Articles

Inhibition of effector B cells by ibrutinib in systemic sclerosis

Systemic sclerosis (SSc) is a connective tissue disease with a significant morbidity and reduced survival of patients. Effective treatment and clinical control of the disease remain challenging. In particular,...

Authors: Jakob Einhaus, Ann-Christin Pecher, Elisa Asteriti, Hannes Schmid, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Reinhild Klein, Corina Schneidawind, Joerg Henes and Dominik Schneidawind

Iguratimod as an alternative induction therapy for refractory lupus nephritis: a preliminary investigational study

Iguratimod, a novel immunomodulatory agent for rheumatoid arthritis, has been shown to be effective against murine lupus. The aim of this study was to make a preliminary evaluation of the efficacy and safety o...

Authors: Yuening Kang, Qingran Yan, Qiong Fu, Ran Wang, Min Dai, Fang Du, Qing Dai, Ping Ye, Chunmei Wu, Liangjing Lu and Chunde Bao

Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) suppresses Staphylococcus aureus-induced CD80, CD86, and pro-inflammatory cytokine expression in human B cells

Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) competes with CD28 for binding CD80/CD86 on antigen-presenting cells (APCs) to limit T cell activation. B cells are believed to be important APCs in t...

Authors: Po-Chun Liu, Chih-Tai Ssu, Yen-Po Tsao, Teh-Ling Liou, Chang-Youh Tsai, Chung-Tei Chou, Ming-Han Chen and Chuen-Miin Leu

Reduction of circulating innate lymphoid cell progenitors results in impaired cytokine production by innate lymphoid cells in patients with lupus nephritis

Innate lymphoid cells (ILCs) play an essential role in maintaining homeostasis; however, they can also cause chronic inflammation and autoimmune disease. This study aimed to identify the role of ILCs in the pa...

Authors: Seungwon Ryu, Eun Young Lee, Dong Ki Kim, Yon Su Kim, Doo Hyun Chung, Ji Hyung Kim, Hajeong Lee and Hye Young Kim

Biological potential alterations of migratory chondrogenic progenitor cells during knee osteoarthritic progression

Although increasing studies have demonstrated that chondrogenic progenitor cells (CPCs) remain present in human osteoarthritic cartilage, the biological alterations of the CPCs from the less diseased lateral t...

Authors: Yu-Xing Wang, Zhi-Dong Zhao, Qian Wang, Zhong-Li Li, Ya Huang, Sen Zhao, Wei Hu, Jia-Wu Liang, Pei-Lin Li, Hua Wang, Ning Mao, Chu-Tse Wu and Heng Zhu

Resolvin D1 suppresses pannus formation via decreasing connective tissue growth factor caused by upregulation of miRNA-146a-5p in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint stiffness, finally leading to tissue destruction. Connective tissue growth factor (CTGF) is a critical factor i...

Authors: Weiwei Sun, Jinglan Ma, Han Zhao, Chipeng Xiao, Hao Zhong, Hanzhi Ling, Zhen Xie, Qingqing Tian, Huaijun Chen, Tingting Zhang, Mu Chen, Shengwei Jin and Jianguang Wang

Comparative clinical efficacy and safety of the proposed biosimilar ABP 710 with infliximab reference product in patients with rheumatoid arthritis

ABP 710 is being developed as a biosimilar to infliximab reference product (RP). Analytical similarity and pharmacokinetic equivalence between the two have been previously demonstrated. Here we report results ...

Authors: Mark C. Genovese, Juan Sanchez-Burson, MyungShin Oh, Eva Balazs, Jeffrey Neal, Andrea Everding, Tomas Hala, Rafal Wojciechowski, Gary Fanjiang and Stanley Cohen

ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis—a EUSTAR analysis

To investigate the effect of ACE inhibitors (ACEi) on the incidence of scleroderma renal crisis (SRC) when given prior to SRC in the prospectively collected cohort from the European Scleroderma Trial and Resea...

