Volume 14 Supplement 1

Proceedings of the 8th Global Arthritis Research Network (GARN) Meeting and 1st Bio-Rheumatology International Congress (BRIC)

Meeting abstracts

8th Global Arthritis Research Network (GARN) Meeting and 1st Bio-Rheumatology International Congress (BRIC).

Tokyo, Japan14-16 November 2011

Page 2 of 3

A novel role for monosodium urate monohydrate crystals and gouty synovial fluids in monocyte migration in gout

Authors: M Asif Amin, Qiang Shu, Jonathon W Vargo, Jeffrey H Ruth, Takeo Isozaki, Solhee Lee and Alisa E Koch

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P5

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Intermittent cold stress-induced experimental fibromyalgia model in mice - pharmacology and neurobiology

Authors: Kohei Araki, Michiko Nishiyori and Hiroshi Ueda

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P6

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Frequency of appearance of anemias at rheumatoid arthritis - a disease of autoimmune genesis (on the data of retrospective study)

Authors: Abdumalik N Aripov, Marif SH Karimov and Aida A Eshmurzaeva

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P7

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The bacterial effector protein YopM reduces rheumatoid arthritis (RA) outcome by inhibiting inflammation and bone destruction

Authors: J Bertrand, C Rueter, C Cromme, J Scharnert, A Schmidt and T Pap

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P8

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PTEN in antigen presenting cells is a master regulator for Th17-mediated autoimmune pathology

Authors: Stephan Blüml, Gernot Schabbauer, Eva Hainzl, Birgit Niederreiter, Anastasia Hladik, Tobias Lohmeyer, Michael Bonelli, Elisabeth Zinser, Marije Koenders, Wim van den Berg, Giulio Superti-Furga, Josef S Smolen and Kurt Redlich

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P9

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Acute Serum Amyloid A induces cell migration cytoskeletal rearrangement and Notch signalling in rheumatoid arthritis

Authors: Mary Connolly, Peadar Rooney, Wei Gao, Douglas Veale and Ursula Fearon

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P10

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Cigarette smoke downregulates HDAC2 in rheumatoid arthritis synovial fibroblasts

Authors: Anna Engler, Astrid Jüngel, Christoph Kolling, Beat A Michel, Renate Gay, Steffen Gay and Caroline Ospelt

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P11

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Egr-1 mediates the suppressive effect of IL-1 on PPARg expression in human OA chondrocytes

Authors: Sarah S Nebbaki, Fatima Ezzahra El Mansouri, Mohamed Benderdour, Johanne Martel-Pelletier, Jean-Pierre Pelletier and Hassan Fahmi

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P12

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Prevalence of interstitial lung disease among patients with systemic sclerosis in Iraqi Kurdistan

Authors: Taha Ahmad Qaradakhy, Kosar Mohamed Ali and Omer Hama Karim

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P13

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MiRs in RA: possible biomarkers and therapeutic targets

Authors: Maria Filkova, Caroline Ospelt, Joanna Stanczyk, Serena Vettori, Ladislav Senolt, Mojca Frank, Christoph Kolling, Beat A Michel, Renate E Gay, Steffen Gay and Astrid Jüngel

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P14

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Immune cell - derived microparticles contribute to the resistance of rheumatoid arthritis synovial fibroblasts to death receptor-mediated apoptosis

Authors: Mojca Frank, Meike Dahlhaus, Maria Filkova, Christoph Kolling, Beat A Michel, Diego Kyburz, Blaž Rozman, Renate E Gay, David Pisetsky, Steffen Gay and Astrid Jüngel

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P15

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Increased concentration of serum soluble LAG3 in systemic lupus erythematosus

Authors: Seri Yu, Keishi Fujio, Kazuyoshi Ishigaki, Hirofumi Shoda, Tomohisa Okamura, Tanita Noor, Shuji Sumitomo and Kazuhiko Yamamoto

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P16

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GCIP, Id like HLH protein, negatively regulates cell proliferation of rheumatoid synovial cells via interaction with CBP

Authors: Hidetoshi Fujita, Minako Nakazawa, Satoko Aratani, Kusuki Nishioka, Akiyoshi Fukamizu and Toshihiro Nakajima

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P17

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Unc93 homolog B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9 response

Authors: Ryutaro Fukui, Shin-Ichiroh Saitoh, Atsuo Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida and Kensuke Miyake

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P18

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Balb/c FasKO mice develop allergic blepharitis associated with hyper-production of IgE

Authors: Ayumi Fukuoka, Shizue Yumikura-Futatsugi, Suzuka Takahashi, Hirotaka Kazama, Kenji Nakanishi and Shin Yonehara

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P19

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Stimulation of bone formation in cortical bone of the mice treated with a novel bone anabolic peptide with osteoclastogenesis inhibitory activity

