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  1. Models to predict disease course and long-term outcome based on clinical characteristics at disease onset may guide early treatment strategies in juvenile idiopathic arthritis (JIA). Before a prediction model ...

    Authors: Veronika Rypdal, Jaime Guzman, Andrew Henrey, Thomas Loughin, Mia Glerup, Ellen Dalen Arnstad, Kristiina Aalto, Marite Rygg, Susan Nielsen, Troels Herlin, Anders Fasth, Lillemor Berntson, Martin Rypdal and Ellen Nordal

    Citation: Arthritis Research & Therapy 2019 21:270

    Content type: Research article

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  2. PF-06650833 is a potent, selective inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). Two randomized, double-blind, sponsor-open phase 1 studies evaluated the safety, pharmacokinetics, and pharma...

    Authors: Spencer I. Danto, Negin Shojaee, Ravi Shankar P. Singh, Cheryl Li, Steven A. Gilbert, Zorayr Manukyan and Iain Kilty

    Citation: Arthritis Research & Therapy 2019 21:269

    Content type: Research article

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  3. To investigate whether calprotectin (S100A8/A9 or MRP8/14), an inflammatory complex released by monocytes, could indicate residual subclinical inflammation in rheumatoid arthritis (RA) patients who are in stab...

    Authors: Emma C. de Moel, Jürgen Rech, Michael Mahler, Johannes Roth, Thomas Vogl, Anne Schouffoer, Robbert J. Goekoop, Tom W. J. Huizinga, Cornelia F. Allaart, René E. M. Toes, Georg Schett and Diane van der Woude

    Citation: Arthritis Research & Therapy 2019 21:268

    Content type: Research article

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  4. The information concerning non-invasive, easily obtainable, and accurate biomarkers for diagnosis of lupus nephritis (LN) is extremely limited. The aim of this study was to evaluate the diagnostic performance ...

    Authors: Bei Xu, Ya-mei Zhang, Yu-wei Yang, Yun-shuang Liu and Jia-fu Feng

    Citation: Arthritis Research & Therapy 2019 21:267

    Content type: Research article

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  5. Enthesitis is one of the psoriatic arthritis (PsA) domains. Patients with enthesitis are associated with worse outcomes than those without enthesitis. The effect of secukinumab on the resolution of enthesitis ...

    Authors: Laura C. Coates, Johan K. Wallman, Dennis McGonagle, Georg A. Schett, Iain B. McInnes, Philip J. Mease, Lawrence Rasouliyan, Erhard Quebe-Fehling, Darren L. Asquith, Andreas E. R. Fasth, Luminita Pricop and Corine Gaillez

    Citation: Arthritis Research & Therapy 2019 21:266

    Content type: Research article

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  6. Although the short-term effects of tumor necrosis factor alpha (TNF-α) and interleukin-17A (IL-17A) inhibition on the structural changes in psoriatic arthritis (PsA) using high-resolution peripheral quantitati...

    Authors: Dongze Wu, James F. Griffith, Steven H. M. Lam, Priscilla C. H. Wong, Lin Shi, Edmund K. Li, Isaac T. Cheng, Tena K. Li, Vivian W. Hung, Ling Qin and Lai-Shan Tam

    Citation: Arthritis Research & Therapy 2019 21:265

    Content type: Research article

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  7. In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring systems, and no systematic relationship with functional deficits has ...

    Authors: Anne-Laure Mausset-Bonnefont, Maïlys Cren, Rita Vicente, Julie Quentin, Christian Jorgensen, Florence Apparailly and Pascale Louis-Plence

    Citation: Arthritis Research & Therapy 2019 21:264

    Content type: Research article

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  8. Patient-reported outcomes (PROs) are important when evaluating treatment benefits in rheumatoid arthritis (RA). We compared upadacitinib, an oral, selective JAK-1 inhibitor, with placebo to assess clinically m...

    Authors: Vibeke Strand, Michael Schiff, Namita Tundia, Alan Friedman, Sebastian Meerwein, Aileen Pangan, Arijit Ganguli, Mahesh Fuldeore, Yan Song and Janet Pope

    Citation: Arthritis Research & Therapy 2019 21:263

    Content type: Research article

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  9. Elevated levels of C-reactive protein (CRP) in systemic sclerosis (SSc) have been linked to early inflammatory stages of the disease. This study has been designed to investigate CRP levels longitudinally in a ...

