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  1. To determine (i) correlates for etanercept (ETA) discontinuation after achieving an inactive disease and for the subsequent risk of flare and (ii) to analyze the effectiveness of ETA in the re-treatment after ...

    Authors: Jens Klotsche, Ariane Klein, Martina Niewerth, Paula Hoff, Daniel Windschall, Ivan Foeldvari, Johannes-Peter Haas, Gerd Horneff and Kirsten Minden
    Citation: Arthritis Research & Therapy 2021 23:118
  2. This multi-center, retrospective study aimed to clarify retention rates and reasons for discontinuation of either tumor necrosis factor inhibitors (TNFi) or interleukin-6 inhibitors (IL-6i) in patients with el...

    Authors: Sadao Jinno, Akira Onishi, Maureen Dubreuil, Motomu Hashimoto, Wataru Yamamoto, Koichi Murata, Tohru Takeuchi, Takuya Kotani, Yuichi Maeda, Kosuke Ebina, Yonsu Son, Hideki Amuro, Ryota Hara, Masaki Katayama and Jun Saegusa
    Citation: Arthritis Research & Therapy 2021 23:116
  3. Gout stems from both modifiable and genetic sources. We evaluated the risk of gout among Taiwanese adults with aldehyde dehydrogenase-2 (ALDH2) rs671 single nucleotide polymorphism (SNP) according to body mass...

    Authors: Yu-Ruey Liu, Disline Manli Tantoh, Chuan-Chao Lin, Chih-Hsuan Hsiao and Yung-Po Liaw
    Citation: Arthritis Research & Therapy 2021 23:115
  4. Ribonucleases (RNases) play central roles in the post-transcriptional regulation of mRNA stability. Our preliminary results revealed that the endonuclease Regnase-1 is specifically upregulated in osteoarthriti...

    Authors: Jeong-In Yang and Jang-Soo Chun
    Citation: Arthritis Research & Therapy 2021 23:114
  5. Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as a major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be respo...

    Authors: Anne Gigout, Donata Harazin, Louise M. Topping, Didier Merciris, Sven Lindemann, Christian Brenneis and Ahuva Nissim
    Citation: Arthritis Research & Therapy 2021 23:113
  6. Timely diagnosis and treatment are essential in the effective management of inflammatory rheumatic diseases (IRDs). Symptom checkers (SCs) promise to accelerate diagnosis, reduce misdiagnoses, and guide patien...

    Authors: Johannes Knitza, Jacob Mohn, Christina Bergmann, Eleni Kampylafka, Melanie Hagen, Daniela Bohr, Harriet Morf, Elizabeth Araujo, Matthias Englbrecht, David Simon, Arnd Kleyer, Timo Meinderink, Wolfgang Vorbrüggen, Cay Benedikt von der Decken, Stefan Kleinert, Andreas Ramming…
    Citation: Arthritis Research & Therapy 2021 23:112
  7. Vaspin is a novel anti-inflammatory adipokine associated with cardiovascular (CV) disease and inflammation in chronic inflammatory conditions different from axial spondyloarthritis (axSpA). Given the high inci...

    Authors: Javier Rueda-Gotor, Raquel López-Mejías, Sara Remuzgo-Martínez, Verónica Pulito-Cueto, Alfonso Corrales, Leticia Lera-Gómez, Virginia Portilla, Íñigo González-Mazón, Ricardo Blanco, Rosa Expósito, Cristina Mata, Javier Llorca, Vanesa Hernández-Hernández, Carlos Rodríguez-Lozano, Nuria Barbarroja, Rafaela Ortega Castro…
    Citation: Arthritis Research & Therapy 2021 23:111
  8. Osteoarthritis (OA) has long been regarded as a disease of cartilage degeneration, whereas mounting evidence implies that low-grade inflammation contributes to OA. Among inflammatory cells involved, macrophage...

    Authors: Xiaobo Zhu, Chien-Wei Lee, Hongtao Xu, Yu-Fan Wang, Patrick S. H. Yung, Yangzi Jiang and Oscar K. Lee
    Citation: Arthritis Research & Therapy 2021 23:110
  9. Neutrophils are the most prevalent immune cells in the synovial fluid in inflamed joints of children with oligoarticular juvenile idiopathic arthritis (JIA). Despite this, little is known about neutrophil func...