Authors: Lukas Bütikofer, Pierre A. Varisco, O. Distler, O. Kowal-Bielecka, Y. Allanore, G. Riemekasten, P. M. Villiger and S. Adler

Spondyloarthritis Research Consortium of Canada sacroiliac joint inflammation and structural scores: change score reliability and recalibration utility in children

The SPARCC sacroiliac joint inflammation (SIS) and structural (SSS) scores are reliable measures to quantify abnormalities in the pediatric sacroiliac joint. We aimed to evaluate the utility of online calibrat...

Authors: Pamela F. Weiss, Walter P. Maksymowych, Rui Xiao, David M. Biko, Michael L. Francavilla, Robert G. Lambert, Jacob L. Jaremko, Merav Heshin-Bekenstein, Timothy G. Brandon and Nancy A. Chauvin

Post-traumatic osteoarthritis following ACL injury

Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review, we outline the inciden...

Authors: Li-Juan Wang, Ni Zeng, Zhi-Peng Yan, Jie-Ting Li and Guo-Xin Ni

Treatment modalities and drug survival in a systemic sclerosis real-life patient cohort

European data indicate that systemic sclerosis (SSc)-related death rates are increasing, thus raising concerns about SSc’s optimal management. Herein, we describe current treatment modalities and drug survival...

Authors: S. Panopoulos, Κ. Chatzidionysiou, M. G. Tektonidou, V. K. Bournia, A. A. Drosos, Stamatis-Nick C. Liossis, T. Dimitroulas, L. Sakkas, D. Boumpas, P. V. Voulgari, D. Daoussis, K. Thomas, G. Georgiopoulos, G. Vosvotekas, Α. Garyfallos, P. Sidiropoulos…

Response to: “Does ACPA-negative RA consist of subgroups related to sustained DMARD-free remission and serological markers at disease presentation” by Masi and Fleischmann

Authors: Debbie M. Boeters and Annette H. M. van der Helm–van Mil

A consensus-based framework for conducting and reporting osteoarthritis phenotype research

The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research...

Authors: W. E. van Spil, S. M. A. Bierma-Zeinstra, L. A. Deveza, N. K. Arden, A.-C. Bay-Jensen, V. Byers Kraus, L. Carlesso, R. Christensen, M. Van Der Esch, P. Kent, J. Knoop, C. Ladel, C. B. Little, R. F. Loeser, E. Losina, K. Mills…

A Canadian evaluation framework for quality improvement in childhood arthritis: key performance indicators of the process of care

The evaluation of quality of care in juvenile idiopathic arthritis (JIA) is critical for advancing patient outcomes but is not currently part of routine care across all centers in Canada. The study objective i...

Authors: Claire E. H. Barber, Marinka Twilt, Tram Pham, Gillian R. Currie, Susanne Benseler, Rae S. M. Yeung, Michelle Batthish, Nicholas Blanchette, Jaime Guzman, Bianca Lang, Claire LeBlanc, Deborah M. Levy, Christine O’Brien, Heinrike Schmeling, Gordon Soon, Lynn Spiegel…

Low frequency of flares during pregnancy and post-partum in stable lupus patients

Lupus patients are at risk for pregnancy loss, and it has been generally accepted that women with SLE should have low disease activity prior to conception. However, there are conflicting results regarding the ...

Authors: Julia Davis-Porada, Mimi Y. Kim, Marta M. Guerra, Carl A. Laskin, Michelle Petri, Michael D. Lockshin, Lisa R. Sammaritano, D. Ware Branch, Allen Sawitzke, Joan T. Merrill, Jill P. Buyon and Jane E. Salmon

Lipocalin 2 links inflammation and ankylosis in the clinical overlap of inflammatory bowel disease (IBD) and ankylosing spondylitis (AS)

Little is known about the mechanisms underlying the clinical overlap between gut inflammation and joint ankylosis, as exemplified by the concurrence of inflammatory bowel diseases (IBD) and ankylosing spondyli...

Authors: Aifeng Lin, Robert D. Inman, Catherine J. Streutker, Zhenbo Zhang, Kenneth P. H. Pritzker, Hing Wo Tsui and Florence W. L. Tsui

How much of skin improvement over time in systemic sclerosis is due to normal ageing? A prospective study with shear-wave elastography

Measurement of skin involvement is essential for the diagnosis and assessment of prognosis and disease progression in systemic sclerosis (SSc). The modified Rodnan skin score (mRSS) is the gold standard measur...

