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  1. Previously, fragments from Sirtuin 1 (SIRT1) were identified in preclinical and clinical samples to display an increase in serum levels for N-terminal (NT) SIRT1 vs. C-terminal (CT) SIRT1, indicative of early ...

    Authors: Miya Marco, Mylène Jansen, Goran van der Weiden, Eli Reich, Yonathan H. Maatuf, Simon C. Mastbergen and Mona Dvir-Ginzberg
    Citation: Arthritis Research & Therapy 2024 26:106
  2. Tofacitinib is an oral Janus kinase inhibitor for treatment of ankylosing spondylitis (AS). Time to improvement in core domains of AS was estimated in tofacitinib-treated patients with AS.

    Authors: Victoria Navarro-Compán, Atul Deodhar, Rachid Bahiri, Andrew G. Bushmakin, Joseph C. Cappelleri and Jihane Rammaoui
    Citation: Arthritis Research & Therapy 2024 26:105
  3. Epidemiological observational studies have elucidated a correlation between rheumatoid arthritis (RA) and bronchiectasis. However, the causal nature of this association remains ambiguous. To clarify this poten...

    Authors: Zehu Chen, Xuegang Li, Honglei Shi, Yiying Huang and Jing Liu
    Citation: Arthritis Research & Therapy 2024 26:104
  4. Fibroblast-like synoviocytes (FLSs) play a central role in RA pathogenesis and are the main cellular component in the inflamed synovium of patients with rheumatoid arthritis (RA). FLSs are emerging as promisin...

    Authors: Hongyan Qian, Chaoqiong Deng, Shiju Chen, Xinwei Zhang, Yan He, Jingying Lan, Aodi Wang, Guixiu Shi and Yuan Liu
    Citation: Arthritis Research & Therapy 2024 26:103
  5. To perform a detailed morphological analysis of the inorganic portion of two different clinical presentations of calcium-based deposits retrieved from subjects with SSc and identify a chemical dissolution of t...

    Authors: Phillip Lee, Lorraine Green, Bartosz Marzec, Fiona Meldrum, Francesco Del Galdo and Begonya Alcacer-Pitarch
    Citation: Arthritis Research & Therapy 2024 26:102
  6. Exploring the pathogenesis of osteoarthritis (OA) is important for its prevention, diagnosis, and treatment. Therefore, we aimed to construct novel signature genes (c-FRGs) combining cuproptosis-related genes ...

    Authors: Baoqiang He, Yehui Liao, Minghao Tian, Chao Tang, Qiang Tang, Fei Ma, Wenyang Zhou, Yebo Leng and Dejun Zhong
    Citation: Arthritis Research & Therapy 2024 26:100
  7. This study aims to elucidate the transcriptomic signatures and dysregulated pathways in patients with Systemic Lupus Erythematosus (SLE), with a particular focus on those persisting during disease remission.

    Authors: Frank Qingyun Wang, Li Shao, Xiao Dang, Yong-Fei Wang, Shuxiong Chen, Zhongyi Liu, Yujing Mao, Yuping Jiang, Fei Hou, Xianghua Guo, Jian Li, Lili Zhang, Yuting Sang, Xuan Zhao, Ruirui Ma, Kai Zhang…
    Citation: Arthritis Research & Therapy 2024 26:99
  8. Targeted small-molecule drugs in the treatment of systemic lupus erythematosus (SLE) have attracted increasing attention from clinical investigators. However, there is still a lack of evidence on the differenc...

    Authors: Shiheng Wang, Wanling Ning, Hanqing Tang, Chaochao Mu and Xiaosong Huang
    Citation: Arthritis Research & Therapy 2024 26:98
  9. The macrophage activation syndrome (MAS) secondary to systemic lupus erythematosus (SLE) is a severe and life-threatening complication. Early diagnosis of MAS is particularly challenging. In this study, machin...

    Authors: Wenxun Lin, Xi Xie, Zhijun Luo, Xiaoqi Chen, Heng Cao, Xun Fang, You Song, Xujing Yuan, Xiaojing Liu and Rong Du
    Citation: Arthritis Research & Therapy 2024 26:92
  10. Neutrophil extracellular trap formation and cell-free DNA (cfDNA) contribute to the inflammation in rheumatoid arthritis (RA), but it is unknown if mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) is more abund...

