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  1. Changes in sulfation of cartilage glycosaminoglycans as mediated by sulfatases can regulate growth factor signaling. The aim of this study was to analyze expression patterns of recently identified extracellula...

    Authors: Shuhei Otsuki, Noboru Taniguchi, Shawn P Grogan, Darryl D'Lima, Mitsuo Kinoshita and Martin Lotz
    Citation: Arthritis Research & Therapy 2008 10:R61
    Content type: Research article Published on:

  2. The endogenous pain-relieving system depends in part on the regulation of nociceptive signals through binding of opioids to the corresponding opioid receptor. Interfering with the trans-repression effect of do...

    Authors: Nataša Reisch, Andrea Engler, André Aeschlimann, Beat R Simmen, Beat A Michel, Renate E Gay, Steffen Gay and Haiko Sprott
    Citation: Arthritis Research & Therapy 2008 10:R60
    Content type: Research article Published on:

  3. In July 2007 a subject died while enrolled in an arthritis gene therapy trial. The study was placed on clinical hold while the circumstances surrounding this tragedy were investigated. Early in December 2007 t...

    Authors: Christopher H Evans, Steven C Ghivizzani and Paul D Robbins
    Citation: Arthritis Research & Therapy 2008 10:110
    Content type: Commentary Published on:

  4. Rheumatoid arthritis (RA) is associated with altered metabolism leading to muscle wasting. In the general population, cigarette smoking is known to affect body composition by reducing fat and inhibiting muscle...

    Authors: Antonios Stavropoulos-Kalinoglou, Giorgos S Metsios, Vasileios F Panoulas, Karen MJ Douglas, Alan M Nevill, Athanasios Z Jamurtas, Marina Kita, Yiannis Koutedakis and George D Kitas
    Citation: Arthritis Research & Therapy 2008 10:R59
    Content type: Research article Published on:

  5. Meniscal injury is a risk factor for the development and progression of knee osteoarthritis, yet little is known about risk factors for meniscal pathology. Joint loading mediated via gait parameters may be ass...

    Authors: Miranda L Davies-Tuck, Anita E Wluka, Andrew J Teichtahl, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Graeme Jones, Changhai Ding, Susan R Davis and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2008 10:R58
    Content type: Research article Published on:

  9. While consumption of omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) has been recommended for those at risk of inflammatory disease such as rheumatoid arthritis, the mechanism of their anti-inflammato...

    Authors: Violet R Mukaro, Maurizio Costabile, Karen J Murphy, Charles S Hii, Peter R Howe and Antonio Ferrante
    Citation: Arthritis Research & Therapy 2008 10:R57
    Content type: Research article Published on:

  10. We evaluated polysomnograms of chronic fatigue syndrome (CFS) patients with and without fibromyalgia to determine whether patients in either group had elevated rates of sleep-disturbed breathing (obstructive s...

    Authors: Fumiharu Togo, Benjamin H Natelson, Neil S Cherniack, Jennifer FitzGibbons, Carmen Garcon and David M Rapoport
    Citation: Arthritis Research & Therapy 2008 10:R56
    Content type: Research article Published on:

  11. The purpose of this study was to analyze the data of patients with T-cell large granular lymphocyte (T-LGL) lymphocytosis associated with inflammatory arthropathy or with no arthritis symptoms.

    Authors: Monika Prochorec-Sobieszek, Grzegorz Rymkiewicz, Hanna Makuch-Łasica, Mirosław Majewski, Katarzyna Michalak, Robert Rupiński, Krzysztof Warzocha and Renata Maryniak
    Citation: Arthritis Research & Therapy 2008 10:R55
    Content type: Research article Published on:

  12. Conflicting findings on the association of single nucleotide polymorphisms (SNPs) in RHOB and TXNDC3 with susceptibility to knee osteoarthritis (OA) have been reported in European Caucasians. To examine the assoc...

