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  1. Content type: Research article

    Lysophosphatidic acid (LPA), generated by autotaxin (ATX), is a bioactive lipid mediator that binds to the receptors (LPA1–6), and serves as an important mediator in inflammation. Previous studies have demonstrat...

    Authors: Chie Miyabe, Yoshishige Miyabe, Jun Nagai, Noriko N. Miura, Naohito Ohno, Jerold Chun, Ryoji Tsuboi, Hiroshi Ueda, Masayuki Miyasaka, Nobuyuki Miyasaka and Toshihiro Nanki

    Citation: Arthritis Research & Therapy 2019 21:191

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  2. Content type: Research article

    To evaluate the safety and efficacy of intravenous golimumab + methotrexate (MTX) in patients with active rheumatoid arthritis (RA) aged < 65 years and those ≥ 65 years who were enrolled in the GO-FURTHER study.

    Authors: John Tesser, Shelly Kafka, Raphael J. DeHoratius, Stephen Xu, Elizabeth C. Hsia and Anthony Turkiewicz

    Citation: Arthritis Research & Therapy 2019 21:190

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  3. Content type: Research article

    In clinical practice, discrimination between central nervous system (CNS) infections in patients with systemic lupus erythematosus (SLE) and neuropsychiatric lupus erythematosus (NPSLE) could be urgent and cri...

    Authors: Mengdi Jiang, Xiaochun Shi, Xin Gao, Jingwen Niu, Xiaomin Hu, Lidan Zhao and Xuan Zhang

    Citation: Arthritis Research & Therapy 2019 21:189

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  4. Content type: Research article

    Despite their efficacy in the treatment of chronic inflammation, the prolonged application of therapeutic glucocorticoids (GCs) is limited by significant systemic side effects including glucocorticoid-induced ...

    Authors: C. G. Fenton, C. L. Doig, S. Fareed, A. Naylor, A. P. Morrell, O. Addison, C. Wehmeyer, C. D. Buckley, M. S. Cooper, G. G. Lavery, K. Raza and R. S. Hardy

    Citation: Arthritis Research & Therapy 2019 21:188

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  5. Content type: Research article

    The purpose of the present study was to demonstrate whether alcohol consumption could predict spinal structural damage in axial spondyloarthritis (axSpA) in a prospective cohort study.

    Authors: Hong Ki Min, Jennifer Lee, Ji Hyeon Ju, Sung-Hwan Park and Seung-Ki Kwok

    Citation: Arthritis Research & Therapy 2019 21:187

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  6. Content type: Research article

    Previous studies suggest that regulatory microRNAs (miRs) may modulate neuro-inflammatory processes. The purpose of the present study was to examine the role of miR-17 following intervertebral disc herniation.

    Authors: Eivind Hasvik, Tiril Schjølberg, Daniel Pitz Jacobsen, Anne Julsrud Haugen, Lars Grøvle, Elina Iordanova Schistad and Johannes Gjerstad

    Citation: Arthritis Research & Therapy 2019 21:186

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  7. Content type: Correction

    Following publication of the original article [1], it was brought to our attention that the fifth author’s name was incorrectly published. The original article [1] is corrected.

    Authors: Ling Qin, Samantha Stanley, Huihua Ding, Ting Zhang, Van Thi Thanh Truong, Teja Celhar, Anna-Marie Fairhurst, Claudia Pedroza, Michelle Petri, Ramesh Saxena and Chandra Mohan

    Citation: Arthritis Research & Therapy 2019 21:185

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    The original article was published in Arthritis Research & Therapy 2019 21:176

  8. Content type: Research article

    Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a sometimes life-threatening complication in RA patients. SKG mice develop not only arthritis but also an ILD resembling RA-ILD. We previou...

    Authors: Sho Sendo, Jun Saegusa, Hirotaka Yamada, Keisuke Nishimura and Akio Morinobu

    Citation: Arthritis Research & Therapy 2019 21:184

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  9. Content type: Research article

    The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the cellular level.

