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  1. This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory cytokines and oxidative str...

    Authors: Georg Schett, Makiyeh Tohidast-Akrad, Günter Steiner and Josef Smolen
    Citation: Arthritis Research & Therapy 2001 3:80
  2. Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages are attracted i...

    Authors: Kenji Hayashida, Toshihiro Nanki, Hermann Girschick, Sule Yavuz, Takahiro Ochi and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2001 3:118
  3. The causes of rheumatoid arthritis (RA) are largely unknown. However, RA is most probably a multifactorial disease with contributions from genetic and environmental factors. Searches for genes that influence R...

    Authors: Johan Jirholt, Anna-Karin B Lindqvist and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2000 3:87
  4. The underlying molecular defect resulting in the abnormal calcification observed in ank/ank mice has been identified. The responsible nonsense mutation affects the protein product of ank, resulting in diminished ...

    Authors: Lawrence M Ryan
    Citation: Arthritis Research & Therapy 2000 3:77
  5. Most anti-inflammatory drugs have been associated with an increased risk of serious upper gastrointestinal complications. Epidemiological studies have estimated the magnitude of the risk for specific anti-infl...

    Authors: Luis Alberto García Rodríguez and Sonia Hernández-Díaz
    Citation: Arthritis Research & Therapy 2000 3:98
  6. To reduce culture artifacts by conventional repeated passaging and long-term culture in vitro, the isolation of synovial fibroblasts (SFB) was attempted from rheumatoid arthritis (RA) synovial membranes by trypsi...

    Authors: Thomas Zimmermann, Elke Kunisch, Robert Pfeiffer, Astrid Hirth, Hans-Detlev Stahl, Ulrich Sack, Anke Laube, Eckehard Liesaus, Andreas Roth, Ernesta Palombo-Kinne, Frank Emmrich and Raimund W Kinne
    Citation: Arthritis Research & Therapy 2000 3:72
  7. Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are considered to be master cytokines in chronic, destructive arthritis. Therapeutic approaches in rheumatoid arthritis (RA) patients have so far focused ma...

    Authors: Wim B van den Berg
    Citation: Arthritis Research & Therapy 2000 3:18
  8. Paired synovial tissue samples were obtained from both clinically uninvolved (CU) and clinically involved (CI) knee joints of eight rheumatoid arthritis (RA) patients. In addition, biopsies were taken from fiv...

    Authors: Maarten C Kraan, Dhavalkumar D Patel, Jasper J Haringman, Malcolm D Smith, Helen Weedon, Michael J Ahern, Ferdinand C Breedveld and Paul P Tak
    Citation: Arthritis Research & Therapy 2000 3:65
  9. We discuss major topics presented at this recent international workshop, illustrating how recent progress in areas as diverse as free radical biochemistry, developmental biology, molecular genetics and vascula...

    Authors: Frank A Wollheim, Christopher P Denton and David J Abraham
    Citation: Arthritis Research & Therapy 2000 3:34
  10. The present study demonstrates that endogenous production of IL-12 is crucial for survival in Staphylococcus aureus-induced arthritis in mice. Staphylococcal load is enhanced in several organs, because of lack of...

    Authors: Olof H Hultgren, Martin Stenson and Andrzej Tarkowski
    Citation: Arthritis Research & Therapy 2000 3:41
  11. CD4+ memory T cells (Tm) from rheumatoid arthritis peripheral blood (RAPB) or peripheral blood from normal donors produced IL-2, whereas fewer cells secreted IFN-γ or IL-4 after a brief stimulation. RAPB Tm conta...

    Authors: Laurie S Davis, John J Cush, Hendrik Schulze-Koops and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2000 3:54
  12. The contribution of osteoclasts to the process of bone loss in inflammatory arthritis has recently been demonstrated. Studies in osteoclast biology have led to the identification of factors responsible for the...

    Authors: Ellen M Gravallese, Deborah L Galson, Steven R Goldring and Philip E Auron
    Citation: Arthritis Research & Therapy 2000 3:6
  13. We have analyzed the pattern of procoagulant and fibrinolytic gene expression in affected joints during the course of arthritis in two murine models. In both models, we found an increased expression of tissue ...

    Authors: Roberto Salvi, Veronique Péclat, Alexander So and Nathalie Busso
    Citation: Arthritis Research & Therapy 2000 2:504

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