    Authors: Dongquan Shi, Takahiro Nakamura, Masahiro Nakajima, Jin Dai, Jianghui Qin, Haijian Ni, Yong Xu, Chen Yao, Jia Wei, Baorui Liu, Shiro Ikegawa and Qing Jiang
    Citation: Arthritis Research & Therapy 2008 10:R54
    Content type: Research article Published on:

  13. Subjects with metabolic syndrome–a constellation of cardiovascular risk factors of which central obesity and insulin resistance are the most characteristic–are at increased risk for developing diabetes mellitu...

    Authors: Prodromos I Sidiropoulos, Stylianos A Karvounaris and Dimitrios T Boumpas
    Citation: Arthritis Research & Therapy 2008 10:207
    Content type: Review Published on:

  14. Patient adherence to therapy in clinical practice is often low, and the difference between efficacy measured in clinical trials and effectiveness in clinical practice is probably a function of discontinuation ...

    Authors: R Andrew Moore, Sheena Derry and Henry J McQuay
    Citation: Arthritis Research & Therapy 2008 10:R53
    Content type: Research article Published on:

  15. PTPN22, PADI-4, and CTLA-4 have been associated with risk for rheumatoid arthritis (RA). We investigated whether polymorphisms in these genes were associated with RA in Caucasian women included in two large prosp...

    Authors: Karen H Costenbader, Shun-Chiao Chang, Immaculata De Vivo, Robert Plenge and Elizabeth W Karlson
    Citation: Arthritis Research & Therapy 2008 10:R52
    Content type: Research article Published on:

  16. The purpose of this study was to investigate the prevalence of cyclic citrullinated peptide antibodies (anti-CCP) in patients with primary Sjögren syndrome (pSS) and its correlation with clinical and laborator...

    Authors: Fabiola Atzeni, Piercarlo Sarzi-Puttini, Nicola Lama, Eleonora Bonacci, Francesca Bobbio-Pallavicini, Carlomaurizio Montecucco and Roberto Caporali
    Citation: Arthritis Research & Therapy 2008 10:R51
    Content type: Research article Published on:

  17. About 30% of rheumatoid arthritis patients fail to respond adequately to TNFα-blocking therapy. There is a medical and socioeconomic need to identify molecular markers for an early prediction of responders and...

    Authors: Dirk Koczan, Susanne Drynda, Michael Hecker, Andreas Drynda, Reinhard Guthke, Joern Kekow and Hans-Juergen Thiesen
    Citation: Arthritis Research & Therapy 2008 10:R50
    Content type: Research article Published on:

  18. Oral tolerance induction is thought to depend on special antigen presenting cells in the gut. A new report in the previous issue of Arthritis Research & Therapy supports this idea by demonstrating that indoleamin...

    Authors: Jun Wang and Rene EM Toes
    Citation: Arthritis Research & Therapy 2008 10:108
    Content type: Editorial Published on:

  19. Several systemic autoimmune diseases are associated with an increased prevalence of atherosclerosis which could not be explained by traditional risk factors alone. In systemic sclerosis (SSc), microvascular ab...

    Authors: Martha E Hettema, Dan Zhang, Karina de Leeuw, Ymkje Stienstra, Andries J Smit, Cees GM Kallenberg and Hendrika Bootsma
    Citation: Arthritis Research & Therapy 2008 10:R49
    Content type: Research article Published on:

  20. Fibroblast growth factor 2 (FGF2) is a growth factor that is immediately released after cartilage injury and plays a pivotal role in cartilage homeostasis. In human adult articular cartilage, FGF2 mediates ant...

    Authors: Xin Li, Howard S An, Michael Ellman, Frank Phillips, Eugene J Thonar, Daniel K Park, Ranjith K Udayakumar and Hee-Jeong Im
    Citation: Arthritis Research & Therapy 2008 10:R48
    Content type: Research article Published on:

  21. A surprising feature of the inflammatory infiltrate in rheumatoid arthritis is the accumulation of neutrophils within synovial fluid and at the pannus cartilage boundary. Recent findings suggest that a distinc...