    Authors: Julia Lehmann, Stavros Giaglis, Diego Kyburz, Douglas Daoudlarian and Ulrich A. Walker
    Citation: Arthritis Research & Therapy 2024 26:97
  11. Gout is caused by monosodium urate (MSU) crystals deposition to trigger immune response. A recent study suggested that inhibition of Class I Histone deacetylases (HDACs) can significantly reduce MSU crystals-i...

    Authors: Qi-Bin Yang, Meng-Yun Zhang, Liu Yang, Jie Wang, Qing-Sheng Mi and Jing-Guo Zhou
    Citation: Arthritis Research & Therapy 2024 26:96
  12. Rheumatoid arthritis (RA) related interstitial lung disease (ILD) impacts on the treatment strategy and its prognosis in patients with RA. However, the relationship between RA disease activity and the severity...

    Authors: Yuhei Ito, Yasutaka Ichikawa, Shuichi Murashima, Hajime Sakuma and Ayako Nakajima
    Citation: Arthritis Research & Therapy 2024 26:95
  13. Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury and inflammation, followed by excessive fibrosis of the skin and other internal organs, including the lungs. CX3CL1 (fractalki...

    Authors: Takumi Hasegawa, Akira Utsunomiya, Takenao Chino, Hiroshi Kasamatsu, Tomomi Shimizu, Takashi Matsushita, Takashi Obara, Naoto Ishii, Hideaki Ogasawara, Wataru Ikeda, Toshio Imai, Noritaka Oyama and Minoru Hasegawa
    Citation: Arthritis Research & Therapy 2024 26:94
  14. Anti-SS-A/Ro antibody (anti-SSA), the diagnostic marker of Sjögren’s syndrome (SS), is often detected in systemic sclerosis (SSc). Some patients are diagnosed with SSc/SS overlap syndromes, while there are ant...

    Authors: Tomoya Watanabe, Yasushi Ototake, Asami Akita, Mao Suzuki, Miwa Kanaoka, Jun Tamura, Yusuke Saigusa and Yukie Yamaguchi
    Citation: Arthritis Research & Therapy 2024 26:93
  15. To characterize aspects of triiodothyronine (T3) induced chondrocyte terminal maturation within the molecular osteoarthritis pathophysiology using the previously established T3 human ex vivo osteochondral explant...

    Authors: N. M. Korthagen, E. Houtman, I. Boone, R. Coutinho de Almeida, K. Sivasubramaniyan, R. Mahdad, R. G. H. H Nelissen, Y. F. M. Ramos, M. A Tessari and I. Meulenbelt
    Citation: Arthritis Research & Therapy 2024 26:91
  16. We aimed to investigate whether there are sex differences in disease activity measures among patients with axial spondyloarthritis (axSpA) and to determine any potential impact on the assessment of treatment r...

    Authors: Seulkee Lee, Seonyoung Kang, Hyungjin Kim, Jaejoon Lee, Min-Ji Kim and Hoon-Suk Cha
    Citation: Arthritis Research & Therapy 2024 26:90
  17. We aimed to reveal the effect of abatacept (ABT) on atherosclerosis in rheumatoid arthritis (RA) patients, 3-year efficacy for arthritis, and safety in a population of older vs. younger patients.

    Authors: Zento Yamada, Sei Muraoka, Mai Kawazoe, Wataru Hirose, Hajime Kono, Shinsuke Yasuda, Takahiko Sugihara and Toshihiro Nanki
    Citation: Arthritis Research & Therapy 2024 26:87
  18. Little is known about long-term clinical outcomes or urate-lowering (ULT) therapy use following pegloticase discontinuation. We examined ULT use, serum urate (SU), inflammatory biomarkers, and renal function f...

    Authors: Emily E. Holladay, Amy S. Mudano, Fenglong Xie, Jingyi Zhang, Ted R. Mikuls, Brian LaMoreaux, Lissa Padnick-Silver and Jeffrey R. Curtis
    Citation: Arthritis Research & Therapy 2024 26:86
  19. Immunoglobulin A vasculitis (IgAV) in adults has a variable disease course, with patients often developing gastrointestinal and renal involvement and thus contributing to higher mortality. Due to understudied ...

