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  1. Although treatment options and algorithms for rheumatoid arthritis (RA) have improved remarkably in recent decades, there continues to be no definitive cure or pharmacologic intervention with reliable long-ter...

    Authors: H. Mark Kenney, Ronald W. Wood, Gabriel Ramirez, Richard D. Bell, Kiana L. Chen, Lindsay Schnur, Homaira Rahimi, Benjamin D. Korman, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz and Calvin L. Cole
    Citation: Arthritis Research & Therapy 2023 25:17
  2. People with dermatomyositis (DM) or polymyositis (PM) often die from cancer, pulmonary, cardiac complications, or infections. In such cases, DM or PM might not be designated as the underlying cause of death (...

    Authors: Pengyan Qiao, Qianyu Guo, Jinfang Gao, Dan Ma, Sumiao Liu, Xiang Gao, Tsung-Hsueh Lu and Liyun Zhang
    Citation: Arthritis Research & Therapy 2023 25:16
  3. The study of molecular mechanisms characterizing disease progression may be relevant to get insights into systemic sclerosis (SSc) pathogenesis and to intercept patients at very early stage. We aimed at invest...

    Authors: Chiara Bellocchi, Shervin Assassi, Marka Lyons, Maurizio Marchini, Chandra Mohan, Alessandro Santaniello and Lorenzo Beretta
    Citation: Arthritis Research & Therapy 2023 25:15
  4. Hip and knee osteoarthritis (HKOA) is a chronic disease characterized by joint pain that leads to reduced physical function and health-related quality of life (HRQoL). At present, no cure is available. Clinica...

    Authors: David G. Lopes, Daniela Costa, Eduardo B. Cruz, Nuno Mendonça, Ana Rita Henriques, Jaime Branco, Helena Canhão and Ana M. Rodrigues
    Citation: Arthritis Research & Therapy 2023 25:14
  5. To evaluate the safety, efficacy, and maternal and fetal outcomes of assisted reproductive therapy (ART) in systemic lupus erythematosus (SLE).

    Authors: Minxi Lao, Peiyin Dai, Guangxi Luo, Xing Yang, Miaoguan Peng, Yuyi Chen, Yanfeng Zhan, Zhongping Zhan and Dongying Chen
    Citation: Arthritis Research & Therapy 2023 25:13
  6. Systemic sclerosis is a rheumatoid disease best known for its fibrotic skin manifestations called scleroderma. Alternatively activated (M2-type) macrophages are normally involved in the resolution of inflammat...

    Authors: Ilari Mäki-Opas, Mari Hämäläinen, Eeva Moilanen and Morena Scotece
    Citation: Arthritis Research & Therapy 2023 25:12
  7. Lack of robust, feasible, and quantitative outcomes impedes Raynaud phenomenon (RP) clinical trials in systemic sclerosis (SSc) patients. Hyperspectral imaging (HSI) non-invasively measures oxygenated and deox...

    Authors: Shannon Teaw, Akash Gupta, Alyssa Williams, F. Perry Wilson, Brandon J. Sumpio, Bauer E. Sumpio and Monique Hinchcliff
    Citation: Arthritis Research & Therapy 2023 25:10
  8. Enthesitis represents one of the most important peripheral musculoskeletal manifestations in patients with axial spondyloarthritis (axSpA). However, studies specifically evaluating Achilles tendon enthesitis a...

    Authors: Clementina López-Medina, M. Ángeles Puche-Larrubia, Raquel Granados, Lourdes Ladehesa-Pineda, Desirée Ruiz-Vilchez, M. Carmen Ábalos-Aguilera, Pilar Font-Ugalde and Eduardo Collantes-Estévez
    Citation: Arthritis Research & Therapy 2023 25:8
  9. Hypertension is a common comorbidity of osteoarthritis (OA) with known autonomic dysregulation; thus, the autonomic nervous system may provide a shared underlying mechanism. The objective of this study was to ...