    Authors: Greg Parsonage, Andrew Filer, Magdalena Bik, Debbie Hardie, Sian Lax, Katherine Howlett, Leigh D Church, Karim Raza, See-Heng Wong, Emily Trebilcock, Dagmar Scheel-Toellner, Mike Salmon, Janet M Lord and Christopher D Buckley
    Citation: Arthritis Research & Therapy 2008 10:R47
    Content type: Research article Published on:

  22. The avascular nature of the human intervertebral disc (IVD) is thought to play a major role in disc pathophysiology by limiting nutrient supply to resident IVD cells. In the human IVD, the central IVD cells at...

    Authors: William EB Johnson, Simon Stephan and Sally Roberts
    Citation: Arthritis Research & Therapy 2008 10:R46
    Content type: Research article Published on:

  23. The risk of malignancies in patients with rheumatoid arthritis (RA) has raised some concern, particularly with immunosuppressive approaches to disease management.

    Authors: Allison L Smitten, Teresa A Simon, Marc C Hochberg and Samy Suissa
    Citation: Arthritis Research & Therapy 2008 10:R45
    Content type: Research article Published on:

    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:232

  24. The discovery in mice of a new lineage of CD4+ effector T helper (Th) cells that selectively produce IL-17 has provided exciting new insights into immune regulation, host defence, and the pathogenesis of autoimmu...

    Authors: Sergio Romagnani
    Citation: Arthritis Research & Therapy 2008 10:206
    Content type: Review Published on:

  27. Cannabis-based medicines have a number of therapeutic indications, including anti-inflammatory and analgesic effects. The endocannabinoid receptor system, including the cannabinoid receptor 1 (CB1) and receptor 2...

    Authors: Denise Richardson, Richard G Pearson, Nisha Kurian, M Liaque Latif, Michael J Garle, David A Barrett, David A Kendall, Brigitte E Scammell, Alison J Reeve and Victoria Chapman
    Citation: Arthritis Research & Therapy 2008 10:R43
    Content type: Research article Published on:

  28. Tissue factor (TF) activation of the coagulation proteases enhances inflammation in animal models of arthritis and endotoxemia, but the mechanism of this effect is not yet fully understood – in particular, whe...

    Authors: Nathalie Busso, Veronique Chobaz-Péclat, Justin Hamilton, Pieter Spee, Nicolai Wagtmann and Alexander So
    Citation: Arthritis Research & Therapy 2008 10:R42
    Content type: Research article Published on:

  29. It was recently suggested that heat shock protein (HSP)70, an intracellular protein, is a potential mediator of inflammatory disease when it is released into the extracellular compartment. Although elevated HS...

    Authors: Xinjing Luo, Xiaoxia Zuo, Yaou Zhou, Bing Zhang, Yongzhong Shi, Meidong Liu, Kangkai Wang, D Randy McMillian and Xianzhong Xiao
    Citation: Arthritis Research & Therapy 2008 10:R41
    Content type: Research article Published on:

  30. Bacteria and/or their antigens have been implicated in the pathogenesis of reactive arthritis (ReA). Several studies have reported the presence of bacterial antigens and nucleic acids of bacteria other than th...

    Authors: Mariam Siala, Benoit Jaulhac, Radhouane Gdoura, Jean Sibilia, Hela Fourati, Mohamed Younes, Sofien Baklouti, Naceur Bargaoui, Slaheddine Sellami, Abir Znazen, Cathy Barthel, Elody Collin, Adnane Hammami and Abdelghani Sghir
    Citation: Arthritis Research & Therapy 2008 10:R40
    Content type: Research article Published on:

  31. Osteoarthritis trials usually report average changes in visual analogue scale (VAS) pain, and examine the difference between treatment and placebo. We investigated whether dichotomous responder analysis provid...