    Authors: Iain B. McInnes, Nicole L. Byers, Richard E. Higgs, Jonathan Lee, William L. Macias, Songqing Na, Robert A. Ortmann, Guilherme Rocha, Terence P. Rooney, Thomas Wehrman, Xin Zhang, Steven H. Zuckerman and Peter C. Taylor

    Citation: Arthritis Research & Therapy 2019 21:183

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  10. Content type: Research article

    Patients with rheumatoid arthritis (RA) experience extra-articular manifestations including osteoporosis and muscle wasting, which closely associate with severity of disease. Whilst therapeutic glucocorticoids...

    Authors: C. G. Fenton, J. M. Webster, C. S. Martin, S. Fareed, C. Wehmeyer, H. Mackie, R. Jones, A. P. Seabright, J. W. Lewis, Y. C. Lai, C. S. Goodyear, S. W Jones, M. S. Cooper, G. G. Lavery, R. Langen, K. Raza…

    Citation: Arthritis Research & Therapy 2019 21:182

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  11. Content type: Research article

    Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of primary Sjögren’s syndrome (pSS). Non-SS sic...

    Authors: Lara A. Aqrawi, Hilde Kanli Galtung, Eduarda M. Guerreiro, Reidun Øvstebø, Bernd Thiede, Tor Paaske Utheim, Xiangjun Chen, Øygunn Aass Utheim, Øyvind Palm, Kathrine Skarstein and Janicke Liaaen Jensen

    Citation: Arthritis Research & Therapy 2019 21:181

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  12. Content type: Research article

    The aim of this study was to assess the anti-inflammatory effects of local cryotherapy in human non-septic knee arthritis.

    Authors: X. Guillot, N. Tordi, C. Laheurte, L. Pazart, C. Prati, P. Saas and D. Wendling

    Citation: Arthritis Research & Therapy 2019 21:180

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  13. Content type: Research article

    Comparison of two doses of bio-optimized Curcuma longa extract (BCL) in the management of symptomatic knee osteoarthritis (OA).

    Authors: Y. Henrotin, M. Malaise, R. Wittoek, K. de Vlam, J.-P. Brasseur, F. P. Luyten, Q. Jiangang, M. Van den Berghe, R. Uhoda, J. Bentin, T. De Vroey, L. Erpicum, A. F. Donneau and Y. Dierckxsens

    Citation: Arthritis Research & Therapy 2019 21:179

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  14. Content type: Research article

    A specific subset of psoriasis patients is characterized by subclinical inflammatory changes. These patients frequently present with arthralgia and have a higher risk to develop psoriatic arthritis (PsA). We h...

    Authors: Eleni Kampylafka, David Simon, Isabelle d’Oliveira, Christina Linz, Veronika Lerchen, Matthias Englbrecht, Juergen Rech, Arnd Kleyer, Michael Sticherling, Georg Schett and Axel J. Hueber

    Citation: Arthritis Research & Therapy 2019 21:178

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  15. Content type: Research article

    The impact of smoking on TNF inhibition (TNFi) therapy is unclear. We examined the effect of smoking on all-cause and cause-specific TNFi discontinuation in axial spondyloarthritis (axSpA).

    Authors: Sizheng Steven Zhao, Kazuki Yoshida, Gareth T. Jones, David M. Hughes, Stephen J. Duffield, Sara K. Tedeschi, Houchen Lyu, Robert J. Moots, Daniel H. Solomon and Nicola J. Goodson

    Citation: Arthritis Research & Therapy 2019 21:177

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  16. Content type: Research article

    This study evaluates the utility of urinary pro-thrombotic molecules such as tissue factor (TF), anti-thrombotic molecules such as tissue factor pathway inhibitor (TFPI), and fibrinolytic molecules such as pla...

    Authors: Ling Qin, Samantha Stanley, Huihua Ding, Ting Zhang, Van Thi Thanh Truong, Teja Celhar, Anna-Marie Fairhurst, Claudia Pedroza, Michelle Petri, Ramesh Saxena and Chandra Mohan

    Citation: Arthritis Research & Therapy 2019 21:176

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    The Correction to this article has been published in Arthritis Research & Therapy 2019 21:185

  17. Content type: Research article

    Primary Sjögren syndrome (pSS) is characterized by T and B cell infiltration of exocrine glands. The cysteine protease cathepsin S (CatS) is crucially involved in MHCII processing and T cell stimulation, and e...