    Authors: Taylor D. Yeater, Jacob L. Griffith, Carlos J. Cruz, Folly M. Patterson, Jessica L. Aldrich and Kyle D. Allen
    Citation: Arthritis Research & Therapy 2023 25:7
  10. Platelet-rich plasma (PRP) therapy is increasingly popular to treat musculoskeletal diseases, including tendinopathies and osteoarthritis (OA). To date, it remains unclear to which extent PRP compositions are ...

    Authors: Marcel Niemann, Melanie Ort, Luis Lauterbach, Mathias Streitz, Andreas Wilhelm, Gerald Grütz, Florian N. Fleckenstein, Frank Graef, Antje Blankenstein, Simon Reinke, Ulrich Stöckle, Carsten Perka, Georg N. Duda, Sven Geißler, Tobias Winkler and Tazio Maleitzke
    Citation: Arthritis Research & Therapy 2023 25:6
  11. Behçet’s disease (BD) is a systemic inflammatory disease that involves various organs. The clinical manifestation-based diagnosis of BD is a time-consuming process, which makes it difficult to distinguish from...

    Authors: Soo Jin Park, Mi Jin Park, Sun Park, Eun-So Lee and Do Yup Lee
    Citation: Arthritis Research & Therapy 2023 25:5
  12. Immunoglobulin-G4-related disease (IgG4-RD) is a distinct systemic autoimmune-mediated disease manifesting as chronic inflammation and tissue fibrosis. Since the role of DNA methylation in the pathogenesis of ...

    Authors: Xunyao Wu, Anqi Wang, Mu Wang, Yu Peng, Yingying Chen, Jieqiong Li, Zheng Liu, Hui Lu, Jiaxin Zhou, Linyi Peng, Yan Zhao, Xiaofeng Zeng, Yunyun Fei and Wen Zhang
    Citation: Arthritis Research & Therapy 2023 25:4
  13. Osteoarthritis (OA) is a common and prevalent degenerative joint disease characterized by degradation of the articular cartilage. However, none of disease-modifying OA drugs is approved currently. Teriparatide...

    Authors: Guoqing Li, Su Liu, Huihui Xu, Yixiao Chen, Jiapeng Deng, Ao Xiong, Deli Wang, Jian Weng, Fei Yu, Liang Gao, Changhai Ding and Hui Zeng
    Citation: Arthritis Research & Therapy 2023 25:3
  14. Data on the association of vitamin D levels and clinical phenotype and disease activity in systemic lupus erythematosus (SLE) is controversial. Further, the optimal dose of oral vitamin D supplementation in SL...

    Authors: Chengappa Kavadichanda, Pratibha Singh, Supriya Maurya, Sneha Tota, Aberaame Kiroubagarin, Deepika Kounassegarane, Swathi Anand, Vir Singh Negi and Amita Aggarwal
    Citation: Arthritis Research & Therapy 2023 25:2
  15. Giant cell arteritis (GCA) is a primary large-vessel vasculitis (LVV) of unknown origin. Its management is a challenge due to the late onset of disease symptoms and frequent relapse; therefore, clarifying the ...

    Authors: Kotaro Matsumoto, Katsuya Suzuki, Hiroto Yoshida, Mayu Magi, Yoshihiro Matsumoto, Mariko Noguchi-Sasaki, Keiko Yoshimoto, Tsutomu Takeuchi and Yuko Kaneko
    Citation: Arthritis Research & Therapy 2023 25:1
  16. Osteoarthritis (OA) is mainly characterized by the progressive destruction of articular cartilage. Mounting studies have revealed that disruption of extracellular matrix (ECM) homeostasis, aberrant chondrocyte...