Authors: T. Santiago, M. Santiago, M. Coutinho, M. J. Salvador and J. A. P. Da Silva

The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H₂S) pathway against experimental osteoarthritis

Osteoarthritis (OA) is characterized by the formation and deposition of calcium-containing crystals in joint tissues, but the underlying mechanisms are poorly understood. The gasotransmitter hydrogen sulfide (H₂S...

Authors: Sonia Nasi, Driss Ehirchiou, Athanasia Chatzianastasiou, Noriyuki Nagahara, Andreas Papapetropoulos, Jessica Bertrand, Giuseppe Cirino, Alexander So and Nathalie Busso

High-throughput quantitative histology in systemic sclerosis skin disease using computer vision

Skin fibrosis is the clinical hallmark of systemic sclerosis (SSc), where collagen deposition and remodeling of the dermis occur over time. The most widely used outcome measure in SSc clinical trials is the mo...

Authors: Chase Correia, Seamus Mawe, Shane Lofgren, Roberta G. Marangoni, Jungwha Lee, Rana Saber, Kathleen Aren, Michelle Cheng, Shannon Teaw, Aileen Hoffmann, Isaac Goldberg, Shawn E. Cowper, Purvesh Khatri, Monique Hinchcliff and J. Matthew Mahoney

Safety and effectiveness of peficitinib (ASP015K) in patients with rheumatoid arthritis: interim data (22.7 months mean peficitinib treatment) from a long-term, open-label extension study in Japan, Korea, and Taiwan

Peficitinib (ASP015K), a novel oral Janus kinase inhibitor, has demonstrated efficacy and safety for the treatment of rheumatoid arthritis (RA) in randomized, controlled trials of up to 52 weeks’ duration. How...

Authors: Tsutomu Takeuchi, Yoshiya Tanaka, Sakae Tanaka, Atsushi Kawakami, Yeong-Wook Song, Yi-Hsing Chen, Mitsuhiro Rokuda, Hiroyuki Izutsu, Satoshi Ushijima, Yuichiro Kaneko, Yoshihiro Nakashima, Teruaki Shiomi and Emi Yamada

Identification of molecules associated with response to abatacept in patients with rheumatoid arthritis

Abatacept (ABA) is a biological disease-modifying antirheumatic drug (bDMARD) for rheumatoid arthritis (RA). The aim of this study was to identify molecules that are associated with therapeutic responses to AB...

Authors: Waka Yokoyama-Kokuryo, Hayato Yamazaki, Tsutomu Takeuchi, Koichi Amano, Jun Kikuchi, Tsuneo Kondo, Seiji Nakamura, Ryoko Sakai, Fumio Hirano, Toshihiro Nanki, Ryuji Koike and Masayoshi Harigai

Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout

The ABCG2 Q141K (rs2231142) and rs10011796 variants associate with hyperuricaemia (HU). The effect size of ABCG2 rs2231142 on urate is ~ 60% that of SLC2A9, yet the effect size on gout is greater. We tested the h...

Authors: Rebekah Wrigley, Amanda J. Phipps-Green, Ruth K. Topless, Tanya J. Major, Murray Cadzow, Philip Riches, Anne-Kathrin Tausche, Matthijs Janssen, Leo A. B. Joosten, Tim L. Jansen, Alexander So, Jennie Harré Hindmarsh, Lisa K. Stamp, Nicola Dalbeth and Tony R. Merriman

Genetic predisposition to smoking is associated with risk of rheumatoid arthritis: a Mendelian randomization study

Although observational epidemiological studies have found that smoking is positively associated with risk of rheumatoid arthritis (RA), assessing the causality of this relationship has remained elusive because...

