Articles

Handwork vs machine: a comparison of rheumatoid arthritis patient populations as identified from EHR free-text by diagnosis extraction through machine-learning or traditional criteria-based chart review

Electronic health records (EHRs) offer a wealth of observational data. Machine-learning (ML) methods are efficient at data extraction, capable of processing the information-rich free-text physician notes in EH...

Authors: T. D. Maarseveen, M. P. Maurits, E. Niemantsverdriet, A. H. M. van der Helm-van Mil, T. W. J. Huizinga and R. Knevel

The effect of a 24-week training focused on activities of daily living, muscle strengthening, and stability in idiopathic inflammatory myopathies: a monocentric controlled study with follow-up

The structural and functional changes of the skeletal muscles in idiopathic inflammatory myopathies (IIM) caused by inflammation and immune changes can be severely disabling. The objective of this study was to...

Authors: Maja Špiritović, Barbora Heřmánková, Sabína Oreská, Hana Štorkánová, Olga Růžičková, Lucia Vernerová, Martin Klein, Kateřina Kubínová, Hana Šmucrová, Adéla Rathouská, Petr Česák, Martin Komarc, Václav Bunc, Karel Pavelka, Ladislav Šenolt, Heřman Mann…

Biomechanical stress in the context of competitive sports training triggers enthesitis

To evaluate the influence of mechanical stress on the development of immediate enthesitis.

Authors: David Simon, Arnd Kleyer, Sara Bayat, Johannes Knitza, Larissa Valor-Mendez, Marina Schweiger, Georg Schett, Koray Tascilar and Axel J. Hueber

Identification of monoclonal antibodies against human renal glomerular endothelial cells in lupus nephritis that induce endothelial interferon-alpha production

The pathogenesis of lupus nephritis (LN) remains not fully understood. In this study, we aimed to explore the pathogenic roles of autoantibodies against human renal glomerular endothelial cells (HRGEC) in LN p...

Authors: Ya-Chiao Hu, I-Jung Tsai, Hui-Yao Hsu, Bor-Luen Chiang and Yao-Hsu Yang

Clinical characteristics, visceral involvement, and mortality in at-risk or early diffuse systemic sclerosis: a longitudinal analysis of an observational prospective multicenter US cohort

Early diffuse cutaneous systemic sclerosis (dcSSc) has the highest case fatality among rheumatic diseases. We report baseline characteristics, current immunosuppressive therapies, progression of skin and inter...

Authors: Sara Jaafar, Alain Lescoat, Suiyuan Huang, Jessica Gordon, Monique Hinchcliff, Ami A. Shah, Shervin Assassi, Robyn Domsic, Elana J. Bernstein, Virginia Steen, Sabrina Elliott, Faye Hant, Flavia V. Castelino, Victoria K. Shanmugam, Chase Correia, John Varga…

Predictors of unacceptable pain with and without low inflammation over 5 years in early rheumatoid arthritis—an inception cohort study

Pain is a major symptom in patients with rheumatoid arthritis (RA). In early RA, pain is usually due to synovitis, but can also persist despite effective anti-inflammatory treatment. The objective of this stud...

Authors: Anna Eberhard, Stefan Bergman, Thomas Mandl, Tor Olofsson, Maria Rydholm, Lennart Jacobsson and Carl Turesson

Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review

Twenty to thirty percent of psoriasis (Pso) patients will develop psoriatic arthritis (PsA). Detection of Pso patients that are (at risk for) developing PsA is essential to prevent structural damage. We conduc...

Authors: Michelle L. M. Mulder, Tamara W. van Hal, Mark H. Wenink, Hans J. P. M. Koenen, Frank H. J. van den Hoogen, Elke M. G. J. de Jong, Juul M. P. A. van den Reek and Johanna E. Vriezekolk

Therapeutic potential of targeting Tfr/Tfh cell balance by low-dose-IL-2 in active SLE: a post hoc analysis from a double-blind RCT study

To investigate the regulation of T follicular regulatory (Tfr) and T follicular (Tfh) cell subtypes by low-dose IL-2 in systemic lupus erythematosus (SLE) in a randomized, double-blind, placebo-controlled clin...