    Authors: Kaibo Sun, Yuangang Wu, Yi Zeng, Jiawen Xu, Limin Wu, Mingyang Li and Bin Shen
    Citation: Arthritis Research & Therapy 2022 24:286
  17. Sugiyama et al. recently described in “Latent class analysis of 216 patients with adult-onset Still’s disease,” baseline characteristics, laboratory tests, treatment, relapse, and death of adult-onset Still’s ...

    Authors: Marion Delplanque, Arsène Mekinian and Sophie Georgin-Lavialle
    Citation: Arthritis Research & Therapy 2022 24:285
  18. Lupus nephritis (LN) is the most common and serious complication of systemic lupus erythematosus (SLE). LN pathogenesis is not fully understood. Axl receptor tyrosine kinase is upregulated and contributes to t...

    Authors: Yuxuan Zhen, Yan Ren, Mario Medvedovic, David E. Adams, Diping Wang and Wen-Hai Shao
    Citation: Arthritis Research & Therapy 2022 24:284
  19. Psoriatic arthritis (PsA) patient data from two phase 3 secukinumab trials (FUTURE 1, 5) were analysed to quantify the prevalence and extent of pre-existing radiographic damage (RD) at baseline; investigate th...

    Authors: Philip Mease, Désirée van der Heijde, Bruce Kirkham, Georg Schett, Ana-Maria Orbai, Christopher Ritchlin, Joseph F. Merola, Luminita Pricop, David A. James, Xuan Zhu and Gregory Ligozio
    Citation: Arthritis Research & Therapy 2022 24:283
  20. The infrapatellar fat pad (IFP) is the largest adipose deposit in the knee; however, its contributions to the homeostasis of this organ remain undefined. To determine the influence of the IFP and its associate...

    Authors: Maryam F. Afzali, Lauren B. Radakovich, Madeline M. Sykes, Margaret A. Campbell, Kayley M. Patton, Joseph L. Sanford, Nicole Vigon, Ryan Ek, Gerardo E. Narez, Angela J. Marolf, Katie J. Sikes, Tammy L. Haut Donahue and Kelly S. Santangelo
    Citation: Arthritis Research & Therapy 2022 24:282
  21. Uncontrolled/refractory gout patients are recalcitrant/intolerant to oral urate-lowering therapies (ULTs), experiencing frequent gout flares, functionally limiting tophi, and low quality of life. Pegloticase l...

    Authors: John K. Botson, Katie Obermeyer, Brian LaMoreaux, Lin Zhao, Michael E. Weinblatt and Jeff Peterson
    Citation: Arthritis Research & Therapy 2022 24:281
  22. Interstitial lung disease, a common extra-articular complication of connective tissue disease, is characterized by progressive and irreversible pulmonary inflammation and fibrosis, which causes significant mor...

    Authors: Ziye Qu, Wencan Dou, Kexin Zhang, Lili Duan, Dongmei Zhou and Songlou Yin
    Citation: Arthritis Research & Therapy 2022 24:280
  23. In axial spondyloarthritis (axSpA) inflammation of the sacroiliac joints and spine is associated with local extracellular matrix (ECM) remodeling of affected tissues. We aimed to investigate the association of...

    Authors: Signe Holm Nielsen, Shu Sun, Anne C. Bay-Jensen, Morten Karsdal, Inge Juul Sørensen, Ulrich Weber, Anne Gitte Loft, Gina Kollerup, Gorm Thamsborg, Ole Rintek Madsen, Jakob Møller, Mikkel Østergaard and Susanne Juhl Pedersen
    Citation: Arthritis Research & Therapy 2022 24:279
  24. In patients affected by connective tissue diseases (CTDs), the identification of wide autoantibody profiles may prove useful in early diagnosis, in the evaluation of prognosis (risk stratification), and in pre...