    Authors: Sabine Arve-Butler, Tobias Schmidt, Anki Mossberg, Elisabet Berthold, Birgitta Gullstrand, Anders A. Bengtsson, Fredrik Kahn and Robin Kahn
    Citation: Arthritis Research & Therapy 2021 23:109
  10. Hormonal reproductive factors have been suggested to play an important role in the etiology of rheumatoid arthritis (RA), an autoimmune inflammatory disorder affecting primarily women. We conducted a two-sampl...

    Authors: Jingjing Zhu, Zheng Niu, Lars Alfredsson, Lars Klareskog, Leonid Padyukov and Xia Jiang
    Citation: Arthritis Research & Therapy 2021 23:108

    The Correspondence to this article has been published in Arthritis Research & Therapy 2022 24:237

  11. To perform a meta-analysis comparing the structural progression and clinical symptom outcomes as well as adverse events experienced from intra-articular injections of sprifermin compared to a placebo treatment...

    Authors: Ni Zeng, Xin-Yuan Chen, Zhi-Peng Yan, Jie-Ting Li, Tao Liao and Guo-Xin Ni
    Citation: Arthritis Research & Therapy 2021 23:107
  12. Radiographs of the sacroiliac joints are commonly used for the diagnosis and classification of axial spondyloarthritis. The aim of this study was to develop and validate an artificial neural network for the de...

    Authors: Keno K. Bressem, Janis L. Vahldiek, Lisa Adams, Stefan Markus Niehues, Hildrun Haibel, Valeria Rios Rodriguez, Murat Torgutalp, Mikhail Protopopov, Fabian Proft, Judith Rademacher, Joachim Sieper, Martin Rudwaleit, Bernd Hamm, Marcus R. Makowski, Kay-Geert Hermann and Denis Poddubnyy
    Citation: Arthritis Research & Therapy 2021 23:106
  13. The dietary inflammatory index (DII®), a quantitative measure of the inflammatory potential of daily food and nutrient intake, and associations between a variety of health outcomes have been reported. However,...

    Authors: Yoshinari Matsumoto, Nitin Shivappa, Yuko Sugioka, Masahiro Tada, Tadashi Okano, Kenji Mamoto, Kentaro Inui, Daiki Habu, James R. Hebert and Tatsuya Koike
    Citation: Arthritis Research & Therapy 2021 23:105
  14. Elevated levels of periostin (Postn) in the cartilage and bone are associated with osteoarthritis (OA). However, it remains unknown whether Postn loss-of-function can delay or prevent the development of OA. In...

    Authors: Mukundan Attur, Xin Duan, Lei Cai, Tianzhen Han, Weili Zhang, Eric D. Tycksen, Jonathan Samuels, Robert H. Brophy, Steven B. Abramson and Muhammad Farooq Rai
    Citation: Arthritis Research & Therapy 2021 23:104
  15. C–C chemokine receptor 2 (CCR2) signaling plays a key role in pain associated with experimental murine osteoarthritis (OA) after destabilization of the medial meniscus (DMM). Here, we aimed to assess if CCR2 e...

    Authors: Shingo Ishihara, Alia M. Obeidat, David L. Wokosin, Dongjun Ren, Richard J. Miller, Anne-Marie Malfait and Rachel E. Miller
    Citation: Arthritis Research & Therapy 2021 23:103
  16. Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized systemic, immune-mediated, and fibro-inflammatory disease. Hypocomplementemia was found in part of IgG4-RD patients especially in the setting o...

    Authors: Linyi Peng, Hui Lu, Jiaxin Zhou, Panpan Zhang, Jieqiong Li, Zheng Liu, Di Wu, Shangzhu Zhang, Yunjiao Yang, Wei Bai, Li Wang, Yunyun Fei, Wen Zhang, Yan Zhao, Xiaofeng Zeng and Fengchun Zhang
    Citation: Arthritis Research & Therapy 2021 23:102
  17. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Emily Mirizio, Tracy Tabib, Xinjun Wang, Wei Chen, Christopher Liu, Robert Lafyatis, Heidi Jacobe and Kathryn S. Torok
    Citation: Arthritis Research & Therapy 2021 23:101

    The original article was published in Arthritis Research & Therapy 2020 22:263

  18. This study aimed to analyze the literature systematically to determine the clinical characteristics and prognosis of patients with connective tissue disease (CTD) with combined pulmonary fibrosis and emphysema...