Authors: Miao Miao, Xian Xiao, Jiayi Tian, Yunzhi Zhufeng, Ruiling Feng, Ruijun Zhang, Jiali Chen, Xiaoying Zhang, Bo Huang, Yuebo Jin, Xiaolin Sun, Jing He and Zhanguo Li

Does methotrexate influence COVID-19 infection? Case series and mechanistic data

To investigate whether methotrexate treatment may affect the susceptibility to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Authors: Fabian Schälter, Kerstin Dürholz, Laura Bucci, Gerd Burmester, Roberto Caporali, Camille Figuereido, Jaime Fogagnolo Cobra, Bernhard Manger, Mario M. Zaiss and Georg Schett

Site-specific resolution of enthesitis in patients with axial spondyloarthritis treated with tumor necrosis factor inhibitors

Enthesitis is a hallmark of spondyloarthritis (SpA) with a substantial impact on quality of life. Reports of treatment effectiveness across individual enthesitis sites in real-world patients with axial SpA (ax...

Authors: Michael J. Nissen, Burkhard Möller, Adrian Ciurea, Ruediger B. Mueller, Patrick Zueger, Martin Schulz, Fabiana Ganz, Almut Scherer, Eleftherios Papagiannoulis and Thomas Hügle

Plasma metabolomic profiling in patients with rheumatoid arthritis identifies biochemical features predictive of quantitative disease activity

Rheumatoid arthritis (RA) is a chronic, autoimmune disorder characterized by joint inflammation and pain. In patients with RA, metabolomic approaches, i.e., high-throughput profiling of small-molecule metaboli...

Authors: Benjamin Hur, Vinod K. Gupta, Harvey Huang, Kerry A. Wright, Kenneth J. Warrington, Veena Taneja, John M. Davis III and Jaeyun Sung

Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis

Mucosal sites are hypothesized to play a role in the development of rheumatoid arthritis (RA). Since serum anti-peptidylarginine deiminase (PAD)4 antibodies, including a subset that cross-react with PAD3 (PAD3...

Authors: M. Kristen Demoruelle, Hong Wang, Ryan L. Davis, Ashley Visser, Johnny Hoang, Jill M. Norris, V. Michael Holers, Kevin D. Deane and Erika Darrah

Disease activity influences the reclassification of rheumatoid arthritis into very high cardiovascular risk

Previous studies have shown that risk chart algorithms, such as the Systematic Coronary Risk Assessment (SCORE), often underestimate the actual cardiovascular (CV) risk of patients with rheumatoid arthritis (R...

Authors: Iván Ferraz-Amaro, Alfonso Corrales, Juan Carlos Quevedo-Abeledo, Nuria Vegas-Revenga, Ricardo Blanco, Virginia Portilla, Belén Atienza-Mateo and Miguel Á. González-Gay

Is Behçet’s syndrome associated with an increased risk of ischemic heart disease? A real-world evidence in Taiwan

A variety of chronic inflammatory diseases are linked to ischemic heart disease (IHD); however, this association is less well studied in patients with Behçet’s syndrome (BS). The primary objective of this stud...

Authors: Chun-Yu Lin, Hung-An Chen, Chun-Hsin Wu, Yu-Jih Su, Tsai-Ching Hsu and Chung-Yuan Hsu

Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study

The aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over 1 to 2 years in people with painful medial knee osteoarthritis.

Authors: Milena Simic, Alison R. Harmer, Maria Agaliotis, Lillias Nairn, Lisa Bridgett, Lyn March, Milana Votrubec, John Edmonds, Mark Woodward, Richard Day and Marlene Fransen

Exosomal circ-BRWD1 contributes to osteoarthritis development through the modulation of miR-1277/TRAF6 axis

Circular RNAs (circRNAs) can act as vital players in osteoarthritis (OA). However, the roles of circRNAs in OA remain obscure. Herein, we explored the roles of exosomal circRNA bromodomain and WD repeat domain...

Authors: Zhenye Guo, Huan Wang, Feng Zhao, Min Liu, Feida Wang, Mingming Kang, Weifu He and Zhi Lv

Tumour necrosis factor inhibitors reduce aortic stiffness progression in patients with long-standing rheumatoid arthritis

Aortic stiffness index (AoSI) has to be considered a proxy outcome measure in patients with rheumatoid arthritis (RA). The aim of this study was to comparatively describe AoSI progression in two groups of RA p...