Authors: Yuriko Furuya, Kohji Uchida and Hisataka Yasuda

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P20

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T-regs/Th17 function defect in systemic autoimmunity as a result of "recent thymic emigrants" maturation defect

Authors: Mark Goloviznin, Natalia Lakhonina, Alexander Yarilin, Yulia Buldakova, Vitaly Timofeev, Tatiana Kremenchugskaya and Marina Struchkova

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P21

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Dendritic cell immunoreceptor (DCIR) is associated with anti-cyclic citrullinated peptides (anti-CCP) antibody - negative rheumatoid arthritis in Chinese Han population

Authors: Jianping Guo, Xinyu Wu, Xiaolan Lu, Yin Su, Ru Li, Jing He, Xu Liu and Zhanguo Li

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P22

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Association between serum level of Vitamin D with autoantibodies expression, disease activity (SLEDAI) and bone mineral density (BMD) in patients with Systemic Lupus Erythematosus (SLE)

Authors: Handono Kalim, Singgih Wahono, Putra Suryana BP, Lenny Puspitasari, Fajar Hadi Wijayanto and Kusworini Handono

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P23

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Uncoupling protein 3 attenuates generation of reactive oxygen species by interacting with thioredoxin 2 in the mitochondrial intermembrane space

Authors: Katsuya Hirasaka, Edward M Mills, Shohei Kohno, Tomoki Abe, Chika Ikeda, Tasuku Maeda, Shigetada Kondo, Ayako Maita, Yuushi Okumura and Takeshi Nikawa

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P24

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Conditional inactivation of the ectodomain shedding of pro-TNFα in monocytes prevents lethality from LPS-induced septic shock

Authors: Keisuke Horiuchi, Tokuhiro Kimura, Yasunori Okada, Kazuhiro Chiba, Carl P Blobel and Yoshiaki Toyama

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P25

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Community-based epidemiological study on hyperuricemia and gout over 5 years in Huang-pu district, Shanghai

Authors: Hui Du, Shun-Le Chen, Chun-De Bao, Xiao-Dong Wang, Yuan Wang, Yue-Ying Gu and Kusuki Nishioka

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P26

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Adrenal function in rheumatoid arthritis: a correlation with disease activity

Authors: Richard Imrich, Miroslav Vlcek, Jana Kerlik, Michael Vogeser, Fabian Kirchhoff, Adela Penesova, Zofia Radikova, Jozef Lukac and Jozef Rovensky

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P27

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Rheumatoid arthritis fibroblast-like synoviocytes show the upregulation of myeloid cell specific transcription factor PU.1 and B cell specific transcriptional co-activator OBF-1, and express functional BCMA

Authors: Kenji Itoh and Katsuya Nagatani

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P28

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Methyl glyoxal increase apoptosis (CASPASE-3 expression) in pre-osteoblast MC3T3E1 cell line via SOD activity

Authors: Izaak Zoelkarnain Akbar, Handono Kalim, Djoko Wahono Soeatmadji and Mohammad Hidayat

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P29

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Discrepancy between patient and physician in assessment of global severity in early rheumatoid arthritis

Authors: Yuko Kaneko, Masataka Kuwana and Tsutomu Takeuchi

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P30

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Cartilage-specific deletion of prar-gamma in mice results in early endochondral ossification defects and accelerated aging-dependent development of osteoarthritis

Authors: Roxana Monemdjou, Faezeh Vasheghani, Hassan Fahmi, Gemma Perez, Meryem Blati, Noboru Taniguchi, Martin Lotz, René St-Arnaud, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Frank Beier and Mohit Kapoor

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P31

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Average findings of uric acid in blood in patients with gout with different categories of hyperglycemia

Authors: Ulugbek K Kayumov, Marif Sh Karimov and Nargiza A Abdukhakimova

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P32

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Effect of B cell depletion using peptide tetramers in collagen-induced arthritis

Authors: Kazuya Michishita, Kimito Kawahata, Takeyuki Kanzaki, Lisa Akahira, Toshiki Eri and Kazuhiko Yamamoto

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P33

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Peripheral tolerance induced by apoptotic cells and PD-1+ CD8 T cells

Authors: Hirotaka Kazama, Tomonori Iyoda, Satoko Yokoyama, Kayo Inaba, Thomas A Ferguson and Shin Yonehara

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P34

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Decreased plating efficiency, proliferation and osteogenic differentiation of synovial fluid mesenchymal progenitors as a marker of severity of juvenile idiopathic arthritis

Authors: Elvira Lazic Mosler, Marija Jelusic-Drazic, Danka Grcevic, Ana Marusic and Natasa Kovacic

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P35

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LC-MS/MS-based shotgun proteomics identified the targets of arthritis-related microRNA

Authors: Riho Kurata, Tomo Yonezawa, Hideki Nakajima, Shyuji Takada and Hiroshi Asahara

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P36

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T cell receptor rearrangement excision circles (TREC) study as an approach to "in vivo" thymus gland function investigation