    Authors: Nicola Bizzaro, Danilo Villalta, Vittorio Bini, Paola Migliorini, Franco Franceschini, Silvia Piantoni, Emirena Garrafa, Valeria Riccieri, Antonella Fioravanti, Francesca Bellisai, Marilina Tampoia, Marco Fornaro, Florenzo Iannone, Anna Ghirardello, Margherita Zen, Boaz Palterer…
    Citation: Arthritis Research & Therapy 2022 24:278
  25. Rheumatoid arthritis patients usually suffer from arthritic chronic pain. However, due to an incomplete understanding of the mechanisms underlying autoimmune disorders, the management of arthritic pain is unsa...

    Authors: Yue-Peng Jiang, Song Wang, Wei-Dong Lai, Xue-Qing Wu, Yan Jin, Zheng-Hao Xu, Aubin Moutal, Rajesh Khanna, Ki Duk Park, Zhi-Ming Shan, Cheng-Ping Wen and Jie Yu
    Citation: Arthritis Research & Therapy 2022 24:277
  26. To evaluate the effects of tumor necrosis factor inhibitors (TNFi), interleukin-6 receptor inhibitors (IL-6Ri), and Janus kinase inhibitors (JAKi) on hemoglobin (Hb) and C-reactive protein (CRP) levels in adul...

    Authors: Anthony S. Padula, Dimitrios A. Pappas, Stefano Fiore, Taylor S. Blachley, Kerri Ford, Kelechi Emeanuru and Joel M. Kremer
    Citation: Arthritis Research & Therapy 2022 24:276

    The Research to this article has been published in Arthritis Research & Therapy 2022 24:207

  27. Neutrophil extracellular traps (NETs) are critically involved in microscopic polyangiitis (MPA) pathogenesis, and some patients with MPA possess anti-NET antibody (ANETA). Anti-myosin light chain 6 (MYL6) anti...

    Authors: Miku Yoshinari, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Yoshihiro Arimura, Koichi Amano, Yukio Yuzawa, Ken-Ei Sada, Tatsuya Atsumi, Hiroaki Dobashi, Hitoshi Hasegawa, Masayoshi Harigai, Seiichi Matsuo, Hirofumi Makino and Akihiro Ishizu
    Citation: Arthritis Research & Therapy 2022 24:274
  28. Bone marrow-derived mesenchymal stem cells (BMSCs) are general progenitor cells of osteoblasts and adipocytes and they are characterized as a fundamental mediator for bone formation. The current research studi...

    Authors: Lixia Fan, Kaiyun Yang, Ruixuan Yu, Houde Hui and Wenliang Wu
    Citation: Arthritis Research & Therapy 2022 24:273
  29. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13075-022-02973-w.

    Authors: Gianluca Bagnato, Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Donatella Sangari, Maurizio Cinquegrani, William Neal Roberts, Marco Atteritano, Domenica Altavilla, Francesco Squadrito, Gianfilippo Bagnato and Antonino Saitta
    Citation: Arthritis Research & Therapy 2022 24:272
  30. To analyze therapy adherence, safety, and outcome in adult patients with juvenile idiopathic arthritis (JIA) treated with the etanercept biosimilar Benepali® (Biogen Inc, Cambridge, USA).

    Authors: Kristina Vollbach, Klaus Tenbrock, Nobert Wagner, Gerd Horneff, Ariane Klein, Ivan Foeldvari, Johannes-Peter Haas, Peer Aries, Georg Gauler, Frank Striesow, Paula Hoff, Christine Scholz, Stefanie Tatsis, Eva Seipelt, Jens Klotsche and Kirsten Minden
    Citation: Arthritis Research & Therapy 2022 24:271
  31. The associations of rheumatoid arthritis (RA) with risk of site-specific cancers beyond lymphohematopoietic cancer have been scarcely explored. We conducted a Mendelian randomization investigation of the assoc...

    Authors: Shuai Yuan, Jie Chen, Xixian Ruan, Mathew Vithayathil, Siddhartha Kar, Xue Li, Amy M. Mason, Stephen Burgess and Susanna C. Larsson
    Citation: Arthritis Research & Therapy 2022 24:270
  32. Although cross-sectional and cohort data suggest that higher serum blood glucose levels in patients with knee osteoarthritis (KOA) are associated with more severe knee symptoms, little is known about the longi...