    Authors: Matija Bajželj, Matjaž Hladnik, Rok Blagus, Vesna Jurčić, Ana Markež, Tanya Deniz Toluay, Snežna Sodin-Šemrl, Alojzija Hočevar and Katja Lakota
    Citation: Arthritis Research & Therapy 2024 26:85
  20. We attempted to identify abnormal immune cell components and signaling pathways in lupus nephritis (LN) and to identify potential therapeutic targets.

    Authors: Shuping Wei, Haiyun Shen, Yidan Zhang, Chunrui Liu, Shoushan Li, Jing Yao, Zhibin Jin and Hongliang Yu
    Citation: Arthritis Research & Therapy 2024 26:84
  21. Hip and knee osteoarthritis (OA) are highly prevalent worldwide. The guidelines recommend physical activity and education as the core treatments for osteoarthritis. Digital health has the potential to engage p...

    Authors: F. Weber, C. Kloek, S. Stuhrmann, Y. Blum, C. Grüneberg and C. Veenhof
    Citation: Arthritis Research & Therapy 2024 26:83
  22. Previous studies have shown that growing up with rheumatic conditions can fuel dissatisfaction and psychological distress, which in turn affects disease self-management and treatment adherence. Primary objecti...

    Authors: Florian Milatz, Jens Klotsche, Martina Niewerth, Claudia Sengler, Daniel Windschall, Tilmann Kallinich, Frank Dressler, Ralf Trauzeddel, Reinhard W. Holl, Ivan Foeldvari, Normi Brück, Svenja Temming, Toni Hospach, Petra Warschburger, Rainer Berendes, Gabriele Erbis…
    Citation: Arthritis Research & Therapy 2024 26:82
  23. Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere and Maurizio Cutolo
    Citation: Arthritis Research & Therapy 2024 26:81

    The original article was published in Arthritis Research & Therapy 2024 26:74

  24. Our study aimed to provide real-world evidence on the treatment patterns, effectiveness and safety of canakinumab in France in Familial Mediterranean Fever (FMF), Mevalonate Kinase Deficiency (MKD), and Tumor ...

    Authors: Isabelle Koné-Paut, Sophie Georgin-Lavialle, Alexandre Belot, Magali Jover, Mathilde Pouriel, Laure Lacoin, Pascal Pillet and Véronique Hentgen
    Citation: Arthritis Research & Therapy 2024 26:80
  25. Idiopathic inflammatory myopathies (IIM) represent a rare and heterogenous group diseases, and their treatment is not fully defined yet. According to previous small case series, the combination of mycophenolat...

    Authors: Corrado Campochiaro, Nicola Farina, Giacomo De Luca, Veronica Batani, Giorgia Trignani, Davide Vignale, Anna Palmisano, Marco Matucci-Cerinic and Lorenzo Dagna
    Citation: Arthritis Research & Therapy 2024 26:79
  26. Transitioning from a genetic association signal to an effector gene and a targetable molecular mechanism requires the application of functional fine-mapping tools such as reporter assays and genome editing. In...

    Authors: Jack B. Roberts, Olivia L.G. Boldvig, Guillaume Aubourg, S. Tanishq Kanchenapally, David J. Deehan, Sarah J. Rice and John Loughlin
    Citation: Arthritis Research & Therapy 2024 26:78
  27. Peptidoglycan (PG) is an arthritogenic bacterial cell wall component whose role in human osteoarthritis is poorly understood. The purpose of this study was to determine if PG is present in synovial tissue of o...

    Authors: Meaghan N Holub, Amanda Wahhab, Joseph R Rouse, Rebecca Danner, Lauren G Hackner, Christine B Duris, Mecaila E McClune, Jules M Dressler, Klemen Strle, Brandon L Jutras, Adam I Edelstein and Robert B Lochhead
    Citation: Arthritis Research & Therapy 2024 26:77
  28. Autoimmune responses have been suggested to involvement in patients with Behcet’s syndrome (BS). There has been growing attention towards the roles of cutaneous lymphocyte antigen (CLA)+ regular T cells (Tregs) i...