    Authors: Aleksey Mitev, Lisa Christ, Daria Feldmann, Moritz Binder, Kim Möller, Anna-Maria Kanne, Thomas Hügle, Peter M. Villiger, Reinhard E. Voll, Stephanie Finzel and Florian Kollert

    Citation: Arthritis Research & Therapy 2019 21:262

    Content type: Research article

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  10. Lupus nephritis (LN) is a common and serious complication of systemic lupus erythematosus. Anti-double-stranded (ds) DNA immunoglobulin G (IgG) plays a pivotal role in the pathogenesis of LN. Currently, there ...

    Authors: Huixia Wang, Mei Lu, Siyue Zhai, Kunyi Wu, Lingling Peng, Jie Yang and Yumin Xia

    Citation: Arthritis Research & Therapy 2019 21:261

    Content type: Research article

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  11. Patients with incomplete systemic lupus erythematosus (iSLE) have lupus features, but do not meet classification criteria for SLE. Type I interferons (IFN) are important early mediators in SLE, and IFN upregul...

    Authors: Wietske M. Lambers, Karina de Leeuw, Berber Doornbos-van der Meer, Gilles F.H. Diercks, Hendrika Bootsma and Johanna Westra

    Citation: Arthritis Research & Therapy 2019 21:260

    Content type: Research article

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  12. Immune complexes are of importance in systemic lupus erythematosus pathogenesis, and autoantibodies are believed to participate in immune complex formation. Quantification of autoantibody levels in circulating...

    Authors: Azita Sohrabian, Ioannis Parodis, Nellie Carlströmer-Berthén, Martina Frodlund, Andreas Jönsen, Agneta Zickert, Christopher Sjöwall, Anders A. Bengtsson, Iva Gunnarsson and Johan Rönnelid

    Citation: Arthritis Research & Therapy 2019 21:259

    Content type: Research article

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  13. In previous studies, we demonstrated that the NEMO score, i.e. the cumulative number of microhaemorrhages (MHEs) and microthromboses (MTs), observed in nailfold videocapillaroscopy was a good indicator of the ...

    Authors: Francesca Pignataro, Wanda Maglione, Antonina Minniti, Domenico Sambataro, Gianluca Sambataro, Francesco Campanaro, Gabriele Valentini, Claudio Vitali and Nicoletta Del Papa

    Citation: Arthritis Research & Therapy 2019 21:258

    Content type: Research article

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  14. In well-controlled rheumatoid arthritis (RA) without significant joint damage, a substantial proportion of patients complain of persistent pain. Previous studies have identified different pain phenotypes in RA...

    Authors: P. M. ten Klooster, N. de Graaf and H. E. Vonkeman

    Citation: Arthritis Research & Therapy 2019 21:257

    Content type: Research article

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  15. To identify a therapeutic target interval for certolizumab pegol drug levels and examine the influence of anti-drug antibodies in patients with inflammatory joint diseases.

    Authors: Johanna Elin Gehin, Guro Løvik Goll, David John Warren, Silje Watterdal Syversen, Joseph Sexton, Eldri Kveine Strand, Tore Kristian Kvien, Nils Bolstad and Elisabeth Lie

    Citation: Arthritis Research & Therapy 2019 21:256

    Content type: Research article

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  16. The prophylaxis for hepatitis B virus (HBV) reactivation assumes that hepatic injury after reactivation is often rapidly progressive and can evoke fulminant hepatitis. The incidence and prognosis of reactivati...

    Authors: Wataru Fukuda, Tadamasa Hanyu, Masaki Katayama, Shinichi Mizuki, Akitomo Okada, Masayuki Miyata, Yuichi Handa, Masatoshi Hayashi, Yoshinobu Koyama, Kaoru Arii, Toshiyuki Kitaori, Hiroyuki Hagiyama, Yoshinori Urushidani, Takahito Yamasaki, Yoshihiko Ikeno, Takeshi Suzuki…

    Citation: Arthritis Research & Therapy 2019 21:255

    Content type: Research article

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  17. Osteoarthritis is increasingly recognized as the result of a complex interplay between inflammation, chrondrodegeneration, and pain. Joint mast cells are considered to play a key role in orchestrating this det...

    Authors: Marika Cordaro, Rosalba Siracusa, Daniela Impellizzeri, Ramona D’ Amico, Alessio Filippo Peritore, Rosalia Crupi, Enrico Gugliandolo, Roberta Fusco, Rosanna Di Paola, Carlo Schievano and Salvatore Cuzzocrea

    Citation: Arthritis Research & Therapy 2019 21:254

    Content type: Research article

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  18. While microangiopathy is well-documented in systemic sclerosis (SSc), a potential link between SSc and macrovascular disease is highly debated and remains to be established. The aim of the present study is to ...

