami, Angelo Fassio, Luca Idolazzi, Davide Gatti, Maurizio Rossini and Ombretta Viapiana

    Citation: Arthritis Research & Therapy 2021 23:158

    Content type: Research article

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  17. Chronic synovial inflammation is an important hallmark of inflammatory arthritis, but the cells and mechanisms involved are incompletely understood. Previously, we have shown that CCR6+ memory T-helper (memTh)...

    Authors: Wendy Dankers, Hannah den Braanker, Sandra M. J. Paulissen, Jan Piet van Hamburg, Nadine Davelaar, Edgar M. Colin and Erik Lubberts

    Citation: Arthritis Research & Therapy 2021 23:157

    Content type: Research article

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  18. There is paucity of data on the prevalence of ultrasound-detected synovial abnormalities in the general population, and the relationship between synovial changes and knee pain remains unclear. We examined the ...

    Authors: Ting Jiang, Tuo Yang, Weiya Zhang, Michael Doherty, Yuqing Zhang, Jie Wei, Aliya Sarmanova, Michelle Hall, Zidan Yang, Jiatian Li, Gwen S. Fernandes, Abasiama D. Obotiba, Sameer A. Gohir, Philip Courtney, Chao Zeng and Guanghua Lei

    Citation: Arthritis Research & Therapy 2021 23:156

    Content type: Research article

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  19. To estimate the relationship between serum TNFα, IL-6, and serum CZP levels and the clinical response to CZP in RA patients in the TSUBAME study.

    Authors: Yusuke Miyazaki, Kazuhisa Nakano, Shingo Nakayamada, Satoshi Kubo, Shigeru Iwata, Kentaro Hanami, Shunsuke Fukuyo, Ippei Miyagawa, Ayako Yamaguchi, Akio Kawabe, Kazuyoshi Saito and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2021 23:154

    Content type: Research article

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  20. Most patients with systemic lupus erythematosus (SLE) have IgG autoantibodies against the RNA-binding p40 (ORF1p) protein encoded by the L1 retroelement. This study tested if these autoantibodies are also pres...

    Authors: Kennedy C. Ukadike, Kathryn Ni, Xiaoxing Wang, Martin S. Taylor, John LaCava, Lauren M. Pachman, Mary Eckert, Anne Stevens, Christian Lood and Tomas Mustelin

    Citation: Arthritis Research & Therapy 2021 23:153

    Content type: Research article

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  21. Although adjacent segmental intervertebral disc degeneration (ASDD) is one of the most common complications after lumbar fusion, its exact mechanism remains unclear. As an antibody to RANKL, denosumab (Dmab) e...

    Authors: Qi Sun, Fa-Ming Tian, Fang Liu, Jia-Kang Fang, Yun-Peng Hu, Qiang-Qiang Lian, Zhuang Zhou and Liu Zhang

    Citation: Arthritis Research & Therapy 2021 23:152

    Content type: Research article

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  22. Multimorbidity raises the number of essential information needed for delivery of high-quality care in patients with chronic diseases like rheumatoid arthritis (RA). We evaluated an innovative ICT platform for ...

    Authors: Jutta G. Richter, Gamal Chehab, Catarina Schwartz, Elisabeth Ricken, Monika Tomczak, Hasan Acar, Henrike Gappa, Carlos A. Velasco, Peter Rosengren, Armanas Povilionis, Matthias Schneider and Jesper Thestrup

    Citation: Arthritis Research & Therapy 2021 23:151

    Content type: Research article

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  23. Immunoglobulin G4-related disease (IgG4-RD) is characterized by increased serum IgG4 concentration and infiltration of IgG4+ plasma cells in the affected organs. The present study aimed to characterize the serum ...

    Authors: Haruki Matsumoto, Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Yashiro-Furuya, Tomoyuki Asano, Shuzo Sato, Hiroshi Watanabe, Eiji Suzuki, Sosuke Tsuji, Shoichi Fukui, Masataka Umeda, Naoki Iwamoto, Atsushi Kawakami and Kiyoshi Migita

    Citation: Arthritis Research & Therapy 2021 23:148

    Content type: Research article

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  24. Axial spondyloarthritis (axSpA) has strong connections with intestinal inflammation as occurs in Crohn’s disease (CD). However, the immunologic mechanisms that distinguish axSpA, CD, and those with features of...

    Authors: Adam R. Lefferts, Emilie H. Regner, Andrew Stahly, Becky O’Rourke, Mark E. Gerich, Blair P. Fennimore, Frank I. Scott, Alison E. Freeman, Ken Jones and Kristine A. Kuhn

    Citation: Arthritis Research & Therapy 2021 23:147

    Content type: Research article

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  25. Opioids are frequently prescribed for pain control in knee osteoarthritis patients, despite recommendations by current guidelines. Previous studies have investigated the chondrotoxicity of different opioid sub...