    Authors: Patrick Hargreaves, Douglas Daoudlarian, Michel Theron, Fabrice A. Kolb, Marianne Manchester Young, Bernhard Reis, Andre Tiaden, Bettina Bannert, Diego Kyburz and Tobias Manigold

    Citation: Arthritis Research & Therapy 2019 21:175

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  18. Content type: Research article

    Rheumatoid arthritis (RA) is known to cause secondary osteoporosis and fragility fractures. This study aimed to identify biomarkers predictive of bone mineral density (BMD) change at three anatomical sites in ...

    Authors: T. Tomizawa, H. Ito, K. Murata, M. Hashimoto, M. Tanaka, K. Murakami, K. Nishitani, M. Azukizawa, A. Okahata, K. Doi, M. Saito, M. Furu, M. Hamaguchi, T. Mimori and S. Matsuda

    Citation: Arthritis Research & Therapy 2019 21:174

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  19. Content type: Review

    To evaluate contextual effects in the form of placebo responses (PRs) for patient-reported pain and function and objectively measured function in osteoarthritis (OA) clinical trials.

    Authors: ZeYu Huang, Jing Chen, Qin Sheng Hu, Qiang Huang, Jun Ma, Fu Xing Pei, Bin Shen and Virginia Byers Kraus

    Citation: Arthritis Research & Therapy 2019 21:173

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  20. Content type: Research article

    Syndecans are heparan sulfate proteoglycans that occur in membrane-bound or soluble forms. Syndecan-3, the least well-characterised of the syndecan family, is highly expressed on synovial endothelial cells in ...

    Authors: Andrew D. Eustace, Emily F. McNaughton, Sophie King, Oksana Kehoe, Andreas Kungl, Derek Mattey, Angela H. Nobbs, Neil Williams and Jim Middleton

    Citation: Arthritis Research & Therapy 2019 21:172

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  21. Content type: Research article

    Autophagy induction is an effective approach for OA therapy. IL-1β is one of the major inflammatory cytokines linked to OA pathological progression, and its receptor blockade interrupts OA cartilage destructio...

    Authors: Fen Wang, Jijie Liu, Xiaolei Chen, Xinpeng Zheng, Ning Qu, Bing Zhang and Chun Xia

    Citation: Arthritis Research & Therapy 2019 21:171

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  22. Content type: Correction

    Following publication of the original article [1], it has come to our attention that we did not appropriately convert the units for CRP from the National Health and Nutrition Examination Survey (NHANES) from m...

    Authors: Zhi Yu, Seoyoung C. Kim, Kathleen Vanni, Jie Huang, Rishi Desai, Shawn N. Murphy, Daniel H. Solomon and Katherine P. Liao

    Citation: Arthritis Research & Therapy 2019 21:170

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    The original article was published in Arthritis Research & Therapy 2018 20:107

  23. Content type: Research article

    Triggering receptor expressed on myeloid cells-1 (TREM-1) is inducible on monocyte/macrophages and neutrophils and amplifies the inflammatory response. The aim of this study was to determine whether rheumatoid...

    Authors: Anping Peng, Xinyi Lu, Jun Huang, Min He, Jianhua Xu, Hui Huang and Qubo Chen

    Citation: Arthritis Research & Therapy 2019 21:169

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  24. Content type: Research article

    To compare the long-term disease state, in terms of activity and damage, of children with juvenile idiopathic arthritis (JIA) who had their disease onset in methotrexate (MTX) or biologic eras.

    Authors: Gabriella Giancane, Valentina Muratore, Valentina Marzetti, Neus Quilis, Belen Serrano Benavente, Francesca Bagnasco, Alessandra Alongi, Adele Civino, Lorenzo Quartulli, Alessandro Consolaro and Angelo Ravelli

    Citation: Arthritis Research & Therapy 2019 21:168

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  25. Content type: Research article

    While bone marrow-derived mesenchymal stem cells (BMSC) are established sources for stem cell-based cartilage repair therapy, articular cartilage-derived mesenchymal stem cells from osteoarthritis patients (OA...