Authors: Yu Qian, Lingzhi Zhang, David J. H. Wu, Zhijun Xie, Chengping Wen and Yingying Mao

Inhibition of radiographic progression across levels of composite index-defined disease activity in patients with active psoriatic arthritis treated with intravenous golimumab: results from a phase-3, double-blind, placebo-controlled trial

In the GO-VIBRANT trial of intravenous golimumab in psoriatic arthritis (PsA), golimumab significantly inhibited radiographic progression. In post hoc analyses, we evaluated changes in total PsA-modified Sharp...

Authors: Philip Mease, M. Elaine Husni, Shelly Kafka, Soumya D. Chakravarty, Diane D. Harrison, Kim Hung Lo, Stephen Xu, Elizabeth C. Hsia and Arthur Kavanaugh

TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?

The pathophysiology of systemic sclerosis (SSc) is closely linked to overactive TGFβ signaling. TGFβ is produced and circulates in latent form, making its activation crucial for signaling. This activation can ...

Authors: A. van Caam, J. Aarts, T. van Ee, E. Vitters, M. Koenders, F. van de Loo, P. van Lent, F. van den Hoogen, R. Thurlings, M. C. Vonk and P. M. van der Kraan

Insensitivity versus poor response to tumour necrosis factor inhibitors in rheumatoid arthritis: a retrospective cohort study

With advancement in the treatment options of rheumatoid arthritis (RA), optimising the outcomes of difficult-to-treat patients has become increasingly important in clinical practice. In particular, insensitivi...

Authors: Sae Ochi, Kazuyoshi Saito, Fumitaka Mizoguchi, Shigeaki Kato and Yoshiya Tanaka

High-resolution MRI of flexor tendon pulleys using a 16-channel hand coil: disease detection and differentiation of psoriatic and rheumatoid arthritis

To evaluate the value of 3 Tesla (T) magnetic resonance imaging (MRI) changes of flexor tendon pulleys for the differentiation of psoriatic (PsA) and rheumatoid arthritis (RA), using a novel 16-channel high-re...

Authors: Daniel B. Abrar, Christoph Schleich, Sven Nebelung, Miriam Frenken, Karl Ludger Radke, Stefan Vordenbäumen, Ralph Brinks, Matthias Schneider, Benedikt Ostendorf, Dennis McGonagle and Philipp Sewerin

Seasonal effect on fatigue, pain and dryness in primary Sjögren’s syndrome

To assess the presence of a seasonal effect on fatigue, pain and dryness in primary Sjögren’s syndrome (pSS).

Authors: Pierre-Marie Duret, Nicolas Meyer, Alain Saraux, Valérie Devauchelle-Pensec, Raphaele Seror, Véronique Le-Guern, Claire Larroche, Aleth Perdriger, Jean Sibilia, Vianney Guardiolle, Xavier Mariette and Jacques-Eric Gottenberg

Unstimulated whole saliva flow for diagnosis of primary Sjögren’s syndrome: time to revisit the threshold?

Unstimulated whole saliva (UWS) flow rate is one of the ACR/EULAR 2016 criteria for primary Sjögren’s syndrome (pSS). With a single threshold of ≤ 0.1 mL/min, UWS flow does not take into account the age- and s...

Authors: Valentin Lacombe, Carole Lacout, Pierre Lozac’h, Alaa Ghali, Aline Gury, Christian Lavigne and Geoffrey Urbanski

Association between serum level of urate and subclinical atherosclerosis: results from the SCAPIS Pilot

Hyperuricemia is closely associated with cardiovascular disease (CVD). However, it has not been definitively established whether this association is independent of traditional cardiovascular risk factors (CVRF...

Authors: Panagiota Drivelegka, Helena Forsblad-d’Elia, Oskar Angerås, Göran Bergström, Caroline Schmidt, Lennart T. H. Jacobsson and Mats Dehlin

Prime-boost vaccination strategy enhances immunogenicity compared to single pneumococcal conjugate vaccination in patients receiving conventional DMARDs, to some extent in abatacept but not in rituximab-treated patients

To explore whether a prime-boost vaccination strategy, i.e., a dose of pneumococcal conjugate vaccine (PCV) and a dose of 23-valent polysaccharide vaccine (PPV23), enhances antibody response compared to single...

