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  1. Research article

    Childhood Takayasu arteritis: disease course and response to therapy

    Takayasu arteritis (TAK) is a large vessel vasculitis that rarely affects children. Data on childhood TAK are scarce. The aim of this study was to analyze the presenting features, course and outcome of childre...

    Florence A. Aeschlimann, Simon W. M. Eng, Shehla Sheikh, Ronald M. Laxer, Diane Hebert, Damien Noone, Marinka Twilt, Christian Pagnoux, Susanne M. Benseler and Rae S. M. Yeung

    Arthritis Research & Therapy 2017 19:255

    Published on: 22 November 2017

  2. Research article

    Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice

    In the present study, we sought to evaluate the feasibility of targeting vascular adhesion protein-1 (VAP-1) by positron emission tomography (PET) for the longitudinal quantitative assessment of Borrelia burgdorf...

    Riikka Siitonen, Annukka Pietikäinen, Heidi Liljenbäck, Meeri Käkelä, Mirva Söderström, Sirpa Jalkanen, Jukka Hytönen and Anne Roivainen

    Arthritis Research & Therapy 2017 19:254

    Published on: 22 November 2017

  3. Research article

    Experience with etanercept, tocilizumab and interleukin-1 inhibitors in systemic onset juvenile idiopathic arthritis patients from the BIKER registry

    Treatment of systemic onset juvenile idiopathic arthritis JIA (sJIA), although dramatically improved, remains a challenge. Experience from clinical practice will be presented using data from the German Biologi...

    Gerd Horneff, Anna Carina Schulz, Jens Klotsche, Anton Hospach, Kirsten Minden, Ivan Foeldvari, Ralf Trauzeddel, Gerd Ganser, Frank Weller-Heinemann and Johannes Perter Haas

    Arthritis Research & Therapy 2017 19:256

    Published on: 22 November 2017

  4. Research article

    Serum connective tissue growth factor is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

    Our previous proteomic study indicated that connective tissue growth factor (CTGF) may be a potential biomarker for rheumatoid arthritis (RA) diagnosis. The aim was to assess the performance of CTGF as a bioma...

    Xinyu Yang, Ke Lin, Shanmin Ni, Jianmin Wang, Qingqing Tian, Huaijun Chen, Matthew A. Brown, Kaidi Zheng, Weitao Zhai, Li Sun, Shengwei Jin and Jianguang Wang

    Arthritis Research & Therapy 2017 19:257

    Published on: 22 November 2017

  5. Research article

    Similar short-term clinical response to high-dose versus low-dose methotrexate in monotherapy and combination therapy in patients with rheumatoid arthritis

    Aiming at rapid decrease of disease activity, there has been a trend to start with higher doses of methotrexate (MTX) in patients newly diagnosed with rheumatoid arthritis (RA), both as monotherapy and in comb...

    Sytske Anne Bergstra, Cornelia F. Allaart, Rosaline van den Berg, Arvind Chopra, Nimmisha Govind, Tom W. J. Huizinga and Robert B. M. Landewe

    Arthritis Research & Therapy 2017 19:258

    Published on: 22 November 2017

  6. Research article

    Chinese Registry of rheumatoid arthritis (CREDIT): II. prevalence and risk factors of major comorbidities in Chinese patients with rheumatoid arthritis

    Rheumatoid arthritis patients are at higher risk of developing comorbidities. The main objective of this study was to evaluate the prevalence of major comorbidities in Chinese rheumatoid arthritis patients. We...

    Shangyi Jin, Mengtao Li, Yongfei Fang, Qin Li, Ju Liu, Xinwang Duan, Yi Liu, Rui Wu, Xiaofei Shi, Yongfu Wang, Zhenyu Jiang, Yanhong Wang, Chen Yu, Qian Wang, Xinping Tian, Yan Zhao…

    Arthritis Research & Therapy 2017 19:251

    Published on: 15 November 2017

  7. Research article

    Factors associated with oral glucocorticoid use in patients with rheumatoid arthritis: a drug use study from a prospective national biologics registry

    Glucocorticoids (GCs) are used in ~ 60% of patients with rheumatoid arthritis (RA). Although disease-modifying, they also have significant adverse effects. Understanding factors associated with GC use may help...