    Authors: Jiachen Li, Feng Sun, Danxue Zhu, Yuke Hou, Gong Cheng, Ping Wang, Xu Jin, Wenyan Zhou, Xiaolin Sun, Zhanguo Li and Tian Liu
    Citation: Arthritis Research & Therapy 2024 26:76
  29. Treatment with high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (aHSCT) is an intensive treatment option for patients with severe forms of systemic sclerosis (SSc). Even th...

    Authors: Ann-Christin Pecher, Reinhild Klein, Ina Koetter, Marieke Wagner, Wichard Vogel, Stefan Wirths, Claudia Lengerke and Joerg Christoph Henes
    Citation: Arthritis Research & Therapy 2024 26:75
  30. Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy and progressive fibrosis of skin and several internal organs, including lungs. Macrophages are the main cells i...

    Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere and Maurizio Cutolo
    Citation: Arthritis Research & Therapy 2024 26:74

    The Correction to this article has been published in Arthritis Research & Therapy 2024 26:81

  31. Pain from osteoarthritis (OA) is one of the top causes of disability worldwide, but effective treatment is lacking. Nociceptive factors are released by activated synovial macrophages in OA, but depletion of sy...

    Authors: Garth Blackler, Yue Lai-Zhao, Joseph Klapak, Holly T. Philpott, Kyle K. Pitchers, Andrew R. Maher, Benoit Fiset, Logan A. Walsh, Elizabeth R. Gillies and C. Thomas Appleton
    Citation: Arthritis Research & Therapy 2024 26:73
  32. Transferrin receptor-1 (TfR1) plays important roles in controlling cellular iron levels, but its role in OA pathology is unknown. Herein we aim to investigate the role of TfR1 in OA progression and its underly...

    Authors: Wenchao Wang, Zhenkai Ma, Xuemin Feng, Jiabin Ren, Shengyao Sun, Yuandong Shao, Weimin Zhang, Xiaoxia Yang, Jiaming Zhang and Xingzhi Jing
    Citation: Arthritis Research & Therapy 2024 26:71
  33. Although B-cell depleting therapy in rheumatoid arthritis (RA) is clearly effective, response is variable and does not correlate with B cell depletion itself.

    Authors: Sabrina Pollastro, Anne Musters, Giulia Balzaretti, Ilse Niewold, Barbera van Schaik, Signe Hässler, Catharina M. Verhoef, Marc Pallardy, Antoine van Kampen, Xavier Mariette and Niek de Vries
    Citation: Arthritis Research & Therapy 2024 26:70
  34. To evaluate long-term outcomes and prognostic factors in patients with juvenile idiopathic arthritis (JIA), presenting as oligoarthritis, who received IAC as the first treatment for their disease.

    Authors: Mojca Zajc Avramovič, Nataša Toplak, Gašper Markelj, Nina Emeršič and Tadej Avčin
    Citation: Arthritis Research & Therapy 2024 26:69
  35. To investigate the clinical phenotype and treatment response in patients with rheumatoid arthritis (RA) with and without concomitant Sjögren’s disease (SjD).

    Authors: Lisa Christ, Seraphina Kissling, Axel Finckh, Benjamin A. Fisher, Sabine Adler, Britta Maurer, Burkhard Möller and Florian Kollert
    Citation: Arthritis Research & Therapy 2024 26:68
  36. To investigate the role of antiphospholipid antibodies (aPLs) in the disease severity and prognosis of SLE-related thrombocytopenia (SLE-TP).

    Authors: Jun Li, Liying Peng, Lijun Wu, Yufang Ding, Xinwang Duan, Jian Xu, Wei Wei, Zhen Chen, Cheng Zhao, Min Yang, Nan Jiang, Shangzhu Zhang, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng…
    Citation: Arthritis Research & Therapy 2024 26:67
  37. CRISPR-Cas9-based genome engineering represents a powerful therapeutic tool for cartilage tissue engineering and for understanding molecular pathways driving cartilage diseases. However, primary chondrocytes a...

    Authors: Simone Ponta, Angela Bonato, Philipp Neidenbach, Valentino F. Bruhin, Alexis Laurent, Lee Ann Applegate, Marcy Zenobi-Wong and Goncalo Barreto
    Citation: Arthritis Research & Therapy 2024 26:66
  38. Lymphopenia, autoantibodies and activation of the type I interferon (IFN) system are common features in systemic lupus erythematosus (SLE). We speculate whether lymphocyte subset counts are affected by pregnan...