    Authors: Stergios Soulaidopoulos, Eleni Pagkopoulou, Niki Katsiki, Eva Triantafyllidou, Asterios Karagiannis, Alexandros Garyfallos, George D. Kitas and Theodoros Dimitroulas

    Citation: Arthritis Research & Therapy 2019 21:253

    Content type: Research article

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  19. Intra-articular adipose tissues (IAATs) are involved in osteoarthritis (OA) pathophysiology. We hypothesize that mesenchymal cells residing in IAATs may account for the specific inflammatory and metabolic patt...

    Authors: Florent Eymard, Audrey Pigenet, Cindy Rose, Anouchka Bories, Charles-Henri Flouzat-Lachaniette, Francis Berenbaum, Xavier Chevalier, Xavier Houard and Geoffroy Nourissat

    Citation: Arthritis Research & Therapy 2019 21:252

    Content type: Research article

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  20. Primary Sjögren’s syndrome (pSS) is associated with dental caries. Pilocarpine, a salivary stimulant, can improve the amount and flow rate of saliva in patients with pSS. This study aimed to assess whether the...

    Authors: Chung-Yuan Hsu, Kuo-Chun Hung, Ming-Shyan Lin, Chi-Hua Ko, Yu-Sheng Lin, Tien-Hsing Chen, Chun-Yu Lin and Ying-Chou Chen

    Citation: Arthritis Research & Therapy 2019 21:251

    Content type: Research article

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  21. Hydroxychloroquine (HCQ) is used for the treatment of patients with rheumatic diseases. We tested the hypothesis that HCQ affects the NLRP3 inflammasome, which is involved in autoinflammation.

    Authors: Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Yashiro Furuya, Tomoyuki Asano, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Takeshi Urano, Hideko Kozuru, Hiroshi Yatsuhashi, Tomohiro Koga, Atsushi Kawakami and Kiyoshi Migita

    Citation: Arthritis Research & Therapy 2019 21:250

    Content type: Research article

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  22. Based on a unique cohort of clinically suspect arthralgia (CSA) patients, we analysed which combinations of MRI features at onset were predictive for rheumatoid arthritis (RA) development. This was done to inc...

    Authors: Xanthe M. E. Matthijssen, Fenne Wouters, Debbie M. Boeters, Aleid C. Boer, Yousra J. Dakkak, Ellis Niemantsverdriet and Annette H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2019 21:249

    Content type: Research article

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  23. Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in t...

    Authors: Eva Klingberg, Maria K. Magnusson, Hans Strid, Anna Deminger, Arne Ståhl, Johanna Sundin, Magnus Simrén, Hans Carlsten, Lena Öhman and Helena Forsblad-d’Elia

    Citation: Arthritis Research & Therapy 2019 21:248

    Content type: Research article

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  24. Both loss- and gain-of-function of Wnt/β-catenin signaling in chondrocytes result in exacerbation of osteoarthritis (OA). Here, we examined the activity and roles of Wnt/β-catenin signaling in the superficial ...

    Authors: Fengjun Xuan, Fumiko Yano, Daisuke Mori, Ryota Chijimatsu, Yuji Maenohara, Hideki Nakamoto, Yoshifumi Mori, Yuma Makii, Takeshi Oichi, Makoto Mark Taketo, Hironori Hojo, Shinsuke Ohba, Ung-il Chung, Sakae Tanaka and Taku Saito

    Citation: Arthritis Research & Therapy 2019 21:247

    Content type: Research article

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  25. Anti-citrullinated protein antibodies (ACPA) are central to rheumatoid arthritis (RA) pathogenesis and may develop at inflamed mucosa. We investigated whether asthma, a disease of airway mucosal inflammation, ...

    Authors: Alessandra Zaccardelli, Xinyi Liu, Julia A. Ford, Jing Cui, Bing Lu, Su H. Chu, Peter H. Schur, Cameron B. Speyer, Karen H. Costenbader, William H. Robinson, Jeremy Sokolove, Elizabeth W. Karlson, Carlos A. Camargo Jr and Jeffrey A. Sparks

    Citation: Arthritis Research & Therapy 2019 21:246

    Content type: Research article

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  26. Circulating endothelial progenitor cells (EPCs) are biologic markers of endothelial function. In patients with systemic lupus erythematosus (SLE), the numerical reduction and functional impairment of EPCs cont...