    Rachel J. Black, Susan Lester, Rachelle Buchbinder, Claire Barrett, Marissa Lassere, Lyn March, Samuel Whittle and Catherine L. Hill

    Arthritis Research & Therapy 2017 19:253

    Published on: 15 November 2017

  8. Research article

    Matrix metalloproteinase-3 and the 7-joint ultrasound score in the assessment of disease activity and therapeutic efficacy in patients with moderate to severe rheumatoid arthritis

    This study aimed to investigate the reliability and validity of serum matrix metalloproteinase-3 (MMP-3) levels and articular ultrasound (US) scores in assessing disease activity and therapeutic response in rh...

    Ling Zhou, Geng Wang, Xin Liu, Jing Song, Ling Chen and Huji Xu

    Arthritis Research & Therapy 2017 19:250

    Published on: 15 November 2017

  9. Research article

    Whole blood microRNA expression pattern differentiates patients with rheumatoid arthritis, their seropositive first-degree relatives, and healthy unrelated control subjects

    Epigenetic mechanisms can integrate gene-environment interactions that mediate disease transition from preclinical to clinically overt rheumatoid arthritis (RA). To better understand their role, we evaluated m...

    Vidyanand Anaparti, Irene Smolik, Xiaobo Meng, Victor Spicer, Neeloffer Mookherjee and Hani El-Gabalawy

    Arthritis Research & Therapy 2017 19:249

    Published on: 10 November 2017

  10. Research article

    Failure to achieve lupus low disease activity state (LLDAS) six months after diagnosis is associated with early damage accrual in Caucasian patients with systemic lupus erythematosus

    The aim was to assess the attainability and outcome of the lupus low disease activity state (LLDAS) in the early stages of systemic lupus erythematosus (SLE).

    Matteo Piga, Alberto Floris, Giulia Cappellazzo, Elisabetta Chessa, Mattia Congia, Alessandro Mathieu and Alberto Cauli

    Arthritis Research & Therapy 2017 19:247

    Published on: 10 November 2017

  11. Research article

    TLR2 stimulation impairs anti-inflammatory activity of M2-like macrophages, generating a chimeric M1/M2 phenotype

    Toll-like receptors (TLRs) and macrophages play an important role in rheumatoid arthritis (RA). Currently, it is not clear whether inflammatory M1 or anti-inflammatory M2 predominate among the resident macroph...

    Lilian Quero, Edveena Hanser, Tobias Manigold, André N. Tiaden and Diego Kyburz

    Arthritis Research & Therapy 2017 19:245

    Published on: 2 November 2017

  12. Research article

    Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis

    Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in huma...

    Marije K. Verheul, Michel P. M. Vierboom, Bert A. ’t Hart, Rene E. M. Toes and Leendert A. Trouw

    Arthritis Research & Therapy 2017 19:246

    Published on: 2 November 2017

  13. Research article

    Assessing risk of liver enzyme elevation in patients with immune-mediated diseases and different hepatitis B virus serostatus receiving anti-TNF agents: a nested case-control study

    Liver enzyme elevation is an important and common adverse effect among patients with immune-mediated diseases who receive tumour necrosis factor inhibitors (anti-TNF), and has various causes. Hence, we evaluat...

    Ying-Ming Chiu, Mei-Shu Lai and K. Arnold Chan

    Arthritis Research & Therapy 2017 19:214

    Published on: 1 November 2017

  14. Research article

    Biological function integrated prediction of severe radiographic progression in rheumatoid arthritis: a nested case control study

    Radiographic progression is reported to be highly heritable in rheumatoid arthritis (RA). However, previous study using genetic loci showed an insufficient accuracy of prediction for radiographic progression. ...

    Young Bin Joo, Yul Kim, Youngho Park, Kwangwoo Kim, Jeong Ah Ryu, Seunghun Lee, So-Young Bang, Hye-Soon Lee, Gwan-Su Yi and Sang-Cheol Bae

    Arthritis Research & Therapy 2017 19:244

    Published on: 25 October 2017

  15. Research article

    Changes in clinical disease activity are weakly linked to changes in MRI inflammation on treat-to-target escalation of therapy in rheumatoid arthritis

    Rheumatoid arthritis (RA) treat-to-target (T2T) regimens often use the disease activity score (28 joints) incorporating C-reactive protein (DAS28CRP) as an outcome measure. We compared changes in the DAS28CRP wit...