    Authors: Daisuke Chiba, Tetsushi Ohyama, Eiji Sasaki, Makoto Daimon, Shigeyuki Nakaji and Yasuyuki Ishibashi
    Citation: Arthritis Research & Therapy 2022 24:269
  33. Rheumatoid arthritis is an autoimmune condition that predominantly affects the synovial joints, causing joint destruction, pain, and disability. Historically, the standard for measuring the long-term efficacy ...

    Authors: Alix Bird, Lauren Oakden-Rayner, Christopher McMaster, Luke A. Smith, Minyan Zeng, Mihir D. Wechalekar, Shonket Ray, Susanna Proudman and Lyle J. Palmer
    Citation: Arthritis Research & Therapy 2022 24:268
  34. Lupus nephritis (LN) is an inflammatory disease of the kidneys affecting patients with systemic lupus erythematosus. Current immunosuppressive and cytotoxic therapies are associated with serious side effects a...

    Authors: Justin Knapp, Marsela Braunstein, Spencer Iner Thomas Berg and Cody Shirriff
    Citation: Arthritis Research & Therapy 2022 24:267
  35. Takayasu arteritis (TAK) is characterized by pro-inflammatory M1 macrophage infiltration and increased interferon (IFN)-γ expression in vascular lesions. IFN-γ is a key cytokine involved in M1 polarization. Ma...

    Authors: Rongyi Chen, Jinghua Wang, Xiaojuan Dai, Sifan Wu, Qingrong Huang, Lindi Jiang and Xiufang Kong
    Citation: Arthritis Research & Therapy 2022 24:266
  36. Loss of bone is a common medical problem and, while it can be treated with available therapies, some of these therapies have critical side effects. We have previously demonstrated that CGS21680, a selective A2A a...

    Authors: Ane Larrañaga-Vera, Kiran S. Toti, James S. Flatow, Alexandra J. Haraczy, Eugene Warnick, Harsha Rao, Zhan-Guo Gao, Sarah M. Sussman, Aranzazu Mediero, Philipp Leucht, Kenneth A. Jacobson and Bruce N. Cronstein
    Citation: Arthritis Research & Therapy 2022 24:265
  37. This exploratory study compared the inhibition of bone erosion progression in rheumatoid arthritis (RA) patients treated with a conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) plus denos...

    Authors: Naoki Iwamoto, Ko Chiba, Shuntaro Sato, Kazuteru Shiraishi, Kounosuke Watanabe, Nozomi Oki, Akitomo Okada, Tomohiro Koga, Shin-ya Kawashiri, Mami Tamai, Naoki Hosogaya, Masako Furuyama, Makiko Kobayashi, Kengo Saito, Naoki Okubo, Masataka Uetani…
    Citation: Arthritis Research & Therapy 2022 24:264
  38. The autoimmune exocrinopathy, Sjögren’s syndrome (SjS), is associated with secretory defects in salivary glands. The cystic fibrosis transmembrane conductance regulator (CFTR) of the chloride channel is a mast...

    Authors: Qi Zhang, Xiuying Lv, Ying Wang, Bin Wang, Yan He, Chubing Chen, Guixiu Shi and Yan Li
    Citation: Arthritis Research & Therapy 2022 24:263
  39. Psoriatic Arthritis (PsA) is an immune-mediated disease with heterogenous symptoms indicating differences in the underlying immunopathogenesis. The primary objective of the study explored the dynamic mechanism...

    Authors: Marie Skougaard, Sisse B. Ditlev, Zara R. Stisen, Laura C. Coates, Karen Ellegaard and Lars Erik Kristensen
    Citation: Arthritis Research & Therapy 2022 24:262
  40. Numerous potential therapeutic alternatives for intervertebral disc degeneration (IDD) have been investigated, the most promising of which are based on biological variables such as microRNAs (miRNAs). Therefor...