    Authors: Bon San Koo, Kyu Yong Park, Hyun Jung Lee, Hyun Jung Kim, Hyeong Sik Ahn, Shin-Young Yim and Jae-Bum Jun
    Citation: Arthritis Research & Therapy 2021 23:100
  19. Sjögren’s syndrome (SjS), one of the most common autoimmune diseases, impacts millions of people annually. SjS results from autoimmune attack on exocrine (salivary and lacrimal) glands, and women are nine time...

    Authors: Ali Akgul, Massimo Maddaloni, Sang Mu Jun, Andrew S. Nelson, Vanessa Aguilera Odreman, Carol Hoffman, Ella Bhagyaraj, Alexandria Voigt, Jeffrey R. Abbott, Cuong Q. Nguyen and David W. Pascual
    Citation: Arthritis Research & Therapy 2021 23:99
  20. IgG4-related ophthalmic disease (IgG4-ROD) is one of the phenotypes of IgG4-related disease (IgG4-RD), and its lesions are mainly located in the ocular. Currently, there are few studies on IgG4-ROD and no stud...

    Authors: Zhen Zhao, Dapeng Mou, Ziqiao Wang, Qiaozhu Zeng, Zhenfan Wang, Jimeng Xue, Limin Ren, Yanying Liu and Yin Su
    Citation: Arthritis Research & Therapy 2021 23:98
  21. To investigate the potential utility of quantitative parameters obtained by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the assessment of disease severity and the o...

    Authors: Liyan Wan, Yuting Gao, Jieyu Gu, Huihui Chi, Zhihong Wang, Qiongyi Hu, Jinchao Jia, Tingting Liu, Biao Li, Jialin Teng, Honglei Liu, Xiaobing Cheng, Junna Ye, Yutong Su, Chengde Yang, Hui Shi…
    Citation: Arthritis Research & Therapy 2021 23:97
  22. Excessive salt intake is thought to exacerbate both development of hypertension and autoimmune diseases in animal models, but the clinical impact of excessive salt in rheumatoid arthritis (RA) patients is stil...

    Authors: Hiroto Minamino, Masao Katsushima, Motomu Hashimoto, Yoshihito Fujita, Tamami Yoshida, Kaori Ikeda, Nozomi Isomura, Yasuo Oguri, Wataru Yamamoto, Ryu Watanabe, Kosaku Murakami, Koichi Murata, Kohei Nishitani, Masao Tanaka, Hiromu Ito, Koichiro Ohmura…
    Citation: Arthritis Research & Therapy 2021 23:96

    The Letter to this article has been published in Arthritis Research & Therapy 2021 23:195

    The Letter to this article has been published in Arthritis Research & Therapy 2021 23:183

  23. To explore glucose metabolism in rheumatoid arthritis (RA) and its association with insulin resistance (IR) risk factors and disease activity indicators, including matrix metalloproteinase-3 (MMP3).

    Authors: Gorica G. Ristić, Vesna Subota, Dejana Stanisavljević, Danilo Vojvodić, Arsen D. Ristić, Branislava Glišić, Milan Petronijević and Dušan Z. Stefanović
    Citation: Arthritis Research & Therapy 2021 23:95
  24. In psoriatic arthritis (PsA), further understanding of the relationships between clinical measures and patient-reported outcomes (PROs) is needed. This post hoc analysis evaluated associations between minimal ...

    Authors: Laura C. Coates, Andrew G. Bushmakin, Oliver FitzGerald, Dafna D. Gladman, Lara Fallon, Joseph C. Cappelleri, Ming-Ann Hsu and Philip S. Helliwell
    Citation: Arthritis Research & Therapy 2021 23:94
  25. Obesity is one of the largest modifiable risk factors for the development of musculoskeletal diseases, including intervertebral disc (IVD) degeneration and back pain. Despite the clinical association, no studi...