    Fiona M. McQueen, Peter Chapman, Terina Pollock, Dena D’Souza, Arier C. Lee, Nicola Dalbeth, Lisa Stamp, Karen Lindsay and Anthony Doyle

    Arthritis Research & Therapy 2017 19:241

    Published on: 24 October 2017

  16. Research article

    Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review

    The aim of this study was to identify the most reliable biomarkers in the literature that could be used as flare predictors in systemic lupus erythematosus (SLE).

    Noémie Gensous, Aurélie Marti, Thomas Barnetche, Patrick Blanco, Estibaliz Lazaro, Julien Seneschal, Marie-Elise Truchetet, Pierre Duffau and Christophe Richez

    Arthritis Research & Therapy 2017 19:238

    Published on: 24 October 2017

  17. Research article

    Urine S100 proteins as potential biomarkers of lupus nephritis activity

    Improved, noninvasive biomarkers are needed to accurately detect lupus nephritis (LN) activity. The purpose of this study was to evaluate five S100 proteins (S100A4, S100A6, S100A8/9, and S100A12) in both seru...

    Jessica L. Turnier, Ndate Fall, Sherry Thornton, David Witte, Michael R. Bennett, Simone Appenzeller, Marisa S. Klein-Gitelman, Alexei A. Grom and Hermine I. Brunner

    Arthritis Research & Therapy 2017 19:242

    Published on: 24 October 2017

  18. Research article

    Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis

    The aim was to assess serum magnesium levels in relation to prevalence of knee chondrocalcinosis in two population-based Chinese studies.

    Chao Zeng, Jie Wei, Robert Terkeltaub, Tuo Yang, Hyon K. Choi, Yi-lun Wang, Dong-xing Xie, David J. Hunter, Yuqing Zhang, Hui Li, Yang Cui, Liang-jun Li and Guang-hua Lei

    Arthritis Research & Therapy 2017 19:236

    Published on: 24 October 2017

  19. Research article

    Ultrasound verified inflammation and structural damage in patients with hereditary haemochromatosis-related arthropathy

    Chronic arthropathy occurs in approximately two thirds of patients with hereditary haemochromatosis (HH). The aim was to study inflammatory and structural lesions in patients with HH with (HH-A) and without ar...

    Christian Dejaco, Andreas Stadlmayr, Christina Duftner, Viktoria Trimmel, Rusmir Husic, Elisabeth Krones, Shahin Zandieh, Emma Husar-Memmer, Gernot Zollner, Josef Hermann, Judith Gretler, Angelika Lackner, Anja Ficjan, Christian Datz, Roland Axman and Jochen Zwerina

    Arthritis Research & Therapy 2017 19:243

    Published on: 24 October 2017

  20. Research article

    Relevance of structural damage in the sacroiliac joints for the functional status and spinal mobility in patients with axial spondyloarthritis: results from the German Spondyloarthritis Inception Cohort

    Functional status and spinal mobility in patients with axial spondyloarthritis (axSpA) are known to be determined both by disease activity and by structural damage in the spine. The impact of structural damage...

    Mikhail Protopopov, Joachim Sieper, Hildrun Haibel, Joachim Listing, Martin Rudwaleit and Denis Poddubnyy

    Arthritis Research & Therapy 2017 19:240

    Published on: 24 October 2017

  21. Research article

    Severe intestinal dysbiosis is prevalent in primary Sjögren’s syndrome and is associated with systemic disease activity

    Altered microbial composition of the intestine, commonly referred to as dysbiosis, has been associated with several autoimmune diseases including primary Sjögren’s syndrome (pSS). The aims of the current study...

    Thomas Mandl, Jan Marsal, Peter Olsson, Bodil Ohlsson and Kristofer Andréasson

    Arthritis Research & Therapy 2017 19:237

    Published on: 24 October 2017

  22. Research article

    Soluble CD40L is associated with increased oxidative burst and neutrophil extracellular trap release in Behçet’s disease

    Studies have suggested that soluble factors in plasma from patients with active (aBD) and inactive (iBD) Behçet’s disease (BD) stimulate neutrophil function. Soluble CD40 ligand (sCD40L) is an important mediat...

    Sandro Félix Perazzio, Paulo Vitor Soeiro-Pereira, Viviane Cardoso dos Santos, Marlon Vilela de Brito, Bruno Salu, Maria Luiza Vilela Oliva, Anne Margherite Stevens, Alexandre Wagner Silva de Souza, Hans D. Ochs, Troy R. Torgerson, Antonio Condino-Neto and Luis Eduardo Coelho Andrade

    Arthritis Research & Therapy 2017 19:235

    Published on: 19 October 2017

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