Authors: Natalia Lakhonina, Mark Goloviznin, Almira Donetskova, Margarita Nikonova, Alexander Yarilin, Yulia Buldakova and Anna Tektova

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P37

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Fas deficiency attenuates bone loss during antigen induced arthritis in mice

Authors: Elvira Lazic Mosler, Sania Kuzmac, Sanja Ivcevic, Danka Grcevic, Ana Marusic and Natasa Kovacic

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P38

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Abnormal expressions of immune response-related genes in RA bone marrow cells

Authors: Hooi-Ming Lee, Chieko Aoki, Yasunori Shimaoka, Kensuke Ochi, Takahiro Ochi and Norihiro Nishimoto

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P39

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Risk factors for latent tuberculosis infection in RA patients treated with anti-tumor necrosis factor

Authors: Shiang-Fen Huang, Wei-Juin Su, Sheng-Yuan Ruan, Chong-Jen Yu, Song-Chou Hsieh, Yu-Chih Liu, Yeong-Jian Jan Wu and Hsiao-Yi Lin

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P40

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TGF-β signaling induces SnoN to suppress BMP-induced hypertrophic maturation of chondrocytes

Authors: Shingo Maeda, Ichiro Kawamura, Yasuhiro Ishidou, Katsuyuki Imamura, Masahiro Yokouchi and Setsuro Komiya

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P41

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Activation of TRPV4 promotes osteoclasts differentiation

Authors: Ritsuko Masuyama

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P42

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STAT3 is critical to promote inflammatory cytokines and RANKL expression in inflammatory arthritis

Authors: Takeshi Miyamoto, Tomoaki Mori, Akihiko Yoshimura and Toshiaki Toyama

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P43

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Combined depletion of interleukin-1 and interleukin-6 does not exceed single depletion of interleukin -1 in TNF-mediated arthritis

Authors: Silvia Hayer, B Niederreiter, J Smolen and K Redlich

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P44

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The functions of the post-translational modifications in rheumatoid arthritis

Authors: Satoko Aratani, Naoko Yagishita, Teruhisa Kanazawa, Fukami Nakajima, Yoshihisa Yamano, Kusuki Nishioka and Toshihiro Nakajima

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P45

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Neutrophils are the source of IL-17 and RANKL in zymosan induced arthritis

Authors: Viktoriya I Milanova, Nina D Ivanovska and Petya A Dimitrova

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P46

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Role of HLA-antigens class 1 in the development of rheumatoid arthritis in Uzbek women

Authors: Nazima N Mirakhmedova and Mavlyuda I Mirzakhanova

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P47

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SNP algorithms for prediction of efficacy and adverse events of abatacept (ABT)

Authors: James E Middleton, Tsukasa Matsubara, Keiko Funahashi, Satoru Koyano, Takafumi Hagiwara, Takako Miura, Kosuke Okuda, Takeshi Nakamura, Mitsuyoshi Iwahashi, Tomomi Tsuru, Shoichi Uchimura and Shigeru Honjo

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P48

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Maintenance of mitochondrial DNA copy number is essential for osteoclast survival

Authors: Tsuyoshi Miyazaki, Shuuichi Mori, Kazuhiro Shigemoto, Nils-Goran Larsson, Takeshi Nakamura, Shigekaki Kato, Tomoki Nakashima, Hiroshi Takayanagi and Sakae Tanaka

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P49

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Over expression of toll-like receptors in peripheral blood and synovial fluid monocytes of enthesitis related arthritis category of juvenile idiopathic arthritis (JIA-ERA) patients contributes to secretion of inflammatory mediators

Authors: Arpita Myles and Amita Aggarwal

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P50

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Pilocarpine suppresses hyperalgesia induced by intermittent cold stress (ICS) as an experimental fibromyalgia model in mice

Authors: Jun Nagai, Michiko Nishiyori and Hiroshi Ueda

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P51

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Application of tetraspanin CD81 RNAi for diagnosis and therapy of rheumatoid arthritis (RA)

Authors: Tohru Nakanishi, Yuji Arai, Hiroki Mori, Toshihiro Nakajima and Toshikazu Kubo

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P52

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The crucial role of osteocyte-derived RANKL in bone homeostasis

Authors: Tomoki Nakashima, Mikihito Hayashi and Hiroshi Takayanagi

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P53

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Active repression by Blimp1 play an important role in osteoclast differentiation

Authors: Keizo Nishikawa, Tomoki Nakashima, Mikihito Hayashi, Takanobu Fukunaga, Shigeaki Kato, Tatsuhiko Kodama, Satoru Takahashi, Kathryn Calame and Hiroshi Takayanagi

Citation: Arthritis Research & Therapy 2012 14(Suppl 1):P54

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Proceedings of the 8th Global Arthritis Research Network (GARN) Meeting and 1st Bio-Rheumatology International Congress (BRIC)

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