    Authors: Nan Hu, Yun Gao, Chathuraka T. Jayasuriya, Wenguang Liu, Heng Du, Jing Ding, Meng Feng and Qian Chen

    Citation: Arthritis Research & Therapy 2019 21:167

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  26. Content type: Research article

    To assess if the right hand, the dominant hand, or the hand with more clinically swollen joints (SwJ) is per se the most inflamed and exhibits the greatest change during treatment and hence preferred for unila...

    Authors: Lene Terslev, Robin Christensen, Anna-Birgitte Aga, Joe Sexton, Espen A. Haavardsholm and Hilde B. Hammer

    Citation: Arthritis Research & Therapy 2019 21:166

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  27. Content type: Research article

    Low back pain is the largest contributor to disability worldwide. The role of body composition as a risk factor for back pain remains unclear. Our aim was to examine the relationship between fat mass and fat d...

    Authors: Sharmayne R. E. Brady, Donna M. Urquhart, Sultana Monira Hussain, Andrew Teichtahl, Yuanyuan Wang, Anita E. Wluka and Flavia Cicuttini

    Citation: Arthritis Research & Therapy 2019 21:165

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  28. Content type: Research article

    Biologic disease-modifying antirheumatic drugs (bDMARDs) are important options for managing rheumatoid arthritis (RA). Once patients achieve disease control, clinicians may consider dose reduction or withdrawa...

    Authors: Yoshiya Tanaka, Josef S. Smolen, Heather Jones, Annette Szumski, Lisa Marshall and Paul Emery

    Citation: Arthritis Research & Therapy 2019 21:164

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  29. Content type: Research article

    To investigate the association between the extent of tapering tumor necrosis factor inhibitor (TNFi) and the likelihood of achieving inactive disease in patients with axial spondyloarthritis (axSpA)

    Authors: Jun Won Park, Hyoun-Ah Kim, Kichul Shin, Yong-Beom Park, Tae-Hwan Kim, Yeong Wook Song and Eun Young Lee

    Citation: Arthritis Research & Therapy 2019 21:163

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  30. Content type: Research article

    To address whether the use of methotrexate (MTX) and biological disease-modifying anti-rheumatic drugs (bDMARDs) impacts bone structure and biomechanical properties in patients with psoriatic arthritis (PsA).

    Authors: David Simon, Arnd Kleyer, Sara Bayat, Koray Tascilar, Eleni Kampylafka, Timo Meinderink, Louis Schuster, Ramona Petrov, Anna-Maria Liphardt, Juergen Rech, Georg Schett and Axel J. Hueber

    Citation: Arthritis Research & Therapy 2019 21:162

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  31. Content type: Research article

    Thrombocytopenia is a manifestation associated with primary antiphospholipid syndrome (PAPS), and many studies have stressed the leading role played by platelets in the pathogenesis of antiphospholipid syndrom...

    Authors: C. Barbati, L. Stefanini, T. Colasanti, E. Cipriano, A. Celia, G. Gabriele, M. Vomero, F. Ceccarelli, F. R. Spinelli, A. Finucci, M. Speziali, G. Orso, D. P. E. Margiotta, F. Conti, F. Violi, A. Afeltra…

    Citation: Arthritis Research & Therapy 2019 21:161

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  32. Content type: Research article

    To examine the feasibility, preference, and satisfaction of an interactive voice response (IVR) system versus a customized smartphone application (StudyBuddy) to capture gout flares

    Authors: Nada Elmagboul, Brian W. Coburn, Jeffrey Foster, Amy Mudano, Joshua Melnick, Debra Bergman, Shuo Yang, David Redden, Lang Chen, Cooper Filby, Jeffrey R. Curtis, Ted R. Mikuls and Kenneth G. Saag

    Citation: Arthritis Research & Therapy 2019 21:160

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  33. Content type: Research article

    Th17 cells are involved in the pathogenesis of ankylosing spondylitis (AS). However, the mechanism underlying enhanced Th17 cell accumulation in AS remains unknown. The prostaglandin E2 receptor EP2/EP4 signaling...