Authors: Per Nived, Göran Jönsson, Bo Settergren, Jon Einarsson, Tor Olofsson, Charlotte Sværke Jørgensen, Lillemor Skattum and Meliha C. Kapetanovic

Investigating lupus retention in care to inform interventions for disparities reduction: an observational cohort study

Systemic lupus erythematous (SLE) disproportionately impacts patients of color and socioeconomically disadvantaged patients. Similar disparities in HIV were reduced through a World Health Organization-endorsed...

Authors: Christie M. Bartels, Ann Rosenthal, Xing Wang, Umber Ahmad, Ian Chang, Nnenna Ezeh, Shivani Garg, Maria Schletzbaum and Amy Kind

Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior

Metformin could activate adenosine monophosphate-activated protein kinase (AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study aimed to examine the effects of metformin ...

Authors: Hui Li, Xiang Ding, Robert Terkeltaub, Hang Lin, Yuqing Zhang, Bin Zhou, Ke He, Kun Li, Zhichen Liu, Jie Wei, Yuanheng Yang, Hui Xie, Chao Zeng and Guanghua Lei

“Non-criteria” antiphospholipid antibodies add value to antiphospholipid syndrome diagnoses in a large Chinese cohort

Despite expansion in the 2006 Sydney antiphospholipid syndrome (APS) classification criteria to include IgG/IgM anti-β2-glycoprotein (aβ2GPI) antibodies in addition to IgG/IgM anti-cardiolipin antibodies (aCL)...

Authors: Tingting Liu, Jieyu Gu, Liyan Wan, Qiongyi Hu, Jialin Teng, Honglei Liu, Xiaobing Cheng, Junna Ye, Yutong Su, Yue Sun, Jinfeng Zhou, Gary L. Norman, Xuefeng Wang, Chengde Yang and Hui Shi

Detecting gastrointestinal manifestations in patients with systemic sclerosis using anti-gAChR antibodies

Patients with systemic sclerosis (SSc) complicated by gastrointestinal dysmotility are difficult to treat and have high mortality. To clarify the pathogenesis of gastrointestinal manifestations, we aimed to de...

Authors: Shunya Nakane, Masataka Umeda, Shin-ya Kawashiri, Akihiro Mukaino, Kunihiro Ichinose, Osamu Higuchi, Yasuhiro Maeda, Hideki Nakamura, Hidenori Matsuo and Atsushi Kawakami

Acute kidney injury after primary total hip arthroplasty: a risk multiplier for complication, mortality, and healthcare utilization

To assess whether acute kidney injury (AKI) is associated with more complications and higher healthcare utilization in people undergoing primary total hip arthroplasty (THA).

Authors: Jasvinder A. Singh and John D. Cleveland

Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis

Systemic sclerosis (SSc) is a severe and highly heterogeneous disease. The modified Rodnan skin score (mRSS) is a widely used tool for the assessment of the extent and degree of skin thickness. This study aime...

Authors: Emmanuel Ledoult, David Launay, Hélène Béhal, Luc Mouthon, Grégory Pugnet, Jean-Christophe Lega, Christian Agard, Yannick Allanore, Patrick Jego, Anne-Laure Fauchais, Jean-Robert Harlé, Sabine Berthier, Achille Aouba, Arsène Mekinian, Elisabeth Diot, Marie-Elise Truchetet…

The relationship between synovial inflammation, structural pathology, and pain in post-traumatic osteoarthritis: differential effect of stem cell and hyaluronan treatment

Synovitis is implicated in the severity and progression of pain and structural pathology of osteoarthritis (OA). Increases in inflammatory or immune cell subpopulations including macrophages and lymphocytes ha...

Authors: Cindy C. Shu, Sanaa Zaki, Varshini Ravi, Antonella Schiavinato, Margaret M. Smith and Christopher B. Little

Adverse events during oral colchicine use: a systematic review and meta-analysis of randomised controlled trials

Colchicine is a widely used drug to treat inflammatory diseases. Due to its long historical use in medicine, controlled clinical trials have been small and there remains some caution with the use of this drug ...