    Authors: Agnes Torell, Marit Stockfelt, Kaj Blennow, Henrik Zetterberg, Tansim Akhter, Dag Leonard, Lars Rönnblom, Sofia Pihl, Muna Saleh, Christopher Sjöwall, Helena Strevens, Andreas Jönsen, Anders A. Bengtsson, Estelle Trysberg, Maria Majczuk Sennström, Agneta Zickert…
    Citation: Arthritis Research & Therapy 2024 26:65
  39. Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus (SLE). The limited treatment options for LN increase the economic burdens on patients. Because fibrotic progression leads to...

    Authors: Chen Cheng, Hao Yang, Chan Yang, Juan Xie, Jinshen Wang, Luping Cheng, Jianfu He, Honglian Li, Haoxing Yuan, Fangfang Guo, Minmin Li and Shuwen Liu
    Citation: Arthritis Research & Therapy 2024 26:64
  40. Remission is a key treatment target in systemic lupus erythematosus (SLE) management. Given the direct correlation between lupus flares and elevated risks of adverse pregnancy outcomes (APOs), securing remissi...

    Authors: Takehiro Nakai, Nanase Honda, Eri Soga, Sho Fukui, Ayako Kitada, Naoto Yokogawa and Masato Okada
    Citation: Arthritis Research & Therapy 2024 26:63
  41. Primary Sjogren’s syndrome (pSS) is a complex autoimmune disease featuring damage to salivary and lacrimal glands, with the possibility of manifestations across multiple organs. Antibody-producing B cells have...

    Authors: Ling Chang, Zihan Zheng, Yiwen Zhou, Kun Liu, Yinong Li, Bing Zhong, Zihua Zhao, Chengshun Chen, Can Qian, Qingshan Ni, Qinghua Zou, Yuzhang Wu, Jingyi Li and Liyun Zou
    Citation: Arthritis Research & Therapy 2024 26:62
  42. Disease-modifying antirheumatic drugs (DMARDs) are widely used for treating rheumatoid arthritis (RA). However, there are no established biomarkers to predict a patient’s response to these therapies. Prostanoi...

    Authors: Jianyang Liu, Helena Idborg, Marina Korotkova, Kristina Lend, Ronald van Vollenhoven, Jon Lampa, Anna Rudin, Dan Nordström, Bjorn Gudbjornsson, Gerdur Gröndal, Till Uhlig, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Michael Nurmohamed and Per-Johan Jakobsson
    Citation: Arthritis Research & Therapy 2024 26:61
  43. The association of longitudinal uric acid (UA) changes with cardiac conduction block risk is unclear. We aimed to identify the trajectories of UA and explore its association with cardiac conduction block.

    Authors: Na Li, Liufu Cui, Rong Shu, Haicheng Song, Jierui Wang, Shuohua Chen, Gary Tse, Nan Zhang, Xuemei Yang, Wenqi Xu, Shouling Wu and Tong Liu
    Citation: Arthritis Research & Therapy 2024 26:59
  44. The study investigated the pathogenesis of Yao syndrome (YAOS), a rare systemic autoinflammatory disease associated with the nucleotide-binding oligomerization domain containing 2 (NOD2) gene variants.

    Authors: Jingyuan Zhang, Yi Luo, Bingxuan Wu, Xin Huang, Mengzhu Zhao, Na Wu, Junke Miao, Ji Li, Lei Zhu, Di Wu and Min Shen
    Citation: Arthritis Research & Therapy 2024 26:58
  45. Patients with Rheumatoid Arthritis (RA) have a higher prevalence of comorbidities compared to the general population. However, the implications of multimorbidity on therapeutic response and treatment retention...

    Authors: Jerusalem Calvo-Gutiérrez, Clementina López-Medina, Lucía Otero-Varela, Alejandro Escudero-Contreras, Rafaela Ortega-Castro, Lourdes Ladehesa-Pineda, Cristina Campos, Pilar Bernabeu-Gonzalvez, Ana Pérez-Gómez, Alicia García-Dorta, Dolores Ruiz-Montesino, Manuel Pombo-Suarez, Inmaculada Ros-Vilamajo, Fernando Sánchez-Alonso and Isabel Castrejón
    Citation: Arthritis Research & Therapy 2024 26:57

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