Authors: Alessandro Giollo, Giovanni Cioffi, Federica Ognibeni, Giovanni Orsolini, Andrea Dalbeni, Riccardo Bixio, Giovanni Adami, Angelo Fassio, Luca Idolazzi, Davide Gatti, Maurizio Rossini and Ombretta Viapiana

The heterogeneous human memory CCR6+ T helper-17 populations differ in T-bet and cytokine expression but all activate synovial fibroblasts in an IFNγ-independent manner

Chronic synovial inflammation is an important hallmark of inflammatory arthritis, but the cells and mechanisms involved are incompletely understood. Previously, we have shown that CCR6+ memory T-helper (memTh)...

Authors: Wendy Dankers, Hannah den Braanker, Sandra M. J. Paulissen, Jan Piet van Hamburg, Nadine Davelaar, Edgar M. Colin and Erik Lubberts

Prevalence of ultrasound-detected knee synovial abnormalities in a middle-aged and older general population—the Xiangya Osteoarthritis Study

There is paucity of data on the prevalence of ultrasound-detected synovial abnormalities in the general population, and the relationship between synovial changes and knee pain remains unclear. We examined the ...

Authors: Ting Jiang, Tuo Yang, Weiya Zhang, Michael Doherty, Yuqing Zhang, Jie Wei, Aliya Sarmanova, Michelle Hall, Zidan Yang, Jiatian Li, Gwen S. Fernandes, Abasiama D. Obotiba, Sameer A. Gohir, Philip Courtney, Chao Zeng and Guanghua Lei

An update on targeted therapies in systemic sclerosis based on a systematic review from the last 3 years

New molecular mechanisms that can be targeted with specific drugs have recently emerged for the treatment of systemic sclerosis (SSc) patients. Over the past 3 years, the achievement of one large phase 3 trial...

Authors: Corrado Campochiaro and Yannick Allanore

Serum TNFα levels at 24 h after certolizumab pegol predict effectiveness at week 12 in patients with rheumatoid arthritis from TSUBAME study

To estimate the relationship between serum TNFα, IL-6, and serum CZP levels and the clinical response to CZP in RA patients in the TSUBAME study.

Authors: Yusuke Miyazaki, Kazuhisa Nakano, Shingo Nakayamada, Satoshi Kubo, Shigeru Iwata, Kentaro Hanami, Shunsuke Fukuyo, Ippei Miyagawa, Ayako Yamaguchi, Akio Kawabe, Kazuyoshi Saito and Yoshiya Tanaka

IgG and IgA autoantibodies against L1 ORF1p expressed in granulocytes correlate with granulocyte consumption and disease activity in pediatric systemic lupus erythematosus

Most patients with systemic lupus erythematosus (SLE) have IgG autoantibodies against the RNA-binding p40 (ORF1p) protein encoded by the L1 retroelement. This study tested if these autoantibodies are also pres...

Authors: Kennedy C. Ukadike, Kathryn Ni, Xiaoxing Wang, Martin S. Taylor, John LaCava, Lauren M. Pachman, Mary Eckert, Anne Stevens, Christian Lood and Tomas Mustelin

Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats

Although adjacent segmental intervertebral disc degeneration (ASDD) is one of the most common complications after lumbar fusion, its exact mechanism remains unclear. As an antibody to RANKL, denosumab (Dmab) e...

Authors: Qi Sun, Fa-Ming Tian, Fang Liu, Jia-Kang Fang, Yun-Peng Hu, Qiang-Qiang Lian, Zhuang Zhou and Liu Zhang

The PICASO cloud platform for improved holistic care in rheumatoid arthritis treatment—experiences of patients and clinicians

Multimorbidity raises the number of essential information needed for delivery of high-quality care in patients with chronic diseases like rheumatoid arthritis (RA). We evaluated an innovative ICT platform for ...