    Authors: Geoffrey J. Kerr, Bethia To, Ian White, Magali Millecamps, Frank Beier, Matthew W. Grol, Laura S. Stone and Cheryle A. Séguin
    Citation: Arthritis Research & Therapy 2021 23:93
  26. Giant cell arteritis (GCA) may lead to vision loss. To what extent tocilizumab (TCZ) is able to prevent vision loss is unknown. The aim was to analyze the occurrence of vision loss in a large GCA cohort treate...

    Authors: Jennifer Amsler, Iveta Kysela, Christoph Tappeiner, Luca Seitz, Lisa Christ, Godehard Scholz, Odile Stalder, Florian Kollert, Stephan Reichenbach and Peter M. Villiger
    Citation: Arthritis Research & Therapy 2021 23:92
  27. We previously identified tissue inhibitor of metalloproteinase 1 (TIMP-1) as a biomarker of disease activity that distinguished mildly or highly active antineutrophil cytoplasmic antibody (ANCA)-associated vas...

    Authors: Jun Ishizaki, Ayako Takemori, Kenta Horie, Daisuke Hiraoka, Koichiro Suemori, Takuya Matsumoto, Ken-ei Sada, Koichi Amano, Masayoshi Harigai, Yoshihiro Arimura, Hirofumi Makino, Katsuto Takenaka, Nobuaki Takemori and Hitoshi Hasegawa
    Citation: Arthritis Research & Therapy 2021 23:91
  28. Serious infections (SI) are common in patients with ANCA-associated vasculitides (AAV) like granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Real-life data regarding their incidence a...

    Authors: Konstantinos Thomas, Evangelia Argyriou, Noemin Kapsala, Alexandros Panagiotopoulos, Aglaia Chalkia, Emilia Hadziyannis, Kyriaki Boki, Pelagia Katsimbri, Dimitrios T. Boumpas, Panagiota Giannou, Dimitrios Petras and Dimitrios Vassilopoulos
    Citation: Arthritis Research & Therapy 2021 23:90
  29. Several studies on community populations found that metabolic syndrome (MetS) is associated with higher risk for total incident cancer with a predisposition for specific types of cancer. These findings have ne...

    Authors: Giovanni Cioffi, Ombretta Viapiana, Luigi Tarantini, Giovanni Orsolini, Luca Idolazzi, Federica Ognibeni, Andrea Dalbeni, Davide Gatti, Angelo Fassio, Giovanni Adami, Maurizio Rossini and Alessandro Giollo
    Citation: Arthritis Research & Therapy 2021 23:89
  30. Monosodium urate (MSU) crystals, i.e., the central etiological factors in gouty arthritis, induce the formation of neutrophil extracellular traps (NETs). We investigated whether synovial macrophages could clea...

    Authors: Ji Hye Jeong, Su Jin Choi, Soo Min Ahn, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo and Seokchan Hong
    Citation: Arthritis Research & Therapy 2021 23:88
  31. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Øystein Maugesten, Alexander Mathiessen, Hilde Berner Hammer, Sigrid Valen Hestetun, Tore Kristian Kvien, Till Uhlig, Sarah Ohrndorf and Ida Kristin Haugen
    Citation: Arthritis Research & Therapy 2021 23:87

    The original article was published in Arthritis Research & Therapy 2020 22:98

  32. Mepolizumab (MPZ), an anti-interleukin-5 antibody, is effective for the treatment of eosinophilic granulomatosis with polyangiitis (EGPA). However, its effectiveness has not been adequately evaluated in real-w...

    Authors: Masanobu Ueno, Ippei Miyagawa, Kazuhisa Nakano, Shigeru Iwata, Kentaro Hanami, Shunsuke Fukuyo, Satoshi Kubo, Yusuke Miyazaki, Akio Kawabe, Hiroko Yoshinari, Shingo Nakayamada and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2021 23:86
  33. Receptor-interacting protein kinase 1 (RIPK1) is a key mediator of inflammation through cell death and proinflammatory cytokine production. This multicenter, randomized, double-blind (sponsor-unblinded), place...