    Authors: Charlotte Klasen, Anja Meyer, Paula S. Wittekind, Iris Waqué, Schafiq Nabhani and David M. Kofler

    Citation: Arthritis Research & Therapy 2019 21:159

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  34. Content type: Research article

    People with hand-related rheumatoid arthritis (RA) experience problems performing activities of daily living (ADL). Compensatory strategies to improve ADL ability have shown effective. Similarly, hand exercise...

    Authors: Karen Ellegaard, Cecilie von Bülow, Alice Røpke, Cecilie Bartholdy, Inge Skovby Hansen, Signe Rifbjerg-Madsen, Marius Henriksen and Eva Ejlersen Wæhrens

    Citation: Arthritis Research & Therapy 2019 21:158

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  35. Content type: Research article

    Low-dose methotrexate (MTX) is the first-line therapy in early rheumatoid arthritis (eRA). Up to 40% of eRA patients do not benefit from MTX therapy. MTX has been shown to inhibit one-carbon metabolism, which ...

    Authors: Helen R. Gosselt, Bertrand D. van Zelst, Maurits C. F. J. de Rotte, Johanna M. W. Hazes, Robert de Jonge and Sandra G. Heil

    Citation: Arthritis Research & Therapy 2019 21:157

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  36. Content type: Research article

    GATA3 is a transcription factor that is important during development and plays a role in differentiation and activity of immune cells, particularly T cells. Abnormal T cell function is found in autoimmune arth...

    Authors: Anna E. Patrick, Wei Wang, Elly Brokamp, Thomas Brent Graham, Thomas M. Aune and Jessica B. Duis

    Citation: Arthritis Research & Therapy 2019 21:156

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  37. Content type: Research article

    Healthcare access, utilization, and quality play critical roles in shaping mortality and morbidity among patients diagnosed with systemic lupus erythematosus (SLE), and yet healthcare access, utilization, and ...

    Authors: Abena A. Twumasi, Anna Shao, Charmayne Dunlop-Thomas, Cristina Drenkard and Hannah L. F. Cooper

    Citation: Arthritis Research & Therapy 2019 21:155

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  38. Content type: Research article

    Our objective was to determine the survival and causes of death in a large and well-characterized cohort of patients with giant cell arteritis (GCA).

    Authors: L. K. Brekke, B.-T. S. Fevang, A. P. Diamantopoulos, J. Assmus, E. Esperø and C. G. Gjesdal

    Citation: Arthritis Research & Therapy 2019 21:154

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  39. Content type: Research article

    Anti-malarial drug artesunate can suppress inflammation and prevent cartilage and bone destruction in collagen-induced arthritis model in rats—suggesting it may be a potent drug for rheumatoid arthritis (RA) t...

    Authors: Jian-Da Ma, Jun Jing, Jun-Wei Wang, Tao Yan, Qian-Hua Li, Ying-Qian Mo, Dong-Hui Zheng, Jin-Long Gao, Ky-Anh Nguyen and Lie Dai

    Citation: Arthritis Research & Therapy 2019 21:153

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  40. Content type: Research article

    The importance of systemic sclerosis (SSc) autoantibodies for diagnosis has become recognized by their incorporation into the 2013 ACR/EULAR classification criteria. Clear prognostic and phenotypic association...

    Authors: Claudio Corallo, Sara Cheleschi, Maurizio Cutolo, Stefano Soldano, Antonella Fioravanti, Nila Volpi, Daniela Franci, Ranuccio Nuti and Nicola Giordano

    Citation: Arthritis Research & Therapy 2019 21:152

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  41. Content type: Research article

    Tumor necrosis factor (TNF) inhibitors (TNF-i) are effective in the treatment of entero-Behcet’s disease (BD). However, there is no objective tool for assessment of disease activity in entero-BD; therefore, it...