Authors: Sarah Stewart, Kevin Chih Kai Yang, Kate Atkins, Nicola Dalbeth and Philip C. Robinson

Association between periodontitis and anti-citrullinated protein antibodies in rheumatoid arthritis patients: a cross-sectional study

The aim of this study was to evaluate the association between periodontal parameters related with the periodontal disease severity and the presence and levels of anti-citrullinated protein antibodies (ACPAs) i...

Authors: Jerián González-Febles, Beatriz Rodríguez-Lozano, Carlos Sánchez-Piedra, Jorge Garnier-Rodríguez, Sagrario Bustabad, Martina Hernández-González, Enrique González-Dávila, Mariano Sanz and Federico Díaz-González

A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

C-reactive protein (CRP) is often normal in patients with psoriatic disease. Herein, we aimed to define markers of systemic inflammation in patients with monomorphic and polymorphic psoriatic skin, entheseal, ...

Authors: Maria V. Sokolova, David Simon, Kemal Nas, Mario M. Zaiss, Yubin Luo, Yi Zhao, Jürgen Rech and Georg Schett

Innate lymphoid cells in inflammatory arthritis

Aberrant activation and dysregulation of immune system is a common feature of many forms of inflammatory arthritis. Since their identification as a distinctive population of leukocytes, innate lymphoid cells (...

Authors: Weiting Fang, Yuanyuan Zhang and Zhu Chen

Tumour necrosis factor alpha promotes secretion of 14-3-3η by inducing necroptosis in macrophages

14-3-3η is an intracellular protein also detected in the serum and synovial fluid of patients with rheumatoid arthritis (RA). It is closely related to disease activity and anti-cyclic citrullinated peptide ant...

Authors: Gulzhan Trimova, Kaoru Yamagata, Shigeru Iwata, Shintaro Hirata, Tong Zhang, Fumi Uemura, Minoru Satoh, Norma Biln, Shingo Nakayamada, Walter P. Maksymowych and Yoshiya Tanaka

Responses to “Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study”: authors’ reply

Authors: Yves Henrotin, Anne-Françoise Donneau, Kurt de Vlam, Ruth Wittoek and Frank Luyten

Response to “Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study”

Authors: Jean-Pierre Pelletier and Jean-Pierre Raynauld

Reply to: “Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study”

Authors: Nicola Veronese

Aryl hydrocarbon receptor signals attenuate lung fibrosis in the bleomycin-induced mouse model for pulmonary fibrosis through increase of regulatory T cells

Interstitial lung disease (ILD) is a serious complication of connective tissue diseases (CTDs). Although immune dysregulation triggered by genetic and environmental factors is thought to provoke inflammation a...

Authors: Hiroshi Takei, Hidekata Yasuoka, Keiko Yoshimoto and Tsutomu Takeuchi

Serial magnetic resonance imaging and ultrasound examinations demonstrate differential inflammatory lesion patterns in soft tissue and bone upon patient-reported flares in rheumatoid arthritis

Magnetic resonance imaging (MRI) and ultrasonography (US) are more sensitive than clinical evaluation in assessing inflammation in rheumatoid arthritis (RA). Data is scarce regarding potential link between pat...

Authors: Dorota Kuettel, Daniel Glinatsi, Mikkel Østergaard, Lene Terslev, Jette Primdahl, Sören Möller, Andreas Pedersen, Randi Petersen, Ulrich Weber and Kim Hørslev-Petersen

Assessing structural damage progression in psoriatic arthritis and its role as an outcome in research

Psoriatic arthritis (PsA) is an immune-mediated, clinically heterogeneous disease characterized by arthritis, enthesitis, dactylitis, spondylitis, and psoriasis of the skin and nails. Persistent articular infl...

Authors: Désirée van der Heijde, Dafna D. Gladman, Arthur Kavanaugh and Philip J. Mease

Does ACPA-negative RA consist of subgroups related to sustained DMARD-free remission and serological markers at disease presentation? Comment on article by Boeters DM et al.

Authors: Alfonse T. Masi and Roy Fleischmann