    Authors: Kathleen Weisel, Scott Berger, Katie Thorn, Peter C. Taylor, Charles Peterfy, Hilary Siddall, Debra Tompson, Susanne Wang, Emilia Quattrocchi, Susan W. Burriss, Jochen Walter and Paul Peter Tak
    Citation: Arthritis Research & Therapy 2021 23:85
  34. The transforming growth factor-β (TGF-β) signaling pathway plays an essential role in maintaining homeostasis in joints affected by osteoarthritis (OA). However, the specific mechanism of non-SMAD and classica...

    Authors: Wenjuan Wang, Yanhui Zhu, Zhenyu Sun, Chen Jin and Xiang Wang
    Citation: Arthritis Research & Therapy 2021 23:84
  35. This study aimed to investigate the ability of whole-body bone scintigraphy (WB-BS) in the detection of multifocal osteonecrosis (ON) compared to whole-body magnetic resonance imaging (WB-MRI) and to clarify t...

    Authors: Shunichi Yokota, Keita Sakamoto, Yukie Shimizu, Tsuyoshi Asano, Daisuke Takahashi, Kohsuke Kudo, Norimasa Iwasaki and Tomohiro Shimizu
    Citation: Arthritis Research & Therapy 2021 23:83
  36. Giant cell arteritis (GCA) is a common large vessel vasculitis in those over age 50 years. This meta-analysis examined the geographical and temporal distribution of the incidence, prevalence, and mortality of ...

    Authors: Katherine J. Li, Daniel Semenov, Matthew Turk and Janet Pope
    Citation: Arthritis Research & Therapy 2021 23:82
  37. Osteoarthritis (OA) is a common skeletal system disease that has been partially attributed to genetic factors. The hand is frequently affected, which seriously affects the patient’s quality of life. However, t...

    Authors: Jiawen Xu, Yi Zeng, Haibo Si, Yuan Liu, Mingyang Li, Junfeng Zeng and Bin Shen
    Citation: Arthritis Research & Therapy 2021 23:81
  38. Despite the success of TNF-inhibitor therapy in rheumatoid arthritis treatment, up to 40% of patients fail to respond adequately. This study aimed to identify transcriptome-based biomarkers of adalimumab respo...

    Authors: James Oliver, Nisha Nair, Gisela Orozco, Samantha Smith, Kimme L. Hyrich, Ann Morgan, John Isaacs, Anthony G. Wilson, Anne Barton and Darren Plant
    Citation: Arthritis Research & Therapy 2021 23:80

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:139

  39. While survival of systemic lupus erythematosus (SLE) patients has improved substantially, problems remain in the management of their emotional health. Medium to high-dose glucocorticoid doses are known to wors...

    Authors: Yoshia Miyawaki, Sayaka Shimizu, Yusuke Ogawa, Ken-ei Sada, Yu Katayama, Yosuke Asano, Keigo Hayashi, Yuriko Yamamura, Sumie Hiramatsu-Asano, Keiji Ohashi, Michiko Morishita, Haruki Watanabe, Mariko Takano-Narazaki, Yoshinori Matsumoto, Nobuyuki Yajima, Ryusuke Yoshimi…
    Citation: Arthritis Research & Therapy 2021 23:79
  40. Osteoarthritis (OA) is a disabling joint disease that causes articular cartilage degeneration. It has been implicated that altered expression of histone deacetylase 2 (HDAC2) is found in patients with OA. Howe...

    Authors: Zheng Wang, Nan Zhou, Wengang Wang, Yangke Yu, Lei Xia and Ning Li
    Citation: Arthritis Research & Therapy 2021 23:78
  41. To investigate whether serum chitinase-3-like 1 protein (YKL-40) is associated with disease activity in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

    Authors: Sung Soo Ahn, Taejun Yoon, Yong-Beom Park, Maria Prendecki, Gurjeet Bhangal, Stephen P. McAdoo and Sang-Won Lee
    Citation: Arthritis Research & Therapy 2021 23:77
  42. Interstitial lung disease is a common complication of systemic sclerosis (SSc-ILD), and it remains difficult to accurately predict its course. Progressing ILD could be more metabolically active, suggesting tha...