Authors: Jutta G. Richter, Gamal Chehab, Catarina Schwartz, Elisabeth Ricken, Monika Tomczak, Hasan Acar, Henrike Gappa, Carlos A. Velasco, Peter Rosengren, Armanas Povilionis, Matthias Schneider and Jesper Thestrup

Expanding diagnostic approach in patients with osteonecrosis

Authors: José A. Gómez-Puerta and Pilar Peris

Correction to: The effects of WeChat-based educational intervention in patients with ankylosing spondylitis: a randomized controlled trial

Authors: Yuqing Song, Xia Xie, Yanling Chen, Ying Wang, Hui Yang, Anliu Nie and Hong Chen

Serum checkpoint molecules in patients with IgG4-related disease (IgG4-RD)

Immunoglobulin G4-related disease (IgG4-RD) is characterized by increased serum IgG4 concentration and infiltration of IgG4⁺ plasma cells in the affected organs. The present study aimed to characterize the serum ...

Authors: Haruki Matsumoto, Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Yashiro-Furuya, Tomoyuki Asano, Shuzo Sato, Hiroshi Watanabe, Eiji Suzuki, Sosuke Tsuji, Shoichi Fukui, Masataka Umeda, Naoki Iwamoto, Atsushi Kawakami and Kiyoshi Migita

Circulating mature granzyme B+ T cells distinguish Crohn’s disease-associated axial spondyloarthritis from axial spondyloarthritis and Crohn’s disease

Axial spondyloarthritis (axSpA) has strong connections with intestinal inflammation as occurs in Crohn’s disease (CD). However, the immunologic mechanisms that distinguish axSpA, CD, and those with features of...

Authors: Adam R. Lefferts, Emilie H. Regner, Andrew Stahly, Becky O’Rourke, Mark E. Gerich, Blair P. Fennimore, Frank I. Scott, Alison E. Freeman, Ken Jones and Kristine A. Kuhn

Opioid users show worse baseline knee osteoarthritis and faster progression of degenerative changes: a retrospective case-control study based on data from the Osteoarthritis Initiative (OAI)

Opioids are frequently prescribed for pain control in knee osteoarthritis patients, despite recommendations by current guidelines. Previous studies have investigated the chondrotoxicity of different opioid sub...

Authors: Jannis Bodden, Gabby B. Joseph, Silvia Schirò, John A. Lynch, Nancy E. Lane, Charles E. McCulloch, Michael C. Nevitt and Thomas M. Link

Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs

Intervertebral disc degeneration contributes to low back pain. The avascular intervertebral disc consists of a central hypoxic nucleus pulpous (NP) surrounded by the more oxygenated annulus fibrosus (AF). Lact...

Authors: Dong Wang, Robert Hartman, Chao Han, Chao-ming Zhou, Brandon Couch, Matias Malkamaki, Vera Roginskaya, Bennett Van Houten, Steven J. Mullett, Stacy G. Wendell, Michael J. Jurczak, James Kang, Joon Lee, Gwendolyn Sowa and Nam Vo

Tofacitinib downregulates antiviral immune defence in keratinocytes and reduces T cell activation

Tofacitinib is a novel Janus kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. In clinical trials, the most common adverse events observed ...

Authors: Heike C. Hawerkamp, Alina Domdey, Lisa Radau, Philipp Sewerin, Péter Oláh, Bernhard Homey and Stephan Meller

Assessment of the efficacy and safety of tocilizumab in patients over 80 years old with giant cell arteritis

To assess the efficacy and tolerance of tocilizumab (TCZ) in giant cell arteritis (GCA) patients over 80.

Authors: Hubert de Boysson, Maelle Le Besnerais, Félix Blaison, Aurélie Daumas, Pierre-André Jarrot, François Perrin, Nathalie Tieulié, Alexandre Maria, Pierre Duffau, Bruno Gombert, Maxime Samson, Olivier Espitia, Marc Lambert, Arsène Mékinian and Achille Aouba

Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways

To investigate the role and regulatory mechanisms of fargesin, one of the main components of Magnolia fargesii, in macrophage reprogramming and crosstalk across cartilage and synovium during osteoarthritis (OA) d...

Authors: Jiansen Lu, Hongbo Zhang, Jianying Pan, Zhiqiang Hu, Liangliang Liu, Yanli Liu, Xiao Yu, Xiaochun Bai, Daozhang Cai and Haiyan Zhang

Serial Lipocalin 2 and Oncostatin M levels reflect inflammation status and treatment response in axial spondyloarthritis

Informative serum biomarkers for monitoring inflammatory activity and treatment responses in axial spondyloarthritis (axSpA) are lacking. We assessed whether Lipocalin 2 (LCN2) and Oncostatin M (OSM), both hav...