    Authors: Francesca Romana Spinelli, Cristiana Barbati, Fulvia Cecarelli, Francesca Morello, Tania Colasanti, Marta Vomero, Laura Massaro, Valeria Orefice, Cristiano Alessandri, Guido Valesini and Fabrizio Conti

    Citation: Arthritis Research & Therapy 2019 21:245

    Content type: Research article

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  27. Early seronegative rheumatoid arthritis (RA) is considered a specific entity, especially regarding diagnostic issues and prognosis. Little is known about its potentially different initial clinical presentation...

    Authors: Cédric Lukas, Julia Mary, Michel Debandt, Claire Daïen, Jacques Morel, Alain Cantagrel, Bruno Fautrel and Bernard Combe

    Citation: Arthritis Research & Therapy 2019 21:243

    Content type: Research article

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  28. The collaborative initiative of the European Network of Pregnancy Registers in Rheumatology (EuNeP) aims to combine data available in nationwide pregnancy registers to increase knowledge on pregnancy outcomes ...

    Authors: Yvette Meissner, Anja Strangfeld, Nathalie Costedoat-Chalumeau, Frauke Förger, Doreen Goll, Anna Molto, Rebecca Özdemir, Marianne Wallenius and Rebecca Fischer-Betz

    Citation: Arthritis Research & Therapy 2019 21:241

    Content type: Research article

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  29. A pivotal effect of lymphatic vessel (LV) function in joint homeostasis was identified in the tumor necrosis factor-transgenic (TNF-Tg) mouse model of rheumatoid arthritis (RA). Specifically, loss of LV contra...

    Authors: Richard D. Bell, Pamelia N. Slattery, Emily K. Wu, Lianping Xing, Christopher T. Ritchlin and Edward M. Schwarz

    Citation: Arthritis Research & Therapy 2019 21:240

    Content type: Research article

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  30. Bone marrow mesenchymal stem cells (BM-MSCs) can dampen inflammation in animal models of inflammatory rheumatisms and human osteoarthritis. They are expected to be a solution for numerous human conditions. How...

    Authors: Jean-Marie Berthelot, Benoit Le Goff and Yves Maugars

    Citation: Arthritis Research & Therapy 2019 21:239

    Content type: Review

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  31. Most in vitro studies of potential osteoarthritis (OA) therapies have used cartilage monocultures, even though synovium is a key player in mediating joint inflammation and, thereby, cartilage degeneration. In ...

    Authors: Shikhar Mehta, Sumayyah Akhtar, Ryan M. Porter, Patrik Önnerfjord and Ambika G. Bajpayee

    Citation: Arthritis Research & Therapy 2019 21:238

    Content type: Research article

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  32. The aim of this retrospective study was to examine the longitudinal association between disease activity and radiographic damage in a cohort of patients with early RA (symptom onset < 1 year) treated according...

    Authors: Peter M. ten Klooster, Letty G. A. Versteeg, Martijn A. H. Oude Voshaar, Inmaculada de la Torre, Francesco De Leonardis, Walid Fakhouri, Liliana Zaremba-Pechmann and Mart van de Laar

    Citation: Arthritis Research & Therapy 2019 21:237

    Content type: Research article

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  33. Blau syndrome (BS) is a rare dominantly inherited autoinflammatory disorder associated with mutations in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene. Biologic therapy of BS yielded dive...

    Authors: Jing Chen, Yi Luo, Mengzhu Zhao, Di Wu, Yunjiao Yang, Wen Zhang and Min Shen

    Citation: Arthritis Research & Therapy 2019 21:236

    Content type: Research article

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  34. Reduced renal clearance of uric acid is a major contributor to hyperuricemia. The aim of this study was to examine clinical and genetic variables associated with fractional excretion of uric acid (FEUA).

    Authors: Ravi K. Narang, Zoe Vincent, Amanda Phipps-Green, Lisa K. Stamp, Tony R. Merriman and Nicola Dalbeth

    Citation: Arthritis Research & Therapy 2019 21:234

    Content type: Research article

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  35. Over the past 20 years, the rheumatoid arthritis (RA) treatment landscape has been continuously evolving. A range of novel biologic agents, different from the conventional therapies, became available. However,...