    Authors: Jannis Bodden, Gabby B. Joseph, Silvia Schirò, John A. Lynch, Nancy E. Lane, Charles E. McCulloch, Michael C. Nevitt and Thomas M. Link

    Citation: Arthritis Research & Therapy 2021 23:146

    Content type: Research article

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  26. Intervertebral disc degeneration contributes to low back pain. The avascular intervertebral disc consists of a central hypoxic nucleus pulpous (NP) surrounded by the more oxygenated annulus fibrosus (AF). Lact...

    Authors: Dong Wang, Robert Hartman, Chao Han, Chao-ming Zhou, Brandon Couch, Matias Malkamaki, Vera Roginskaya, Bennett Van Houten, Steven J. Mullett, Stacy G. Wendell, Michael J. Jurczak, James Kang, Joon Lee, Gwendolyn Sowa and Nam Vo

    Citation: Arthritis Research & Therapy 2021 23:145

    Content type: Research article

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  27. Tofacitinib is a novel Janus kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. In clinical trials, the most common adverse events observed ...

    Authors: Heike C. Hawerkamp, Alina Domdey, Lisa Radau, Philipp Sewerin, Péter Oláh, Bernhard Homey and Stephan Meller

    Citation: Arthritis Research & Therapy 2021 23:144

    Content type: Research article

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  28. To assess the efficacy and tolerance of tocilizumab (TCZ) in giant cell arteritis (GCA) patients over 80.

    Authors: Hubert de Boysson, Maelle Le Besnerais, Félix Blaison, Aurélie Daumas, Pierre-André Jarrot, François Perrin, Nathalie Tieulié, Alexandre Maria, Pierre Duffau, Bruno Gombert, Maxime Samson, Olivier Espitia, Marc Lambert, Arsène Mékinian and Achille Aouba

    Citation: Arthritis Research & Therapy 2021 23:143

    Content type: Research article

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  29. To investigate the role and regulatory mechanisms of fargesin, one of the main components of Magnolia fargesii, in macrophage reprogramming and crosstalk across cartilage and synovium during osteoarthritis (OA) d...

    Authors: Jiansen Lu, Hongbo Zhang, Jianying Pan, Zhiqiang Hu, Liangliang Liu, Yanli Liu, Xiao Yu, Xiaochun Bai, Daozhang Cai and Haiyan Zhang

    Citation: Arthritis Research & Therapy 2021 23:142

    Content type: Research article

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  30. Informative serum biomarkers for monitoring inflammatory activity and treatment responses in axial spondyloarthritis (axSpA) are lacking. We assessed whether Lipocalin 2 (LCN2) and Oncostatin M (OSM), both hav...

    Authors: Florence W. L. Tsui, Aifeng Lin, Ismail Sari, Zhenbo Zhang, Hing Wo Tsui and Robert D. Inman

    Citation: Arthritis Research & Therapy 2021 23:141

    Content type: Research article

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  31. This study aimed to clarify predictors of preterm birth in pregnancy of women with systemic lupus erythematosus (SLE). We investigated the predictors of preterm birth before pregnancy from the perspective of t...

    Authors: Yuri Hiramatsu, Kentaro Isoda, Takuya Kotani, Eri Nakamura, Yumiko Wada, Youhei Fujiki, Shigeki Makino, Daisuke Fujita and Tohru Takeuchi

    Citation: Arthritis Research & Therapy 2021 23:140

    Content type: Research article

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  32. Several studies suggested that thrombotic and obstetric antiphospholipid syndromes could be independent identities, but few have systematically compared their clinical characteristics and prognosis.

    Authors: Hui Jiang, Chu-Han Wang, Nan Jiang, Jing Li, Chan-Yuan Wu, Qian Wang, Meng-Tao Li, Xin-Ping Tian, Jiu-Liang Zhao, Yan Zhao and Xiao-Feng Zeng

    Citation: Arthritis Research & Therapy 2021 23:138

    Content type: Research article

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  33. Aldehyde dehydrogenase 1 family member A1 (RALDH1)-producing dermal dendritic cells (DCs), a conventional DC subset regulating skin fibrosis, are decreased in the involved skin of patients with systemic sclero...

    Authors: Shunsuke Miura, Yusuke Watanabe, Ryosuke Saigusa, Takashi Yamashita, Kouki Nakamura, Megumi Hirabayashi, Takuya Miyagawa, Ayumi Yoshizaki, Maria Trojanowska, Shinichi Sato and Yoshihide Asano

    Citation: Arthritis Research & Therapy 2021 23:137

    Content type: Research article

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  34. Leukocyte activation by anti-neutrophil cytoplasmic antibody (ANCA) and the subsequent leukocyte–endothelium interaction play a key role in the development of endothelial damage in ANCA-associated vasculitis (...

    Authors: Kotaro Matsumoto, Takahiko Kurasawa, Keiko Yoshimoto, Katsuya Suzuki and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2021 23:136

    Content type: Research article

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  35. Earlier, we reported that the microRNA (miR)-155 expression in dendritic cells (DCs) from Behcet’s disease (BD) patients was decreased and affected cytokine production of DCs. In this study, we investigated th...

    Authors: Liang Liang, Qingyun Zhou and Lujia Feng

    Citation: Arthritis Research & Therapy 2021 23:135

    Content type: Research article

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  36. The criteria for antiphospholipid syndrome (APS) include severe preeclampsia and/or placental insufficiency leading to preterm delivery before 34 weeks of gestation, but this APS manifestation has been rarely ...