    Authors: R Andrew Moore, Owen A Moore, Sheena Derry and Henry J McQuay
    Citation: Arthritis Research & Therapy 2008 10:R39
    Content type: Research article Published on:

  33. In the past few years considerable advances have been made in the genetics of susceptibility to rheumatoid arthritis (RA). For decades the HLA-DRB1 alleles were the only extensively replicated genetic factor, ...

    Authors: Annette HM van der Helm-van Mil and Tom WJ Huizinga
    Citation: Arthritis Research & Therapy 2008 10:205
    Content type: Review Published on:

  34. The objective of the present study was to investigate the role of the stromal cell-derived factor 1 (SDF-1)/CXCR4 axis in TNF-induced mobilization of osteoclast precursors (OCPs) from bone marrow.

    Authors: Qian Zhang, Ruolin Guo, Edward M Schwarz, Brendan F Boyce and Lianping Xing
    Citation: Arthritis Research & Therapy 2008 10:R37
    Content type: Research article Published on:

  35. Previously we described a system whereby human peripheral blood T cells stimulated for 8 days in a cytokine cocktail acquired effector function for contact-dependent induction of proinflammatory cytokines from...

    Authors: Fionula M Brennan, Nicola MG Smith, Sally Owen, Ching Li, Parisa Amjadi, Patricia Green, Anna Andersson, Andrew C Palfreeman, Philippa Hillyer, Andrew Foey, Jonathan T Beech and Marc Feldmann
    Citation: Arthritis Research & Therapy 2008 10:R36
    Content type: Research article Published on:

  36. Nitric oxide and prostaglandin E2 (PGE2play pivotal roles in both the pathogenesis of osteoarthritis and catabolic processes in articular cartilage. These mediators are influenced by both IL-1β and mechanical loa...

    Authors: TT Chowdhury, S Arghandawi, J Brand, OO Akanji, DL Bader, DM Salter and DA Lee
    Citation: Arthritis Research & Therapy 2008 10:R35
    Content type: Research article Published on:

  37. The purpose of this study was to investigate the effects of vegan diet in patients with rheumatoid arthritis (RA) on blood lipids oxidized low-density lipoprotein (oxLDL) and natural atheroprotective antibodie...

    Authors: Ann-Charlotte Elkan, Beatrice Sjöberg, Björn Kolsrud, Bo Ringertz, Ingiäld Hafström and Johan Frostegård
    Citation: Arthritis Research & Therapy 2008 10:R34
    Content type: Research article Published on:

  38. High-mobility group box chromosomal protein 1 (HMGB1) has recently been identified as an endogenous mediator of arthritis. TNF and IL-1β, pivotal cytokines in arthritis pathogenesis, both have the ability to i...

    Authors: Erik Sundberg, Cecilia Grundtman, Erik af Klint, Johan Lindberg, Sofia Ernestam, Ann-Kristin Ulfgren, Helena Erlandsson Harris and Ulf Andersson
    Citation: Arthritis Research & Therapy 2008 10:R33
    Content type: Research article Published on:

  39. Progress into the understanding of immunopathology in rheumatoid arthritis is reviewed in the present article with regard to pro-inflammatory cytokine production, cell activation and recruitment, and osteoclas...

    Authors: Anna K Andersson, Ching Li and Fionula M Brennan
    Citation: Arthritis Research & Therapy 2008 10:204
    Content type: Review Published on:

  40. Mannose-binding lectin (MBL) is an innate immune protein. The aim of our study was to determine whether genetically determined MBL deficiency is associated with susceptibility to juvenile rheumatoid arthritis ...

    Authors: Koert M Dolman, Nannette Brouwer, Florine NJ Frakking, Berit Flatø, Paul P Tak, Taco W Kuijpers, Øystein Førre and Anna Smerdel-Ramoya
    Citation: Arthritis Research & Therapy 2008 10:R32
    Content type: Research article Published on:

  41. In the present issue of Arthritis Research & Therapy data are presented suggesting that antirheumatic therapies decrease the risk of cardiovascular disease in patients with rheumatoid arthritis. The QUEST-RA grou...