Authors: Florence W. L. Tsui, Aifeng Lin, Ismail Sari, Zhenbo Zhang, Hing Wo Tsui and Robert D. Inman

Pre-pregnancy serum complement C3 level is a predictor of preterm birth for pregnancies with systemic lupus erythematosus

This study aimed to clarify predictors of preterm birth in pregnancy of women with systemic lupus erythematosus (SLE). We investigated the predictors of preterm birth before pregnancy from the perspective of t...

Authors: Yuri Hiramatsu, Kentaro Isoda, Takuya Kotani, Eri Nakamura, Yumiko Wada, Youhei Fujiki, Shigeki Makino, Daisuke Fujita and Tohru Takeuchi

Correction to: Transcriptome-wide study of TNF-inhibitor therapy in rheumatoid arthritis reveals early signature of successful treatment

Authors: James Oliver, Nisha Nair, Gisela Orozco, Samantha Smith, Kimme L. Hyrich, Ann Morgan, John Isaacs, Anthony G. Wilson, Anne Barton and Darren Plant

Clinical characteristics and prognosis of patients with isolated thrombotic vs. obstetric antiphospholipid syndrome: a prospective cohort study

Several studies suggested that thrombotic and obstetric antiphospholipid syndromes could be independent identities, but few have systematically compared their clinical characteristics and prognosis.

Authors: Hui Jiang, Chu-Han Wang, Nan Jiang, Jing Li, Chan-Yuan Wu, Qian Wang, Meng-Tao Li, Xin-Ping Tian, Jiu-Liang Zhao, Yan Zhao and Xiao-Feng Zeng

Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma

Aldehyde dehydrogenase 1 family member A1 (RALDH1)-producing dermal dendritic cells (DCs), a conventional DC subset regulating skin fibrosis, are decreased in the involved skin of patients with systemic sclero...

Authors: Shunsuke Miura, Yusuke Watanabe, Ryosuke Saigusa, Takashi Yamashita, Kouki Nakamura, Megumi Hirabayashi, Takuya Miyagawa, Ayumi Yoshizaki, Maria Trojanowska, Shinichi Sato and Yoshihide Asano

Identification of neutrophil β2-integrin LFA-1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses

Leukocyte activation by anti-neutrophil cytoplasmic antibody (ANCA) and the subsequent leukocyte–endothelium interaction play a key role in the development of endothelial damage in ANCA-associated vasculitis (...

Authors: Kotaro Matsumoto, Takahiko Kurasawa, Keiko Yoshimoto, Katsuya Suzuki and Tsutomu Takeuchi

Decreased microRNA-155 in Behcet’s disease leads to defective control of autophagy thereby stimulating excessive proinflammatory cytokine production

Earlier, we reported that the microRNA (miR)-155 expression in dendritic cells (DCs) from Behcet’s disease (BD) patients was decreased and affected cytokine production of DCs. In this study, we investigated th...

Authors: Liang Liang, Qingyun Zhou and Lujia Feng

Evaluation of the severe preeclampsia classification criterion for antiphospholipid syndrome in a study of 40 patients

The criteria for antiphospholipid syndrome (APS) include severe preeclampsia and/or placental insufficiency leading to preterm delivery before 34 weeks of gestation, but this APS manifestation has been rarely ...

Authors: Maddalena Larosa, Véronique Le Guern, Nathalie Morel, Mériem Belhocine, Amelia Ruffatti, Nicolas Martin Silva, Romain Paule, Luc Mouthon, Michel Dreyfus, Jean-Charles Piette, Odile Souchaud-Debouverie, Catherine Deneux-Tharaux, Gaelle Guettrot-Imbert, Vassilis Tsatsaris, Emmanuelle Pannier-Metzger, Anne Murarasu…

Soluble guanylate cyclase stimulator reduced the gastrointestinal fibrosis in bleomycin-induced mouse model of systemic sclerosis

Systemic sclerosis (SSc) is a chronic autoimmune-mediated connective tissue disorder. Although the etiology of the disease remains undetermined, SSc is characterized by fibrosis and proliferative vascular lesi...