    Authors: Ippei Miyagawa, Kazuhisa Nakano, Shigeru Iwata, Shingo Nakayamada, Kazuyoshi Saito, Kentaro Hanami, Shunsuke Fukuyo, Satoshi Kubo, Akio Kawabe, Yusuke Miyazaki and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2019 21:151

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  42. Content type: Research article

    Provisional gout remission criteria including five domains (serum urate, tophus, flares, pain due to gout, and patient global assessment) have been proposed. The aim of this study was to test the concurrent va...

    Authors: Nicola Dalbeth, Christopher Frampton, Maple Fung, Scott Baumgartner, Savvas Nicolaou and Hyon K. Choi

    Citation: Arthritis Research & Therapy 2019 21:150

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  43. Content type: Research article

    Osteoarthritis (OA) is a common disease of older individuals that impacts detrimentally on the quality and the length of life. It is characterised by the painful loss of articular cartilage and is polygenic an...

    Authors: Colin Shepherd, Abigail E. Reese, Louise N. Reynard and John Loughlin

    Citation: Arthritis Research & Therapy 2019 21:149

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  44. Content type: Research article

    Sensory disturbances in fibromyalgia extend beyond nociception. It has been proposed that imbalance in the mutual competition between painful input and non-painful sensory activity may, to a significant extent...

    Authors: Jesus Pujol, Daniel Ramos-López, Laura Blanco-Hinojo, Guillem Pujol, Héctor Ortiz, Gerard Martínez-Vilavella, Josep Blanch, Jordi Monfort and Joan Deus

    Citation: Arthritis Research & Therapy 2019 21:148

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  45. Content type: Research article

    To investigate the relationships between interferon alpha (IFNα) and the clinical and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) in order to determine whether a distin...

    Authors: John A. Reynolds, Tracy A. Briggs, Gillian I. Rice, Sathya Darmalinggam, Vincent Bondet, Ellen Bruce, Mumtaz Khan, Sahena Haque, Hector Chinoy, Ariane L. Herrick, Eoghan M. McCarthy, Leo Zeef, Andrew Hayes, Darragh Duffy, Ben Parker and Ian N. Bruce

    Citation: Arthritis Research & Therapy 2019 21:147

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  46. Content type: Research article

    Obesity is a leading risk factor for osteoarthritis (OA). In contrast, calorie restriction (CR) may lessen OA due to improved systemic inflammatory status and reduced weight-bearing. The aim of this study was ...

    Authors: Lauren B. Radakovich, Angela J. Marolf, Lauren A. Culver and Kelly S. Santangelo

    Citation: Arthritis Research & Therapy 2019 21:145

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  47. Content type: Research article

    Activin A and follistatin exhibit immunomodulatory functions, thus affecting autoinflammatory processes as found in rheumatoid arthritis (RA). The impact of both proteins on the behavior of synovial fibroblast...

    Authors: Magnus Diller, Klaus Frommer, Berno Dankbar, Ingo Tarner, Marie-Lisa Hülser, Lali Tsiklauri, Rebecca Hasseli, Michael Sauerbier, Thomas Pap, Stefan Rehart, Ulf Müller-Ladner and Elena Neumann

    Citation: Arthritis Research & Therapy 2019 21:144

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  48. Content type: Research article

    The aim of this study was to compare radiographic progression in patients with ankylosing spondylitis (AS) treated for up to 2 years with secukinumab (MEASURE 1) with a historical cohort of biologic-naïve pati...

    Authors: J. Braun, H. Haibel, M. de Hooge, R. Landewé, M. Rudwaleit, T. Fox, A. Readie, H. B. Richards, B. Porter, R. Martin, D. Poddubnyy, J. Sieper and D. van der Heijde

    Citation: Arthritis Research & Therapy 2019 21:142

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  49. Content type: Research article

    To assess the risks of malignancies, infections and autoimmune diseases in patients with rheumatoid arthritis (RA) treated with abatacept compared with other biologic (b) disease-modifying antirheumatic drugs ...

    Authors: Gulsen Ozen, Sofia Pedro, Rebecca Schumacher, Teresa A. Simon and Kaleb Michaud

    Citation: Arthritis Research & Therapy 2019 21:141

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