    Authors: Ronald F van Vollenhoven
    Citation: Arthritis Research & Therapy 2008 10:105
    Content type: Editorial Published on:

  42. The aim of this study was to compare cardiovascular autonomic nervous system function in patients with primary Sjögren's syndrome (pSS) with that in control individuals, and to correlate the findings with auto...

    Authors: Fin ZJ Cai, Sue Lester, Tim Lu, Helen Keen, Karyn Boundy, Susanna M Proudman, Anne Tonkin and Maureen Rischmueller
    Citation: Arthritis Research & Therapy 2008 10:R31
    Content type: Research article Published on:

  43. We analyzed the prevalence of cardiovascular (CV) disease in patients with rheumatoid arthritis (RA) and its association with traditional CV risk factors, clinical features of RA, and the use of disease-modify...

    Authors: Antonio Naranjo, Tuulikki Sokka, Miguel A Descalzo, Jaime Calvo-Alén, Kim Hørslev-Petersen, Reijo K Luukkainen, Bernard Combe, Gerd R Burmester, Joe Devlin, Gianfranco Ferraccioli, Alessia Morelli, Monique Hoekstra, Maria Majdan, Stefan Sadkiewicz, Miguel Belmonte, Ann-Carin Holmqvist…
    Citation: Arthritis Research & Therapy 2008 10:R30
    Content type: Research article Published on:

    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:242

  44. It is well known that interferon (IFN)-α is important to the pathogenesis of systemic lupus erythematosus (SLE). However, several reports have indicated that the number of IFN-α producing cells are decreased o...

    Authors: Seung-Ki Kwok, June-Yong Lee, Se-Ho Park, Mi-La Cho, So-Youn Min, Sung-Hwan Park, Ho-Youn Kim and Young-Gyu Cho
    Citation: Arthritis Research & Therapy 2008 10:R29
    Content type: Research article Published on:

  45. Prognosis in rheumatoid arthritis (RA) is difficult to assess. The aim of this study was to examine whether serum levels of a spectrum of cytokines were predictive of radiographic progression in early RA patie...

    Authors: Silje W Syversen, Guro L Goll, Espen A Haavardsholm, Pernille Bøyesen, Tor Lea and Tore K Kvien
    Citation: Arthritis Research & Therapy 2008 10:R28
    Content type: Research article Published on:

  46. Elevated serum high sensitivity C-reactive protein (hsCRP) has been reported in established osteoarthritis (OA). The aim of this study was to determine whether serum levels of hsCRP are associated with the var...

    Authors: Fahad S Hanna, Robin J Bell, Flavia M Cicuttini, Sonia L Davison, Anita E Wluka and Susan R Davis
    Citation: Arthritis Research & Therapy 2008 10:R27
    Content type: Research article Published on:

  47. Rheumatoid arthritis (RA) is a complex polygenic disease of unknown etiology. HLA-DRB1 alleles encoding the shared epitope (SE) (RAA amino acid pattern in positions 72 to 74 of the third hypervariable region of t...

    Authors: Thomas Barnetche, Arnaud Constantin, Alain Cantagrel, Anne Cambon-Thomsen and Pierre-Antoine Gourraud
    Citation: Arthritis Research & Therapy 2008 10:R26
    Content type: Research article Published on:

  48. The objectives of the present study were, with multidetector computed tomography (CT) as the reference method, to determine the performance of magnetic resonance imaging (MRI) and radiography for the detection...

    Authors: Uffe Møller Døhn, Bo J Ejbjerg, Maria Hasselquist, Eva Narvestad, Jakob Møller, Henrik S Thomsen and Mikkel Østergaard
    Citation: Arthritis Research & Therapy 2008 10:R25
    Content type: Research article Published on:
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Arthritis Research & Therapy

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