    Authors: Maddalena Larosa, Véronique Le Guern, Nathalie Morel, Mériem Belhocine, Amelia Ruffatti, Nicolas Martin Silva, Romain Paule, Luc Mouthon, Michel Dreyfus, Jean-Charles Piette, Odile Souchaud-Debouverie, Catherine Deneux-Tharaux, Gaelle Guettrot-Imbert, Vassilis Tsatsaris, Emmanuelle Pannier-Metzger, Anne Murarasu…

    Citation: Arthritis Research & Therapy 2021 23:134

    Content type: Research article

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  37. Systemic sclerosis (SSc) is a chronic autoimmune-mediated connective tissue disorder. Although the etiology of the disease remains undetermined, SSc is characterized by fibrosis and proliferative vascular lesi...

    Authors: Yuzuru Yamamoto, Takaichi Okano, Hirotaka Yamada, Kengo Akashi, Sho Sendo, Yo Ueda, Akio Morinobu and Jun Saegusa

    Citation: Arthritis Research & Therapy 2021 23:133

    Content type: Research article

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  38. The objective of the study was to explore the disease pathways activated in the inflammatory foci of skin lesions in cutaneous lupus erythematosus (CLE) and dermatomyositis (DM).

    Authors: Timothy B. Niewold, Alexander Meves, Julia S. Lehman, Karin Popovic-Silwerfeldt, Aliisa Häyry, Therese Söderlund-Matell, Cristine M. Charlesworth, Benjamin Madden, Ingrid E. Lundberg, Marie Wahren-Herlenius, Elisabet Svenungsson and Vilija Oke

    Citation: Arthritis Research & Therapy 2021 23:132

    Content type: Research article

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  39. Calcific tendonitis of the rotator cuff is due to carbonated apatite deposits in the shoulder tendons. During the evolution of the disease, an acute inflammatory episode may occur leading to the disappearance ...

    Authors: Julien Herman, Benoit Le Goff, Julien De Lima, Régis Brion, Catherine Chevalier, Frédéric Blanchard and Christelle Darrieutort-Laffite

    Citation: Arthritis Research & Therapy 2021 23:131

    Content type: Research article

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  40. Gout flare prophylaxis and therapy use in people with underlying chronic kidney disease (CKD) is challenging, given limited treatment options and risk of worsening renal function with inappropriate treatment d...

    Authors: Huai Leng Pisaniello, Mark C. Fisher, Hamish Farquhar, Ana Beatriz Vargas-Santos, Catherine L. Hill, Lisa K. Stamp and Angelo L. Gaffo

    Citation: Arthritis Research & Therapy 2021 23:130

    Content type: Review

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  41. Changes in gait speed are required in various situations and can be achieved by changing stride length, cadence, or both. Differences in strategies for increasing gait speed may have different effects on hip j...

    Authors: Hiroshige Tateuchi, Haruhiko Akiyama, Koji Goto, Kazutaka So, Yutaka Kuroda and Noriaki Ichihashi

    Citation: Arthritis Research & Therapy 2021 23:129

    Content type: Research article

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  42. Gout is an autoinflammatory disease driven by interleukin-1 (IL-1) induction in response to uric acid crystals. IL-1β production is dependent on inflammasome activation, which requires a priming signal, follow...

    Authors: Yuya Fujita, Toru Yago, Haruki Matsumoto, Tomoyuki Asano, Naoki Matsuoka, Jumpei Temmoku, Shuzo Sato, Makiko Yashiro-Furuya, Eiji Suzuki, Hiroshi Watanabe, Atsushi Kawakami and Kiyoshi Migita

    Citation: Arthritis Research & Therapy 2021 23:128

    Content type: Research article

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  43. Patients with rheumatoid arthritis (RA) are at increased risk of fractures. Although their decline in bone mineral density (BMD) is well-established, data regarding the alterations in bone microarchitecture ar...

    Authors: Shangyi Jin, Mengtao Li, Qian Wang, Xiaofeng Zeng, Weibo Xia, Wei Yu, Wenmin Guan and Evelyn Hsieh

    Citation: Arthritis Research & Therapy 2021 23:127

    Content type: Research article

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  44. Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) are manifestations of an autoinflammatory disorder with complex pathophysiology and significant morbidity, together also ter...

    Authors: Cristina Segú-Vergés, Mireia Coma, Christoph Kessel, Serge Smeets, Dirk Foell and Anna Aldea

    Citation: Arthritis Research & Therapy 2021 23:126

    Content type: Research article

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  45. The University of California Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract Instrument 2.0 (UCLA GIT 2.0) is validated to capture gastrointestinal (GI) tract morbidity in patients wit...

    Authors: Norina Zampatti, Alexandru Garaiman, Suzana Jordan, Rucsandra Dobrota, Mike Oliver Becker, Britta Maurer, Oliver Distler and Carina Mihai

    Citation: Arthritis Research & Therapy 2021 23:125

    Content type: Research article

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