Authors: Yuzuru Yamamoto, Takaichi Okano, Hirotaka Yamada, Kengo Akashi, Sho Sendo, Yo Ueda, Akio Morinobu and Jun Saegusa

Proteome study of cutaneous lupus erythematosus (CLE) and dermatomyositis skin lesions reveals IL-16 is differentially upregulated in CLE

The objective of the study was to explore the disease pathways activated in the inflammatory foci of skin lesions in cutaneous lupus erythematosus (CLE) and dermatomyositis (DM).

Authors: Timothy B. Niewold, Alexander Meves, Julia S. Lehman, Karin Popovic-Silwerfeldt, Aliisa Häyry, Therese Söderlund-Matell, Cristine M. Charlesworth, Benjamin Madden, Ingrid E. Lundberg, Marie Wahren-Herlenius, Elisabet Svenungsson and Vilija Oke

Pro-inflammatory effects of human apatite crystals extracted from patients suffering from calcific tendinopathy

Calcific tendonitis of the rotator cuff is due to carbonated apatite deposits in the shoulder tendons. During the evolution of the disease, an acute inflammatory episode may occur leading to the disappearance ...

Authors: Julien Herman, Benoit Le Goff, Julien De Lima, Régis Brion, Catherine Chevalier, Frédéric Blanchard and Christelle Darrieutort-Laffite

Efficacy and safety of gout flare prophylaxis and therapy use in people with chronic kidney disease: a Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN)-initiated literature review

Gout flare prophylaxis and therapy use in people with underlying chronic kidney disease (CKD) is challenging, given limited treatment options and risk of worsening renal function with inappropriate treatment d...

Authors: Huai Leng Pisaniello, Mark C. Fisher, Hamish Farquhar, Ana Beatriz Vargas-Santos, Catherine L. Hill, Lisa K. Stamp and Angelo L. Gaffo

Strategies for increasing gait speed in patients with hip osteoarthritis: their clinical significance and effects on hip loading

Changes in gait speed are required in various situations and can be achieved by changing stride length, cadence, or both. Differences in strategies for increasing gait speed may have different effects on hip j...

Authors: Hiroshige Tateuchi, Haruhiko Akiyama, Koji Goto, Kazutaka So, Yutaka Kuroda and Noriaki Ichihashi

Cold-inducible RNA-binding protein (CIRP) potentiates uric acid-induced IL-1β production

Gout is an autoinflammatory disease driven by interleukin-1 (IL-1) induction in response to uric acid crystals. IL-1β production is dependent on inflammasome activation, which requires a priming signal, follow...

Authors: Yuya Fujita, Toru Yago, Haruki Matsumoto, Tomoyuki Asano, Naoki Matsuoka, Jumpei Temmoku, Shuzo Sato, Makiko Yashiro-Furuya, Eiji Suzuki, Hiroshi Watanabe, Atsushi Kawakami and Kiyoshi Migita

Bone mineral density and microarchitecture among Chinese patients with rheumatoid arthritis: a cross-sectional study with HRpQCT

Patients with rheumatoid arthritis (RA) are at increased risk of fractures. Although their decline in bone mineral density (BMD) is well-established, data regarding the alterations in bone microarchitecture ar...

Authors: Shangyi Jin, Mengtao Li, Qian Wang, Xiaofeng Zeng, Weibo Xia, Wei Yu, Wenmin Guan and Evelyn Hsieh

Application of systems biology-based in silico tools to optimize treatment strategy identification in Still’s disease

Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) are manifestations of an autoinflammatory disorder with complex pathophysiology and significant morbidity, together also ter...

Authors: Cristina Segú-Vergés, Mireia Coma, Christoph Kessel, Serge Smeets, Dirk Foell and Anna Aldea

Performance of the UCLA Scleroderma Clinical Trials Consortium Gastrointestinal Tract 2.0 instrument as a clinical decision aid in the routine clinical care of patients with systemic sclerosis

The University of California Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract Instrument 2.0 (UCLA GIT 2.0) is validated to capture gastrointestinal (GI) tract morbidity in patients wit...

Authors: Norina Zampatti, Alexandru Garaiman, Suzana Jordan, Rucsandra Dobrota, Mike Oliver Becker, Britta Maurer, Oliver Distler and Carina Mihai