    Authors: Emmanuel Ledoult, Maxime Morelle, Michael Soussan, Arsène Mékinian, Hélène Béhal, Vincent Sobanski, Eric Hachulla, Damien Huglo, Noémie Le Gouellec, Martine Remy-Jardin, Clio Baillet and David Launay
    Citation: Arthritis Research & Therapy 2021 23:76
  43. Prevention of hyperuricaemia (HU) is critical to the prevention of gout. Understanding causal relationships and relative contributions of various risk factors to hyperuricemia is therefore important in the pre...

    Authors: Ruth K. G. Topless, Tanya J. Major, Jose C. Florez, Joel N. Hirschhorn, Murray Cadzow, Nicola Dalbeth, Lisa K. Stamp, Philip L. Wilcox, Richard J. Reynolds, Joanne B. Cole and Tony R. Merriman
    Citation: Arthritis Research & Therapy 2021 23:75
  44. Evidence on longitudinal variability of serum uric acid (SUA) and risk of all-cause mortality in the general population is limited, as many prior studies focused on a single measurement of SUA.

    Authors: Xue Tian, Anxin Wang, Yingting Zuo, Shuohua Chen, Licheng Zhang, Shouling Wu and Yanxia Luo
    Citation: Arthritis Research & Therapy 2021 23:74
  45. An amendment to this paper has been published and can be accessed via the original article.

    Authors: David A. Fox, Steven K. Lundy, Michael L. Whitfield, Veronica Berrocal, Phillip Campbell, Stephanie Rasmussen, Ray Ohara, Alexander Stinson, Mikel Gurrea-Rubio, Evan Wiewiora, Catherine Spino, Erica Bush, Daniel Furst, Shiv Pillai and Dinesh Khanna
    Citation: Arthritis Research & Therapy 2021 23:73

    The original article was published in Arthritis Research & Therapy 2021 23:10

  46. Ankylosing spondylitis (AS), as a common inflammatory rheumatic disease, often causes depression and impaired health-related quality of life (QoL). Although positive effects of patient education have been demo...

    Authors: Yuqing Song, Xia Xie, Yanling Chen, Ying Wang, Hui Yang, Anliu Nie and Hong Chen
    Citation: Arthritis Research & Therapy 2021 23:72

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:149

  47. Older adults with concurrent low back and hip pain are predisposed to reductions in physical performance and health-related quality of life. Yet no study to date has assessed whether or not coexisting hip impa...

    Authors: Patrick J. Knox, Peter C. Coyle, Jenifer M. Pugliese, Ryan T. Pohlig, Jaclyn M. Sions and Gregory E. Hicks
    Citation: Arthritis Research & Therapy 2021 23:71
  48. Lupus animal model has shown that arsenic trioxide (ATO), a treatment of acute promyelocytic leukaemia, could be effective in SLE. This is the first clinical study to determine the safety and efficacy of a sho...

    Authors: Mohamed Hamidou, Antoine Néel, Joel Poupon, Zahir Amoura, Mikael Ebbo, Jean Sibilia, Jean-Francois Viallard, Benjamin Gaborit, Christelle Volteau, Jean Benoit Hardouin, Eric Hachulla and François Rieger
    Citation: Arthritis Research & Therapy 2021 23:70
  49. Although the relationship between obesity and incident gout has been clarified, the influence of weight changes during the transition from early adulthood to midlife and the different weight change patterns in...

    Authors: Lu Bai, Jian-Bo Zhou, Tao Zhou, Roger B. Newson and Marly Augusto Cardoso
    Citation: Arthritis Research & Therapy 2021 23:69
  50. Although drug therapy for rheumatoid arthritis (RA) has recently improved, treating patients with established disease, whose hands have three major deformities (thumb deformity, finger deformities, and ulnar d...

    Authors: Shogo Toyama, Daisaku Tokunaga, Shinji Tsuchida, Rie Kushida, Ryo Oda, Yutaka Kawahito and Kenji Takahashi
    Citation: Arthritis Research & Therapy 2021 23:66

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