    Authors: Zhonghui Chen, Jianghua Ming, Yajing Liu, Geliang Hu and Qi Liao
    Citation: Arthritis Research & Therapy 2022 24:261
  41. Intra-articular injection is indicated for mild or moderate osteoarthritis (OA). However, the superiority of cell-based injection and the role of diverse cell sources are still unclear. This study aimed to com...

    Authors: Yijian Zhang, Huilin Yang, Fan He and Xuesong Zhu
    Citation: Arthritis Research & Therapy 2022 24:260
  42. Non-neuropsychiatric systemic lupus erythematosus (non-NPSLE) has been confirmed to have subtle changes in brain structure before the appearance of obvious neuropsychiatric symptoms. Previous literature mainly...

    Authors: Shu Li, Ru Bai, Yifan Yang, Ruotong Zhao, Bibhuti Upreti, Xiangyu Wang, Shuang Liu, Yuqi Cheng and Jian Xu
    Citation: Arthritis Research & Therapy 2022 24:259
  43. Current recommendations on the management of systemic sclerosis (SSc) suggest that autologous hematopoietic stem cell therapy (HSCT) can be a rescue therapy for patients with rapidly progressive SSc.

    Authors: Norbert Blank, Marc Schmalzing, Pia Moinzadeh, Max Oberste, Elise Siegert, Ulf Müller-Ladner, Gabriela Riemekasten, Claudia Günther, Ina Kötter, Gabriele Zeidler, Christiane Pfeiffer, Aaron Juche, Ilona Jandova, Jan Ehrchen, Laura Susok, Tim Schmeiser…
    Citation: Arthritis Research & Therapy 2022 24:258
  44. To investigate the occurrence and frequency of anti-citrullinated protein antibodies (ACPA) to cyclic citrullinated type II collagen (COL2) epitope with a capacity to bind joint cartilage.

    Authors: Qixing Li, Yanpeng Li, Bibo Liang, Rui Xu, Bingze Xu, Erik Lönnblom, Hui Feng, Jing’an Bai, Roma Stawikowska, Changrong Ge, Aiping Lu, Gregg B. Fields, Lianbo Xiao and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2022 24:257
  45. Dysbiotic intestinal and oral microbiota have been implicated in the pathogenesis of rheumatoid arthritis (RA), but the mechanisms how microbiota could impact disease activity have remained elusive. The aim of...

    Authors: J. Parantainen, G. Barreto, R. Koivuniemi, H. Kautiainen, D. Nordström, E. Moilanen, M. Hämäläinen, M. Leirisalo-Repo, K. Nurmi and K. K. Eklund
    Citation: Arthritis Research & Therapy 2022 24:256
  46. The prevalence of rheumatoid arthritis (RA) in persons 60 years or older is estimated to be 2%. Late-onset rheumatoid arthritis (LORA) is traditionally defined as the onset of RA after the age of 60 years. Com...

    Authors: Xiuying Li, Angela Cesta, Mohammad Movahedi and Claire Bombardier
    Citation: Arthritis Research & Therapy 2022 24:255
  47. This study aimed to investigate the trajectory of damage accrual, associated factors, and impact on health-related quality of life (HR-QoL) in a multicenter cohort of patients with Behçet’s syndrome (BS) over ...

    Authors: Alberto Floris, Matteo Piga, Riccardo Laconi, Gerard Espinosa, Giuseppe Lopalco, Luisa Serpa Pinto, Nikolaos Kougkas, Jurgen Sota, Andrea Lo Monaco, Marcello Govoni, Luca Cantarini, George Bertsias, João Correia, Florenzo Iannone, Ricard Cervera, Carlos Vasconcelos…
    Citation: Arthritis Research & Therapy 2022 24:253

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