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  1. We investigated the role of Fcγ receptors (FcγRs) on synovial macrophages in immune-complex-mediated arthritis (ICA). ICA elicited in knee joints of C57BL/6 mice caused a short-lasting, florid inflammation and...

    Authors: Arjen B Blom, Peter L van Lent, Hanneke van Vuuren, Astrid E Holthuysen, Cor Jacobs, Leo B van de Putte, Jan G van de Winkel and Wim B van den Berg
    Citation: Arthritis Research & Therapy 2000 2:489
  2. Mesenchymal precursor cells found in the blood (BMPCs) of normal persons adhere to plastic and glass and proliferate logarithmically in DMEM-20% fetal calf serum (FCS) without growth factors. They form cells w...

    Authors: Nathan J Zvaifler, Lilla Marinova-Mutafchieva, Gill Adams, Christopher J Edwards, Jill Moss, Jan A Burger and Ravinder N Maini
    Citation: Arthritis Research & Therapy 2000 2:477
  3. In rheumatoid arthritis, T cells and B cells participate in the immune responses evolving in the synovial lesions. Interaction between T cells and B cells is probably antigen specific because complex microstru...

    Authors: Cornelia M Weyand, Jörg J Goronzy, Seisuke Takemura and Paul J Kurtin
    Citation: Arthritis Research & Therapy 2000 2:457
  4. The Sa system is a recently described immune system that has a specificity and positive predictive value of nearly 100% for rheumatoid arthritis (RA) in Asia, Europe and the Americas. Its sensitivity of 30-40%...

    Authors: Henri A Ménard, Elvy Lapointe, Moulay D Rochdi and Zhi J Zhou
    Citation: Arthritis Research & Therapy 2000 2:429
  5. The advances in biomedicine over the past decade have provided revolutionary insights into molecules that mediate cell proliferation and differentiation. Findings on the complex interplay of cells, growth fact...

    Authors: Olaf Schultz, Michael Sittinger, Thomas Haeupl and Gerd R Burmester
    Citation: Arthritis Research & Therapy 2000 2:433
  6. Bone loss occurs when the cellular events of bone formation are quantitatively larger than bone formation. This manuscript discusses the measurement of bone loss, occurrence in the population, risk factors and...

    Authors: David J Hunter and Philip N Sambrook
    Citation: Arthritis Research & Therapy 2000 2:441
  7. This study describes the upregulation of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion (DRG) neurons in the course of antigen-induced arthritis (AIA) in the rat knee. In the acute phase of AI...

    Authors: Gisela Segond von Banchet, Peter K Petrow, Rolf Bräuer and Hans-Georg Schaible
    Citation: Arthritis Research & Therapy 2000 2:424
  8. The antigenic specificity of an unusual antinuclear antibody pattern in three patient sera was identified after separating HeLa-cell nuclear extracts by two-dimensional (2D) gel electrophoresis and localizing ...

    Authors: Niels HH Heegaard, Martin R Larsen, Terri Muncrief, Allan Wiik and Peter Roepstorff
    Citation: Arthritis Research & Therapy 2000 2:407
  9. IL-10, IL-13, IFN-γ, tumor necrosis factor (TNF)-α, LT-α, CD154, and TNF-related activation-induced cytokine (TRANCE) were expressed by 2-20% of rheumatoid arthritis (RA) synovial tissue CD4+ memory T cells, wher...

    Authors: Toshihiro Nanki and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2000 2:415
  10. We propose that the phenomenon of X-chromosome inactivation in females may constitute a risk factor for loss of T-cell tolerance; specifically that skewed X-chromosome inactivation in the thymus may lead to in...

    Authors: Smita Chitnis, Joanita Monteiro, David Glass, Brian Apatoff, Jane Salmon, Patrick Concannon and Peter K Gregersen
    Citation: Arthritis Research & Therapy 2000 2:399

    The Erratum to this article has been published in Arthritis Research & Therapy 2001 3:E001

  11. Leukocyte ingress into the synovium is a key process in the pathogenesis of rheumatoid arthritis and other inflammatory conditions. In this review, the role of endothelial cells in leukocyte extravasation will...

    Authors: Zoltan Szekanecz and Alisa E Koch
    Citation: Arthritis Research & Therapy 2000 2:368
  12. The substantial progress in our understanding of molecular and cellular biology has allowed us to design biological therapeutics ('biologicals') with defined targets and effector functions. These biologicals h...

    Authors: Hendrik Schulze-Koops and Joachim R Kalden
    Citation: Arthritis Research & Therapy 2000 2:337

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