    Authors: Teresa A. Simon

    Citation: Arthritis Research & Therapy 2019 21:232

    Content type: Editorial

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    The Research article to this article has been published in Arthritis Research & Therapy 2008 10:R45

  36. The ACR20 has been validated as the best discriminator of efficacy in placebo-controlled trials, but not in head-to-head trials comparing effective therapies in patients with rheumatoid arthritis (RA). We asse...

    Authors: Josef Smolen, Roy Fleischmann, Daniel Aletaha, Yihan Li, Yijie Zhou, Iain Sainsbury and Ivan Lagunes Galindo

    Citation: Arthritis Research & Therapy 2019 21:231

    Content type: Research article

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  37. The response to treatment for juvenile idiopathic arthritis (JIA) can be staged using clinical features. However, objective laboratory biomarkers of remission are still lacking. In this study, we used machine ...

    Authors: Kerry E. Poppenberg, Kaiyu Jiang, Lu Li, Yijun Sun, Hui Meng, Carol A. Wallace, Teresa Hennon and James N. Jarvis

    Citation: Arthritis Research & Therapy 2019 21:230

    Content type: Research article

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  38. For patients with recurrent flares of gout, tophi, urate crystal arthropathy, and renal stones, urate-lowering therapies (ULTs, including allopurinol and febuxostat) are the first-line treatment. Due to the wi...

    Authors: Amayelle Rey, Benjamin Batteux, Solène M. Laville, Justine Marienne, Kamel Masmoudi, Valérie Gras-Champel and Sophie Liabeuf

    Citation: Arthritis Research & Therapy 2019 21:229

    Content type: Research article

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  39. Patients with rheumatoid arthritis (RA) are at an increased risk of developing certain cancers and infections compared with the general population. Biologic and targeted synthetic disease-modifying antirheumat...

    Authors: Teresa A. Simon, Maarten Boers, Marc Hochberg, Nicole Baker, Mary L. Skovron, Nitesh Ray, Sanket Singhal, Samy Suissa and Andres Gomez-Caminero

    Citation: Arthritis Research & Therapy 2019 21:228

    Content type: Research article

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  40. A study by Raza et al., published in this journal in 2005, identified that RA patients, within 3 months of symptom onset, had a synovial fluid cytokine profile that was distinct from that of patients with othe...

    Authors: K. Raza

    Citation: Arthritis Research & Therapy 2019 21:226

    Content type: Editorial

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    The Research article to this article has been published in Arthritis Research & Therapy 2005 7:R784

  41. A decade has passed since the publication on the comparison of the effect of adalimumab with data from a historic cohort on the progression of structural damage in the spine of patients with ankylosing spondyl...

    Authors: Désirée van der Heijde and Robert Landewé

    Citation: Arthritis Research & Therapy 2019 21:225

    Content type: Editorial

    Published on:

    The Research article to this article has been published in Arthritis Research & Therapy 2009 11:R127

  42. Identification of the optimal treatment for a given patient is of paramount importance. This is of particular relevance in osteoarthritis (OA) because of the high prevalence of the disease, extensive heterogen...

    Authors: Guangju Zhai, Jean-Pierre Pelletier, Ming Liu, Edward W. Randell, Proton Rahman and Johanne Martel-Pelletier

    Citation: Arthritis Research & Therapy 2019 21:224

    Content type: Research article

    Published on:

  43. Fatigue is a common symptom of systemic autoimmune rheumatic disease (SARD). Patients with SARD have a protracted pre-clinical phase during which progressive immunologic derangements occur culminating in disea...

    Authors: Waleed Hafiz, Rawad Nori, Ariana Bregasi, Babak Noamani, Dennisse Bonilla, Larissa Lisnevskaia, Earl Silverman, Arthur A. M. Bookman, Sindhu R. Johnson, Carolina Landolt-Marticorena and Joan Wither

    Citation: Arthritis Research & Therapy 2019 21:223

    Content type: Research article

    Published on:

  44. The aim of this study was to explore the impact of sex and disease classification on outcomes in axial spondyloarthritis (axSpA) patients, including both radiographic (r-) axSpA and non-radiographic (nr-) axSp...

    Authors: Rikke A. Andreasen, Lars E. Kristensen, Kenneth Egstrup, Xenofon Baraliakos, Vibeke Strand, Hans Christian Horn, Inger M. J. Hansen, Robin Christensen and Torkell Ellingsen

    Citation: Arthritis Research & Therapy 2019 21:221

    Content type: Research article

    Published on:

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